JP5885244B2 - １つまたは複数の薬剤の徐放性送達 - Google Patents

１つまたは複数の薬剤の徐放性送達 Download PDF

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Publication number
JP5885244B2
JP5885244B2 JP2011548154A JP2011548154A JP5885244B2 JP 5885244 B2 JP5885244 B2 JP 5885244B2 JP 2011548154 A JP2011548154 A JP 2011548154A JP 2011548154 A JP2011548154 A JP 2011548154A JP 5885244 B2 JP5885244 B2 JP 5885244B2
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Prior art keywords
implant
drug
latanoprost
drug core
lacrimal
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Japanese (ja)
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JP2012515628A (ja
Inventor
ブトゥーナー，ズハル
ウッケーデ，ディーパンク
シム，シルヴィー
ジェイ． ワイズマン，デイビッド
ジェイ． ワイズマン，デイビッド
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マティ セラピューティクス，インク．
マティ セラピューティクス，インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00772—Apparatus for restoration of tear ducts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
JP2011548154A 2009-01-23 2010-01-22 １つまたは複数の薬剤の徐放性送達 Active JP5885244B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US14686009P 2009-01-23 2009-01-23
US61/146,860 2009-01-23
US15290909P 2009-02-16 2009-02-16
US61/152,909 2009-02-16
US22889409P 2009-07-27 2009-07-27
US61/228,894 2009-07-27
US27700009P 2009-09-18 2009-09-18
US61/277,000 2009-09-18
PCT/US2010/021868 WO2010085696A2 (en) 2009-01-23 2010-01-22 Sustained released delivery of one or more agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016019437A Division JP2016127945A (ja) 2009-01-23 2016-02-04 １つまたは複数の薬剤の徐放性送達

Publications (2)

Publication Number Publication Date
JP2012515628A JP2012515628A (ja) 2012-07-12
JP5885244B2 true JP5885244B2 (ja) 2016-03-15

Family

ID=42356409

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011548154A Active JP5885244B2 (ja) 2009-01-23 2010-01-22 １つまたは複数の薬剤の徐放性送達
JP2016019437A Pending JP2016127945A (ja) 2009-01-23 2016-02-04 １つまたは複数の薬剤の徐放性送達

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016019437A Pending JP2016127945A (ja) 2009-01-23 2016-02-04 １つまたは複数の薬剤の徐放性送達

Country Status (16)

Country Link
US (3) US20100209477A1 (de)
EP (1) EP2389221B1 (de)
JP (2) JP5885244B2 (de)
KR (1) KR20110129869A (de)
CN (2) CN102341144B (de)
AU (1) AU2010206610A1 (de)
BR (1) BRPI1007318A2 (de)
CA (1) CA2750381C (de)
CO (1) CO6400201A2 (de)
HK (1) HK1162151A1 (de)
IL (1) IL214199A0 (de)
MX (1) MX2011007804A (de)
RU (1) RU2011134043A (de)
SG (1) SG173069A1 (de)
WO (1) WO2010085696A2 (de)
ZA (1) ZA201105345B (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3470108A1 (de) 2004-07-02 2019-04-17 Mati Therapeutics Inc. Vorrichtung zur abgabe eines behandlungsmittels im auge
CN103393483B (zh) 2006-03-31 2016-08-24 玛提治疗有限公司 用于鼻泪系统的药物释放方法、结构及组合物
CN101861135A (zh) 2007-09-07 2010-10-13 Qlt栓塞输送公司 泪道植入物检测
JP5524841B2 (ja) 2007-09-07 2014-06-18 キュー エル ティー インク． 涙管インプラント及び関連する方法
CN102123713A (zh) * 2008-05-09 2011-07-13 Qlt栓塞输送公司 治疗青光眼和眼高血压的活性剂的持续释放递送
MX2011008875A (es) * 2009-02-23 2011-09-26 Quadra Logic Tech Inc Implantes lagrimales y metodos relacionados.
TWI495459B (zh) * 2009-03-31 2015-08-11 Johnson & Johnson Vision Care 淚管塞（二）
US9421127B2 (en) 2009-03-31 2016-08-23 Johnson & Johnson Vision Care, Inc. Punctal plugs
CA2764063C (en) 2009-06-03 2019-05-14 Forsight Labs, Llc Anterior segment drug delivery
TW201127359A (en) * 2009-09-21 2011-08-16 Vidus Ocular Inc Uveoscleral drainage device
US9259352B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
US9259351B2 (en) 2010-03-29 2016-02-16 Johnson & Johnson Vision Care, Inc. Punctal plugs
WO2012021107A2 (en) 2010-08-12 2012-02-16 Nanyang Technological University A liposomal formulation for ocular drug delivery
US8591484B2 (en) 2010-09-15 2013-11-26 AlphaMed, Inc. Lacrimal punctum measurement and occlusion
US8783451B2 (en) * 2011-02-18 2014-07-22 Allergan, Inc. Unit dose breakable vial with integrated brush applicator
EP3967297A1 (de) 2011-04-29 2022-03-16 Allergan, Inc. Latanoprost-implantat mit verzögerter freisetzung
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
JP6100782B2 (ja) 2011-08-29 2017-03-22 キューエルティー インコーポレイテッド 緑内障および高眼圧症を治療するための活性剤の徐放送達
CN106073986B (zh) 2011-09-14 2019-01-11 弗赛特影像5股份有限公司 治疗患者的眼睛的装置
US8834406B2 (en) * 2011-10-21 2014-09-16 Snyder Biomedical Corporation Biocompatible glaucoma drainage device
SG10201508662SA (en) 2011-10-28 2015-11-27 Presage Biosciences Inc Methods for drug delivery
US20130220346A1 (en) * 2012-02-28 2013-08-29 Victor Lust Balloon punctal plug
CN105473130A (zh) * 2012-05-03 2016-04-06 麦提疗法有限公司 治疗开角型青光眼和高眼压症的药物递送系统和方法
US9827250B2 (en) * 2012-07-31 2017-11-28 Johnson & Johnson Vision Care, Inc. Lens incorporating myopia control optics and muscarinic agents
CN103767822A (zh) * 2012-10-24 2014-05-07 鸿富锦精密工业（深圳）有限公司 辅助装置及利用该辅助装置进行眼药水投药的方法
WO2014066775A1 (en) 2012-10-26 2014-05-01 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
WO2014113384A2 (en) * 2013-01-15 2014-07-24 The Regents Of The University Of Colorado, A Body Corporate Lacrimal system drug delivery device
EP3669865A1 (de) * 2013-10-31 2020-06-24 Allergan, Inc. Prostamidhaltige intraokulare implantate und verfahren zur verwendung davon
US9956195B2 (en) 2014-01-07 2018-05-01 Nanyang Technological University Stable liposomal formulations for ocular drug delivery
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
US20180193193A1 (en) * 2015-07-06 2018-07-12 The Regents Of The University Of Colorado, A Body Corporate Lacrimal drainage system diagnostic implant
WO2017015471A1 (en) 2015-07-21 2017-01-26 Avedro, Inc. Systems and methods for treaments of an eye with a photosensitizer
EP3380040B1 (de) 2015-11-23 2023-04-19 The Regents of The University of Colorado, A Body Corporate Tränensystem zur arzneimittelabgabe
RU2613435C1 (ru) * 2015-12-17 2017-03-16 Федеральное государственное автономное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Дренаж для хирургического лечения глаукомы
CA3024912A1 (en) 2016-05-20 2017-11-23 The Regents Of The University Of Colorado, A Body Corporate Lacrimal drug delivery device
EP3474794A4 (de) * 2016-07-13 2019-07-24 Mati Therapeutics Inc. Statisches stifteinsatzwerkzeug für tränenimplantat
US10603274B2 (en) * 2016-09-30 2020-03-31 Mati Therapeutics Inc. Ophthalmic drug sustained release formulation and uses thereof
WO2018064648A1 (en) * 2016-09-30 2018-04-05 Mati Therapeutics Inc. Ophthalmic drug sustained release formulation and uses thereof
CN106963543A (zh) * 2017-02-16 2017-07-21 武汉奥绿新生物科技股份有限公司 引流型柔性微型支架及医疗器械
EP3746018A1 (de) * 2018-02-02 2020-12-09 Tusker Medical, Inc. Systeme, vorrichtung und verfahren zum transport und zur abgabe einer therapeutischen substanz an das mittelohr
WO2019222121A1 (en) * 2018-05-12 2019-11-21 Goldenbiotech, Llc Self-retaining implantable drug delivery device
WO2020006000A1 (en) * 2018-06-25 2020-01-02 Titan Pharmaceuticals, Inc. Implants for release of lipophilic or amphiphilic pharmaceutical substances
EP3946185A4 (de) * 2019-04-02 2022-11-30 The Regents of the University of California Verfahren und vorrichtung zur änderung der hornhaut mittels elektrochemie
US11400039B2 (en) * 2020-01-16 2022-08-02 James W. Hill Changing eye color by gene transduction
WO2021188985A2 (en) * 2020-03-19 2021-09-23 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Concentric permeation system for transfer of neutral gaseous material
US20210338481A1 (en) * 2020-04-20 2021-11-04 Bruce B. Becker Lacrimal gland implant for drug delivery and method
EP4210598A1 (de) * 2020-09-10 2023-07-19 Oasis Medical, Inc. Vorrichtungen und verfahren zum verschliessen der punktförmigen öffnung
WO2022182740A1 (en) 2021-02-24 2022-09-01 Ocular Therapeutix, Inc. Intracanalicular depot inserter device
DE102021202061A1 (de) * 2021-03-03 2022-09-08 B. Braun Melsungen Aktiengesellschaft Medizinprodukt, Funktionsteil für ein Medizinprodukt und Verfahren zum Sterilisieren und/oder zum Herstellen von Sterilisationsbeständigkeit eines Medizinprodukts oder Funktionsteils
AU2022272319A1 (en) * 2021-05-14 2023-12-07 Glaukos Corporation Materials and methods for punctal plugs
WO2024097437A1 (en) * 2022-11-03 2024-05-10 Becker Bruce B Anchored lacrimal caruncle implant for drug delivery and method

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281654A (en) * 1980-04-07 1981-08-04 Alza Corporation Drug delivery system for controlled ocular therapy
ES2078175B1 (es) * 1993-12-31 1996-10-16 Cusi Lab Formulacion farmaceutica conteniendo clobetasona y tobramicina y sus aplicaciones.
US6196993B1 (en) * 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
US6566345B2 (en) * 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6534693B2 (en) * 2000-11-06 2003-03-18 Afmedica, Inc. Surgically implanted devices having reduced scar tissue formation
FR2834446B1 (fr) * 2002-01-08 2004-02-13 Ioltechnologie Production Clou meatique a expansion
EP1466969A4 (de) * 2002-01-18 2006-02-01 Takara Bio Inc Sulfatiertes fucan
US20040043067A1 (en) * 2002-06-19 2004-03-04 Salamone Joseph C. Fluorosiloxane matrix controlled diffusion drug delivery systems
FR2844182B1 (fr) * 2002-09-11 2004-12-03 Humanoptics Ag Bouchon d'obturation d'un canalicule lacrymal
US7785578B2 (en) * 2002-10-11 2010-08-31 Aciont, Inc. Non-invasive ocular drug delivery
EP1603485A4 (de) * 2003-02-26 2011-03-30 Medivas Llc Bioaktive stents und verwendungsverfahren dafür
US7662864B2 (en) 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
US20050129731A1 (en) * 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US7799336B2 (en) * 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20060024350A1 (en) * 2004-06-24 2006-02-02 Varner Signe E Biodegradable ocular devices, methods and systems
US7681614B2 (en) 2004-08-27 2010-03-23 The Yokohama Rubber Co., Ltd. Run flat support body for pneumatic tire
CN103393483B (zh) * 2006-03-31 2016-08-24 玛提治疗有限公司 用于鼻泪系统的药物释放方法、结构及组合物
CN101505695A (zh) * 2006-06-21 2009-08-12 庄臣及庄臣视力保护公司 用于递送活性试剂的泪点塞
CN101505694B (zh) * 2006-06-21 2012-02-22 庄臣及庄臣视力保护公司 用于递送活性试剂的泪点塞
US9173773B2 (en) * 2006-06-21 2015-11-03 Johnson & Johnson Vision Care, Inc. Punctal plugs for the delivery of active agents
CA2674076A1 (en) * 2006-12-26 2008-07-10 Qlt Plug Delivery, Inc. Drug delivery implants for inhibition of optical defects
UY30883A1 (es) * 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
US20080299176A1 (en) * 2007-05-30 2008-12-04 Yu-Chin Lai Drug delivery device comprising crosslinked polyurethane-siloxane-containing copolymers
CN101327357A (zh) * 2007-06-21 2008-12-24 庄臣及庄臣视力保护公司 用于输送活性剂的泪点塞
CN101327356A (zh) * 2007-06-21 2008-12-24 庄臣及庄臣视力保护公司 用于输送活性剂的泪点塞
US20090104243A1 (en) 2007-09-07 2009-04-23 Qlt Plug Delivery, Inc. - Qpdi Drug cores for sustained release of therapeutic agents
JP5524841B2 (ja) * 2007-09-07 2014-06-18 キュー エル ティー インク． 涙管インプラント及び関連する方法
JP2010537776A (ja) * 2007-09-07 2010-12-09 キューエルティー プラグ デリバリー，インク． 涙管インプラント用の挿入および抜き取り工具
CN104856782B (zh) * 2007-09-07 2017-09-12 马缇医疗股份有限公司 泪腺植入物及相关方法
CN101861135A (zh) * 2007-09-07 2010-10-13 Qlt栓塞输送公司 泪道植入物检测
RU2010136822A (ru) * 2008-02-18 2012-03-10 Клт Плаг Диливери, Инк. (Us) Лакримальные имплантаты и связанные с ними способы
US9132088B2 (en) * 2008-04-30 2015-09-15 Mati Therapeutics Inc. Composite lacrimal insert and related methods
CA2730101A1 (en) * 2008-07-08 2010-01-14 Qlt Plug Delivery, Inc. Lacrimal implant body including comforting agent
EP2376019A1 (de) * 2008-12-19 2011-10-19 QLT, Inc. Punktionsimplantate zur freisetzung von stoffen und verfahren
MX2011008875A (es) * 2009-02-23 2011-09-26 Quadra Logic Tech Inc Implantes lagrimales y metodos relacionados.

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MX2011007804A (es) 2011-12-06
CA2750381C (en) 2021-03-16
KR20110129869A (ko) 2011-12-02
WO2010085696A2 (en) 2010-07-29
ZA201105345B (en) 2012-03-28
CN102341144B (zh) 2014-10-29
EP2389221A2 (de) 2011-11-30
CO6400201A2 (es) 2012-03-15
CN104306103B (zh) 2017-04-19
AU2010206610A1 (en) 2011-08-11
WO2010085696A9 (en) 2011-06-03
SG173069A1 (en) 2011-08-29
EP2389221C0 (de) 2023-08-16
JP2016127945A (ja) 2016-07-14
US20150064230A1 (en) 2015-03-05
EP2389221B1 (de) 2023-08-16
HK1162151A1 (en) 2012-08-24
WO2010085696A3 (en) 2010-11-04
EP2389221A4 (de) 2017-11-01
US20100209477A1 (en) 2010-08-19
JP2012515628A (ja) 2012-07-12
RU2011134043A (ru) 2013-02-20
CA2750381A1 (en) 2010-07-29
IL214199A0 (en) 2011-08-31
US20150133546A1 (en) 2015-05-14
CN104306103A (zh) 2015-01-28
BRPI1007318A2 (pt) 2019-04-09

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