JP5855239B2 - ラクトフェリン融合タンパク質及びその製造方法 - Google Patents

ラクトフェリン融合タンパク質及びその製造方法 Download PDF

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JP5855239B2
JP5855239B2 JP2014512737A JP2014512737A JP5855239B2 JP 5855239 B2 JP5855239 B2 JP 5855239B2 JP 2014512737 A JP2014512737 A JP 2014512737A JP 2014512737 A JP2014512737 A JP 2014512737A JP 5855239 B2 JP5855239 B2 JP 5855239B2
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fusion protein
hlf
lactoferrin
hinge
variant
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JPWO2013162050A1 (ja
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佐藤 淳
佐藤  淳
伸治 加賀谷
伸治 加賀谷
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NRL Pharma Inc
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79Transferrins, e.g. lactoferrins, ovotransferrins
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40Transferrins, e.g. lactoferrins, ovotransferrins
    • AHUMAN NECESSITIES
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    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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JP2014512737A 2012-04-23 2013-04-23 ラクトフェリン融合タンパク質及びその製造方法 Active JP5855239B2 (ja)

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JP2012098085 2012-04-23
JP2012098085 2012-04-23
JP2014512737A JP5855239B2 (ja) 2012-04-23 2013-04-23 ラクトフェリン融合タンパク質及びその製造方法
PCT/JP2013/062685 WO2013162050A1 (ja) 2012-04-23 2013-04-23 ラクトフェリン融合タンパク質及びその製造方法

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US (2) US9809641B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP2842969B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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KR (1) KR102177252B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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US10562959B2 (en) 2012-04-23 2020-02-18 Nrl Pharma, Inc. Lactoferrin fusion protein and method for preparation thereof
US11041014B2 (en) 2016-10-28 2021-06-22 S & K Biopharma, Inc. Lactoferrin/albumin fusion protein and production method therefor

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KR102461210B1 (ko) * 2014-02-24 2022-10-31 다케다 게엠베하 Uti 융합 단백질
EP3291670A1 (en) * 2015-05-04 2018-03-14 Laboratoire Français du Fractionnement et des Biotechnologies Transgenic production of fc fusion proteins
WO2016210328A1 (en) 2015-06-24 2016-12-29 Board Of Regents Of The University Of Texas System Methods and compositions for treatment of symptoms associated with intracranial hemorrhage
DK3355913T3 (da) * 2015-09-30 2024-12-02 Igm Biosciences Inc Bindingsmolekyler med modificeret j-kæde
JPWO2018079701A1 (ja) * 2016-10-28 2019-09-19 株式会社Nrlファーマ ラクトフェリン活性を有するタンパク質を含む、抗ガン治療補助剤
CR20190372A (es) 2017-02-17 2019-10-17 Denali Therapeutics Inc Polipéptidos de unión al receptor de transferrina diseñado
CR20200129A (es) 2017-10-02 2020-08-22 Denali Therapeutics Inc Proteínas de fusión que comprenden enzimas de terapia de reemplazo de enzimas
KR20210024999A (ko) * 2018-06-26 2021-03-08 가부시키가이샤 에스 앤드 케이 바이오파마 글리코사미노글리칸 저해제 및 촉진제
US20200024329A1 (en) * 2018-07-17 2020-01-23 Bradley G. Thompson Methods for regulating endogenous production of lactoferrin and sub-peptides thereof
MX2022007486A (es) 2019-12-23 2022-06-29 Denali Therapeutics Inc Variantes de progranulina.
CN116917336A (zh) * 2020-11-25 2023-10-20 阿维鲁斯公司 用于治疗病毒感染的方法和组合物

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JP3681982B2 (ja) * 1998-07-15 2005-08-10 サムヤン ジェネックス コーポレイション 酵母からラクトフェリンポリペプチドを大量生産する方法及びそれに有用な微生物菌株
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US20150093382A1 (en) 2015-04-02
BR112014026162A2 (pt) 2017-10-03
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JPWO2013162050A1 (ja) 2015-12-24
EP2842969B1 (en) 2018-03-14
CN104245739A (zh) 2014-12-24
US20180072794A1 (en) 2018-03-15
KR20150008870A (ko) 2015-01-23
US10562959B2 (en) 2020-02-18
CA2871468A1 (en) 2013-10-31
CA2871468C (en) 2021-09-21
KR102177252B1 (ko) 2020-11-10
WO2013162050A1 (ja) 2013-10-31
JP6356115B2 (ja) 2018-07-11
US9809641B2 (en) 2017-11-07
EP2842969A4 (en) 2016-01-13
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JP2016117717A (ja) 2016-06-30

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