JP5819328B2 - ラキニモドとメトトレキセートとの組合せによる関節リウマチの治療 - Google Patents

ラキニモドとメトトレキセートとの組合せによる関節リウマチの治療 Download PDF

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Publication number
JP5819328B2
JP5819328B2 JP2012556213A JP2012556213A JP5819328B2 JP 5819328 B2 JP5819328 B2 JP 5819328B2 JP 2012556213 A JP2012556213 A JP 2012556213A JP 2012556213 A JP2012556213 A JP 2012556213A JP 5819328 B2 JP5819328 B2 JP 5819328B2
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laquinimod
amount
pharmaceutical composition
composition according
methotrexate
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Japanese (ja)
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JP2013521304A5 (https=
JP2013521304A (ja
Inventor
カイエ、ジョエル
ブラウグルンド、エラン
タルシク、ノラ
Original Assignee
テバ ファーマシューティカル インダストリーズ リミティド
テバ ファーマシューティカル インダストリーズ リミティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012556213A 2010-03-03 2011-03-02 ラキニモドとメトトレキセートとの組合せによる関節リウマチの治療 Expired - Fee Related JP5819328B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33937510P 2010-03-03 2010-03-03
US61/339,375 2010-03-03
PCT/US2011/026885 WO2011109531A1 (en) 2010-03-03 2011-03-02 Treatment of rheumatoid arthritis with a combination of laquinimod and methotrexate

Publications (3)

Publication Number Publication Date
JP2013521304A JP2013521304A (ja) 2013-06-10
JP2013521304A5 JP2013521304A5 (https=) 2014-04-17
JP5819328B2 true JP5819328B2 (ja) 2015-11-24

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ID=44531858

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JP2012556213A Expired - Fee Related JP5819328B2 (ja) 2010-03-03 2011-03-02 ラキニモドとメトトレキセートとの組合せによる関節リウマチの治療

Country Status (22)

Country Link
US (1) US8501766B2 (https=)
EP (1) EP2542079B1 (https=)
JP (1) JP5819328B2 (https=)
KR (1) KR20130014523A (https=)
CN (2) CN102781240A (https=)
AU (1) AU2011223697B2 (https=)
BR (1) BR112012022187A2 (https=)
CA (1) CA2791709A1 (https=)
CL (1) CL2012002424A1 (https=)
CO (1) CO6630085A2 (https=)
DK (1) DK2542079T3 (https=)
EA (1) EA201290860A1 (https=)
ES (1) ES2476368T3 (https=)
MX (1) MX2012010066A (https=)
NZ (1) NZ602478A (https=)
PE (1) PE20130690A1 (https=)
PH (1) PH12012501740A1 (https=)
PT (1) PT2542079E (https=)
SG (1) SG183513A1 (https=)
SI (1) SI2542079T1 (https=)
WO (1) WO2011109531A1 (https=)
ZA (1) ZA201207128B (https=)

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ES2445451T3 (es) 2007-12-20 2014-03-03 Teva Pharmaceutical Industries, Ltd. Preparaciones estables de laquinimod
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RS54328B1 (sr) * 2009-06-19 2016-02-29 Teva Pharmaceutical Industries Ltd. Tretman multiple skleroze lakvinimodom
ME02414B (me) * 2009-07-30 2016-09-20 Teva Pharma Tretman kronove bolesti lakvinimodom
PT2467372T (pt) 2009-08-10 2016-08-23 Teva Pharma Tratamento de distúrbios relacionados com bdnf usando laquinimod
CN102791130B (zh) * 2010-03-03 2015-02-25 泰华制药工业有限公司 使用拉喹莫德治疗狼疮肾炎
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CN106344576A (zh) 2011-10-12 2017-01-25 泰华制药工业有限公司 以拉喹莫德和芬戈莫德的组合治疗多发性硬化症
CN106063787A (zh) 2012-02-03 2016-11-02 泰华制药工业有限公司 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
HK1198296A1 (en) 2012-02-16 2015-03-27 Teva Pharmaceutical Industries Ltd. N-ethyl-n-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinoline carboxamide, preparation and uses thereof
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TW201400117A (zh) 2012-06-05 2014-01-01 Teva Pharma 使用拉喹莫德治療眼發炎疾病
TW201410244A (zh) 2012-08-13 2014-03-16 Teva Pharma 用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
JP2015535287A (ja) 2012-11-07 2015-12-10 テバ ファーマシューティカル インダストリーズ リミティド ラキニモドのアミン塩
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CN115281149A (zh) * 2021-05-12 2022-11-04 四川大学华西医院 一种临床前类风湿关节炎(Pre-RA)小鼠模型

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Publication number Publication date
EP2542079A1 (en) 2013-01-09
WO2011109531A1 (en) 2011-09-09
AU2011223697A1 (en) 2012-10-11
DK2542079T3 (da) 2014-08-25
EA201290860A1 (ru) 2013-04-30
CN105796556A (zh) 2016-07-27
NZ602478A (en) 2014-09-26
PE20130690A1 (es) 2013-07-07
KR20130014523A (ko) 2013-02-07
SI2542079T1 (sl) 2014-08-29
AU2011223697B2 (en) 2016-07-14
PH12012501740A1 (en) 2012-11-12
ZA201207128B (en) 2014-04-30
PT2542079E (pt) 2014-07-18
CN102781240A (zh) 2012-11-14
US20110218203A1 (en) 2011-09-08
JP2013521304A (ja) 2013-06-10
ES2476368T3 (es) 2014-07-14
CA2791709A1 (en) 2011-09-09
EP2542079B1 (en) 2014-05-21
SG183513A1 (en) 2012-09-27
US8501766B2 (en) 2013-08-06
CO6630085A2 (es) 2013-03-01
CL2012002424A1 (es) 2012-12-21
BR112012022187A2 (pt) 2015-09-22
EP2542079A4 (en) 2013-07-24
MX2012010066A (es) 2012-10-03

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