JP5815746B2 - Ｃ型肝炎ウイルス阻害剤 - Google Patents
Ｃ型肝炎ウイルス阻害剤 Download PDFInfo
- Publication number
- JP5815746B2 JP5815746B2 JP2013552620A JP2013552620A JP5815746B2 JP 5815746 B2 JP5815746 B2 JP 5815746B2 JP 2013552620 A JP2013552620 A JP 2013552620A JP 2013552620 A JP2013552620 A JP 2013552620A JP 5815746 B2 JP5815746 B2 JP 5815746B2
- Authority
- JP
- Japan
- Prior art keywords
- hcv
- mmol
- pharmaceutically acceptable
- interferon
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C([C@](C1)([C@]1N=C(c1ccccc1)N)C1CC2(CC2)OCC1)=O Chemical compound *C([C@](C1)([C@]1N=C(c1ccccc1)N)C1CC2(CC2)OCC1)=O 0.000 description 2
- LQWDQTWSVKTRDK-KDXUFGMBSA-N C[C@H](C1)O[C@@H](C)C[C@H]1[C@@H](C(O)=O)NC(OC)=O Chemical compound C[C@H](C1)O[C@@H](C)C[C@H]1[C@@H](C(O)=O)NC(OC)=O LQWDQTWSVKTRDK-KDXUFGMBSA-N 0.000 description 2
- LFALLGRZDGBTMO-JZHWANFVSA-N C[C@@H](CC[C@H]1c2nc(-c(cc3)ccc3-c3ccc(-c4c[nH]c([C@H](CC[C@@H]5C)N5C([C@H](C5C[C@@H](C)O[C@H](C)C5)NC(OC)=O)=O)n4)c(F)c3)c[nH]2)N1C([C@H](C1C[C@@H](C)O[C@H](C)C1)NC(OC)=O)=O Chemical compound C[C@@H](CC[C@H]1c2nc(-c(cc3)ccc3-c3ccc(-c4c[nH]c([C@H](CC[C@@H]5C)N5C([C@H](C5C[C@@H](C)O[C@H](C)C5)NC(OC)=O)=O)n4)c(F)c3)c[nH]2)N1C([C@H](C1C[C@@H](C)O[C@H](C)C1)NC(OC)=O)=O LFALLGRZDGBTMO-JZHWANFVSA-N 0.000 description 1
- OIMSUJOTBLNAJX-NKWVEPMBSA-N C[C@@H](C[C@@H](C1)O)OC1=C Chemical compound C[C@@H](C[C@@H](C1)O)OC1=C OIMSUJOTBLNAJX-NKWVEPMBSA-N 0.000 description 1
- FOWDXUWDCQBJCQ-DFSIKGTRSA-N C[C@H](C1)O[C@@H](C)C[C@H]1C(C(OCc1ccccc1)=O)N=C(c1ccccc1)c1ccccc1 Chemical compound C[C@H](C1)O[C@@H](C)C[C@H]1C(C(OCc1ccccc1)=O)N=C(c1ccccc1)c1ccccc1 FOWDXUWDCQBJCQ-DFSIKGTRSA-N 0.000 description 1
- CGNHNWXBGLAAPM-CMHBHIPBSA-N C[C@H](C1)O[C@H](C)CC1[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(cc2)ccc2-c2c[nH]c([C@H](CCC3)N3C([C@H](C3C[C@@H](C)O[C@H](C)C3)NC(OC)=O)=O)n2)c[nH]1)=O)NC(OC)=O Chemical compound C[C@H](C1)O[C@H](C)CC1[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(cc2)ccc2-c2c[nH]c([C@H](CCC3)N3C([C@H](C3C[C@@H](C)O[C@H](C)C3)NC(OC)=O)=O)n2)c[nH]1)=O)NC(OC)=O CGNHNWXBGLAAPM-CMHBHIPBSA-N 0.000 description 1
- SRKHNWBOWCQLOP-MZPXATCKSA-N C[C@H](CC1CC(OCc2ccccc2)=O)O[C@H](C)C1/[O]=C(\N)/OC Chemical compound C[C@H](CC1CC(OCc2ccccc2)=O)O[C@H](C)C1/[O]=C(\N)/OC SRKHNWBOWCQLOP-MZPXATCKSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161440086P | 2011-02-07 | 2011-02-07 | |
| US61/440,086 | 2011-02-07 | ||
| US201161467602P | 2011-03-25 | 2011-03-25 | |
| US61/467,602 | 2011-03-25 | ||
| PCT/US2012/023595 WO2012109080A1 (en) | 2011-02-07 | 2012-02-02 | Hepatitis c virus inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014504643A JP2014504643A (ja) | 2014-02-24 |
| JP2014504643A5 JP2014504643A5 (enExample) | 2015-03-05 |
| JP5815746B2 true JP5815746B2 (ja) | 2015-11-17 |
Family
ID=45688244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552620A Expired - Fee Related JP5815746B2 (ja) | 2011-02-07 | 2012-02-02 | Ｃ型肝炎ウイルス阻害剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8552047B2 (enExample) |
| EP (1) | EP2673271B1 (enExample) |
| JP (1) | JP5815746B2 (enExample) |
| KR (1) | KR20140048848A (enExample) |
| CN (1) | CN103347878B (enExample) |
| AR (1) | AR085327A1 (enExample) |
| AU (1) | AU2012214767B2 (enExample) |
| BR (1) | BR112013020042A2 (enExample) |
| CA (1) | CA2826774A1 (enExample) |
| CL (1) | CL2013002241A1 (enExample) |
| CO (1) | CO6761335A2 (enExample) |
| EA (1) | EA021538B1 (enExample) |
| ES (1) | ES2540052T3 (enExample) |
| IL (1) | IL227789A0 (enExample) |
| MA (1) | MA34896B1 (enExample) |
| MX (1) | MX2013008419A (enExample) |
| PE (1) | PE20140302A1 (enExample) |
| PH (1) | PH12013501543A1 (enExample) |
| SG (1) | SG192267A1 (enExample) |
| TW (1) | TWI542585B (enExample) |
| UY (1) | UY33897A (enExample) |
| WO (1) | WO2012109080A1 (enExample) |
| ZA (1) | ZA201306720B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9212168B2 (en) | 2011-11-03 | 2015-12-15 | Theravance Biopharma R&D Ip, Llc | Hepatitis C virus inhibitors |
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| PT2850075T (pt) | 2012-04-25 | 2017-05-02 | Theravance Biopharma R&D Ip Llc | Compostos de piperazina-piperidina como inibidores do vírus da hepatite c |
| EP2912031B1 (en) * | 2012-10-24 | 2017-05-31 | Bristol-Myers Squibb Company | Hepatitis c virus inhibitors |
| US9233974B2 (en) * | 2012-12-21 | 2016-01-12 | Gilead Sciences, Inc. | Antiviral compounds |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| EP3021845A1 (en) | 2013-07-17 | 2016-05-25 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of hcv |
| US9762562B2 (en) * | 2013-09-13 | 2017-09-12 | Facebook, Inc. | Techniques for multi-standard peer-to-peer connection |
| US20160311806A1 (en) * | 2013-12-11 | 2016-10-27 | Bristol-Myers Squibb Company | 4,4'-biphenyldiyl-bis-(1 h-imidazolyl) derivatives as hepatitis hcv inhibitors |
| CN104860931A (zh) | 2014-02-21 | 2015-08-26 | 常州寅盛药业有限公司 | 丙肝病毒抑制剂及其制药用途 |
| US20150361087A1 (en) * | 2014-06-12 | 2015-12-17 | Gilead Sciences, Inc. | Antiviral compounds |
| US10518123B2 (en) | 2014-06-13 | 2019-12-31 | Nautilus, Inc. | Adjustable dumbbell system |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| CN109456375B (zh) * | 2018-12-11 | 2019-10-22 | 枣庄学院 | 一种抑制丙肝病毒的含单糖基杂环类化合物及制备方法 |
| US11857827B2 (en) | 2021-11-19 | 2024-01-02 | Nautilus, Inc. | Plate-sensing base for a connected adjustable free weight system |
| CN117105928B (zh) * | 2023-08-22 | 2024-03-26 | 上海蓝木化工有限公司 | 一种蛋白酶抑制剂及其制备方法 |
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| US5654451B1 (en) | 1993-01-14 | 2000-02-22 | Magainin Pharma | Amino acids and peptides having modified c-terminals and modified n-terminals |
| WO2004005264A2 (en) | 2002-07-05 | 2004-01-15 | Axxima Pharmaceuticals Ag | Imidazole compounds for the treatment of hepatitis c virus infections |
| AU2003261434A1 (en) | 2002-08-12 | 2004-02-25 | Bristol-Myers Squibb Company | Iminothiazolidinones as inhibitors of hcv replication |
| DE102004036971B4 (de) | 2004-07-30 | 2009-07-30 | Advanced Micro Devices, Inc., Sunnyvale | Technik zur Bewertung lokaler elektrischer Eigenschaften in Halbleiterbauelementen |
| WO2006022442A1 (ja) | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| GB2438802A (en) | 2005-02-28 | 2007-12-05 | Univ Rockefeller | Structure of the hepatitis C virus NS5A protein |
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| WO2007058384A1 (en) | 2005-11-17 | 2007-05-24 | Osaka University | Method of suppressing replication of hepatitis c virus, inhibitor of replication of the virus and method of screening for the same |
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| CN103347878B (zh) | 2015-05-06 |
| KR20140048848A (ko) | 2014-04-24 |
| CO6761335A2 (es) | 2013-09-30 |
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| AU2012214767B2 (en) | 2016-06-02 |
| CN103347878A (zh) | 2013-10-09 |
| EA021538B1 (ru) | 2015-07-30 |
| EA201391152A1 (ru) | 2013-12-30 |
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| WO2012109080A1 (en) | 2012-08-16 |
| MX2013008419A (es) | 2013-09-13 |
| PE20140302A1 (es) | 2014-03-24 |
| CL2013002241A1 (es) | 2013-12-13 |
| JP2014504643A (ja) | 2014-02-24 |
| BR112013020042A2 (pt) | 2016-10-25 |
| PH12013501543A1 (en) | 2013-09-23 |
| CA2826774A1 (en) | 2012-08-16 |
| MA34896B1 (fr) | 2014-02-01 |
| AU2012214767A1 (en) | 2013-09-26 |
| SG192267A1 (en) | 2013-09-30 |
| UY33897A (es) | 2012-08-31 |
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| US9340520B2 (en) | 2016-05-17 |
| NZ615067A (en) | 2014-12-24 |
| US20130028859A1 (en) | 2013-01-31 |
| AR085327A1 (es) | 2013-09-25 |
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