JP5866116B2 - 嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途 - Google Patents
嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途 Download PDFInfo
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- JP5866116B2 JP5866116B2 JP2010250815A JP2010250815A JP5866116B2 JP 5866116 B2 JP5866116 B2 JP 5866116B2 JP 2010250815 A JP2010250815 A JP 2010250815A JP 2010250815 A JP2010250815 A JP 2010250815A JP 5866116 B2 JP5866116 B2 JP 5866116B2
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Description
剤を対象に投与することを含む、嘔吐および下痢などの副作用を最小限に抑えるか解消し
ながら癌を治療するための方法も提供する。
例えば、本発明は以下の項目を提供する。
(項目1)
(i)(a)(E)−N−(4−(3−クロロ−4−(ピリジン−2−イルメトキシ)
フェニルアミノ)−3−シアノ−7−エトキシキノリン−6−イル)−4−(ジメチルア
ミノ)ブタ−2−エンアミドまたは薬学的に許容できるその塩30〜70重量パーセント
、(b)1つまたは複数の賦形剤20〜30重量パーセント、(c)1つまたは複数の湿
潤剤5〜15重量パーセントを含む球状体粒子(前記球状体粒子は、全組成物の70〜8
3重量パーセントを占める)、(ii)1つまたは複数の薬学的に許容できるセルロース
ベースのポリマー1〜4重量パーセントをさらに含む前記球状体粒子に塗布されるサブコ
ーティングおよび(iii)前記サブコーティングに塗布される腸溶コーティングとして
の1つまたは複数の薬学的に許容できるポリマー16〜30重量パーセント(前記コーテ
ィング成分(ii)および(iii)は、全組成物の17〜30重量パーセントを占める
)の薬学的に許容できる組成物。
(項目2)
(i)(a)(E)−N−(4−(3−クロロ−4−(ピリジン−2−イルメトキシ)
フェニルアミノ)−3−シアノ−7−エトキシキノリン−6−イル)−4−(ジメチルア
ミノ)ブタ−2−エンアミドマレイン酸塩30〜70重量パーセント、(b)微結晶性セ
ルロース20〜30重量パーセント、(c)ポリソルベート5〜15重量パーセントを含
む球状体粒子(前記球状体粒子は、全組成物の70〜84重量パーセントを占める)、(
ii)ヒドロキシプロピルセルロース1〜4重量パーセントをさらに含む前記球状体粒子
に塗布されるサブコーティングおよび(iii)前記サブコーティングに塗布される腸溶
コーティングとしてのメタクリル酸ポリマー16〜30重量パーセント(前記コーティン
グ成分(ii)および(iii)は、全組成物の16〜30重量パーセントを占める)の
薬学的に許容できる組成物。
(項目3)
(E)−N−(4−(3−クロロ−4−(ピリジン−2−イルメトキシ)フェニルアミ
ノ)−3−シアノ−7−エトキシキノリン−6−イル)−4−(ジメチルアミノ)ブタ−
2−エンアミドマレイン酸塩の重量パーセントが、55〜65である、項目2に記載の
組成物。
(項目4)
(E)−N−(4−(3−クロロ−4−(ピリジン−2−イルメトキシ)フェニルアミ
ノ)−3−シアノ−7−エトキシキノリン−6−イル)−4−(ジメチルアミノ)ブタ−
2−エンアミドマレイン酸塩の重量パーセントが、63.6である、項目2に記載の組
成物。
(項目5)
ポリソルベートの重量パーセントが、7〜10である、項目2に記載の組成物。
(項目6)
ポリソルベートの重量パーセントが、約9である、項目2に記載の組成物。
(項目7)
微結晶性セルロースの重量パーセントが、約27である、項目2に記載の組成物。
(項目8)
40mgの経口用量の形態である、項目2に記載の組成物。
(項目9)
80mgの経口用量の形態である、項目2に記載の組成物。
(項目10)
240mgの経口用量の形態である、項目2に記載の組成物。
(項目11)
有効量の項目2に記載の組成物を投与することを含む、癌を治療するための方法。
(項目12)
(i)(a)ネラチニブ、ボスチニブ、エルロチニブ、スーテント、タイケルブ、4−
アミノ−3−シアノキノリン化合物からなる群から選択される活性成分および薬学的に許
容できるその塩30〜70重量パーセント、(b)1つまたは複数の賦形剤20〜30重
量パーセント、(c)1つまたは複数の湿潤剤5〜15重量パーセントを含む球状体粒子
(前記球状体粒子は、全組成物の70〜83重量パーセントを占める)、(ii)1つま
たは複数の薬学的に許容できるセルロースベースのポリマー1〜4重量パーセントをさら
に含む前記球状体粒子に塗布されるサブコーティングおよび(iii)前記サブコーティ
ングに塗布される腸溶コーティングとしての1つまたは複数の薬学的に許容できるポリマ
ー16〜30重量パーセント(前記コーティング成分(ii)および(iii)は、全組
成物の17〜30重量パーセントを占める)の薬学的に許容できる組成物。
本明細書において使用されるように、「有効量」の化合物または薬学的に許容できる組成物は、望ましい治療効果および/または予防効果を達成することができる。一部の実施形態において、「有効量」は、タンパク質チロシンキナーゼのモジュレーションに関係する障害または状態の1つまたは複数の症状を治療するのに十分である、化合物、または化合物を含有する組成物の少なくとも最少量である。ある実施形態において、「有効量」の化合物、または化合物を含有する組成物は、異常なチロシンキナーゼ受容体に関係する疾患(例えば、悪性および良性の腫瘍成長を包含する癌)に伴う症状を治療するのに十分である。
ある実施形態において、本発明は、ネラチニブまたは薬学的に許容できるその塩を含む経口投与のための薬学的に許容できる組成物を提供する。ネラチニブおよびキナーゼ阻害剤として作用することが知られている他の化合物は、とりわけ、米国特許第6,002,008号、第6,288,082号、第6,297,258号、第6,384,051号および第7,399,865号に開示されている。ネラチニブは、化学構造:
USP、Polysorbate 40(商標)USP、Polysorbate 20(商標)USP、Octoxynol−9、Nonoxynol−10(商標)USP、Poloxamer 235(商標)、Poloxamer 188(商標)USPを包含するが、これらに限定されるものではない。一部の実施形態において、提供される湿潤剤は、製剤の全重量を基準として、約5重量%〜約15重量%、約7重量%〜約10重量%、または約9重量%を占める。
ある実施形態において、本発明の組成物、およびその製剤は、本明細書に記載されているような1つまたは複数の障害を治療するために単独で投与することができ、あるいは、本明細書に記載されているような1つまたは複数の障害を治療するのに有用な1つまたは複数の他の活性な薬剤と組み合わせて(同時か順次かにかかわらず)投与することができる。したがって、本発明の組成物、またはその製剤は、1つまたは複数の活性な薬剤と同時に、それに先立って、またはその後に投与することができる。
提供される組成物、およびその製剤は、癌を含む状態の治療において有用でもある。
実施例
ステップ1.マレイン酸ネラチニブ球状体粒子の調製(押し出し/球状化法を使用する):
マレイン酸ネラチニブ(140g)およびAvicel PH101(60g)を3分にわたってプラスチック容器中でバッグブレンドし、Hobartミキサー中に移した。内容物を30秒にわたって乾式混合した。Polysorbate−80(商標)溶液(0.25%w/w)を調製した。次いで、この溶液100gを、内容物を継続的に混合しながら、少しずつ増やしてHobartミキサーに加えた。湿塊が得られた。湿塊を、40rpmのフィーダー速度および80rpmのかき混ぜ機速度に設定されたNica Extruderに通して押し出した。小さな押出物が得られた。次いで、押出物を900rpmの速度に設定されたNica Spheronizer中で3分にわたって球状化させた。球状体を、2.5%(範囲:2〜3%)の最終含水率までトレイ乾燥した。球状体を、18メッシュ(1000ミクロン)および35メッシュ(500ミクロン)スクリーンのカットまで篩にかけた。スクリーニングされた球状体材料(35メッシュスクリーン上に残っている)を、サブコーティングステップで使用した。
HMPCでコーティングされた球状体を、ボトムWusterスプレー付きの流動床プロセッサー中にロードした。20%固形物含量のAcryl−Eze MP(商標)溶液を調製し、腸溶コーティング溶液を、32゜±3℃の入口温度を使用して塗布した。このプロセスを、16.9%(範囲:16〜30%)の重量増加が得られるまで行った。腸溶コーティングされた球状体を、15分にわたって流動床中で乾燥した。次いで、球状体をプラスチック容器中に保存した。
腸溶コーティングされた球状体を、必要とされる強度に従ってHPMCカプセルに充填する。腸溶コーティングされた球状体の抗力は、1カプセル当たりに充填されることになる量を決定した。
経口投与のための発明されたマレイン酸ネラチニブ製剤および2つの他のマレイン酸ネラチニブ製剤を、表1および図1に要約されるように、6頭の絶食雄性ビーグル犬(10.2〜15.7kg)において評価した。
腸溶コーティングされている球状体カプセル剤の形態である本発明のマレイン酸ネラチニブ製剤は、臨床のマレイン酸ネラチニブ錠剤製剤の湿式造粒された錠剤と比較して、有害事象(嘔吐、下痢、悪心)を回避する。実施例3に要約されている試験における有害事象を表2に示す。
臨床試験では、192名の健常対象に5回のマレイン酸ネラチニブの単回投与を行った。有害事象が観察され、以下の通り分類された:
− グレード1胃腸有害事象(GI AE)約25%〜40%
− グレード2胃腸有害事象(GI AE)約15%
癌患者(400名を超える患者)においてマレイン酸ネラチニブ(単剤および組合せ)を使用する6つの異なる複数回投与臨床試験も、胃腸有害事象が、癌患者の臨床試験において観察される有害事象として優位を占めることを示した。癌患者の臨床試験における有害事象が観察され、以下の通り分類された:
− 悪心、嘔吐、下痢、脱水症、食欲不振(約95%)
− 無力症、疲労(約30〜60%)
− 発疹(約20〜25%)
− ALT、AST上昇(<10%)
曝露試験を行い、胃腸耐容性がマレイン酸ネラチニブの全身曝露と関係しているかどうかを決定した。結果は、胃腸耐容性(下痢)が全身曝露と関係していないことを示した。
Claims (11)
- (i)(a)(E)−N−(4−(3−クロロ−4−(ピリジン−2−イルメトキシ)フェニルアミノ)−3−シアノ−7−エトキシキノリン−6−イル)−4−(ジメチルアミノ)ブタ−2−エンアミドマレイン酸塩30〜70重量パーセント、(b)微結晶性セルロース20〜30重量パーセント、(c)ポリソルベート5〜15重量パーセントを含む球状体粒子(前記球状体粒子は、全組成物の70〜84重量パーセントを占める)、(ii)全組成物の1〜4重量パーセントを占めるヒドロキシプロピルセルロースのサブコーティングであって、前記球状体粒子に塗布されるサブコーティングおよび(iii)全組成物の16〜30重量パーセントの、前記サブコーティングに塗布される腸溶コーティングとしてのメタクリル酸ポリマー(前記コーティング成分(ii)および(iii)は、全組成物の16〜30重量パーセントを占める)の薬学的組成物。
- (E)−N−(4−(3−クロロ−4−(ピリジン−2−イルメトキシ)フェニルアミノ)−3−シアノ−7−エトキシキノリン−6−イル)−4−(ジメチルアミノ)ブタ−2−エンアミドマレイン酸塩の重量パーセントが、55〜65である、請求項1に記載の組成物。
- (E)−N−(4−(3−クロロ−4−(ピリジン−2−イルメトキシ)フェニルアミノ)−3−シアノ−7−エトキシキノリン−6−イル)−4−(ジメチルアミノ)ブタ−2−エンアミドマレイン酸塩の重量パーセントが、63.6である、請求項1に記載の組成物。
- ポリソルベートの重量パーセントが、7〜10である、請求項1に記載の組成物。
- ポリソルベートの重量パーセントが、9である、請求項1に記載の組成物。
- 微結晶性セルロースの重量パーセントが、27である、請求項1に記載の組成物。
- 40mgの経口用量の形態である、請求項1に記載の組成物。
- 80mgの経口用量の形態である、請求項1に記載の組成物。
- 240mgの経口用量の形態である、請求項1に記載の組成物。
- 癌を治療するための、請求項1に記載の組成物。
- (i)(a)(E)−N−(4−(3−クロロ−4−(ピリジン−2−イルメトキシ)フェニルアミノ)−3−シアノ−7−エトキシキノリン−6−イル)−4−(ジメチルアミノ)ブタ−2−エンアミドマレイン酸塩63.64重量パーセント、(b)微結晶性セルロース27.27重量パーセント、(c)ポリソルベート9.09重量パーセントを含む球状体粒子(前記球状体粒子は、全組成物の85重量パーセントを占める)、(ii)全組成物の1.2重量パーセントを占めるヒドロキシプロピルセルロースのサブコーティングであって、前記球状体粒子に塗布されるサブコーティングおよび(iii)全組成物の16.9重量パーセントの、前記サブコーティングに塗布される腸溶コーティングとしてのメタクリル酸ポリマー(前記コーティング成分(ii)および(iii)は、全組成物の15.3重量パーセントを占める)の薬学的組成物。
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