JP5893204B1 - 防腐効果のある医薬の組合せ - Google Patents
防腐効果のある医薬の組合せ Download PDFInfo
- Publication number
- JP5893204B1 JP5893204B1 JP2015239244A JP2015239244A JP5893204B1 JP 5893204 B1 JP5893204 B1 JP 5893204B1 JP 2015239244 A JP2015239244 A JP 2015239244A JP 2015239244 A JP2015239244 A JP 2015239244A JP 5893204 B1 JP5893204 B1 JP 5893204B1
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- JP
- Japan
- Prior art keywords
- salt
- pharmaceutical composition
- dorzolamide
- composition according
- timolol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 155
- 229960003933 dorzolamide Drugs 0.000 claims abstract description 70
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 claims abstract description 70
- TWBNMYSKRDRHAT-RCWTXCDDSA-N (S)-timolol hemihydrate Chemical compound O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1.CC(C)(C)NC[C@H](O)COC1=NSN=C1N1CCOCC1 TWBNMYSKRDRHAT-RCWTXCDDSA-N 0.000 claims abstract description 56
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- RBWSWDPRDBEWCR-RKJRWTFHSA-N sodium;(2r)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethanolate Chemical compound [Na+].[O-]C[C@@H](O)[C@H]1OC(=O)C(O)=C1O RBWSWDPRDBEWCR-RKJRWTFHSA-N 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000019337 sorbitan trioleate Nutrition 0.000 description 1
- 229960000391 sorbitan trioleate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960000281 trometamol Drugs 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015239244A JP5893204B1 (ja) | 2015-02-23 | 2015-12-08 | 防腐効果のある医薬の組合せ |
| TW105105102A TW201701877A (zh) | 2015-02-23 | 2016-02-22 | 含有多佐胺之防腐劑 |
| PCT/JP2016/055002 WO2016136651A1 (ja) | 2015-02-23 | 2016-02-22 | ドルゾラミドを含有する防腐剤 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| JP2015032655 | 2015-02-23 | ||
| JP2015032655 | 2015-02-23 | ||
| JP2015116705 | 2015-06-09 | ||
| JP2015116705 | 2015-06-09 | ||
| JP2015239244A JP5893204B1 (ja) | 2015-02-23 | 2015-12-08 | 防腐効果のある医薬の組合せ |
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| JP2016029915A Division JP6707365B2 (ja) | 2015-02-23 | 2016-02-19 | 防腐効果のある医薬の組合せ |
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| JP5893204B1 true JP5893204B1 (ja) | 2016-03-23 |
| JP2016216439A JP2016216439A (ja) | 2016-12-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015239244A Active JP5893204B1 (ja) | 2015-02-23 | 2015-12-08 | 防腐効果のある医薬の組合せ |
| JP2016029915A Active JP6707365B2 (ja) | 2015-02-23 | 2016-02-19 | 防腐効果のある医薬の組合せ |
| JP2020088013A Active JP6877613B2 (ja) | 2015-02-23 | 2020-05-20 | 防腐効果のある医薬の組合せ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016029915A Active JP6707365B2 (ja) | 2015-02-23 | 2016-02-19 | 防腐効果のある医薬の組合せ |
| JP2020088013A Active JP6877613B2 (ja) | 2015-02-23 | 2020-05-20 | 防腐効果のある医薬の組合せ |
Country Status (5)
| Country | Link |
|---|---|
| JP (3) | JP5893204B1 (ru) |
| KR (1) | KR20170118758A (ru) |
| RU (1) | RU2017130858A (ru) |
| TW (1) | TW201636014A (ru) |
| WO (1) | WO2016136642A1 (ru) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05117167A (ja) * | 1991-04-17 | 1993-05-14 | Merck & Co Inc | 炭酸脱水酵素阻害物質とβ−アドレナリン拮抗剤との組合せを含有する眼科薬組成物 |
| WO2011013794A1 (ja) * | 2009-07-30 | 2011-02-03 | わかもと製薬株式会社 | 点眼用水性組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2918891B1 (fr) * | 2007-07-20 | 2009-09-25 | Thea Sa Lab | Solution ophtalmique a base de prostaglandines sans conservateur |
| JP2010537791A (ja) * | 2007-09-07 | 2010-12-09 | リシール インターナショナル リミテッド パートナーシップ | 連続的にシールする一方向バルブアセンブリおよび送達システム |
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2015
- 2015-12-08 JP JP2015239244A patent/JP5893204B1/ja active Active
- 2015-12-09 TW TW104141276A patent/TW201636014A/zh unknown
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2016
- 2016-02-19 JP JP2016029915A patent/JP6707365B2/ja active Active
- 2016-02-22 RU RU2017130858A patent/RU2017130858A/ru unknown
- 2016-02-22 WO PCT/JP2016/054976 patent/WO2016136642A1/ja active Application Filing
- 2016-02-22 KR KR1020177023489A patent/KR20170118758A/ko unknown
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2020
- 2020-05-20 JP JP2020088013A patent/JP6877613B2/ja active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05117167A (ja) * | 1991-04-17 | 1993-05-14 | Merck & Co Inc | 炭酸脱水酵素阻害物質とβ−アドレナリン拮抗剤との組合せを含有する眼科薬組成物 |
| WO2011013794A1 (ja) * | 2009-07-30 | 2011-02-03 | わかもと製薬株式会社 | 点眼用水性組成物 |
Non-Patent Citations (1)
| Title |
|---|
| JPN7015003662; Ｄｒｕｇ Ｄｅｌｉｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ． １０， Ｎｏ． ６, 2010, ｐ． ４６-４９ * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6877613B2 (ja) | 2021-05-26 |
| KR20170118758A (ko) | 2017-10-25 |
| RU2017130858A (ru) | 2019-03-25 |
| WO2016136642A1 (ja) | 2016-09-01 |
| TW201636014A (zh) | 2016-10-16 |
| JP6707365B2 (ja) | 2020-06-10 |
| RU2017130858A3 (ru) | 2019-07-29 |
| JP2016106115A (ja) | 2016-06-16 |
| JP2016216439A (ja) | 2016-12-22 |
| JP2020128422A (ja) | 2020-08-27 |
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