JP5857044B2 - タペンタドールおよびその中間体を合成する新規のプロセス - Google Patents

タペンタドールおよびその中間体を合成する新規のプロセス Download PDF

Info

Publication number
JP5857044B2
JP5857044B2 JP2013517610A JP2013517610A JP5857044B2 JP 5857044 B2 JP5857044 B2 JP 5857044B2 JP 2013517610 A JP2013517610 A JP 2013517610A JP 2013517610 A JP2013517610 A JP 2013517610A JP 5857044 B2 JP5857044 B2 JP 5857044B2
Authority
JP
Japan
Prior art keywords
acid
compound
organic
halide
anhydride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013517610A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013529676A5 (enExample
JP2013529676A (ja
Inventor
モッタ ジュゼッペ
モッタ ジュゼッペ
ベルガーニ ドメニコ
ベルガーニ ドメニコ
ベルトリーニ ジョルジオ
ベルトリーニ ジョルジオ
ランドーニ ニコラ
ランドーニ ニコラ
Original Assignee
ユーティカルズ ソシエタ ペル アチオニ
ユーティカルズ ソシエタ ペル アチオニ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43432160&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP5857044(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ユーティカルズ ソシエタ ペル アチオニ, ユーティカルズ ソシエタ ペル アチオニ filed Critical ユーティカルズ ソシエタ ペル アチオニ
Publication of JP2013529676A publication Critical patent/JP2013529676A/ja
Publication of JP2013529676A5 publication Critical patent/JP2013529676A5/ja
Application granted granted Critical
Publication of JP5857044B2 publication Critical patent/JP5857044B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2013517610A 2010-07-02 2011-06-20 タペンタドールおよびその中間体を合成する新規のプロセス Expired - Fee Related JP5857044B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2010A001224A IT1401109B1 (it) 2010-07-02 2010-07-02 Nuovo processo per la preparazione di tapentadol e suoi intermedi.
ITMI2010A001224 2010-07-02
PCT/IB2011/052685 WO2012001571A1 (en) 2010-07-02 2011-06-20 New process for the synthesis of tapentadol and intermediates thereof

Publications (3)

Publication Number Publication Date
JP2013529676A JP2013529676A (ja) 2013-07-22
JP2013529676A5 JP2013529676A5 (enExample) 2014-05-15
JP5857044B2 true JP5857044B2 (ja) 2016-02-10

Family

ID=43432160

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013517610A Expired - Fee Related JP5857044B2 (ja) 2010-07-02 2011-06-20 タペンタドールおよびその中間体を合成する新規のプロセス

Country Status (13)

Country Link
US (1) US8791287B2 (enExample)
EP (1) EP2588429B1 (enExample)
JP (1) JP5857044B2 (enExample)
CN (1) CN102958868B (enExample)
AU (1) AU2011273044B2 (enExample)
BR (1) BR112012029882A2 (enExample)
CA (1) CA2797757C (enExample)
CL (1) CL2012003760A1 (enExample)
ES (1) ES2572637T3 (enExample)
IL (1) IL223066A (enExample)
IT (1) IT1401109B1 (enExample)
MX (1) MX340833B (enExample)
WO (1) WO2012001571A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013111161A2 (en) * 2012-01-10 2013-08-01 Msn Laboratories Limited Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof
EP2674414A1 (en) 2012-06-15 2013-12-18 Siegfried AG Method for the preparation of 1-aryl-1-alkyl-3-dialkylaminopropane compounds
US9090539B2 (en) 2013-05-24 2015-07-28 Ampac Fine Chemicals Llc Compounds and methods for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
CZ307492B6 (cs) 2014-02-04 2018-10-17 Zentiva, K.S. Pevná forma maleátu tapentadolu a způsob její přípravy
EP4116288A1 (en) 2021-07-08 2023-01-11 KRKA, d.d., Novo mesto Racemization of (s) and/or (r)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1- one and its mixtures
CN113861155A (zh) * 2021-10-21 2021-12-31 华南师范大学 一种二氢异香豆素类衍生物及其制备方法与应用
CN119191999A (zh) * 2024-11-26 2024-12-27 苏州盛迪亚生物医药有限公司 一种制备他喷他多或其可药用盐的方法
CN119176758B (zh) * 2024-11-26 2025-05-09 苏州盛迪亚生物医药有限公司 一种固载催化制备他喷他多或其可药用盐的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US429833A (en) 1890-06-10 Means for creating artificial currents
US3888901A (en) 1972-07-20 1975-06-10 American Cyanamid Co Process of preparing 3-alkyl-3-(benzoyl)propionitriles
DE2901180A1 (de) * 1979-01-13 1980-07-24 Basf Ag Hexahydro-1,4-oxazepine, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE4426245A1 (de) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
DE10326097A1 (de) 2003-06-06 2005-01-05 Grünenthal GmbH Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen
ATE455752T1 (de) * 2006-07-24 2010-02-15 Janssen Pharmaceutica Nv Herstellung von (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpent namin
TWI401237B (zh) * 2006-07-24 2013-07-11 ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備
TWI496762B (zh) * 2006-07-24 2015-08-21 製備（１ｒ，２ｒ）-３-（３-二甲胺基-１-乙基-２-甲基-丙基）-酚之方法

Also Published As

Publication number Publication date
AU2011273044A1 (en) 2012-11-15
ITMI20101224A1 (it) 2012-01-03
CN102958868B (zh) 2014-11-05
CA2797757A1 (en) 2012-01-05
BR112012029882A2 (pt) 2018-05-15
US8791287B2 (en) 2014-07-29
CA2797757C (en) 2018-09-25
CN102958868A (zh) 2013-03-06
IT1401109B1 (it) 2013-07-12
EP2588429A1 (en) 2013-05-08
WO2012001571A1 (en) 2012-01-05
IL223066A0 (en) 2013-02-03
MX340833B (es) 2016-07-27
EP2588429B1 (en) 2016-02-24
MX2012015161A (es) 2013-06-28
AU2011273044B2 (en) 2015-02-12
CL2012003760A1 (es) 2013-12-13
ES2572637T3 (es) 2016-06-01
US20130178644A1 (en) 2013-07-11
IL223066A (en) 2015-09-24
JP2013529676A (ja) 2013-07-22

Similar Documents

Publication Publication Date Title
JP5857044B2 (ja) タペンタドールおよびその中間体を合成する新規のプロセス
KR101766503B1 (ko) 타펜타돌의 제조 방법 및 이의 중간체
CN114901644B (zh) 制备右美托咪定的方法
JP2012229223A (ja) 鏡像異性的に純粋な１−置換−３−アミノアルコールの調製方法
WO2008117305A2 (en) A novel process for preparing pregabalin and its acid addition salts
JP2005519077A (ja) 中間体としてのカルバメート基を有する新規のチオフェン誘導体を経由したｎ−メチル−３−ヒドロキシ−３−（２−チエニル）プロピルアミンの製造
KR20080043811A (ko) 3,3-디페닐프로필아민 수득 방법
EP2619174A1 (en) Process for preparing l-phenyl-3-dimethylaminopropane derivative
EP1939172B1 (en) Method of obtaining phenyl carbamates
CZ296345B6 (cs) Zpusob výroby hydrochloridu (R)-N-methyl-3-(2-methylfenoxy)-3-fenylpropylaminu (atomoxetinu)
SK287537B6 (sk) Spôsob výroby N,N-diizopropyl-3-(2-hydroxy-5-metylfenyl)-3- fenylpropylamínu v jeho racemickej alebo opticky aktívnej forme
WO2013016840A1 (zh) 用于合成他喷他多或其类似物的新中间体
JP2017519832A (ja) 光学的に純粋なβ−アミノアルコールを合成するための新規方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130130

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140328

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140328

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150130

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150210

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150508

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20151117

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20151214

R150 Certificate of patent or registration of utility model

Ref document number: 5857044

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees