JP5927176B2 - 神経組織と相互作用するためのデバイス、ならびにそれを作製および使用する方法 - Google Patents
神経組織と相互作用するためのデバイス、ならびにそれを作製および使用する方法 Download PDFInfo
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- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
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- A61B5/48—Other medical applications
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- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
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- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
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- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
Description
本出願は、2010年4月1日出願の米国仮出願第61/320,089号の優先権を主張し、その内容全体が参照により本明細書に組み入れられる。
本開示は概して、電気プローブを使用する生体組織との相互作用の分野、より特別には、微小電極プローブの使用を通じた神経標的との相互作用に関する。
神経記録および神経刺激は、組織と電気的に相互作用するために使用される医療機器の分類である。神経記録の場合、診断または処置することができる患者の神経組織の生理学的測定を行う。神経刺激の場合、治療成績を作成するかまたは診断を作成するために、電荷を組織に移動させる。神経記録および神経刺激デバイスは今日、蝸牛、網膜、末梢神経系、脊椎、脳および身体の他の部分に使用されている。
本開示は、組織の小さな立体の画像化を組織の立体内の正確な区域を刺激する能力と共に可能にする設計および方法を提供する。この画像化方法は、高価で低分解能のシステムに依存した従来の方法に対する進歩を示す。刺激方法は、有効な治療を行うために必要な、最適な組織活性化立体への電界の正確な方向付けを可能にしなかった従来の技術に対し、進歩を示す。組み合わされたこの画像化および刺激の方法は、初めて、特定の区域および立体における組織の正確で高分解能の刺激を提供する。
[本発明1001]
遠位端および内部管腔を有する細長い軸と、
内部管腔の遠位部にのみ摺動式に配設される支持円柱と、
支持円柱に結合しており、前記細長い軸の遠位端から選択的に延伸されるように配置された複数の軸と、
該複数の軸のそれぞれの上に配設された複数の微小電極要素であって、絶縁層および該絶縁層上に配設された複数の導電性トレースを有する平面状基材を含む微小電極要素と、
内部管腔に取り外し可能に配設されており、埋め込み中に、支持円柱に接触することで前記複数の軸を選択的に延伸させるように構成されたスタイレットと、
前記支持円柱および複数の軸を内部管腔内に選択的に後退させるように支持円柱に結合しているプルワイヤと
を含む、埋め込み式神経プローブ。
[本発明1002]
プルワイヤおよびスタイレットを含むプッシュプルロッドを含む、本発明1001の埋め込み式神経プローブ。
[本発明1003]
細長い軸が、脳深部刺激リードの挿入に許容される手技を使用するヒト身体への挿入用に構成されている、本発明1001の埋め込み式神経プローブ。
[本発明1004]
細長い軸の直径が1mm〜3mmである、本発明1001の埋め込み式神経プローブ。
[本発明1005]
複数の微小電極要素の少なくとも1つが刺激電極であり、複数の微小電極要素の少なくとも1つが検出電極である、本発明1001の埋め込み式神経プローブ。
[本発明1006]
複数の微小電極要素の少なくとも1つが刺激電極および検出電極の両方である、本発明1001の埋め込み式神経プローブ。
[本発明1007]
各微小電極要素が導電性フィルム上に形成され、各微小電極要素が2つの絶縁基材の内部に包埋されている、本発明1001の埋め込み式神経プローブ。
[本発明1008]
微小電極が包埋された基材が円柱状アセンブリに成形可能である、本発明1007の埋め込み式神経プローブ。
[本発明1009]
突出軸が円柱状アセンブリの縦軸から放射状に屈曲するように成形されうる、本発明1008の埋め込み式神経プローブ。
[本発明1010]
突出軸の1つが円柱状アセンブリの縦軸に沿って延伸しかつ中心を有する、本発明1008の埋め込み式神経プローブ。
[本発明1011]
突出軸が支持部材により補剛されている、本発明1009の埋め込み式神経プローブ。
[本発明1012]
縦方向の突出軸が支持部材により補剛されている、本発明1010の埋め込み式神経プローブ。
[本発明1013]
遠位端および内部管腔を有する細長い軸と、
該細長い軸の遠位端から選択的に延伸されるように配置された複数の軸と、
該複数の軸のそれぞれの上に配設された複数の微小電極要素であって、絶縁層および該絶縁層上に配設された複数の導電性トレースを有する平面状基材を含む微小電極要素と
を含む埋め込み式神経プローブであって、
前記複数の軸が、完全に延伸された際に実質的に円柱状の立体を規定する、
埋め込み式神経プローブ。
[本発明1014]
細長い軸が、脳深部刺激リードの挿入に許容される手技を使用するヒト身体への挿入用に構成されている、本発明1013の埋め込み式神経プローブ。
[本発明1015]
細長い軸の直径が1mm〜3mmである、本発明1013の埋め込み式神経プローブ。
[本発明1016]
複数の微小電極要素の少なくとも1つが刺激電極であり、複数の微小電極要素の少なくとも1つが検出電極である、本発明1013の埋め込み式神経プローブ。
[本発明1017]
複数の微小電極要素の少なくとも1つが刺激電極および検出電極の両方である、本発明1013の埋め込み式神経プローブ。
[本発明1018]
各微小電極要素が導電性フィルム上に形成され、各微小電極要素が2つの絶縁基材の内部に包埋されている、本発明1013の埋め込み式神経プローブ。
[本発明1019]
微小電極が包埋された基材が円柱状アセンブリに成形可能である、本発明1018の埋め込み式神経プローブ。
[本発明1020]
突出軸が円柱状アセンブリの縦軸から放射状に屈曲するように成形されうる、本発明1019の埋め込み式神経プローブ。
[本発明1021]
突出軸の1つが円柱状アセンブリの縦軸に沿って延伸しかつ中心を有する、本発明1019の埋め込み式神経プローブ。
[本発明1022]
突出軸が支持部材により補剛されている、本発明1019の埋め込み式神経プローブ。
[本発明1023]
縦方向の突出軸が支持部材により補剛されている、本発明1021の埋め込み式神経プローブ。
[本発明1024]
神経標的部位の近傍内に
遠位端および内部管腔を有する細長い軸と、
内部管腔の遠位部にのみ摺動式に配設される支持円柱と、
支持円柱に結合しており、前記細長い軸の遠位端から選択的に延伸されるように配置された複数の軸と、
該複数の軸のそれぞれの上に配設された複数の微小電極要素であって、絶縁層および該絶縁層上に配設された複数の導電性トレースを有する平面状基材を含む微小電極要素と、
内部管腔に取り外し可能に配設されており、埋め込み中に、支持円柱に接触することで前記複数の軸を選択的に延伸させるように構成されたスタイレットと、
前記支持円柱および複数の軸を内部管腔内に選択的に後退させるように支持円柱に結合しているプルワイヤと
を含む神経プローブを埋め込む段階、
外科的埋め込み前に、前記複数の軸を内部管腔内に後退させる段階、
埋め込み後に、神経標的部位の近傍に前記複数の軸を延伸させる段階、
突出軸の少なくとも1つの上の微小電極要素の少なくとも1つを使用して神経標的部位から電気生理学的信号を記録する段階、ならびに
前記複数の軸の少なくとも1つの上の微小電極要素の少なくとも1つを使用して神経標的を刺激する段階
を含む、神経標的を発見するための方法。
[本発明1025]
記録段階および刺激段階の後の、前記複数の軸を内部管腔内に後退させる段階、および対象から神経プローブを取り外す段階
をさらに含む、本発明1024の方法。
[本発明1026]
突出軸の後退にプルワイヤを使用する、本発明1024の方法。
[本発明1027]
前記複数の軸の延伸にスタイレットを使用する、本発明1024の方法。
[本発明1028]
神経プローブが、プルワイヤおよびスタイレットを含むプッシュプルロッドを含む、本発明1024の方法。
[本発明1029]
電気生理学的信号を記録する段階が、複数の微小電極要素の少なくとも1つにより検出される神経活動を記録する段階、および細長いプローブ軸の遠位端が神経標的部位に十分に位置づけられていることを記録された活動が示すまで、必要に応じて細長い軸の遠位端を再位置決めする段階を含む、本発明1024の方法。
[本発明1030]
前記複数の軸の少なくとも1つの上の複数の微小電極要素の少なくとも1つに電気信号を印加することにより神経活動を刺激する段階、
埋め込まれた患者において刺激部位に対する有効性の臨床評価を行う段階、および
細長い軸の遠位端が神経標的部位に十分に位置づけられていることを患者の応答が示すまで、必要に応じて細長い軸の遠位端を再位置決めする段階
を含む、本発明1024の方法。
[本発明1031]
前記複数の軸の少なくとも1つの上の複数の微小電極要素の少なくとも1つに電気信号を印加することにより神経活動を阻害する段階、
埋め込まれた患者において阻害部位に対する有効性の臨床評価を行う段階、および
細長い軸の遠位端が神経標的部位に十分に位置づけられていることを患者の応答が示すまで、必要に応じて細長い軸の遠位端を再位置決めする段階
を含む、本発明1024の方法。
[本発明1032]
神経標的部位の近傍内に
遠位端および内部管腔を有する細長い軸と、
内部管腔の遠位部にのみ摺動式に配設される支持円柱と、
支持円柱に結合しており、前記細長い軸の遠位端から選択的に延伸されるように配置された複数の軸と、
該複数の軸のそれぞれの上に配設された複数の微小電極要素であって、絶縁層および該絶縁層上に配設された複数の導電性トレースを有する平面状基材を含む微小電極要素と、
内部管腔に取り外し可能に配設されており、埋め込み中に、支持円柱に接触することで前記複数の軸を選択的に延伸させるように構成されたスタイレットと、
前記支持円柱および複数の軸を内部管腔内に選択的に後退させるように支持円柱に結合しているプルワイヤと
を含む神経プローブを埋め込む段階、
外科的埋め込み前に、前記複数の軸を内部管腔内に後退させる段階、
埋め込み後に、神経標的部位の近傍に前記複数の軸を展開させる段階、
前記複数の軸の少なくとも1つの上の微小電極要素の少なくとも2つの間に振動電流を印加する段階、
前記複数の軸の少なくとも1つの上の微小電極要素の少なくとも2つの間の電圧を検出する段階
を含む、神経標的を発見するための方法。
[本発明1033]
検出段階の後の、前記複数の軸を内部管腔内に後退させる段階、および対象から神経プローブを取り外す段階
をさらに含む、本発明1032の方法。
[本発明1034]
印加された振動電流および検出された電圧に基づいて、前記複数の軸の間の神経組織の立体の電気特性を画像化する段階を含む、本発明1032の方法。
[本発明1035]
神経プローブが、プルワイヤおよびスタイレットを含むプッシュプルロッドを含む、本発明1032の方法。
[本発明1036]
神経標的部位の近傍内に
遠位端および内部管腔を有する細長い軸と、
該細長い軸の遠位端から選択的に延伸されるように配置された複数の軸と、
該複数の軸のそれぞれの上に配設された複数の微小電極要素であって、絶縁層および該絶縁層上に配設された複数の導電性トレースを有する平面状基材を含む微小電極要素とを含む神経プローブであって、
前記複数の軸が、完全に延伸された際に実質的に円柱状の立体を規定する、
神経プローブを埋め込む段階、
外科的埋め込み前に、前記複数の軸を内部管腔内に後退させる段階、
埋め込み後に、神経標的部位の近傍に前記複数の軸を延伸させる段階、
突出軸の少なくとも1つの上の微小電極要素の少なくとも1つを使用して神経標的部位から電気生理学的信号を記録する段階、ならびに
前記複数の軸の少なくとも1つの上の微小電極要素の少なくとも1つを使用して神経標的を刺激する段階
を含む、神経標的を発見するための方法。
[本発明1037]
突出軸の後退にプルワイヤを使用する、本発明1036の方法。
[本発明1038]
前記複数の軸の延伸にスタイレットを使用する、本発明1037の方法。
[本発明1039]
神経プローブが、プルワイヤおよびスタイレットを含むプッシュプルロッドを含む、本発明1038の方法。
[本発明1040]
電気生理学的信号を記録する段階が、複数の微小電極要素の少なくとも1つにより検出される神経活動を記録する段階、および細長いプローブ軸の遠位端が神経標的部位に十分に位置づけられていることを記録された活動が示すまで、必要に応じて細長い軸の遠位端を再位置決めする段階を含む、本発明1036の方法。
[本発明1041]
記録段階および刺激段階の後の、前記複数の軸を内部管腔内に後退させる段階、および対象から神経プローブを取り外す段階
をさらに含む、本発明1036の方法。
[本発明1042]
前記複数の軸の少なくとも1つの上の複数の微小電極要素の少なくとも1つに電気信号を印加することにより神経活動を刺激する段階、
埋め込まれた患者において刺激部位に対する有効性の臨床評価を行う段階、および
細長い軸の遠位端が神経標的部位に十分に位置づけられていることを患者の応答が示すまで、必要に応じて細長い軸の遠位端を再位置決めする段階
を含む、本発明1036の方法。
[本発明1043]
前記複数の軸の少なくとも1つの上の複数の微小電極要素の少なくとも1つに電気信号を印加することにより神経活動を阻害する段階、
埋め込まれた患者において阻害部位に対する有効性の臨床評価を行う段階、および
細長い軸の遠位端が神経標的部位に十分に位置づけられていることを患者の応答が示すまで、必要に応じて細長い軸の遠位端を再位置決めする段階
を含む、本発明1036の方法。
[本発明1044]
神経標的部位の近傍内に
遠位端および内部管腔を有する細長い軸と、
該細長い軸の遠位端から選択的に延伸されるように配置された複数の軸と、
該複数の軸のそれぞれの上に配設された複数の微小電極要素であって、絶縁層および該絶縁層上に配設された複数の導電性トレースを有する平面状基材を含む微小電極要素とを含む神経プローブであって、
前記複数の軸が、完全に延伸された際に実質的に円柱状の立体を規定する、
神経プローブを埋め込む段階、
外科的埋め込み前に、前記複数の軸を内部管腔内に後退させる段階、
埋め込み後に、神経標的部位の近傍に前記複数の軸を展開させる段階、
前記複数の軸の少なくとも1つの上の微小電極要素の少なくとも2つの間に振動電流を印加する段階、
前記複数の軸の少なくとも1つの上の微小電極要素の少なくとも2つの間の電圧を検出する段階
を含む、神経標的を発見するための方法。
[本発明1045]
印加された振動電流および検出された電圧に基づいて、前記複数の軸の間の神経組織の立体の電気特性を画像化する段階を含む、本発明1044の方法。
[本発明1046]
検出段階の後の、前記複数の軸を内部管腔内に後退させる段階、および対象から神経プローブを取り外す段階
をさらに含む、本発明1034の方法。
ヒト脳内深部などの動物の神経系に位置し得る、個々のニューロン、ニューロンの群および神経組織などの神経標的の非常に局在化された効率的な電気刺激を行うための、微小電極アレイデバイスならびにその製作および使用の方法が、本明細書に記載される。脚橋被蓋核などの小さく発見困難な脳標的、または視床下核などの非常に局在化されたレベルの神経刺激を必要とする標的では、電気生理学的記録を使用して標的を発見するには、脳領域において多くの微小電極を必要とする。微小電極の数が多いほど、治療的刺激に必要なニューロンを発見する可能性が増加する。標的脳領域に最も近い微小電極または微小電極群を治療的慢性刺激または阻害に使用する。
いくつかの態様では、突出軸は異なる角度に湾曲または屈曲し得る。これは、突出軸の先端がより大きな立体を覆うことができるという利点を有し得る。図24は、突出軸560が細長いプローブの縦軸から湾曲する、遠位微小電極アセンブリ550の一態様を示す。各突出軸上には4つの微小電極要素がある。いくつかの態様では、中心ピンが必要ではないことがあり、図24の態様は中心ピンを含まない。図25は同一態様の平面図であり、図26はさらなる図を示す。
態様を神経記録にのみ使用する場合、マイクロ電子要素300は、電気生理学的に記録されたデータを収集するようにのみ構成され得る。図41は、マイクロ電子要素300内で実現され得る電子回路の模式図を示す。微小電極要素365は神経組織に接触する。微小電極要素365はa〜nと文字が付され、それらの間の点々は可能な微小電極要素365の有限数を記述する。概して少なくとも1つの微小電極要素365が存在し、本態様では15個が必要である。電気生理学的信号は微小電極要素365を脱分極させ、この信号は神経記録マイクロ電子要素320により捕捉され得る。記録を行うように選択される微小電極要素365は、スイッチボックス321を使用して選択され得る。次に、信号はスイッチボックス322に伝送され、スイッチボックスは、増幅器324を使用して局所電界電位を増幅すること、またはスパイク増幅器325を使用してスパイクを増幅することのいずれかを選択することができる。次に、信号は微小電極リードアセンブリ100の遠位端への送信用にエンコードされ得る。デコーダ390、およびディスプレイまたはデータ捕捉装置391が遠位端に接続されるはずである。いくつかの態様では、回路は各微小電極要素365ごとに実現され得る。一般に、記録に必要な周波数帯域幅は、すべての微小電極要素365が同一増幅回路を時分割共用することができる一方でディスプレイ391が記録を同時に報告することができるほど小さい。
図44は、上記のデバイスを使用してどのように電気インピーダンス断層撮影を行うことができるかを示す。第一に、振動電流を2つの微小電極要素865Acおよび865Paの間に通過させる。電流振動は1Hz〜10MHz、好ましくは1kHz〜100KHzの周波数のものであり得る。さらに、電流振動は他の振動周波数を含み得る。続いて、2つの他の微小電極要素865Lcおよび865Lの間で電位を検出する。あるいは、電流を発生させかつ収集する微小電極要素の部位において電位を検出することができる。この電位は、画像化される組織の電気特性を示す。ソース電極および検出電極を2D空間と3D空間との両方で交互にすることで、プロング内に含まれる立体の立体画像および/または断層撮影画像を作成する。電極部位において発生しかつ検出される信号の振幅、周波数および他の特性を変化させることで、導電率、誘電率、導電率方向および/または異方性などの異なる組織特性を画像化することができる。この電気データから、神経線維の位置、方向および種類、わずかな例でしかないが灰白質、白質および水管などの異なる組織種類の記述などの、組織構造の理解を得ることができる。次に画像は臨床医に報告され、さらに、それを公知の解剖学的データにフィッティングさせることでデバイス位置の第1の概算を得ることができる。電極の単一の線状アレイ、または並列される電極(図示せず)を含む、プロング上の電極幾何形状は変動し得る。
微細加工神経刺激デバイスの各種態様を本明細書で説明した。これらの態様は例として示され、本発明の範囲を限定するようには意図されていない。さらに、説明した態様の様々な特徴を様々な方法で組み合わせて数多くのさらなる態様を生成することができるということを認識すべきである。さらに、各種の材料、寸法、形状、埋め込み位置などを、開示された態様での使用について説明したが、開示されたそれら以外の他のものを、本発明の範囲を逸脱することなく利用することができる。
Claims (23)
- 遠位端および内部管腔を有する細長い軸と、
内部管腔の遠位部にのみ摺動式に配設される展開式軸支持体と、
展開式軸支持体に結合しており、前記細長い軸の遠位端から選択的に延伸されるように配置された複数の軸と、
複数のフィルム軸を含む微小電極アレイフィルムであって、該複数のフィルム軸のそれぞれが、複数の微小電極要素を含み、該微小電極アレイフィルムが、前記展開式軸支持体に結合しており、該複数のフィルム軸のそれぞれが、前記複数の軸の1つに対応する、微小電極アレイフィルムと、
内部管腔に取り外し可能に配設されており、埋め込み中に、展開式軸支持体に接触することで前記複数の軸を選択的に延伸させるように構成されたスタイレットと、
前記展開式軸支持体および複数の軸を内部管腔内に選択的に後退させるように展開式軸支持体に結合しているプルワイヤと
を含む、埋め込み式神経プローブ。 - プルワイヤおよびスタイレットを含むプッシュプルロッドを含む、請求項1記載の埋め込み式神経プローブ。
- 細長い軸が、脳深部刺激リードの挿入に許容される手技を使用するヒト身体への挿入用に構成されている、請求項1記載の埋め込み式神経プローブ。
- 細長い軸の直径が1mm〜3mmである、請求項1記載の埋め込み式神経プローブ。
- 複数の微小電極要素の少なくとも1つが刺激電極であり、複数の微小電極要素の少なくとも1つが検出電極である、請求項1記載の埋め込み式神経プローブ。
- 複数の微小電極要素の少なくとも1つが刺激電極および検出電極の両方である、請求項1記載の埋め込み式神経プローブ。
- 前記複数の微小電極要素のそれぞれが導電性フィルム上に形成され、複数の微小電極要素のそれぞれが2つの絶縁基材の内部に包埋されている、請求項1記載の埋め込み式神経プローブ。
- 前記2つの絶縁基材が円柱状アセンブリに成形可能である、請求項7記載の埋め込み式神経プローブ。
- 前記複数の軸が円柱状アセンブリの縦軸から放射状に屈曲するように成形されうる、請求項8記載の埋め込み式神経プローブ。
- 前記複数の軸の1つが円柱状アセンブリの縦軸に沿って延伸しかつ中心を有する、請求項8記載の埋め込み式神経プローブ。
- 前記複数の軸が支持部材により補剛されている、請求項9記載の埋め込み式神経プローブ。
- 前記縦軸に沿って延伸する複数の軸が支持部材により補剛されている、請求項10記載の埋め込み式神経プローブ。
- 遠位端および内部管腔を有する細長い軸と、
該細長い軸の遠位端から選択的に延伸されるように配置された複数の軸と、
複数のフィルム軸を含む微小電極アレイフィルムであって、該複数のフィルム軸のそれぞれが、複数の微小電極要素を含み、該複数のフィルム軸のそれぞれが、前記複数の軸の1つに対応する、微小電極アレイフィルムと
を含む埋め込み式神経プローブであって、
前記複数の軸が、完全に延伸された際に円柱状の立体を規定する、
埋め込み式神経プローブ。 - 細長い軸が、脳深部刺激リードの挿入に許容される手技を使用するヒト身体への挿入用に構成されている、請求項13記載の埋め込み式神経プローブ。
- 細長い軸の直径が1mm〜3mmである、請求項13記載の埋め込み式神経プローブ。
- 複数の微小電極要素の少なくとも1つが刺激電極であり、複数の微小電極要素の少なくとも1つが検出電極である、請求項13記載の埋め込み式神経プローブ。
- 複数の微小電極要素の少なくとも1つが刺激電極および検出電極の両方である、請求項13記載の埋め込み式神経プローブ。
- 前記複数の微小電極要素のそれぞれが導電性フィルム上に形成され、各微小電極要素が2つの絶縁基材の内部に包埋されている、請求項13記載の埋め込み式神経プローブ。
- 前記2つの絶縁基材が円柱状アセンブリに成形可能である、請求項18記載の埋め込み式神経プローブ。
- 前記複数の軸が円柱状アセンブリの縦軸から放射状に屈曲するように成形されうる、請求項19記載の埋め込み式神経プローブ。
- 前記複数の軸の1つが円柱状アセンブリの縦軸に沿って延伸しかつ中心を有する、請求項19記載の埋め込み式神経プローブ。
- 前記複数の軸が支持部材により補剛されている、請求項19記載の埋め込み式神経プローブ。
- 前記縦軸に沿って延伸する複数の軸が支持部材により補剛されている、請求項21記載の埋め込み式神経プローブ。
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