JP5937608B2 - 酵素ｐｄｅ１０ａ阻害剤としてのイミダゾール誘導体 - Google Patents

酵素ｐｄｅ１０ａ阻害剤としてのイミダゾール誘導体 Download PDF

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JP5937608B2
JP5937608B2 JP2013539140A JP2013539140A JP5937608B2 JP 5937608 B2 JP5937608 B2 JP 5937608B2 JP 2013539140 A JP2013539140 A JP 2013539140A JP 2013539140 A JP2013539140 A JP 2013539140A JP 5937608 B2 JP5937608 B2 JP 5937608B2
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triazolo
imidazo
compound
group
dimethyl
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JP2013542963A5 (enExample
JP2013542963A (ja
Inventor
キーラー，ヤン
ニールセン，ヤコブ
マリゴ，マルオ
キルバーン，ジョン，ポール
ランガード，モルテン
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ハー・ルンドベック・アクチエゼルスカベット
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2013539140A 2010-11-19 2011-11-18 酵素ｐｄｅ１０ａ阻害剤としてのイミダゾール誘導体 Expired - Fee Related JP5937608B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41535610P 2010-11-19 2010-11-19
DKPA201001045 2010-11-19
US61/415,356 2010-11-19
DKPA201001045 2010-11-19
PCT/DK2011/000136 WO2012065612A1 (en) 2010-11-19 2011-11-18 Imidazole derivatives as pde10a enzyme inhibitors

Publications (3)

Publication Number Publication Date
JP2013542963A JP2013542963A (ja) 2013-11-28
JP2013542963A5 JP2013542963A5 (enExample) 2015-01-08
JP5937608B2 true JP5937608B2 (ja) 2016-06-22

Family

ID=45217102

Family Applications (1)

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JP2013539140A Expired - Fee Related JP5937608B2 (ja) 2010-11-19 2011-11-18 酵素ｐｄｅ１０ａ阻害剤としてのイミダゾール誘導体

Country Status (32)

Country Link
EP (1) EP2640731B9 (enExample)
JP (1) JP5937608B2 (enExample)
KR (1) KR101916487B1 (enExample)
CN (1) CN103328487B (enExample)
AP (1) AP3342A (enExample)
AR (1) AR083926A1 (enExample)
AU (1) AU2011331607B2 (enExample)
BR (1) BR112013012378A2 (enExample)
CA (1) CA2817663C (enExample)
CR (1) CR20130226A (enExample)
DK (1) DK2640731T3 (enExample)
EA (1) EA027082B1 (enExample)
EC (1) ECSP13012698A (enExample)
ES (1) ES2547090T3 (enExample)
GE (1) GEP20156346B (enExample)
GT (1) GT201300130A (enExample)
HU (1) HUE025596T2 (enExample)
JO (1) JO3089B1 (enExample)
ME (1) ME02193B (enExample)
MY (1) MY163327A (enExample)
NZ (1) NZ610353A (enExample)
PE (1) PE20141534A1 (enExample)
PH (1) PH12013500968A1 (enExample)
PL (1) PL2640731T3 (enExample)
PT (1) PT2640731E (enExample)
RS (1) RS54210B1 (enExample)
SG (1) SG190282A1 (enExample)
SI (1) SI2640731T1 (enExample)
TW (1) TWI541245B (enExample)
UA (1) UA112065C2 (enExample)
WO (1) WO2012065612A1 (enExample)
ZA (1) ZA201303607B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8552045B2 (en) 2010-11-19 2013-10-08 H. Lundbeck A/S Tricyclic imidazole compounds as PDE10 inhibitors
JP6106603B2 (ja) * 2011-01-11 2017-04-05 スノビオン プハルマセウトイカルス インコーポレイテッド ヘテロアリール化合物及びその使用方法
WO2013045607A1 (en) * 2011-09-30 2013-04-04 H. Lundbeck A/S Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors
WO2013107856A1 (en) * 2012-01-20 2013-07-25 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2013192273A1 (en) * 2012-06-19 2013-12-27 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
CN103435617B (zh) * 2013-08-22 2016-04-27 南京华安药业有限公司 一种6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛的合成方法
JO3627B1 (ar) 2015-04-30 2020-08-27 H Lundbeck As إيميدازو بيرازينونات على هيئة مثبطات pde1
TWI729109B (zh) 2016-04-12 2021-06-01 丹麥商Ｈ 朗德貝克公司 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮
US10633382B2 (en) 2016-10-18 2020-04-28 H. Lundbeck A/S Imidazopyrazinones, pyrazolopyrimidinones and pyrazolopyridinones as PDE1 inhibitors
LT3532064T (lt) 2016-10-28 2020-09-25 H. Lundbeck A/S Kompleksiniai gydymai, apimantys imidazopirazonus, skirti psichiatrinių ir (arba) kognityvinių sutrikimų gydymui
RU2019108717A (ru) 2016-10-28 2020-11-30 Х. Лундбекк А/С Комбинированные средства для лечения, предусматривающего введение имидазопиразинонов
WO2020094591A1 (en) 2018-11-06 2020-05-14 H. Lundbeck A/S Pde10a inhibitors for treating negative symptoms and cognitive impairments in a patient suffering from schizophrenia
CN109776527A (zh) * 2019-02-21 2019-05-21 药雅科技(上海)有限公司 一种5-溴-7-氮杂吲哚的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8307865D0 (en) 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
US5571775A (en) 1994-07-11 1996-11-05 Dowelanco N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides
IL149106A0 (en) 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
EP1641457B1 (en) 2003-06-30 2009-08-05 Nycomed GmbH Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
MXPA05013553A (es) 2003-06-30 2006-03-09 Altana Pharma Ag Pirrolodihidroisoquinolinas como inhibidores de pde10.
EP1651251A4 (en) 2003-07-31 2008-06-18 Bayer Pharmaceuticals Corp METHOD FOR THE TREATMENT OF DIABETES AND RELATED DISEASES USING PDE 10A INHIBITORS
EP1723134A2 (en) 2004-02-18 2006-11-22 Pfizer Products Incorporated Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
BRPI0511854A (pt) 2004-06-07 2008-01-15 Pfizer Prod Inc inibição de fosfodiestearase 10 como tratamento para condições relacionados com a obesidade e relacionadas a sìndrome metabólica
US20060019975A1 (en) 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
CA2578996A1 (en) 2004-09-03 2006-03-16 Memory Pharmaceuticals Corporation 4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
US8133897B2 (en) * 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
TWI501965B (zh) * 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
PT2443105E (pt) * 2009-06-19 2015-01-14 Lundbeck & Co As H Novo derivado de fenilimidazole como inibidor da enzima pde10a
TW201200516A (en) * 2009-12-17 2012-01-01 Lundbeck & Co As H Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors
TWI481607B (zh) * 2009-12-17 2015-04-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物
TWI485151B (zh) * 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物

Also Published As

Publication number Publication date
MY163327A (en) 2017-09-15
AR083926A1 (es) 2013-04-10
EP2640731A1 (en) 2013-09-25
BR112013012378A2 (pt) 2016-08-30
AU2011331607B2 (en) 2016-05-19
SG190282A1 (en) 2013-06-28
DK2640731T3 (en) 2015-08-31
AP3342A (en) 2015-07-31
ECSP13012698A (es) 2013-08-30
WO2012065612A1 (en) 2012-05-24
ZA201303607B (en) 2014-07-30
PE20141534A1 (es) 2014-11-16
KR101916487B1 (ko) 2018-11-07
CN103328487A (zh) 2013-09-25
ME02193B (me) 2016-02-20
PT2640731E (pt) 2015-10-13
PL2640731T3 (pl) 2015-11-30
HUE025596T2 (en) 2016-03-29
TWI541245B (zh) 2016-07-11
CA2817663A1 (en) 2012-05-24
KR20140009192A (ko) 2014-01-22
TW201300391A (zh) 2013-01-01
GT201300130A (es) 2015-01-16
AU2011331607A1 (en) 2013-05-30
ES2547090T3 (es) 2015-10-01
EA201390741A1 (ru) 2013-11-29
NZ610353A (en) 2015-01-30
JO3089B1 (ar) 2017-03-15
AP2013006928A0 (en) 2013-06-30
CR20130226A (es) 2013-09-03
GEP20156346B (en) 2015-08-10
PH12013500968A1 (en) 2022-10-24
UA112065C2 (uk) 2016-07-25
EP2640731B9 (en) 2015-11-25
SI2640731T1 (sl) 2015-10-30
CN103328487B (zh) 2015-11-25
EP2640731B1 (en) 2015-07-08
RS54210B1 (sr) 2015-12-31
EA027082B1 (ru) 2017-06-30
CA2817663C (en) 2020-04-28
JP2013542963A (ja) 2013-11-28

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