JP5919192B2 - βアミノ酸の調製 - Google Patents

βアミノ酸の調製 Download PDF

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Publication number
JP5919192B2
JP5919192B2 JP2012528394A JP2012528394A JP5919192B2 JP 5919192 B2 JP5919192 B2 JP 5919192B2 JP 2012528394 A JP2012528394 A JP 2012528394A JP 2012528394 A JP2012528394 A JP 2012528394A JP 5919192 B2 JP5919192 B2 JP 5919192B2
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group
reaction
hydantoinase
enzyme
amino acid
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Expired - Fee Related
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Japanese (ja)
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JP2013504313A5 (https=
JP2013504313A (ja
Inventor
シュナイダー，ニーナ
ハウアー，ベルンハルト
ディトリッヒ，クラウス
オニール，メーヴ
ターナー，ニック
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BASF SE
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BASF SE
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01087—N-Carbamoyl-L-amino-acid hydrolase (3.5.1.87)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02002—Dihydropyrimidinase (3.5.2.2), i.e. hydantoinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02014—N-Methylhydantoinase (ATP-hydrolyzing) (3.5.2.14)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012528394A 2009-09-15 2010-09-15 βアミノ酸の調製 Expired - Fee Related JP5919192B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09170364 2009-09-15
EP09170364.5 2009-09-15
US24530309P 2009-09-24 2009-09-24
US61/245,303 2009-09-24
PCT/EP2010/063558 WO2011032990A1 (en) 2009-09-15 2010-09-15 Preparation of beta-amino acids

Publications (3)

Publication Number Publication Date
JP2013504313A JP2013504313A (ja) 2013-02-07
JP2013504313A5 JP2013504313A5 (https=) 2015-08-13
JP5919192B2 true JP5919192B2 (ja) 2016-05-18

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ID=43259766

Family Applications (1)

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JP2012528394A Expired - Fee Related JP5919192B2 (ja) 2009-09-15 2010-09-15 βアミノ酸の調製

Country Status (6)

Country Link
US (1) US9096841B2 (https=)
EP (1) EP2478098B1 (https=)
JP (1) JP5919192B2 (https=)
CN (1) CN102782128A (https=)
ES (1) ES2628225T3 (https=)
WO (1) WO2011032990A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120070867A1 (en) 2009-06-04 2012-03-22 Basf Se process for the enzymatic reduction of enoates
US20130273619A1 (en) 2012-04-16 2013-10-17 Basf Se Process for the Preparation of (3E, 7E)-Homofarnesol
CN106191147B (zh) * 2016-07-08 2020-03-27 凯莱英医药集团（天津）股份有限公司 手性β-氨基酸的制备方法
CN106831606B (zh) * 2017-01-20 2019-02-22 湖南有色郴州氟化学有限公司 一种5-三氟甲基-5,6-二氢尿嘧啶的制备方法
CN109896980B (zh) * 2017-12-07 2022-04-08 浙江九洲药业股份有限公司 一种西格列汀中间体的生物合成方法
CN119955872B (zh) * 2025-04-11 2025-08-12 中国科学院微生物研究所 R-(-)-3-(氨甲酰甲基)-5-甲基己酸合成蛋白及其突变体与应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06261787A (ja) * 1993-03-10 1994-09-20 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸の製造法
DE19931847A1 (de) 1999-07-09 2001-01-11 Basf Ag Immobilisierte Lipase
DE10019380A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Herstellung von kovalent gebundenen biologisch aktiven Stoffen an Polyurethanschaumstoffen sowie Verwendung der geträgerten Polyurethanschaumstoffe für chirale Synthesen
DE10019377A1 (de) 2000-04-19 2001-10-25 Basf Ag Verfahren zur Immobilisierung von biologisch aktiven Stoffen auf Trägermaterialien und Verwendung der mit biologisch aktiven Stoffen geträgerten Materialien für chirale Synthesen
CN1260347C (zh) * 2002-05-13 2006-06-21 中国人民解放军军事医学科学院生物工程研究所 一株产乙内酰脲酶系的节杆菌
CN1908159B (zh) * 2005-02-07 2011-04-20 中国科学院上海生命科学研究院 D-氨基酸生产菌株及其构建方法
EP2065470A1 (en) 2007-11-28 2009-06-03 Basf Se New malonate decarboxylases for industrial applications
EP2229449A2 (de) 2007-12-10 2010-09-22 Basf Se Verfahren zur enzymatischen reduktion von alpha- und beta-dehydroaminosäuren
KR20100098447A (ko) 2007-12-20 2010-09-06 바스프 에스이 (ｓ)-1-메톡시-2-프로필아민으로부터의 (ｓ)-2-아미노-1-프로판올 (ｌ-알라닌올)의 제조 방법
EP2145904A1 (de) 2008-07-18 2010-01-20 Basf Se Verfahren zur enzymkatalysierten Hydrolyse von Polyacrylsäureestern sowie dafür zu verwendende Esterasen
JP2012511922A (ja) 2008-12-17 2012-05-31 ビーエーエスエフ ソシエタス・ヨーロピア デュロキセチンアルコールを製造するための改良型生体触媒
EP2387556B1 (de) 2009-01-16 2014-07-30 Basf Se Trennung eines enantiomerengemischs von (r)- und (s)-3-amino-1-butanol
DE102009003035A1 (de) 2009-05-12 2010-11-18 Basf Se Verfahren zur Herstellung von urethangruppenhaltigen (Meth)acrylsäureestern
US20120070867A1 (en) 2009-06-04 2012-03-22 Basf Se process for the enzymatic reduction of enoates
EP3404108A1 (de) 2009-06-05 2018-11-21 Basf Se Biokatalytische herstellung von ambroxan
WO2011012632A2 (en) 2009-07-30 2011-02-03 Basf Se Biocatalyst for catalytic hydroamination

Also Published As

Publication number Publication date
US9096841B2 (en) 2015-08-04
EP2478098A1 (en) 2012-07-25
WO2011032990A1 (en) 2011-03-24
EP2478098B1 (en) 2017-03-15
US20120270280A1 (en) 2012-10-25
ES2628225T3 (es) 2017-08-02
JP2013504313A (ja) 2013-02-07
CN102782128A (zh) 2012-11-14

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