JP5793188B2 - 自己免疫疾患治療及び予防薬としてのctrp6 - Google Patents

自己免疫疾患治療及び予防薬としてのctrp6 Download PDF

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JP5793188B2
JP5793188B2 JP2013515089A JP2013515089A JP5793188B2 JP 5793188 B2 JP5793188 B2 JP 5793188B2 JP 2013515089 A JP2013515089 A JP 2013515089A JP 2013515089 A JP2013515089 A JP 2013515089A JP 5793188 B2 JP5793188 B2 JP 5793188B2
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ctrp6
disease
complement
mice
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洋一郎 岩倉
洋一郎 岩倉
正承 村山
正承 村山
晴道 石亀
晴道 石亀
角田 茂
茂 角田
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JP2013515089A 2011-05-13 2012-05-09 自己免疫疾患治療及び予防薬としてのctrp6 Active JP5793188B2 (ja)

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JP2013515089A JP5793188B2 (ja) 2011-05-13 2012-05-09 自己免疫疾患治療及び予防薬としてのctrp6

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US201161485746P 2011-05-13 2011-05-13
US61/485746 2011-05-13
JP2011219350 2011-10-03
JP2011219350 2011-10-03
JP2013515089A JP5793188B2 (ja) 2011-05-13 2012-05-09 自己免疫疾患治療及び予防薬としてのctrp6
PCT/JP2012/061827 WO2012157479A1 (fr) 2011-05-13 2012-05-09 Ctrp6 qui peut être utilisée à titre d'agent thérapeutique et prophylactique pour les maladies auto-immunes

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JPWO2012157479A1 JPWO2012157479A1 (ja) 2014-07-31
JP5793188B2 true JP5793188B2 (ja) 2015-10-14

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JP6551886B2 (ja) * 2013-11-15 2019-07-31 学校法人東京理科大学 自己免疫疾患の治療薬及び治療方法
WO2018124132A1 (fr) * 2016-12-26 2018-07-05 日本ビーシージー製造株式会社 Préparation d'émulsion huile dans eau contenant un composant de squelette à paroi cellulaire bactérienne
US20200397827A1 (en) * 2018-02-14 2020-12-24 Tokyo University Of Science Foundation Chondrocyte proliferation promoter, chondrocyte proliferation promotion method, screening method for chondrocyte proliferation promoters
CN111298121B (zh) * 2020-02-26 2022-02-18 嘉兴学院 Ctrp6基因缺失在抑制肿瘤生长中的应用
CN111778284B (zh) * 2020-06-24 2023-09-22 西安医学院 通过ctrp6介导的动脉粥样化动物模型及其建立方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530452A (ja) * 2004-03-10 2007-11-01 ペプジェン コーポレイション インターロイキン−τを用いる処置を最適化する方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5037100A (en) * 1999-05-27 2000-12-18 Zymogenetics Inc. Adipocyte complement related protein homolog zacrp6
US20040248156A1 (en) 2001-12-03 2004-12-09 Tianhua Hu Methods and materials relating to novel C1q domain-containing polypeptides and polynucleotides
ES2387275T3 (es) 2003-05-15 2012-09-19 Genentech, Inc. Métodos y composiciones para la prevención y el tratamiento de la sepsis
CN101018807A (zh) 2004-05-21 2007-08-15 赞科股份有限公司 免疫原性改变的C1q家族成员蛋白
US7385066B2 (en) 2005-03-16 2008-06-10 Janssen Pharmaceutica N.V. Thiophene sulfoximines, compositions thereof, and methods of treating complement-mediated diseases and conditions
BRPI0708588A2 (pt) 2006-03-08 2011-06-07 Archemix Corp aptámeros de ligaçao ao complemento e agentes anti-c5 usados no tratamento de desordens oculares

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530452A (ja) * 2004-03-10 2007-11-01 ペプジェン コーポレイション インターロイキン−τを用いる処置を最適化する方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6014042344; KIM,M.-J. et al.: 'C1qTNF-related protein-6 increases the expression ofinterleukin-10 in macrophages' Molecules and Cells Vol.30, No.1, 2010, p.59-64 *
JPN6014042345; KEYSTONE,E. et al.: 'IL-10 as a therapeutic strategy in the treatment ofrheumatoid arthritis' Rheumatic Disease Clinics of North America Vol.24, No.3, 1998, p.629-639 *
JPN7014002903; WONG, G. W. et al.: 'A family of Acrp30/adiponectin structural andfunctional paralogs' Proc Natl Acad Sci USA Vol.101, No.28, 2004, p.10302-10307 *

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EP2708233A4 (fr) 2015-01-07
EP2708233B1 (fr) 2018-06-27
EP2708233A1 (fr) 2014-03-19
WO2012157479A1 (fr) 2012-11-22
JPWO2012157479A1 (ja) 2014-07-31
US9175054B2 (en) 2015-11-03
US20140194343A1 (en) 2014-07-10

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