JP5812478B2 - 抗癌剤結合性核酸アプタマー及びその利用 - Google Patents

抗癌剤結合性核酸アプタマー及びその利用 Download PDF

Info

Publication number
JP5812478B2
JP5812478B2 JP2011177072A JP2011177072A JP5812478B2 JP 5812478 B2 JP5812478 B2 JP 5812478B2 JP 2011177072 A JP2011177072 A JP 2011177072A JP 2011177072 A JP2011177072 A JP 2011177072A JP 5812478 B2 JP5812478 B2 JP 5812478B2
Authority
JP
Japan
Prior art keywords
dna
seq
sequence
added
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2011177072A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013040118A5 (enExample
JP2013040118A (ja
Inventor
正靖 桑原
正靖 桑原
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gunma University
Original Assignee
Gunma University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gunma University filed Critical Gunma University
Priority to JP2011177072A priority Critical patent/JP5812478B2/ja
Publication of JP2013040118A publication Critical patent/JP2013040118A/ja
Publication of JP2013040118A5 publication Critical patent/JP2013040118A5/ja
Application granted granted Critical
Publication of JP5812478B2 publication Critical patent/JP5812478B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011177072A 2011-08-12 2011-08-12 抗癌剤結合性核酸アプタマー及びその利用 Expired - Fee Related JP5812478B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2011177072A JP5812478B2 (ja) 2011-08-12 2011-08-12 抗癌剤結合性核酸アプタマー及びその利用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2011177072A JP5812478B2 (ja) 2011-08-12 2011-08-12 抗癌剤結合性核酸アプタマー及びその利用

Publications (3)

Publication Number Publication Date
JP2013040118A JP2013040118A (ja) 2013-02-28
JP2013040118A5 JP2013040118A5 (enExample) 2014-09-25
JP5812478B2 true JP5812478B2 (ja) 2015-11-11

Family

ID=47888859

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011177072A Expired - Fee Related JP5812478B2 (ja) 2011-08-12 2011-08-12 抗癌剤結合性核酸アプタマー及びその利用

Country Status (1)

Country Link
JP (1) JP5812478B2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10385090B2 (en) 2013-10-31 2019-08-20 National University Corporation Gunma University Nucleotide derivative or salt thereof, nucleotide-derived 5′-phosphate ester or salt thereof, nucleotide-derived 3′-phosphoramidite compound or salt thereof, and polynucleotide
US10640772B2 (en) 2015-11-30 2020-05-05 Nissan Chemical Industries, Ltd. DNA aptamers binding to molecular targeted agents and detection method of molecular targeted medicine using the same
EP3514237B1 (en) * 2016-09-15 2021-07-14 NEC Solution Innovators, Ltd. Secretory immunoglobulin a (siga)-binding nucleic acid molecule, sensor for siga analysis, and analysis method for siga
WO2018051580A1 (ja) * 2016-09-15 2018-03-22 Ｎｅｃソリューションイノベータ株式会社 ヌクレオシド誘導体またはその塩、ポリヌクレオチドの合成試薬、ポリヌクレオチドの製造方法、ポリヌクレオチド、および結合核酸分子の製造方法
WO2018051581A1 (ja) 2016-09-15 2018-03-22 Ｎｅｃソリューションイノベータ株式会社 ヌクレオシド誘導体またはその塩、ポリヌクレオチドの合成試薬、ポリヌクレオチドの製造方法、ポリヌクレオチド、および結合核酸分子の製造方法
US11643660B2 (en) 2016-11-28 2023-05-09 Nec Solution Innovators, Ltd. Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule
JP2019149979A (ja) * 2018-03-05 2019-09-12 Ｎｅｃソリューションイノベータ株式会社 分泌型免疫グロブリンＡ（ｓＩｇＡ）結合核酸分子、ｓＩｇＡ検出用センサ、ｓＩｇＡ検出試薬、およびｓＩｇＡの分析方法
CN113495111A (zh) * 2020-04-02 2021-10-12 北京化工大学 一种表征适配体与靶标分子结合亲和性的方法及应用
CN120958033B (zh) * 2023-08-04 2026-03-31 映恩生物制药（苏州）有限公司 抗体药物偶联物的识别抗体及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4621921B2 (ja) * 2005-07-27 2011-02-02 国立大学法人群馬大学 新規核酸誘導体及びそれを用いたポリヌクレオチドの製造方法
US8853373B2 (en) * 2009-08-14 2014-10-07 Hitachi, Ltd. Method and reagent for gene sequence analysis

Also Published As

Publication number Publication date
JP2013040118A (ja) 2013-02-28

Similar Documents

Publication Publication Date Title
JP2013040118A (ja) 抗癌剤結合性核酸アプタマー及びその利用
JP6884250B2 (ja) ペプチドオリゴヌクレオチドコンジュゲート
JP7057385B2 (ja) 延長リピート病を処置するためのオリゴヌクレオチド
JP6758335B2 (ja) テロメラーゼ阻害のための改変オリゴヌクレオチド
JP6496549B2 (ja) 脊髄性筋萎縮症における誘発されたエクソン包含
CN108136041B (zh) 寡核苷酸缀合方法
TW202220695A (zh) 寡核苷酸之全身遞送
JPH06128284A (ja) 合成触媒オリゴヌクレオチド構造、核酸の目標配列の切断方法、抗ウイルス治療用薬剤ならびにその製造方法、診断試薬及びその製造方法
JPH10509740A (ja) カチオン性オリゴヌクレオチド、ならびに関連の合成および使用の方法
JP2018531245A6 (ja) オリゴヌクレオチドコンジュゲーション方法
TW202227135A (zh) 用於遞送治療劑之脂質結合物
WO2012029870A1 (ja) オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤
CN116655715A (zh) 一种GalNAc衍生物、缀合物、组合物以及它们的用途
TW202613310A (zh) 含有三氮唑結構的GalNAc化合物及其寡核苷酸綴合物
JP6704196B2 (ja) オリゴヌクレオチド
CN118984717A (zh) Arnatar化合物和用于增强细胞摄取的方法
CN116903684B (zh) 一种肝靶向化合物和寡核苷酸缀合物及其应用
JP6368318B2 (ja) ヌクレオシド誘導体又はその塩、ヌクレオシド誘導体の５’−リン酸エステル又はその塩、ヌクレオシド誘導体の３’−ホスホロアミダイト化物又はその塩、並びにポリヌクレオチド
US20040170980A1 (en) Molecules capable of binding to telomere and the like and method with the use of the same
WO1993006122A1 (en) Duplex-forming, polynucleotide conjugates
WO2022220216A1 (ja) アプタマー型マルチウォーヘッド共有結合性薬剤
Avino et al. Solid-phase synthesis of oligomers carrying several chromophore units linked by phosphodiester backbones
WO2023176773A1 (ja) キメラ分子の製造方法
Park et al. Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents
TW202542313A (zh) 含脂質修飾單體的雙鏈寡核苷酸及其用途

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140808

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140808

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150609

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150731

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150818

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150911

R150 Certificate of patent or registration of utility model

Ref document number: 5812478

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees