JP2014508581A - 脊髄刺激のためのパリレンベースのマイクロ電極アレイインプラント - Google Patents
脊髄刺激のためのパリレンベースのマイクロ電極アレイインプラント Download PDFInfo
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Abstract
【選択図】図1
Description
本願は、参照することによって、全体として本明細書に組み込まれる、2011年1月21日出願の米国仮出願61/435,188号の利益を主張するものである。
連邦政府による資金提供を受けた研究開発の記載
本発明は、米国陸軍医学研究及び物資司令部によって付与された認可番号W81XWH−09−2−0024、および国立衛生研究所によって付与された認可番号EB007615の下、政府支援によって行われた。政府は本発明において一定の権利を所有している。
背景技術
脊髄損傷は、米国だけで1,300万人を超える人々が悩ませられていると推定され、5百万人を超える人々が麻痺状態であると推定されている。「One Degree of Separation: Paralysis and Spinal Cord Injury in the United States」 Christopher and Dana Reeve Foundation (2009)を参照されたい。麻痺の消耗性性質は、生活の質に深刻な影響を及ぼし、部分的に有効な治療でさえ、科学界にとって、非常に望ましい目標となっている。
アセンブリ100は、パリレン−金属−パリレンのサンドイッチ状構造を形成する方法を説明する、D.C. Rodger, et al., “Flexible microfabricated parylene multielectrode arrays for retinal stimulation and spinal cord field modulation,“Proc. 4th International IEEE−EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, Okinawa, Japan, pp. 31−34 (2006)に説明されるものと若干類似する方法を使用して製作されてもよい。
ケーブルシステム300(図3参照)の実装は、ラット内に埋め込まれ、最大8週間、機能した。本レベルの信頼性は、ケーブルシステム300(および、アセンブリ100)を経時的歩進能力の研究のために好適なものとする。ケーブルシステム300(および、アセンブリ100)はまた、高密度微小製作電極アレイ120によってもたらされる、部位選択性を提供する。
Claims (27)
- 脊髄と併用するための埋め込み型デバイスであって、
周辺部分と、実質的に電気的に非伝導性の材料で構成される第1の層と、を有する、本体部分であって、前記第1の層は、第1の部分および第2の部分を有し、前記第1の部分は、前記脊髄に平行して位置付け可能であり、かつ第1の複数の開口部を備え、前記第2の部分は、第2の複数の開口部を備える、本体部分と、
前記周辺部分の内側に、かつ前記第1の層の前記第1の部分に平行して位置付けられる複数の電極であって、前記第1の複数の開口部のうちの少なくとも1つは、前記電極のそれぞれに隣接して、前記第1の部分が前記脊髄に平行して位置付けられるときに、前記電極が電気刺激を前記脊髄に提供し得る経路を提供する、複数の電極と、
前記周辺部分の内側に、かつ前記第1の層に平行して位置付けられる複数のトレースであって、前記第2の複数の開口部のうちの少なくとも1つは、前記トレースのそれぞれに隣接して、前記トレースが電気刺激を受容し得る経路を提供し、前記トレースのうちの1つ以上は、前記電極のそれぞれに接続され、かつ前記トレースのうちの1つ以上によって受容される電気刺激を前記電極に伝導するように構成される、複数のトレースと、
を備える、デバイス。 - 前記複数のトレースは、異なる電気刺激を前記複数の電極のうちの異なる電極に伝導するように構成される、請求項1に記載のデバイス。
- 前記複数のトレースは、電気刺激を前記複数の電極のすべてよりも少ない電極に伝導するように構成される、請求項1に記載のデバイス。
- 前記第1の層の前記第1の部分は、前記脊髄の硬膜に対して位置付け可能であり、前記複数の電極は、電気刺激を前記硬膜に提供するように構成される、請求項1に記載のデバイス。
- 前記周辺部分は、前記第1の層に隣接して位置付けられるフレームを備える、請求項1に記載のデバイス。
- 前記第1の層は、複数のグリッド構造を備え、前記グリッド構造のうちの異なるグリッド構造は、前記複数の電極のそれぞれに隣接し、
それぞれのグリッド構造は、複数のセルを備え、
前記複数の電極のそれぞれに対して、前記電極に隣接する前記第1の複数の開口部のうちの前記少なくとも1つはそれぞれ、前記電極に隣接する前記グリッド構造の前記セルのうちの異なるセルの内側に位置付けられる、
請求項1に記載のデバイス。 - 前記複数の電極のそれぞれに隣接する前記第1の複数の開口部のうちの前記少なくとも1つは、2つ以上の開口部を備える、請求項6に記載のデバイス。
- 前記電極のそれぞれに接続される前記トレースのうちの前記1つ以上は、2つのトレースを備える、請求項1に記載のデバイス。
- 前記本体部分は、第2の層をさらに備え、前記複数の電極および前記複数のトレースは、前記第1の層と前記第2の層との間に位置付けられる、請求項1に記載のデバイス。
- 前記本体部分の前記第2の層の少なくとも一部と、前記第1の層の前記第1の部分と前記第1の層の前記第2の部分との間の前記第1の層の一部と、をコーティングする可撓性外側コーティングをさらに備える、請求項9に記載のデバイス。
- 前記外側コーティングは、生物医学グレードのエポキシおよびシリコーンエラストマーのうちの少なくとも1つを備える、請求項10に記載のデバイス。
- 前記第1の層および前記第2の層はそれぞれ、パリレン−A、パリレン−C、パリレン−AM、パリレン−F、パリレン−N、およびパリレン−Dのうちの少なくとも1つで構成される、請求項9に記載のデバイス。
- 前記第1の層は、パリレン−A、パリレン−C、パリレン−AM、パリレン−F、パリレン−N、およびパリレン−Dのうちの少なくとも1つで構成される、請求項1に記載のデバイス。
- 埋め込み型電極アレイアセンブリを構成する方法であって、
少なくとも1つのトレースが複数の電極のそれぞれに接続される、前記複数の電極および複数のトレースを画定する電気的に伝導性の材料のパターン化された層を形成することと、
第1の層が隣接する前記パターン化された層である、実質的に電気的に非伝導性の材料の前記第1の層を形成することと、
第1の開口部が前記第1の層を通る前記複数の電極へのアクセスを提供し、前記第1の開口部の異なるグリッド画定部分が前記電極のそれぞれに隣接し、それぞれのグリッド画定部分が前記電極の複数の接点を前記グリッド画定部分が隣接する部分に暴露する、複数の前記第1の開口部を前記第1の層内に形成することと、
第2の開口部が前記第1の層を通る前記複数のトレースへのアクセスを提供する、複数の前記第2の開口部を前記第1の層内に形成することと、
を含む、方法。 - 犠牲層を基板上に位置付けることと、
前記パターン化された層が第2の層上に位置付けられる、実質的に電気的に非伝導性の材料の前記第2の層を前記犠牲層上に形成することと、
前記犠牲層を除去し、それによって、前記第2の層を前記基板から解放することと、
をさらに含む、請求項14に記載の方法。 - フレーム層を前記基板上に形成することをさらに含み、前記フレーム層は、前記第2の層の下にあり、前記フレーム層は、フレームを前記パターン化された層の周囲に少なくとも部分的に画定する、請求項15に記載の方法。
- 前記第1の層および前記第2の層はそれぞれ、パリレン−A、パリレン−C、パリレン−AM、パリレン−F、パリレン−N、およびパリレン−Dのうちの少なくとも1つから形成される、請求項15に記載の方法。
- 前記第1の層および前記第2の層は、同一の材料から形成される、請求項15に記載の方法。
- 前記パターン化された層は、金属付着技術を用いて前記第2の層上に形成される、請求項15に記載の方法。
- 前記金属付着技術は、電子ビーム蒸着である、請求項19に記載の方法。
- 前記犠牲層は、フォトレジスト材料を備える、請求項15に記載の方法。
- 前記基板は、シリコンウエハである、請求項15に記載の方法。
- 前記第2の層の少なくとも一部および前記第1の層の少なくとも一部にコーティングを塗布することをさらに含む、請求項15に記載の方法。
- 前記複数の第1の開口部は、前記第1の層内にエッチングされる、請求項14に記載の方法。
- 前記複数の第2の開口部は、前記第1の層内にエッチングされる、請求項14に記載の方法。
- 電気刺激を発生させるように構成される、刺激発生器と、
少なくとも1つの椎骨に接続可能な近位端部分と、前記脊髄に沿って位置付け可能な遠位端部分と、を有する、埋め込み型電極アレイアセンブリであって、前記近位端部分は、前記遠位端部分上に位置付けられる複数の電極との複数の電気的接続を有する、埋め込み型電極アレイアセンブリと、
前記少なくとも1つの椎骨に接続され、かつ前記アセンブリを前記少なくとも1つの椎骨に接続するように構成される、ベースプレートと、
前記ベースプレートおよび前記刺激発生器に接続される複数のワイヤであって、前記複数のワイヤは、前記刺激発生器が発生した電気刺激を前記ベースプレートに伝導するように構成され、前記ベースプレートは、前記電気刺激を前記アセンブリの前記近位端部分の前記複数の電気的接続に伝導するように構成される、複数のワイヤと、
を備える、システム。 - 前記ベースプレートに接続され、かつ前記アセンブリの前記近位部分の少なくとも一部に張り出して、前記アセンブリの外部の動的組織からの保護を支援するように位置付けられる張り出し部分をさらに備える、請求項26に記載のシステム。
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PCT/US2012/022257 WO2012100260A2 (en) | 2011-01-21 | 2012-01-23 | A parylene-based microelectrode array implant for spinal cord stimulation |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018187434A (ja) * | 2014-05-28 | 2018-11-29 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 可撓性導電トラック構成の製造方法、可撓性導電トラック構成及び神経刺激システム |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4201475A1 (en) | 2011-01-03 | 2023-06-28 | The Regents of the University of California | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
ES2640110T3 (es) | 2011-01-21 | 2017-10-31 | California Institute Of Technology | Un implante de serie de microelectrodos basado en parileno para la estimulación de la médula espinal |
CA2825550C (en) | 2011-03-24 | 2022-07-12 | California Institute Of Technology | Neurostimulator |
US10092750B2 (en) | 2011-11-11 | 2018-10-09 | Neuroenabling Technologies, Inc. | Transcutaneous neuromodulation system and methods of using same |
BR112014011409A2 (pt) | 2011-11-11 | 2017-05-02 | Neuroenabling Tech Inc | dispositivo de neuromodulação não invasivo para permitir a recuperação de função motora, sensorial, autonômica, sexual, vasomotora e cohnitiva |
WO2013071309A1 (en) | 2011-11-11 | 2013-05-16 | The Regents Of The University Of California | Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry |
US9956396B2 (en) | 2012-02-08 | 2018-05-01 | Medtronic Bakken Research Center B.V. | Thin film for a lead for brain applications |
EP3878507A1 (en) | 2013-03-15 | 2021-09-15 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
WO2015048563A2 (en) | 2013-09-27 | 2015-04-02 | The Regents Of The University Of California | Engaging the cervical spinal cord circuitry to re-enable volitional control of hand function in tetraplegic subjects |
US20150217120A1 (en) | 2014-01-13 | 2015-08-06 | Mandheerej Nandra | Neuromodulation systems and methods of using same |
US20180338712A1 (en) * | 2014-07-17 | 2018-11-29 | Imperial Innovations Limited | Mutli-probe microstructured arrays |
AU2015305237B2 (en) | 2014-08-21 | 2020-06-18 | The Regents Of The University Of California | Regulation of autonomic control of bladder voiding after a complete spinal cord injury |
US10773074B2 (en) | 2014-08-27 | 2020-09-15 | The Regents Of The University Of California | Multi-electrode array for spinal cord epidural stimulation |
EP3185950A4 (en) * | 2014-08-27 | 2018-04-11 | The Regents of The University of California | Methods of fabricating a multi-electrode array for spinal cord epidural stimulation |
US10507321B2 (en) | 2014-11-25 | 2019-12-17 | Medtronic Bakken Research Center B.V. | Multilayer structure and method of manufacturing a multilayer structure |
EP3331603A4 (en) * | 2015-08-06 | 2019-01-23 | The Regents of The University of California | METHODS OF MAKING ELECTRODE NETWORK FOR TRANSCUTANEOUS ELECTRICAL STIMULATION OF SPINAL CORD |
US11298533B2 (en) | 2015-08-26 | 2022-04-12 | The Regents Of The University Of California | Concerted use of noninvasive neuromodulation device with exoskeleton to enable voluntary movement and greater muscle activation when stepping in a chronically paralyzed subject |
US11097122B2 (en) | 2015-11-04 | 2021-08-24 | The Regents Of The University Of California | Magnetic stimulation of the spinal cord to restore control of bladder and/or bowel |
TWI647101B (zh) | 2016-06-02 | 2019-01-11 | 美樺興業股份有限公司 | 圖案化鍍膜結構、圖案化鍍膜複合結構、選擇性抑制有機鍍膜形成的方法與選擇性調整有機鍍膜厚度的方法 |
EP3535018A4 (en) | 2016-11-07 | 2020-07-01 | Micro-Leads, Inc. | ARRAY OF MULTIPLE UNIT BODY ELECTRODES |
WO2018136822A1 (en) | 2017-01-19 | 2018-07-26 | Micro-Leads, Inc. | Spinal cord stimulation method to treat lateral neural tissues |
EP3573517B1 (en) | 2017-01-24 | 2023-10-18 | The Regents of the University of California | Accessing spinal network to enable respiratory function |
US10523258B2 (en) | 2017-03-06 | 2019-12-31 | Samsung Electronics Co., Ltd. | Communication device to perform wireless communication and wireless power transfer, and electrode device to transmit and receive electrical signal from target |
EP3974021B1 (en) | 2017-06-30 | 2023-06-14 | ONWARD Medical N.V. | A system for neuromodulation |
US11992684B2 (en) | 2017-12-05 | 2024-05-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | System for planning and/or providing neuromodulation |
AU2019207902A1 (en) * | 2018-01-12 | 2020-08-20 | University Of Louisville Research Foundation Inc. | Normalization of blood pressure with spinal cord epidural stimulation |
DE18205821T1 (de) | 2018-11-13 | 2020-12-24 | Gtx Medical B.V. | Steuerungssystem zur bewegungsrekonstruktion und/oder wiederherstellung für einen patienten |
KR102318885B1 (ko) * | 2018-11-13 | 2021-11-02 | 단국대학교 천안캠퍼스 산학협력단 | 척수 자극용 전극 |
EP3653260A1 (en) | 2018-11-13 | 2020-05-20 | GTX medical B.V. | Sensor in clothing of limbs or footwear |
US11395924B2 (en) | 2019-01-07 | 2022-07-26 | Micro-Leads, Inc. | Implantable devices with welded multi-contact electrodes and continuous conductive elements |
EP3695878B1 (en) | 2019-02-12 | 2023-04-19 | ONWARD Medical N.V. | A system for neuromodulation |
US11065461B2 (en) | 2019-07-08 | 2021-07-20 | Bioness Inc. | Implantable power adapter |
CN110772251B (zh) * | 2019-10-28 | 2020-11-17 | 浙江大学 | 一种软性双面神经探针及其制备方法 |
US11417987B2 (en) * | 2019-11-25 | 2022-08-16 | Northeastern University | Magnetic matrix connector for high density, soft neural interface |
EP3827871A1 (en) | 2019-11-27 | 2021-06-02 | ONWARD Medical B.V. | Neuromodulation system |
WO2022076497A1 (en) * | 2020-10-06 | 2022-04-14 | The Johns Hopkins University | Acute cerebrospinal fluid management implant |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009111142A2 (en) * | 2008-03-06 | 2009-09-11 | Stryker Corporation | Foldable, implantable electrode array assembly and tool for implanting same |
Family Cites Families (224)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3543761A (en) | 1967-10-05 | 1970-12-01 | Univ Minnesota | Bladder stimulating method |
US3662758A (en) | 1969-06-30 | 1972-05-16 | Mentor Corp | Stimulator apparatus for muscular organs with external transmitter and implantable receiver |
US3724467A (en) | 1971-04-23 | 1973-04-03 | Avery Labor Inc | Electrode implant for the neuro-stimulation of the spinal cord |
US4044774A (en) | 1976-02-23 | 1977-08-30 | Medtronic, Inc. | Percutaneously inserted spinal cord stimulation lead |
US4102344A (en) | 1976-11-15 | 1978-07-25 | Mentor Corporation | Stimulator apparatus for internal body organ |
US4141365A (en) | 1977-02-24 | 1979-02-27 | The Johns Hopkins University | Epidural lead electrode and insertion needle |
US4285347A (en) | 1979-07-25 | 1981-08-25 | Cordis Corporation | Stabilized directional neural electrode lead |
US4340063A (en) | 1980-01-02 | 1982-07-20 | Empi, Inc. | Stimulation device |
US4379462A (en) | 1980-10-29 | 1983-04-12 | Neuromed, Inc. | Multi-electrode catheter assembly for spinal cord stimulation |
US4414986A (en) | 1982-01-29 | 1983-11-15 | Medtronic, Inc. | Biomedical stimulation lead |
US4538624A (en) | 1982-12-08 | 1985-09-03 | Cordis Corporation | Method for lead introduction and fixation |
US4549556A (en) | 1982-12-08 | 1985-10-29 | Cordis Corporation | Implantable lead |
US4800898A (en) | 1983-10-07 | 1989-01-31 | Cordis Corporation | Neural stimulator electrode element and lead |
US4934368A (en) | 1988-01-21 | 1990-06-19 | Myo/Kinetics Systems, Inc. | Multi-electrode neurological stimulation apparatus |
US5081989A (en) | 1989-04-07 | 1992-01-21 | Sigmedics, Inc. | Microprocessor-controlled enhanced multiplexed functional electrical stimulator for surface stimulation in paralyzed patients |
US5002053A (en) | 1989-04-21 | 1991-03-26 | University Of Arkansas | Method of and device for inducing locomotion by electrical stimulation of the spinal cord |
US5031618A (en) | 1990-03-07 | 1991-07-16 | Medtronic, Inc. | Position-responsive neuro stimulator |
US5121754A (en) | 1990-08-21 | 1992-06-16 | Medtronic, Inc. | Lateral displacement percutaneously inserted epidural lead |
US5354320A (en) | 1991-09-12 | 1994-10-11 | Biotronik Mess- Und Therapiegerate Gmbh & Co., Ingenieurburo Berlin | Neurostimulator for production of periodic stimulation pulses |
EP0580928A1 (en) | 1992-07-31 | 1994-02-02 | ARIES S.r.l. | A spinal electrode catheter |
US5344439A (en) | 1992-10-30 | 1994-09-06 | Medtronic, Inc. | Catheter with retractable anchor mechanism |
US5417719A (en) | 1993-08-25 | 1995-05-23 | Medtronic, Inc. | Method of using a spinal cord stimulation lead |
US5501703A (en) | 1994-01-24 | 1996-03-26 | Medtronic, Inc. | Multichannel apparatus for epidural spinal cord stimulator |
US5562718A (en) | 1994-06-03 | 1996-10-08 | Palermo; Francis X. | Electronic neuromuscular stimulation device |
US5733322A (en) | 1995-05-23 | 1998-03-31 | Medtronic, Inc. | Positive fixation percutaneous epidural neurostimulation lead |
US6066163A (en) | 1996-02-02 | 2000-05-23 | John; Michael Sasha | Adaptive brain stimulation method and system |
CA2171067A1 (en) | 1996-03-05 | 1997-09-06 | Brian J. Andrews | Neural prosthesis |
US6505078B1 (en) | 1996-04-04 | 2003-01-07 | Medtronic, Inc. | Technique for adjusting the locus of excitation of electrically excitable tissue |
US6609031B1 (en) | 1996-06-07 | 2003-08-19 | Advanced Neuromodulation Systems, Inc. | Multiprogrammable tissue stimulator and method |
EP0910434B1 (en) | 1996-06-13 | 2004-06-09 | The Victoria University Of Manchester | Stimulation of muscles |
US5983141A (en) | 1996-06-27 | 1999-11-09 | Radionics, Inc. | Method and apparatus for altering neural tissue function |
RU2130326C1 (ru) | 1996-08-20 | 1999-05-20 | Шапков Юрий Тимофеевич | Способ лечения больных с поражением спинного мозга |
RU2141851C1 (ru) | 1997-03-31 | 1999-11-27 | Российский научный центр реабилитации и физиотерапии | Способ лечения диспластического сколиоза у детей |
US5948007A (en) | 1997-04-30 | 1999-09-07 | Medtronic, Inc. | Dual channel implantation neurostimulation techniques |
EP1075302A1 (en) | 1998-04-30 | 2001-02-14 | Medtronic, Inc. | Multiple electrode lead body for spinal cord stimulation |
US6319241B1 (en) | 1998-04-30 | 2001-11-20 | Medtronic, Inc. | Techniques for positioning therapy delivery elements within a spinal cord or a brain |
US6366813B1 (en) | 1998-08-05 | 2002-04-02 | Dilorenzo Daniel J. | Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease |
US7209787B2 (en) | 1998-08-05 | 2007-04-24 | Bioneuronics Corporation | Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease |
US6104957A (en) | 1998-08-21 | 2000-08-15 | Alo; Kenneth M. | Epidural nerve root stimulation with lead placement method |
US6470213B1 (en) | 1999-03-30 | 2002-10-22 | Kenneth A. Alley | Implantable medical device |
RU2178319C2 (ru) | 1999-05-11 | 2002-01-20 | Российский научно-исследовательский нейрохирургический институт им. проф. А.Л. Поленова | Электростимулятор |
US6516227B1 (en) | 1999-07-27 | 2003-02-04 | Advanced Bionics Corporation | Rechargeable spinal cord stimulator system |
WO2001014018A1 (en) | 1999-08-20 | 2001-03-01 | The Regents Of The University Of California | Method, apparatus and system for automation of body weight support training (bwst) of biped locomotion over a treadmill using a programmable stepper device (psd) operating like an exoskeleton drive system from a fixed base |
US6308103B1 (en) | 1999-09-13 | 2001-10-23 | Medtronic Inc. | Self-centering epidural spinal cord lead and method |
RU2160127C1 (ru) | 1999-09-16 | 2000-12-10 | Вязников Александр Леонидович | Способ лечения заболеваний и реабилитации локальной импульсной электростимуляцией |
US7949395B2 (en) | 1999-10-01 | 2011-05-24 | Boston Scientific Neuromodulation Corporation | Implantable microdevice with extended lead and remote electrode |
RU2192897C2 (ru) | 1999-11-17 | 2002-11-20 | Красноярская государственная медицинская академия | Способ лечения постинсультных парезов |
CA2397607A1 (en) | 1999-12-17 | 2001-06-21 | Carla M. Mann | Magnitude programming for implantable electrical stimulator |
US7096070B1 (en) | 2000-02-09 | 2006-08-22 | Transneuronix, Inc. | Medical implant device for electrostimulation using discrete micro-electrodes |
US7024247B2 (en) | 2001-10-15 | 2006-04-04 | Northstar Neuroscience, Inc. | Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures |
US7831305B2 (en) | 2001-10-15 | 2010-11-09 | Advanced Neuromodulation Systems, Inc. | Neural stimulation system and method responsive to collateral neural activity |
US6895283B2 (en) | 2000-08-10 | 2005-05-17 | Advanced Neuromodulation Systems, Inc. | Stimulation/sensing lead adapted for percutaneous insertion |
US6662053B2 (en) | 2000-08-17 | 2003-12-09 | William N. Borkan | Multichannel stimulator electronics and methods |
US6871099B1 (en) | 2000-08-18 | 2005-03-22 | Advanced Bionics Corporation | Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain |
US7065408B2 (en) | 2001-01-11 | 2006-06-20 | Herman Richard M | Method for restoring gait in individuals with chronic spinal cord injury |
US6892098B2 (en) | 2001-04-26 | 2005-05-10 | Biocontrol Medical Ltd. | Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders |
US6839594B2 (en) | 2001-04-26 | 2005-01-04 | Biocontrol Medical Ltd | Actuation and control of limbs through motor nerve stimulation |
DE60207069T2 (de) | 2001-05-16 | 2006-07-27 | Fondation Suisse Pour Les Cybertheses | Therapeutische und/oder übungsvorrichtung für die unteren gliedmassen einer person |
US6685729B2 (en) | 2001-06-29 | 2004-02-03 | George Gonzalez | Process for testing and treating aberrant sensory afferents and motors efferents |
US7167753B2 (en) | 2001-07-03 | 2007-01-23 | The Trustees Of The University Of Pennsylvania | Device and method for electrically inducing osteogenesis in the spine |
US7263402B2 (en) * | 2001-08-13 | 2007-08-28 | Advanced Bionics Corporation | System and method of rapid, comfortable parameter switching in spinal cord stimulation |
CA2461934A1 (en) | 2001-09-28 | 2003-04-03 | Meagan Medical, Inc. | Method and apparatus for controlling percutaneous electrical signals |
AU2002334749A1 (en) | 2001-09-28 | 2003-04-07 | Northstar Neuroscience, Inc. | Methods and implantable apparatus for electrical therapy |
US7127296B2 (en) | 2001-11-02 | 2006-10-24 | Advanced Bionics Corporation | Method for increasing the therapeutic ratio/usage range in a neurostimulator |
US6975907B2 (en) | 2001-11-13 | 2005-12-13 | Dynamed Systems, Llc | Apparatus and method for repair of spinal cord injury |
US6829510B2 (en) | 2001-12-18 | 2004-12-07 | Ness Neuromuscular Electrical Stimulation Systems Ltd. | Surface neuroprosthetic device having an internal cushion interface system |
US7110820B2 (en) | 2002-02-05 | 2006-09-19 | Tcheng Thomas K | Responsive electrical stimulation for movement disorders |
AUPS042802A0 (en) | 2002-02-11 | 2002-03-07 | Neopraxis Pty Ltd | Distributed functional electrical stimulation system |
US7239920B1 (en) | 2002-02-12 | 2007-07-03 | Advanced Bionics Corporation | Neural stimulation system providing auto adjustment of stimulus output as a function of sensed pressure changes |
US7697995B2 (en) | 2002-04-25 | 2010-04-13 | Medtronic, Inc. | Surgical lead paddle |
US6937891B2 (en) | 2002-04-26 | 2005-08-30 | Medtronic, Inc. | Independent therapy programs in an implantable medical device |
US6950706B2 (en) | 2002-04-26 | 2005-09-27 | Medtronic, Inc. | Wave shaping for an implantable medical device |
MXPA04010883A (es) | 2002-05-03 | 2006-08-11 | Afferent Corp | Un metodo y aparato para mejorar el desempeno neurofisiologico. |
US8147421B2 (en) | 2003-01-15 | 2012-04-03 | Nuvasive, Inc. | System and methods for determining nerve direction to a surgical instrument |
GB2405592A (en) | 2002-05-29 | 2005-03-09 | Oklahoma Foundation For Digest | Spinal cord stimulation as treatment for functional bowel disorders |
US7047079B2 (en) | 2002-07-26 | 2006-05-16 | Advanced Neuromodulation Systems, Inc. | Method and system for energy conservation in implantable stimulation devices |
US7228179B2 (en) | 2002-07-26 | 2007-06-05 | Advanced Neuromodulation Systems, Inc. | Method and apparatus for providing complex tissue stimulation patterns |
US7027860B2 (en) | 2002-08-29 | 2006-04-11 | Department Of Veterans Affairs | Microstimulator neural prosthesis |
WO2004036370A2 (en) | 2002-10-15 | 2004-04-29 | Medtronic Inc. | Channel-selective blanking for a medical device system |
AU2003285888A1 (en) | 2002-10-15 | 2004-05-04 | Medtronic Inc. | Medical device system with relaying module for treatment of nervous system disorders |
US7797057B2 (en) | 2002-10-23 | 2010-09-14 | Medtronic, Inc. | Medical paddle lead and method for spinal cord stimulation |
RU2226114C1 (ru) | 2002-11-05 | 2004-03-27 | Беленький Виктор Евгеньевич | Способ электротерапии |
US7020521B1 (en) | 2002-11-08 | 2006-03-28 | Pacesetter, Inc. | Methods and apparatus for detecting and/or monitoring heart failure |
US7035690B2 (en) | 2002-11-15 | 2006-04-25 | Medtronic, Inc. | Human-implantable-neurostimulator user interface having multiple levels of abstraction |
US7047084B2 (en) | 2002-11-20 | 2006-05-16 | Advanced Neuromodulation Systems, Inc. | Apparatus for directionally stimulating nerve tissue |
TR200202651A2 (tr) | 2002-12-12 | 2004-07-21 | Met�N�Tulgar | VücutÁdışındanÁdirekÁtedaviÁsinyaliÁtransferliÁÁbeyinÁpili |
AR043467A1 (es) | 2003-03-05 | 2005-07-27 | Osmotica Argentina S A | Combinacion de drogas para la disfuncion motora en la enfermedad de parkinson |
IL154801A0 (en) | 2003-03-06 | 2003-10-31 | Karotix Internat Ltd | Multi-channel and multi-dimensional system and method |
US7103417B1 (en) | 2003-04-18 | 2006-09-05 | Advanced Bionics Corporation | Adaptive place-pitch ranking procedure for optimizing performance of a multi-channel neural stimulator |
US7463928B2 (en) | 2003-04-25 | 2008-12-09 | Medtronic, Inc. | Identifying combinations of electrodes for neurostimulation therapy |
US20070083240A1 (en) | 2003-05-08 | 2007-04-12 | Peterson David K L | Methods and systems for applying stimulation and sensing one or more indicators of cardiac activity with an implantable stimulator |
US6999820B2 (en) | 2003-05-29 | 2006-02-14 | Advanced Neuromodulation Systems, Inc. | Winged electrode body for spinal cord stimulation |
US20050004622A1 (en) | 2003-07-03 | 2005-01-06 | Advanced Neuromodulation Systems | System and method for implantable pulse generator with multiple treatment protocols |
RU2258496C2 (ru) | 2003-07-15 | 2005-08-20 | Саратовский научно-исследовательский институт травматологии и ортопедии (СарНИИТО) Министерства здравоохранения РФ | Способ лечения больных с травматическими и дегенеративными поражениями позвоночника и спинного мозга |
US7184837B2 (en) | 2003-09-15 | 2007-02-27 | Medtronic, Inc. | Selection of neurostimulator parameter configurations using bayesian networks |
US7252090B2 (en) | 2003-09-15 | 2007-08-07 | Medtronic, Inc. | Selection of neurostimulator parameter configurations using neural network |
US7200443B2 (en) | 2003-10-07 | 2007-04-03 | John Faul | Transcutaneous electrical nerve stimulator for appetite control |
US8260436B2 (en) | 2003-10-31 | 2012-09-04 | Medtronic, Inc. | Implantable stimulation lead with fixation mechanism |
WO2005051480A2 (en) | 2003-11-20 | 2005-06-09 | Advanced Neuromodulation Systems, Inc. | Electrical stimulation system, lead, and method providing reduced neuroplasticity effects |
AU2005205853B2 (en) | 2004-01-22 | 2011-01-27 | 2249020 Alberta Ltd. | Method of routing electrical current to bodily tissues via implanted passive conductors |
US9238137B2 (en) | 2004-02-05 | 2016-01-19 | Motorika Limited | Neuromuscular stimulation |
US8165695B2 (en) | 2004-02-11 | 2012-04-24 | Ethicon, Inc. | System and method for selectively stimulating different body parts |
US7590454B2 (en) | 2004-03-12 | 2009-09-15 | Boston Scientific Neuromodulation Corporation | Modular stimulation lead network |
US7330760B2 (en) | 2004-03-16 | 2008-02-12 | Medtronic, Inc. | Collecting posture information to evaluate therapy |
WO2005094476A2 (en) | 2004-03-23 | 2005-10-13 | Matsushita Electric Industrial Co., Ltd. | High throughput electrophysiology system |
WO2005102449A1 (en) | 2004-04-14 | 2005-11-03 | Medtronic, Inc. | Collecting posture and activity information to evaluate therapy |
US20050246004A1 (en) | 2004-04-28 | 2005-11-03 | Advanced Neuromodulation Systems, Inc. | Combination lead for electrical stimulation and sensing |
US9308382B2 (en) | 2004-06-10 | 2016-04-12 | Medtronic Urinary Solutions, Inc. | Implantable pulse generator systems and methods for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue |
US8195304B2 (en) | 2004-06-10 | 2012-06-05 | Medtronic Urinary Solutions, Inc. | Implantable systems and methods for acquisition and processing of electrical signals |
US20060041295A1 (en) | 2004-08-17 | 2006-02-23 | Osypka Thomas P | Positive fixation percutaneous epidural neurostimulation lead |
US7463927B1 (en) | 2004-09-02 | 2008-12-09 | Intelligent Neurostimulation Microsystems, Llc | Self-adaptive system for the automatic detection of discomfort and the automatic generation of SCS therapies for chronic pain control |
US7450993B2 (en) | 2004-09-08 | 2008-11-11 | Spinal Modulation, Inc. | Methods for selective stimulation of a ganglion |
US9050455B2 (en) | 2004-10-21 | 2015-06-09 | Medtronic, Inc. | Transverse tripole neurostimulation methods, kits and systems |
US20060089696A1 (en) * | 2004-10-21 | 2006-04-27 | Medtronic, Inc. | Implantable medical lead with reinforced outer jacket |
WO2006047291A2 (en) | 2004-10-21 | 2006-05-04 | Advanced Neuromodulation Systems, Inc. | Spinal cord stimulation to treat auditory dysfunction |
US8095209B2 (en) | 2005-01-06 | 2012-01-10 | Braingate Co., Llc | Biological interface system with gated control signal |
US20080009927A1 (en) | 2005-01-11 | 2008-01-10 | Vilims Bradley D | Combination Electrical Stimulating and Infusion Medical Device and Method |
US8788044B2 (en) | 2005-01-21 | 2014-07-22 | Michael Sasha John | Systems and methods for tissue stimulation in medical treatment |
US7415308B2 (en) | 2005-02-23 | 2008-08-19 | Medtronic, Inc. | Implantable medical device providing adaptive neurostimulation therapy for incontinence |
US20070060954A1 (en) | 2005-02-25 | 2007-03-15 | Tracy Cameron | Method of using spinal cord stimulation to treat neurological disorders or conditions |
US8082033B2 (en) | 2005-04-13 | 2011-12-20 | The Cleveland Clinic Foundation | System and method for providing a waveform for stimulating biological tissue |
WO2006113593A2 (en) | 2005-04-14 | 2006-10-26 | Advanced Neuromodulation Systems, Inc. | Electrical stimulation lead, system, and method |
US8244360B2 (en) | 2005-06-09 | 2012-08-14 | Medtronic, Inc. | Regional therapies for treatment of pain |
WO2007002741A1 (en) | 2005-06-28 | 2007-01-04 | Bioness Development, Llc | Improvements to an implant, system and method using implanted passive conductors for routing electrical current |
DK1909890T3 (da) | 2005-07-01 | 2010-05-03 | Imec | Organ til funktionel genskabelse af et beskadiget nervesystem |
US7415309B2 (en) | 2005-07-11 | 2008-08-19 | Boston Scientific Scimed, Inc. | Percutaneous access for neuromodulation procedures |
US20070049814A1 (en) | 2005-08-24 | 2007-03-01 | Muccio Philip E | System and device for neuromuscular stimulation |
US7856264B2 (en) | 2005-10-19 | 2010-12-21 | Advanced Neuromodulation Systems, Inc. | Systems and methods for patient interactive neural stimulation and/or chemical substance delivery |
US7660636B2 (en) | 2006-01-04 | 2010-02-09 | Accelerated Care Plus Corp. | Electrical stimulation device and method for the treatment of dysphagia |
US8195267B2 (en) * | 2006-01-26 | 2012-06-05 | Seymour John P | Microelectrode with laterally extending platform for reduction of tissue encapsulation |
US7979131B2 (en) | 2006-01-26 | 2011-07-12 | Advanced Neuromodulation Systems, Inc. | Method of neurostimulation of distinct neural structures using single paddle lead to treat multiple pain locations and multi-column, multi-row paddle lead for such neurostimulation |
US7801601B2 (en) | 2006-01-27 | 2010-09-21 | Cyberonics, Inc. | Controlling neuromodulation using stimulus modalities |
US7467016B2 (en) | 2006-01-27 | 2008-12-16 | Cyberonics, Inc. | Multipolar stimulation electrode with mating structures for gripping targeted tissue |
US20070191709A1 (en) | 2006-02-10 | 2007-08-16 | Swanson John W | Self-folding paddle lead and method of fabricating a paddle lead |
CA2641821C (en) | 2006-02-16 | 2017-10-10 | Imthera Medical, Inc. | An rfid-based apparatus, system, and method for therapeutic treatment of a patient |
US7729781B2 (en) | 2006-03-16 | 2010-06-01 | Greatbatch Ltd. | High efficiency neurostimulation lead |
ITMO20060087A1 (it) | 2006-03-17 | 2007-09-18 | Lorenz Biotech Spa | Apparato e metodo di elettrostimolazione |
US20120109251A1 (en) | 2006-03-23 | 2012-05-03 | Valery Pavlovich Lebedev | Transcranial electrostimulation device |
US8099172B2 (en) * | 2006-04-28 | 2012-01-17 | Advanced Neuromodulation Systems, Inc. | Spinal cord stimulation paddle lead and method of making the same |
US7613522B2 (en) | 2006-06-09 | 2009-11-03 | Cardiac Pacemakers, Inc. | Multi-antenna for an implantable medical device |
US20100152811A1 (en) | 2006-06-30 | 2010-06-17 | Flaherty Christopher J | Nerve regeneration system and lead devices associated therewith |
US7765011B2 (en) * | 2006-08-21 | 2010-07-27 | Medtronic, Inc. | Assembly methods for medical electrical leads |
US8532778B2 (en) | 2006-08-28 | 2013-09-10 | The United States Of America As Represented By The Department Of Veterans Affairs | Restoring cough using microstimulators |
US8170638B2 (en) * | 2006-09-11 | 2012-05-01 | University Of Florida Research Foundation, Inc. | MEMS flexible substrate neural probe and method of fabricating same |
JP4839163B2 (ja) | 2006-09-14 | 2011-12-21 | テルモ株式会社 | 電気刺激による脚運動装置 |
US9643004B2 (en) | 2006-10-31 | 2017-05-09 | Medtronic, Inc. | Implantable medical elongated member with adhesive elements |
US7831307B1 (en) | 2006-11-07 | 2010-11-09 | Boston Scientific Neuromodulation Corporation | System and method for computationally determining migration of neurostimulation leads |
CN101573150B (zh) | 2006-12-06 | 2012-03-14 | 脊髓调制公司 | 用于刺激多个脊椎节段上的神经组织的输送装置和系统 |
WO2008070809A2 (en) | 2006-12-06 | 2008-06-12 | Spinal Modulation, Inc. | Implantable flexible circuit leads and methods of use |
US7734351B2 (en) | 2006-12-15 | 2010-06-08 | Medtronic Xomed, Inc. | Method and apparatus for assisting deglutition |
US20080234791A1 (en) | 2007-01-17 | 2008-09-25 | Jeffrey Edward Arle | Spinal cord implant systems and methods |
US8554337B2 (en) | 2007-01-25 | 2013-10-08 | Giancarlo Barolat | Electrode paddle for neurostimulation |
US7949403B2 (en) | 2007-02-27 | 2011-05-24 | Accelerated Care Plus Corp. | Electrical stimulation device and method for the treatment of neurological disorders |
US10188853B2 (en) * | 2007-03-08 | 2019-01-29 | Second Sight Medical Products, Inc. | Flexible circuit electrode array with a drum stress relief |
US8428728B2 (en) | 2007-03-09 | 2013-04-23 | Mainstay Medical Limited | Muscle stimulator |
WO2008115754A1 (en) | 2007-03-16 | 2008-09-25 | Advanced Neuromodulation Systems, Inc. | Paddle lead comprising opposing diagonal arrangements of electrodes |
US8180445B1 (en) | 2007-03-30 | 2012-05-15 | Boston Scientific Neuromodulation Corporation | Use of interphase to incrementally adjust the volume of activated tissue |
US8364273B2 (en) | 2007-04-24 | 2013-01-29 | Dirk De Ridder | Combination of tonic and burst stimulations to treat neurological disorders |
US7742810B2 (en) | 2007-05-23 | 2010-06-22 | Boston Scientific Neuromodulation Corporation | Short duration pre-pulsing to reduce stimulation-evoked side-effects |
US7769463B2 (en) | 2007-06-19 | 2010-08-03 | Kalaco Scientific, Inc. | Multi-channel electrostimulation apparatus and method |
RU2361631C2 (ru) | 2007-07-04 | 2009-07-20 | Федеральное государственное учреждение здравоохранения Центральная клиническая больница восстановительного лечения Федерального медико-биологического агентства (ФГУЗ ЦКБВЛ ФМБА России) | Способ лечения больных травматической болезнью спинного мозга |
US20100268055A1 (en) * | 2007-07-19 | 2010-10-21 | Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University | Self-Anchoring MEMS Intrafascicular Neural Electrode |
BRPI0817271A2 (pt) | 2007-09-26 | 2015-06-16 | Univ Duke | Método de tratamento da doença de parkinson e outros distúrbios relacionados |
US7983757B2 (en) | 2007-10-26 | 2011-07-19 | Medtronic, Inc. | Medical device configuration based on sensed brain signals |
DE102007051848B4 (de) | 2007-10-30 | 2014-01-02 | Forschungszentrum Jülich GmbH | Vorrichtung zur Stimulation von Neuronenverbänden |
US20090204173A1 (en) | 2007-11-05 | 2009-08-13 | Zi-Ping Fang | Multi-Frequency Neural Treatments and Associated Systems and Methods |
US8170660B2 (en) | 2007-12-05 | 2012-05-01 | The Invention Science Fund I, Llc | System for thermal modulation of neural activity |
US9259568B2 (en) | 2008-04-29 | 2016-02-16 | Cardiac Pacemakers, Inc. | Systems and methods for delivering electric current for spinal cord stimulation |
US7890182B2 (en) | 2008-05-15 | 2011-02-15 | Boston Scientific Neuromodulation Corporation | Current steering for an implantable stimulator device involving fractionalized stimulation pulses |
RU2368401C1 (ru) | 2008-05-26 | 2009-09-27 | Андрей Александрович Олейников | Способ лечения грыж поясничных межпозвонковых дисков |
US8108052B2 (en) | 2008-05-29 | 2012-01-31 | Nervo Corporation | Percutaneous leads with laterally displaceable portions, and associated systems and methods |
US20090306491A1 (en) | 2008-05-30 | 2009-12-10 | Marcus Haggers | Implantable neural prosthetic device and methods of use |
AU2009260499A1 (en) * | 2008-05-30 | 2009-12-23 | Stryker Corporation | Method of assembling an electrode array that includes a plastically deformable carrier |
CA2727498C (en) | 2008-07-02 | 2020-04-21 | Niveus Medical, Inc. | Systems and methods for automated muscle stimulation |
RU2396995C2 (ru) | 2008-07-14 | 2010-08-20 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" | Способ лечения больных с остеохондрозом поясничного отдела позвоночника с корешковым синдромом |
US8155750B2 (en) | 2008-07-24 | 2012-04-10 | Boston Scientific Neuromodulation Corporation | System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation |
US8055337B2 (en) | 2008-07-24 | 2011-11-08 | Boston Scientific Neuromodulation Corporation | System and method for maintaining a distribution of currents in an electrode array using independent voltage sources |
US20100023103A1 (en) | 2008-07-28 | 2010-01-28 | Boston Scientific Neuromodulation Corporation | Systems and Methods for Treating Essential Tremor or Restless Leg Syndrome Using Spinal Cord Stimulation |
US8137285B1 (en) * | 2008-08-26 | 2012-03-20 | Rhythmlink International, Llc | Monopolar stimulation probe system |
US8442655B2 (en) | 2008-09-04 | 2013-05-14 | Boston Scientific Neuromodulation Corporation | Multiple tunable central cathodes on a paddle for increased medial-lateral and rostral-caudal flexibility via current steering |
US7987000B2 (en) | 2008-09-04 | 2011-07-26 | Boston Scientific Neuromodulation Corporation | Multiple tunable central cathodes on a paddle for increased medial-lateral and rostral-caudal flexibility via current steering |
US8050773B2 (en) | 2008-09-28 | 2011-11-01 | Jie Zhu | Expandable neuromodular stimulation lead |
CN102202729B (zh) | 2008-10-27 | 2014-11-05 | 脊髓调制公司 | 选择性刺激系统和用于医疗状况的信号参数 |
US8311639B2 (en) | 2009-07-08 | 2012-11-13 | Nevro Corporation | Systems and methods for adjusting electrical therapy based on impedance changes |
WO2010057046A2 (en) | 2008-11-13 | 2010-05-20 | Proteus Biomedical, Inc. | Multiplexed multi-electrode neurostimulation devices |
US8504160B2 (en) | 2008-11-14 | 2013-08-06 | Boston Scientific Neuromodulation Corporation | System and method for modulating action potential propagation during spinal cord stimulation |
RU2387467C1 (ru) | 2008-11-18 | 2010-04-27 | Инна Игоревна Русинова | Способ коррекции мышечного дисбаланса у детей с нарушением осанки и сколиозом 1 и 2 степени |
RU2397788C2 (ru) | 2008-11-21 | 2010-08-27 | Государственное учреждение Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (МОНИКИ им. М.Ф. Владимирского) | Способ восстановления микроциркуляции пораженных тканей |
US8352036B2 (en) | 2009-01-19 | 2013-01-08 | Anthony DiMarco | Respiratory muscle activation by spinal cord stimulation |
EP2393551A4 (en) | 2009-02-09 | 2013-04-17 | Proteus Digital Health Inc | MULTIPLEX AND MULTILECTRODE NEUROSTIMULATION DEVICES WITH AN INTEGRATED CIRCUIT WITH INTEGRATED ELECTRODES |
CA3051810A1 (en) | 2009-02-10 | 2010-08-19 | Nevro Corporation | Systems and methods for delivering neural therapy correlated with patient status |
EP2414035B1 (en) * | 2009-04-03 | 2014-07-30 | Stryker Corporation | Delivery assembly for percutaneously delivering and deploying an electrode array at a target location, the assembly capable of steering the electrode array to the target location |
EP2421600B1 (en) | 2009-04-22 | 2014-03-05 | Nevro Corporation | Spinal cord modulation systems for inducing paresthetic and anesthetic effects |
US8781600B2 (en) * | 2009-08-05 | 2014-07-15 | Stryker Corporation | Implantable electrode array assembly including a carrier in which control modules for regulating the operation of the electrodes are disposed and electrodes that are disposed on top of the carrier |
US8543200B2 (en) | 2009-08-28 | 2013-09-24 | Boston Scientific Neuromodulation Corporation | Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse placement |
US9724513B2 (en) | 2009-08-28 | 2017-08-08 | Boston Scientific Neuromodulation Corporation | Methods to avoid frequency locking in a multi-channel neurostimulation system using pulse shifting |
US9061134B2 (en) * | 2009-09-23 | 2015-06-23 | Ripple Llc | Systems and methods for flexible electrodes |
US8412345B2 (en) | 2009-11-03 | 2013-04-02 | Boston Scientific Neuromodulation Corporation | System and method for mapping arbitrary electric fields to pre-existing lead electrodes |
TW201117849A (en) | 2009-11-30 | 2011-06-01 | Unimed Invest Inc | Implantable pulsed-radiofrequency micro-stimulation system |
US8774937B2 (en) | 2009-12-01 | 2014-07-08 | Ecole Polytechnique Federale De Lausanne | Microfabricated surface neurostimulation device and methods of making and using the same |
CA2785799A1 (en) | 2009-12-30 | 2011-07-07 | Boston Scientific Neuromodulation Corporation | System and method for independently operating multiple neurostimulation channels |
US8626295B2 (en) | 2010-03-04 | 2014-01-07 | Cardiac Pacemakers, Inc. | Ultrasonic transducer for bi-directional wireless communication |
CA2792529C (en) | 2010-03-11 | 2018-06-05 | Mainstay Medical, Inc. | Modular stimulator for treatment of back pain, implantable rf ablation system and methods of use |
AU2011234422B2 (en) | 2010-04-01 | 2015-11-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Device for interacting with neurological tissue and methods of making and using the same |
US9272139B2 (en) | 2010-07-01 | 2016-03-01 | Marilyn J. Hamilton | Universal closed-loop electrical stimulation system |
JP5577469B2 (ja) | 2010-09-15 | 2014-08-20 | カーディアック ペースメイカーズ, インコーポレイテッド | 神経刺激リードのリード構成の自動選択 |
US9155891B2 (en) | 2010-09-20 | 2015-10-13 | Neuropace, Inc. | Current management system for a stimulation output stage of an implantable neurostimulation system |
US8239038B2 (en) | 2010-10-14 | 2012-08-07 | Wolf Ii Erich W | Apparatus and method using near infrared reflectometry to reduce the effect of positional changes during spinal cord stimulation |
US20120123293A1 (en) | 2010-11-11 | 2012-05-17 | IINN, Inc. | Motor nerve root stimulation |
RU2445990C1 (ru) | 2010-11-12 | 2012-03-27 | Государственное учреждение Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (ГУ МОНИКИ им. М.Ф. Владимирского) | Способ лечения парезов и параличей |
AU2011336606B2 (en) | 2010-11-30 | 2016-06-23 | Nevro Corporation | Extended pain relief via high frequency spinal cord modulation, and associated systems and methods |
EP4201475A1 (en) | 2011-01-03 | 2023-06-28 | The Regents of the University of California | High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury |
ES2640110T3 (es) | 2011-01-21 | 2017-10-31 | California Institute Of Technology | Un implante de serie de microelectrodos basado en parileno para la estimulación de la médula espinal |
US20120232615A1 (en) | 2011-03-07 | 2012-09-13 | Giancarlo Barolat | Modular Limb Peripheral Nerve Stimulation System and Method of Use |
RU2471518C2 (ru) | 2011-03-23 | 2013-01-10 | Учреждение Российской Академии Наук Институт физиологии им. И.П. Павлова ИФ РАН | Способ электрической стимуляции спинного мозга |
CA2825550C (en) | 2011-03-24 | 2022-07-12 | California Institute Of Technology | Neurostimulator |
RU2475283C2 (ru) | 2011-05-10 | 2013-02-20 | Федеральное государственное бюджетное учреждение "Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии" Министерства здравоохранения и социального развития Российской Федерации | Способ восстановления движений рук у больных с верхними параличами и парезами |
US8688233B2 (en) | 2011-06-23 | 2014-04-01 | Boston Scientific Neuromodulation Corporation | System and method for spinal cord stimulation to treat motor disorders |
BR112014011409A2 (pt) | 2011-11-11 | 2017-05-02 | Neuroenabling Tech Inc | dispositivo de neuromodulação não invasivo para permitir a recuperação de função motora, sensorial, autonômica, sexual, vasomotora e cohnitiva |
WO2013071309A1 (en) | 2011-11-11 | 2013-05-16 | The Regents Of The University Of California | Transcutaneous spinal cord stimulation: noninvasive tool for activation of locomotor circuitry |
US9622671B2 (en) | 2012-03-20 | 2017-04-18 | University of Pittsburgh—of the Commonwealth System of Higher Education | Monitoring and regulating physiological states and functions via sensory neural inputs to the spinal cord |
EP2827942B1 (en) | 2012-03-23 | 2016-04-27 | Boston Scientific Neuromodulation Corporation | Heuristic safety net for transitioning configurations in a neural stimulation system |
EP3878507A1 (en) | 2013-03-15 | 2021-09-15 | The Regents Of The University Of California | Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion |
US20150217120A1 (en) | 2014-01-13 | 2015-08-06 | Mandheerej Nandra | Neuromodulation systems and methods of using same |
-
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- 2012-01-23 CA CA2824782A patent/CA2824782C/en active Active
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Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009111142A2 (en) * | 2008-03-06 | 2009-09-11 | Stryker Corporation | Foldable, implantable electrode array assembly and tool for implanting same |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2018187434A (ja) * | 2014-05-28 | 2018-11-29 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 可撓性導電トラック構成の製造方法、可撓性導電トラック構成及び神経刺激システム |
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CA2824782C (en) | 2020-06-30 |
WO2012100260A3 (en) | 2012-11-01 |
AU2012207115B2 (en) | 2016-03-10 |
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