JP5873717B2 - Ｉｌ−２８及び組成物を用いたワクチン及び免疫治療薬並びにその使用方法 - Google Patents
Ｉｌ−２８及び組成物を用いたワクチン及び免疫治療薬並びにその使用方法 Download PDFInfo
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20130197612A1 (en) * | 2010-02-26 | 2013-08-01 | Jack W. Lasersohn | Electromagnetic Radiation Therapy |
| WO2012047679A2 (en) | 2010-09-27 | 2012-04-12 | The Trustees Of The University Of Pennsylvania | Consensus antigen constructs and vaccines made there form, and methods of using same to treat malaria |
| US8906384B2 (en) * | 2010-12-22 | 2014-12-09 | The United States Of America As Represented By The Secretary Of Agriculture | Antiviral activity of bovine type III interferon against foot-and-mouth disease virus |
| KR102351881B1 (ko) | 2012-04-12 | 2022-01-18 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 필로바이러스 공통 항원, 이로부터 제조된 핵산 구조체 및 백신, 및 이를 사용하는 방법 |
| ES3008560T3 (en) * | 2016-02-19 | 2025-03-24 | Eit Pharma Inc | Treatment of hepatitis delta virus infection with interferon lambda |
| EA201892124A1 (ru) | 2016-12-02 | 2019-04-30 | Дэвид Б. Уэйнер | Днк-конструкции антител и способы их применения |
| CN107519482B (zh) * | 2017-10-10 | 2023-06-02 | 中国人民解放军第四军医大学 | 一种白介素28a作为制备治疗银屑病药物中的应用 |
| CN111479585A (zh) | 2017-12-13 | 2020-07-31 | 艾诺奥医药品有限公司 | 靶向boris的癌症疫苗和其用途 |
| MX2020006217A (es) | 2017-12-13 | 2020-12-03 | Inovio Pharmaceuticals Inc | Vacunas de cáncer dirigidas a muc16 y sus usos. |
| CN111479590A (zh) | 2017-12-13 | 2020-07-31 | 艾诺奥医药品有限公司 | 靶向间皮素的癌症疫苗及其使用 |
| CN110964723B (zh) * | 2019-11-08 | 2022-04-05 | 中山大学 | 一种用于预防和治疗流感病毒的质粒运载纳米颗粒及制备方法 |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5077044A (en) | 1980-05-19 | 1991-12-31 | The Board Of Trustees Of The Leland Stanford Jr. University | Novel non-reverting shigella live vaccines |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5174993A (en) | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
| US5338683A (en) | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US5110587A (en) | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US5223424A (en) | 1985-09-06 | 1993-06-29 | Prutech Research And Development | Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence |
| US5310668A (en) | 1986-06-20 | 1994-05-10 | Merck & Co., Inc. | Varicella-zoster virus as a live recombinant vaccine |
| US5242829A (en) | 1986-09-23 | 1993-09-07 | Therion Biologics Corporation | Recombinant pseudorabies virus |
| US5294441A (en) | 1987-06-04 | 1994-03-15 | Washington University | Avirulent microbes and uses therefor: salmonella typhi |
| US5387744A (en) | 1987-06-04 | 1995-02-07 | Washington University | Avirulent microbes and uses therefor: Salmonella typhi |
| IL86583A0 (en) | 1987-06-04 | 1988-11-15 | Molecular Eng Ass | Vaccine containing a derivative of a microbe and method for the production thereof |
| US5112749A (en) | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
| US5225336A (en) | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
| CH682669A5 (fr) | 1989-03-08 | 1993-10-29 | Health Research Inc | Virus recombinant modifié pour exprimer un produit de gènes chez un hôte, procédés et vaccin correspondants. |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| JP3004049B2 (ja) | 1989-03-31 | 2000-01-31 | ワシントン ユニバーシティー | 病原性のないｐｈｏＰ型微生物を含有するワクチン |
| DE69016956T2 (de) | 1989-12-04 | 1995-07-20 | Akzo Nobel Nv | Rekombinantes Truthahn-Herpesvirus und davon abgeleiteter Lebendimpfstoffvektor. |
| US5294548A (en) | 1990-04-02 | 1994-03-15 | American Biogenetic Sciences, Inc | Recombianant Hepatitis a virus |
| US5462734A (en) | 1990-11-02 | 1995-10-31 | Wisconsin Alumni Research Foundation | Bovine herpesvirus vaccine and method of using same |
| US5240703A (en) | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
| CA2087132A1 (en) | 1992-01-31 | 1993-08-01 | Michael S. Williams | Stent capable of attachment within a body lumen |
| US5273525A (en) | 1992-08-13 | 1993-12-28 | Btx Inc. | Injection and electroporation apparatus for drug and gene delivery |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5439440A (en) | 1993-04-01 | 1995-08-08 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| US5993434A (en) | 1993-04-01 | 1999-11-30 | Genetronics, Inc. | Method of treatment using electroporation mediated delivery of drugs and genes |
| US5702359A (en) | 1995-06-06 | 1997-12-30 | Genetronics, Inc. | Needle electrodes for mediated delivery of drugs and genes |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| NL9401820A (nl) | 1994-11-02 | 1996-06-03 | Meyn Maschf | Inrichting voor het bewerken van aan zijn poten opgehangen gevogelte. |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5810762A (en) | 1995-04-10 | 1998-09-22 | Genetronics, Inc. | Electroporation system with voltage control feedback for clinical applications |
| CA2269074A1 (en) | 1996-10-23 | 1998-04-30 | The Trustees Of The University Of Pennsylvania | Immunotherapy and improved vaccines |
| CA2285056C (en) | 1997-04-03 | 2004-12-14 | Iacob Mathiesen | Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle |
| US6261281B1 (en) | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
| JP2002507985A (ja) | 1997-06-30 | 2002-03-12 | ローヌ−プーラン・ロレ・エス・アー | 横紋筋に核酸を導入する改良法およびその組合せ |
| US6216034B1 (en) | 1997-08-01 | 2001-04-10 | Genetronics, Inc. | Method of programming an array of needle electrodes for electroporation therapy of tissue |
| US6241701B1 (en) | 1997-08-01 | 2001-06-05 | Genetronics, Inc. | Apparatus for electroporation mediated delivery of drugs and genes |
| US6055453A (en) | 1997-08-01 | 2000-04-25 | Genetronics, Inc. | Apparatus for addressing needle array electrodes for electroporation therapy |
| US6135990A (en) | 1997-12-17 | 2000-10-24 | University Of South Florida | Electroporation device and method |
| US6778853B1 (en) | 1997-12-17 | 2004-08-17 | University Of South Florida | Electroporation device |
| US6120493A (en) | 1998-01-27 | 2000-09-19 | Genetronics, Inc. | Method for the introduction of therapeutic agents utilizing an electroporation apparatus |
| AU3973599A (en) | 1998-05-08 | 1999-11-29 | Genetronics, Inc. | Electrically induced vessel vasodilation |
| US20050037018A1 (en) | 2003-06-20 | 2005-02-17 | Innogentics N.V. | HCV combination therapy |
| US6678556B1 (en) | 1998-07-13 | 2004-01-13 | Genetronics, Inc. | Electrical field therapy with reduced histopathological change in muscle |
| US6697669B2 (en) | 1998-07-13 | 2004-02-24 | Genetronics, Inc. | Skin and muscle-targeted gene therapy by pulsed electrical field |
| IL144845A0 (en) | 1999-03-03 | 2002-06-30 | Univ Pennsylvania | Vaccines and gene therapy compositions and methods of making and using the same |
| KR20030016260A (ko) * | 2000-05-12 | 2003-02-26 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 백신 및 이를 이용한 면역제 치료법 |
| US20020155127A1 (en) | 2000-06-02 | 2002-10-24 | Danher Wang | Genetic vaccine against human immunodeficiency virus |
| JP4377126B2 (ja) | 2000-06-30 | 2009-12-02 | ザイモジェネティクス，インコーポレイティド | インターフェロン−様タンパク質ｚｃｙｔｏ２１ |
| US7038032B2 (en) | 2001-04-20 | 2006-05-02 | Zymogenetics, Inc. | Cytokine protein family |
| US8209006B2 (en) | 2002-03-07 | 2012-06-26 | Vgx Pharmaceuticals, Inc. | Constant current electroporation device and methods of use |
| US7245963B2 (en) | 2002-03-07 | 2007-07-17 | Advisys, Inc. | Electrode assembly for constant-current electroporation and use |
| JP2006509041A (ja) * | 2002-10-23 | 2006-03-16 | ザイモジェネティクス，インコーポレイティド | Ｉｌ−２８およびｉｌ−２９を用いるウイルス感染を治療するための方法 |
| AU2004249191B2 (en) | 2003-06-13 | 2011-01-06 | The Trustees Of The University Of Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
| NZ570709A (en) * | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| DK1668031T3 (da) | 2003-08-07 | 2008-06-30 | Zymogenetics Inc | Homogene præparater af IL-29 |
| WO2005027840A2 (en) * | 2003-09-15 | 2005-03-31 | Chiron Corporation | Combination approaches for generating immune responses |
| EP1750749A2 (en) * | 2004-04-02 | 2007-02-14 | ZymoGenetics, Inc. | Il-28 and il-29 cysteine mutants for treating viral infection |
| EP1793845A2 (en) * | 2004-07-29 | 2007-06-13 | ZymoGenetics, Inc. | Use of il-28 and il-29 to treat cancer |
| CN101031316A (zh) * | 2004-07-29 | 2007-09-05 | 津莫吉尼蒂克斯公司 | Il－28和il－29治疗癌症和自身免疫性疾病的用途 |
| US20060165668A1 (en) * | 2004-12-10 | 2006-07-27 | Liu Linda N | Genetically modified tumor cells as cancer vaccines |
| JP2008526889A (ja) | 2005-01-10 | 2008-07-24 | リサーチ ディベロップメント ファウンデーション | 癌治療のための標的化キメラ分子 |
| KR20080012825A (ko) | 2005-01-21 | 2008-02-12 | 인트로겐 테라페티스, 인코퍼레이티드 | 표적 세포가 치료적 및 예방적 핵산에 지속 노출되게 하는국소 투여 |
| EP3501537A1 (en) | 2005-06-30 | 2019-06-26 | Janssen Biotech, Inc. | Anti-il23 antibodies, compositions, methods and uses |
| US9452285B2 (en) | 2006-10-17 | 2016-09-27 | Vgx Pharmaceuticals, Inc. | Electroporation devices and methods of using same for electroporation of cells in mammals |
| CN101918440B (zh) * | 2007-09-20 | 2015-04-22 | 联邦科学技术研究组织 | 禽类细胞因子及编码其的遗传序列的应用 |
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| AU2009231598A1 (en) | 2009-10-08 |
| KR101652767B1 (ko) | 2016-08-31 |
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| US10071154B2 (en) | 2018-09-11 |
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| WO2009124309A3 (en) | 2010-01-07 |
| US10646563B2 (en) | 2020-05-12 |
| EP2265715B1 (en) | 2016-12-28 |
| AU2009231598B2 (en) | 2015-03-12 |
| US20210330784A1 (en) | 2021-10-28 |
| JP2011517938A (ja) | 2011-06-23 |
| US20140335111A1 (en) | 2014-11-13 |
| US20240307527A1 (en) | 2024-09-19 |
| JP2015061878A (ja) | 2015-04-02 |
| EP2265715A4 (en) | 2013-05-15 |
| US20110104105A1 (en) | 2011-05-05 |
| CA2720168C (en) | 2024-04-30 |
| US9744229B2 (en) | 2017-08-29 |
| CN105535961A (zh) | 2016-05-04 |
| US11027009B2 (en) | 2021-06-08 |
| EP2265715A2 (en) | 2010-12-29 |
| CN102016023A (zh) | 2011-04-13 |
| WO2009124309A2 (en) | 2009-10-08 |
| KR20110004417A (ko) | 2011-01-13 |
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