JP5845263B2 - ５−ｈｔ２ｂ受容体アンタゴニスト - Google Patents
５−ｈｔ２ｂ受容体アンタゴニスト Download PDFInfo
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- JP5845263B2 JP5845263B2 JP2013526445A JP2013526445A JP5845263B2 JP 5845263 B2 JP5845263 B2 JP 5845263B2 JP 2013526445 A JP2013526445 A JP 2013526445A JP 2013526445 A JP2013526445 A JP 2013526445A JP 5845263 B2 JP5845263 B2 JP 5845263B2
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- JZNWQLLPLOQGOI-UHFFFAOYSA-N tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(=O)C(F)C1 JZNWQLLPLOQGOI-UHFFFAOYSA-N 0.000 description 1
- LOLMNJCLVIROCK-UHFFFAOYSA-N tert-butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-fluoropiperidine-1-carboxylate Chemical compound COC1=CC(N)=C(Cl)C=C1C(=O)NC1C(F)CN(C(=O)OC(C)(C)C)CC1 LOLMNJCLVIROCK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10174880 | 2010-09-01 | ||
| EP10174880.4 | 2010-09-01 | ||
| PCT/EP2011/064906 WO2012028614A1 (en) | 2010-09-01 | 2011-08-30 | 5-ht2b receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536823A JP2013536823A (ja) | 2013-09-26 |
| JP2013536823A5 JP2013536823A5 (cg-RX-API-DMAC7.html) | 2014-10-16 |
| JP5845263B2 true JP5845263B2 (ja) | 2016-01-20 |
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| Country | Link |
|---|---|
| US (2) | US8703958B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2619180B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5845263B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101815123B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103080089B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011298361B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013004503A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2806647C (cg-RX-API-DMAC7.html) |
| EA (1) | EA020967B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2525515T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2013002409A (cg-RX-API-DMAC7.html) |
| SG (1) | SG188233A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012028614A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201301561B (cg-RX-API-DMAC7.html) |
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| EA020967B1 (ru) | 2010-09-01 | 2015-03-31 | Янссен Фармацевтика Нв | Антагонисты рецептора 5-ht |
| CN103467596A (zh) * | 2012-06-06 | 2013-12-25 | 北京大学 | 一个治疗肺动脉高压的新靶点 |
| EP3113777A4 (en) * | 2014-03-04 | 2017-09-06 | The Children's Hospital of Philadelphia | Methods for managing care of patients predisposed to progressive mitral valve diseases |
| CN110950843B (zh) * | 2019-11-28 | 2022-12-27 | 广东东阳光药业有限公司 | 取代的苯酰胺衍生物及其用途 |
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| US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| CA1183847A (en) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| GB8519707D0 (en) * | 1985-08-06 | 1985-09-11 | Fordonal Sa | Chemical compounds |
| CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
| AU7532601A (en) * | 2000-06-07 | 2001-12-17 | Aryx Therapeutics | Materials and methods for the treatment of gastroesophageal reflux disease |
| US6444477B1 (en) * | 2000-11-28 | 2002-09-03 | Pharmagene Laboratories Limited | Assay method for detecting 5-HT2B antagonists |
| CN1918157B (zh) * | 2004-01-07 | 2010-06-23 | ARYx医疗有限公司 | 立体异构化合物及治疗胃肠道和中枢神经系统紊乱的方法 |
| EP1991545A2 (en) | 2005-12-23 | 2008-11-19 | AstraZeneca AB | Antibacterial pyrrolopyridines, pyrrolopyrimidines, and pyrroloazepines |
| WO2008139152A1 (en) * | 2007-05-11 | 2008-11-20 | Sentinel Oncology Limited | N-oxide-containing pharmaceutical compounds |
| EA020967B1 (ru) | 2010-09-01 | 2015-03-31 | Янссен Фармацевтика Нв | Антагонисты рецептора 5-ht |
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- 2011-08-30 ES ES11748693.6T patent/ES2525515T3/es active Active
- 2011-08-30 CN CN201180041597.9A patent/CN103080089B/zh not_active Expired - Fee Related
- 2011-08-30 SG SG2013011929A patent/SG188233A1/en unknown
- 2011-08-30 KR KR1020137005411A patent/KR101815123B1/ko not_active Expired - Fee Related
-
2013
- 2013-02-28 ZA ZA2013/01561A patent/ZA201301561B/en unknown
- 2013-02-28 US US13/779,962 patent/US8703958B2/en active Active
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2014
- 2014-03-04 US US14/196,502 patent/US9139523B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2525515T3 (es) | 2014-12-23 |
| CN103080089B (zh) | 2015-09-23 |
| MX2013002409A (es) | 2013-04-03 |
| AU2011298361B2 (en) | 2014-03-13 |
| BR112013004503A2 (pt) | 2016-06-07 |
| ZA201301561B (en) | 2014-08-27 |
| EP2619180B1 (en) | 2014-10-08 |
| CA2806647A1 (en) | 2012-03-08 |
| CN103080089A (zh) | 2013-05-01 |
| EA020967B1 (ru) | 2015-03-31 |
| US20140187585A1 (en) | 2014-07-03 |
| US8703958B2 (en) | 2014-04-22 |
| HK1182097A1 (zh) | 2013-11-22 |
| SG188233A1 (en) | 2013-04-30 |
| US9139523B2 (en) | 2015-09-22 |
| WO2012028614A1 (en) | 2012-03-08 |
| EP2619180A1 (en) | 2013-07-31 |
| CA2806647C (en) | 2018-09-18 |
| AU2011298361A1 (en) | 2013-02-14 |
| KR20130101503A (ko) | 2013-09-13 |
| EA201390312A1 (ru) | 2013-07-30 |
| US20130172386A1 (en) | 2013-07-04 |
| KR101815123B1 (ko) | 2018-01-04 |
| JP2013536823A (ja) | 2013-09-26 |
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