JP5840855B2 - 胚性幹細胞から心筋シートを製造する方法 - Google Patents

胚性幹細胞から心筋シートを製造する方法 Download PDF

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JP5840855B2
JP5840855B2 JP2011076235A JP2011076235A JP5840855B2 JP 5840855 B2 JP5840855 B2 JP 5840855B2 JP 2011076235 A JP2011076235 A JP 2011076235A JP 2011076235 A JP2011076235 A JP 2011076235A JP 5840855 B2 JP5840855 B2 JP 5840855B2
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cells
sheet
cardiomyocytes
flk
myocardial
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JP2012210156A (ja
JP2012210156A5 (OSRAM
Inventor
岡野　光夫
光夫 岡野
清水　達也
達也 清水
山下　潤
潤 山下
英利 升本
英利 升本
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Tokyo Womens Medical University
Kyoto University NUC
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Tokyo Womens Medical University
Kyoto University NUC
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Priority to JP2011076235A priority Critical patent/JP5840855B2/ja
Priority to PCT/JP2012/059427 priority patent/WO2012133945A1/ja
Priority to EP12763936.7A priority patent/EP2692859B1/en
Priority to US14/009,018 priority patent/US9623052B2/en
Publication of JP2012210156A publication Critical patent/JP2012210156A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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JP2011076235A 2011-03-30 2011-03-30 胚性幹細胞から心筋シートを製造する方法 Expired - Fee Related JP5840855B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2011076235A JP5840855B2 (ja) 2011-03-30 2011-03-30 胚性幹細胞から心筋シートを製造する方法
PCT/JP2012/059427 WO2012133945A1 (ja) 2011-03-30 2012-03-30 胚性幹細胞から心筋シートを製造する方法
EP12763936.7A EP2692859B1 (en) 2011-03-30 2012-03-30 Method for producing cardiomyocyte sheet from embryonic stem cells
US14/009,018 US9623052B2 (en) 2011-03-30 2012-03-30 Method for producing myocardial sheet from embryonic stem cell

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JP2011076235A JP5840855B2 (ja) 2011-03-30 2011-03-30 胚性幹細胞から心筋シートを製造する方法

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JP2012210156A JP2012210156A (ja) 2012-11-01
JP2012210156A5 JP2012210156A5 (OSRAM) 2014-05-15
JP5840855B2 true JP5840855B2 (ja) 2016-01-06

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US (1) US9623052B2 (OSRAM)
EP (1) EP2692859B1 (OSRAM)
JP (1) JP5840855B2 (OSRAM)
WO (1) WO2012133945A1 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010044417A1 (ja) 2008-10-14 2010-04-22 株式会社セルシード 温度応答性細胞培養器材、及びその製造方法
EP2826855B1 (en) * 2012-03-15 2018-08-29 iHeart Japan Corporation Myocardial sheet
CN105247041B (zh) * 2013-05-31 2018-04-20 爱心细胞有限公司 组入有水凝胶的层叠细胞膜片
JP6248617B2 (ja) * 2013-12-25 2017-12-20 大日本印刷株式会社 細胞シートの製造方法
WO2015166638A1 (ja) * 2014-05-01 2015-11-05 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 Ｃｄ８２陽性心筋前駆細胞
EP3219790B1 (en) 2014-11-12 2021-08-04 Terumo Kabushiki Kaisha Myocardial cell sheet
WO2017038562A1 (ja) * 2015-08-31 2017-03-09 学校法人東京女子医科大学 多能性幹細胞を減少させる方法、多能性幹細胞を減少させた細胞集団の製造方法
CN109996866A (zh) 2016-12-02 2019-07-09 宝生物工程株式会社 用于产生内皮细胞的方法
US11401264B2 (en) 2018-03-30 2022-08-02 Orizuru Therapeutics, Inc. Heterocyclic compound
WO2019189554A1 (ja) 2018-03-30 2019-10-03 国立大学法人京都大学 心筋細胞成熟促進剤

Family Cites Families (11)

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US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
WO2002008387A1 (en) 2000-07-21 2002-01-31 Cellseed Inc. Heart muscle-like cell sheet, three-dimensional construct, heart muscle-like tissue and process for producing the same
EP1659979B1 (en) 2003-08-01 2015-04-01 Cellseed Inc. Three-dimentional tissue structure
BRPI0414961A (pt) 2003-10-03 2006-11-07 Keiichi Fukuda processo de indução da diferenciação de células tronco em células do miocárdio
CA2577201C (en) 2004-08-27 2016-02-09 Daiichi Asubio Pharma Co., Ltd. A method of selecting a cardiomyocyte using intracellular mitochondria as an indicator
KR20130099253A (ko) 2005-06-22 2013-09-05 제론 코포레이션 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화
KR101348325B1 (ko) 2006-01-31 2014-01-08 각고호우징 게이오기주크 줄기세포 및 태아에서 유래된 심근세포 및 예정 심근세포의제조방법
WO2007126077A1 (ja) 2006-04-28 2007-11-08 Asubio Pharma Co., Ltd. 多能性幹細胞から心筋細胞を分化誘導する方法
WO2009118928A1 (en) * 2008-03-26 2009-10-01 Kyoto University Efficient production and use of highly cardiogenic progenitors and cardiomyocytes from embryonic and induced pluripotent stem cells
JP5387294B2 (ja) 2009-09-29 2014-01-15 ブラザー工業株式会社 サーバに接続されるプリンタ及びサーバ
JP5654786B2 (ja) 2010-06-28 2015-01-14 株式会社セルシード アクリルアミド誘導体および該誘導体を含む重合体

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EP2692859B1 (en) 2016-12-28
EP2692859A1 (en) 2014-02-05
WO2012133945A1 (ja) 2012-10-04
EP2692859A4 (en) 2015-01-07
JP2012210156A (ja) 2012-11-01
US9623052B2 (en) 2017-04-18
US20140056859A1 (en) 2014-02-27

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