JP5824055B2 - Ｎ１−ピラゾロスピロケトンアセチル−ＣｏＡカルボキシラーゼ阻害剤 - Google Patents
Ｎ１−ピラゾロスピロケトンアセチル−ＣｏＡカルボキシラーゼ阻害剤 Download PDFInfo
- Publication number
- JP5824055B2 JP5824055B2 JP2013530829A JP2013530829A JP5824055B2 JP 5824055 B2 JP5824055 B2 JP 5824055B2 JP 2013530829 A JP2013530829 A JP 2013530829A JP 2013530829 A JP2013530829 A JP 2013530829A JP 5824055 B2 JP5824055 B2 JP 5824055B2
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- indazole
- carbonyl
- spiro
- isopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c1n[n](*)c2c1*C(CC1)(CCN1C(*I*C(O*)=O)=O)CC2=O Chemical compound *c1n[n](*)c2c1*C(CC1)(CCN1C(*I*C(O*)=O)=O)CC2=O 0.000 description 2
- VQRZNRIPXHCTOL-UHFFFAOYSA-N CC(C)(C)OC(CN(C)c1nc(OC)cc(C(O)=O)c1)=O Chemical compound CC(C)(C)OC(CN(C)c1nc(OC)cc(C(O)=O)c1)=O VQRZNRIPXHCTOL-UHFFFAOYSA-N 0.000 description 1
- UPNVJUTVKMEHNI-UHFFFAOYSA-N CC(C)(C)[n]1ncc(CC(CC2)(CCN2C(OCc2ccccc2)=O)C2Br)c1C2=O Chemical compound CC(C)(C)[n]1ncc(CC(CC2)(CCN2C(OCc2ccccc2)=O)C2Br)c1C2=O UPNVJUTVKMEHNI-UHFFFAOYSA-N 0.000 description 1
- CPQICQZWZUVUIY-UHFFFAOYSA-N CC(C)(C)[n]1ncc(CC(CC2)(CCN2C(c(cc2)ccc2OCc(cc2)ccc2C(OC)=O)=O)C2)c1C2=O Chemical compound CC(C)(C)[n]1ncc(CC(CC2)(CCN2C(c(cc2)ccc2OCc(cc2)ccc2C(OC)=O)=O)C2)c1C2=O CPQICQZWZUVUIY-UHFFFAOYSA-N 0.000 description 1
- YYQWGOFROFKXAZ-UHFFFAOYSA-N CC(C)(C)[n]1ncc(CC2(CCN(CC(c(cc3)ccc3OCc(cc3)ccc3C(O)=O)=O)CC2)C2)c1C2=O Chemical compound CC(C)(C)[n]1ncc(CC2(CCN(CC(c(cc3)ccc3OCc(cc3)ccc3C(O)=O)=O)CC2)C2)c1C2=O YYQWGOFROFKXAZ-UHFFFAOYSA-N 0.000 description 1
- RAGWEVGDRMMGPX-UHFFFAOYSA-N CC(C)[n](c1c2CC(CC3)(CCN3C(OCc3ccccc3)=O)CC1=O)nc2Br Chemical compound CC(C)[n](c1c2CC(CC3)(CCN3C(OCc3ccccc3)=O)CC1=O)nc2Br RAGWEVGDRMMGPX-UHFFFAOYSA-N 0.000 description 1
- UTQOAIWPJIFJIS-UHFFFAOYSA-N CC(C)[n](c1c2CC3(CCNCC3)CC1=O)nc2C#N Chemical compound CC(C)[n](c1c2CC3(CCNCC3)CC1=O)nc2C#N UTQOAIWPJIFJIS-UHFFFAOYSA-N 0.000 description 1
- UKTKIZRBJPLWPJ-UHFFFAOYSA-N CC(C)[n]1nc(C)c(CC2(CCNCC2)C2)c1C2=O Chemical compound CC(C)[n]1nc(C)c(CC2(CCNCC2)C2)c1C2=O UKTKIZRBJPLWPJ-UHFFFAOYSA-N 0.000 description 1
- HXEJBKSDELCRJK-UHFFFAOYSA-N CC(C)[n]1ncc(CC(CC2)(CCN2C(c2cc(OC)nc(-c3cccc(C(O)=O)c3)c2)=O)C2)c1C2=O Chemical compound CC(C)[n]1ncc(CC(CC2)(CCN2C(c2cc(OC)nc(-c3cccc(C(O)=O)c3)c2)=O)C2)c1C2=O HXEJBKSDELCRJK-UHFFFAOYSA-N 0.000 description 1
- ZFXCIWPVPUPDMF-UHFFFAOYSA-N CC(C)[n]1ncc(CC2(CCNCC2)C2)c1C2=O Chemical compound CC(C)[n]1ncc(CC2(CCNCC2)C2)c1C2=O ZFXCIWPVPUPDMF-UHFFFAOYSA-N 0.000 description 1
- QKCMLHYZHDHQFM-UHFFFAOYSA-N CC(C)[n]1ncc(OC2(CCN(Cc3ccccc3)CC2)C2)c1C2=O Chemical compound CC(C)[n]1ncc(OC2(CCN(Cc3ccccc3)CC2)C2)c1C2=O QKCMLHYZHDHQFM-UHFFFAOYSA-N 0.000 description 1
- JPBXJMFKOUSYHN-UHFFFAOYSA-N CC(C)[n]1ncc2c1C=CC(CC1)(CCN1C(OCc1ccccc1)=O)C2 Chemical compound CC(C)[n]1ncc2c1C=CC(CC1)(CCN1C(OCc1ccccc1)=O)C2 JPBXJMFKOUSYHN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38810210P | 2010-09-30 | 2010-09-30 | |
| US61/388,102 | 2010-09-30 | ||
| PCT/IB2011/054119 WO2012042433A1 (en) | 2010-09-30 | 2011-09-20 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540119A JP2013540119A (ja) | 2013-10-31 |
| JP2013540119A5 JP2013540119A5 (enExample) | 2014-10-16 |
| JP5824055B2 true JP5824055B2 (ja) | 2015-11-25 |
Family
ID=44789556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530829A Active JP5824055B2 (ja) | 2010-09-30 | 2011-09-20 | Ｎ１−ピラゾロスピロケトンアセチル−ＣｏＡカルボキシラーゼ阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (8) | US8859577B2 (enExample) |
| EP (1) | EP2621493B1 (enExample) |
| JP (1) | JP5824055B2 (enExample) |
| CA (1) | CA2811033C (enExample) |
| CY (1) | CY1118016T1 (enExample) |
| DK (1) | DK2621493T3 (enExample) |
| ES (1) | ES2602111T3 (enExample) |
| HR (1) | HRP20161178T1 (enExample) |
| HU (1) | HUE031616T2 (enExample) |
| LT (1) | LT2621493T (enExample) |
| PL (1) | PL2621493T3 (enExample) |
| PT (1) | PT2621493T (enExample) |
| RS (1) | RS55224B1 (enExample) |
| SI (1) | SI2621493T1 (enExample) |
| WO (1) | WO2012042433A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040198483A1 (en) | 2003-04-03 | 2004-10-07 | Amaitis Lee M. | System and method for betting on a subset of participants in an event |
| US9098883B2 (en) | 2004-02-03 | 2015-08-04 | Cantor Index, Llc | Managing bets that select events and participants |
| US8636571B2 (en) | 2004-02-03 | 2014-01-28 | Cantor Index, Llc | System and method for managing select five horseracing bets |
| US8318762B2 (en) | 2008-05-28 | 2012-11-27 | Pfizer Inc. | Pyrazolospiroketone acetyl-CoA carboxylase inhibitors |
| EA020153B1 (ru) | 2009-11-10 | 2014-09-30 | Пфайзер Инк. | N1-ПИРАЗОЛОСПИРОКЕТОНОВЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ |
| US8859577B2 (en) | 2010-09-30 | 2014-10-14 | Pfizer Inc. | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors |
| PT2632925E (pt) | 2010-10-29 | 2015-09-01 | Pfizer | Inibidores de n1/n2-lactama da acetil-coa carboxilase |
| PT2699576E (pt) * | 2011-04-22 | 2016-03-09 | Pfizer | Derivados de pirazoloespirocetona para utilização como inibidores de acetil-coa carboxilase |
| WO2013116359A1 (en) | 2012-01-30 | 2013-08-08 | Cfph, Llc | Event wagering with group and/or in run options |
| US11055967B2 (en) | 2014-03-26 | 2021-07-06 | Cfph, Llc | Event wagering with group and/or in run options |
| US20170178994A1 (en) * | 2015-12-21 | 2017-06-22 | Intel Corporation | Integrated circuit package support structures |
| KR102579876B1 (ko) | 2016-02-22 | 2023-09-18 | 삼성전자주식회사 | 반도체 패키지 |
| SG11201909168VA (en) * | 2017-04-18 | 2019-11-28 | Genfit | Combination comprising a ppar agonist such as elafibranor and an acetyl-coa carboxylase (acc) inhibitor |
| IL313710A (en) * | 2017-11-21 | 2024-08-01 | Pfizer | Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid |
| US10934279B2 (en) | 2018-06-13 | 2021-03-02 | Pfizer Inc. | GLP-1 receptor agonists and uses thereof |
| CA3110601C (en) * | 2018-08-31 | 2023-09-05 | Pfizer Inc. | Combinations for treatment of nash/nafld and related diseases |
| CA3140972C (en) * | 2019-05-20 | 2024-06-18 | Pfizer Inc. | Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases |
| CN110183456A (zh) * | 2019-07-11 | 2019-08-30 | 河南师范大学 | 一种2-芳基吲唑琥珀酰亚胺螺环化合物的合成方法 |
| EP4073028A1 (en) | 2019-12-10 | 2022-10-19 | Pfizer Inc. | Solid forms of 2-((4-((s)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d] [1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((s)-oxetan-2-yl)methyl)-1h-benzo[d] imidazole-6-carboxylic acid, 1,3-dihydroxy-2-(hydroxymethyl)propan-2-amine salt |
| US11091447B2 (en) | 2020-01-03 | 2021-08-17 | Berg Llc | UBE2K modulators and methods for their use |
| SMT202400344T1 (it) | 2020-02-07 | 2024-11-15 | Gasherbrum Bio Inc | Agonisti di glp-1 eterociclici |
| JP2021134211A (ja) * | 2020-02-24 | 2021-09-13 | ファイザー・インク | Ｎａｆｌｄ／ｎａｓｈおよび関連疾患の処置のための組合せ |
| JP2022058085A (ja) | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ |
| MX2022010811A (es) | 2020-03-27 | 2022-09-27 | Pfizer | Tratamiento de la diabetes tipo 2 u obesidad o sobrepeso con el acido 2-[(4-{6-[(4-ciano-2-fluorobencil)oxi]piridin-2-il}piperidin -1-il)metil]-1-[(2s)-oxetan-2-ilmetil]-1h-bencimidazol-6-carboxil ico o una sal farmaceutica del mismo. |
| BR112024002129A2 (pt) | 2021-08-31 | 2024-04-30 | Pfizer | Formas sólidas de ácido 2-[(4-{6-[(4-ciano-2-fluorobenzil)óxi]piridin-2-il}piperidin-1-il)metil]-1-[(2s)-oxetan-2-ilmetil]-1h-benzimidazol-6-carboxílico, sal de 1,3-di-hidróxi-2-(hidroximetil)propan-2-amina |
| WO2023169456A1 (en) | 2022-03-09 | 2023-09-14 | Gasherbrum Bio , Inc. | Heterocyclic glp-1 agonists |
| EP4508047A1 (en) | 2022-04-14 | 2025-02-19 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| WO2023228023A1 (en) | 2022-05-23 | 2023-11-30 | Pfizer Inc. | Treatment of type 2 diabetes or weight management control with 2-((4-((s)-2-(5-chloropyridin-2-yl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((s)-oxetan-2-yl)methyl)-1h-benzo[d]imidazole-6-carboxylic acid or a pharmaceutically salt thereof |
| WO2024084360A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers |
| EP4634180A1 (en) | 2022-12-15 | 2025-10-22 | Gasherbrum Bio, Inc. | Salts and solid forms of a compound having glp-1 agonist activity |
| WO2025099561A1 (en) | 2023-11-07 | 2025-05-15 | Pfizer Inc. | Oral controlled-release matrix formulations of 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof |
| WO2025224648A1 (en) | 2024-04-26 | 2025-10-30 | Pfizer Inc. | Oral compositions/formulations of 2-({4-[(2s)-2-(4-chloro-2-fluorophenyl)-2-methyl-1,3-benzodioxol-4-yl]piperidin-1-yl}methyl)-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof |
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| DE60301491T2 (de) | 2002-02-27 | 2006-05-18 | Pfizer Products Inc., Groton | Acc-hemmer |
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| EP2307422B1 (en) * | 2008-07-04 | 2014-03-26 | Msd K.K. | Novel spirochromanone carboxylic acids |
| JP2011528034A (ja) | 2008-07-14 | 2011-11-10 | クロップソリューション，インコーポレイテッド | アセチル−補酵素カルボキシラーゼの修飾因子およびその使用方法 |
| EA020153B1 (ru) * | 2009-11-10 | 2014-09-30 | Пфайзер Инк. | N1-ПИРАЗОЛОСПИРОКЕТОНОВЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ |
| EP2499140A1 (en) | 2009-11-10 | 2012-09-19 | Pfizer Inc. | N2-pyrazolospiroketone acetyl-coa carboxylase inhibitors |
| US8859577B2 (en) * | 2010-09-30 | 2014-10-14 | Pfizer Inc. | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors |
| US20160034775A1 (en) | 2014-08-02 | 2016-02-04 | General Vault, LLC | Methods and apparatus for bounded image data analysis and notification mechanism |
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| US20210047325A1 (en) | 2021-02-18 |
| EP2621493A1 (en) | 2013-08-07 |
| US11673890B2 (en) | 2023-06-13 |
| EP2621493B1 (en) | 2016-08-17 |
| US9908883B2 (en) | 2018-03-06 |
| US20180162858A1 (en) | 2018-06-14 |
| CA2811033C (en) | 2015-10-20 |
| HUE031616T2 (hu) | 2017-07-28 |
| RS55224B1 (sr) | 2017-02-28 |
| SI2621493T1 (sl) | 2016-10-28 |
| US10822335B2 (en) | 2020-11-03 |
| PL2621493T3 (pl) | 2017-01-31 |
| PT2621493T (pt) | 2016-11-14 |
| US20130190334A1 (en) | 2013-07-25 |
| US10294225B2 (en) | 2019-05-21 |
| CY1118016T1 (el) | 2017-05-17 |
| LT2621493T (lt) | 2016-10-25 |
| DK2621493T3 (en) | 2016-10-24 |
| US20150011470A1 (en) | 2015-01-08 |
| JP2013540119A (ja) | 2013-10-31 |
| US20160347752A1 (en) | 2016-12-01 |
| US8859577B2 (en) | 2014-10-14 |
| ES2602111T3 (es) | 2017-02-17 |
| US20190218218A1 (en) | 2019-07-18 |
| WO2012042433A1 (en) | 2012-04-05 |
| HRP20161178T1 (hr) | 2016-11-04 |
| CA2811033A1 (en) | 2012-04-05 |
| US9145416B2 (en) | 2015-09-29 |
| US20230322777A1 (en) | 2023-10-12 |
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