JP5936067B2 - 抗ｐ２ｘ７受容体抗体およびその断片 - Google Patents

抗ｐ２ｘ７受容体抗体およびその断片 Download PDF

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Publication number
JP5936067B2
JP5936067B2 JP2012525000A JP2012525000A JP5936067B2 JP 5936067 B2 JP5936067 B2 JP 5936067B2 JP 2012525000 A JP2012525000 A JP 2012525000A JP 2012525000 A JP2012525000 A JP 2012525000A JP 5936067 B2 JP5936067 B2 JP 5936067B2
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antigen binding
antibody
sequence
binding site
cancer
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Japanese (ja)
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JP2013502204A5 (https=
JP2013502204A (ja
Inventor
ジュリアン・アレクサンダー・バーデン
ニール・ブルース
フィリップ・ジョーンズ
スティーブン・グラント
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バイオセプター・（オーストラリア）・ピーティーワイ・リミテッド
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Priority claimed from AU2009903928A external-priority patent/AU2009903928A0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012525000A 2009-08-20 2010-08-20 抗ｐ２ｘ７受容体抗体およびその断片 Active JP5936067B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2009903928 2009-08-20
AU2009903928A AU2009903928A0 (en) 2009-08-20 Anti P2X7 receptor antibodies and fragments thereof
PCT/AU2010/001070 WO2011020155A1 (en) 2009-08-20 2010-08-20 Anti p2x7 receptor antibodies and fragments thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016019816A Division JP6224141B2 (ja) 2009-08-20 2016-02-04 抗ｐ２ｘ７受容体抗体およびその断片

Publications (3)

Publication Number Publication Date
JP2013502204A JP2013502204A (ja) 2013-01-24
JP2013502204A5 JP2013502204A5 (https=) 2013-10-03
JP5936067B2 true JP5936067B2 (ja) 2016-06-15

Family

ID=43606479

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2012525000A Active JP5936067B2 (ja) 2009-08-20 2010-08-20 抗ｐ２ｘ７受容体抗体およびその断片
JP2016019816A Active JP6224141B2 (ja) 2009-08-20 2016-02-04 抗ｐ２ｘ７受容体抗体およびその断片
JP2017193317A Active JP6417016B2 (ja) 2009-08-20 2017-10-03 抗ｐ２ｘ７受容体抗体およびその断片

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2016019816A Active JP6224141B2 (ja) 2009-08-20 2016-02-04 抗ｐ２ｘ７受容体抗体およびその断片
JP2017193317A Active JP6417016B2 (ja) 2009-08-20 2017-10-03 抗ｐ２ｘ７受容体抗体およびその断片

Country Status (5)

Country Link
US (6) US9127059B2 (https=)
EP (3) EP2467404B1 (https=)
JP (3) JP5936067B2 (https=)
ES (3) ES2704711T3 (https=)
WO (1) WO2011020155A1 (https=)

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WO2011075789A1 (en) 2009-12-24 2011-06-30 Biosceptre International Limited Antibodies to non-functional oligomeric p2x7 receptors
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CN114173811A (zh) * 2019-07-26 2022-03-11 生物权威(澳大利亚)有限责任公司 P2x7受体靶向治疗
CN111171149B (zh) * 2020-02-23 2021-09-07 北京康普美特创新医药科技有限责任公司 一种抗补体c5分子的人源化单链抗体及其应用
CN111234016B (zh) * 2020-02-23 2021-09-07 北京康普美特创新医药科技有限责任公司 一种抗补体c5分子的全人源单克隆抗体及应用
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Also Published As

Publication number Publication date
ES2557456T3 (es) 2016-01-26
US20150266969A1 (en) 2015-09-24
EP3395832B1 (en) 2021-11-24
EP2966090B1 (en) 2018-10-10
US12129295B2 (en) 2024-10-29
US10053508B2 (en) 2018-08-21
ES2904911T3 (es) 2022-04-06
US9127059B2 (en) 2015-09-08
EP2966090A1 (en) 2016-01-13
US20120282278A1 (en) 2012-11-08
EP3395832A1 (en) 2018-10-31
ES2704711T3 (es) 2019-03-19
EP2467404A1 (en) 2012-06-27
EP2467404A4 (en) 2013-01-23
US9688771B2 (en) 2017-06-27
JP6417016B2 (ja) 2018-10-31
JP2016136949A (ja) 2016-08-04
JP2018023396A (ja) 2018-02-15
US20170327576A1 (en) 2017-11-16
EP2467404B1 (en) 2015-09-30
JP2013502204A (ja) 2013-01-24
US20190040129A1 (en) 2019-02-07
HK1168365A1 (en) 2012-12-28
JP6224141B2 (ja) 2017-11-01
US10988532B2 (en) 2021-04-27
US20220315652A1 (en) 2022-10-06
US20250084161A1 (en) 2025-03-13
WO2011020155A1 (en) 2011-02-24

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