JP5789271B2 - 無菌ヒアルロン酸溶液 - Google Patents

無菌ヒアルロン酸溶液 Download PDF

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Publication number
JP5789271B2
JP5789271B2 JP2012552893A JP2012552893A JP5789271B2 JP 5789271 B2 JP5789271 B2 JP 5789271B2 JP 2012552893 A JP2012552893 A JP 2012552893A JP 2012552893 A JP2012552893 A JP 2012552893A JP 5789271 B2 JP5789271 B2 JP 5789271B2
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Japan
Prior art keywords
hyaluronic acid
solution
high salt
salt concentration
aqueous
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Active
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JP2012552893A
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English (en)
Japanese (ja)
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JP2013518926A5 (enExample
JP2013518926A (ja
Inventor
マイケル リウ シャオジュン
マイケル リウ シャオジュン
ジョセフ ヘイラー デイビッド
ジョセフ ヘイラー デイビッド
メンゼル トーマス
メンゼル トーマス
ブロンゴ アビー
ブロンゴ アビー
イー．バーク スーザン
イー．バーク スーザン
カミンズ カール
カミンズ カール
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Bausch and Lomb Inc
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Bausch and Lomb Inc
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Publication of JP2013518926A publication Critical patent/JP2013518926A/ja
Publication of JP2013518926A5 publication Critical patent/JP2013518926A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
JP2012552893A 2010-02-09 2011-01-27 無菌ヒアルロン酸溶液 Active JP5789271B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/702,540 US8283463B2 (en) 2010-02-09 2010-02-09 Sterile hyaluronic acid solutions
US12/702,540 2010-02-09
PCT/US2011/022656 WO2011100114A1 (en) 2010-02-09 2011-01-27 Sterile hyaluronic acid solutions

Publications (3)

Publication Number Publication Date
JP2013518926A JP2013518926A (ja) 2013-05-23
JP2013518926A5 JP2013518926A5 (enExample) 2014-03-13
JP5789271B2 true JP5789271B2 (ja) 2015-10-07

Family

ID=43754892

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012552893A Active JP5789271B2 (ja) 2010-02-09 2011-01-27 無菌ヒアルロン酸溶液

Country Status (8)

Country Link
US (2) US8283463B2 (enExample)
EP (2) EP2865395A1 (enExample)
JP (1) JP5789271B2 (enExample)
BR (1) BR112012019008B8 (enExample)
ES (1) ES2531955T3 (enExample)
PL (1) PL2400993T3 (enExample)
TW (1) TWI405595B (enExample)
WO (1) WO2011100114A1 (enExample)

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US10227289B2 (en) 2010-05-07 2019-03-12 Medicus Biosciences, Llc Methods for treating diseases of the lung
US10111985B2 (en) * 2011-08-10 2018-10-30 Medicus Biosciences, Llc Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules
US11083821B2 (en) * 2011-08-10 2021-08-10 C.P. Medical Corporation Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules
ES2686114T3 (es) * 2011-12-20 2018-10-16 Angioclinic Ag El ácido hialurónico y su uso para el tratamiento de la insuficiencia venosa y las venas varicosas
JP6206987B2 (ja) 2012-05-11 2017-10-04 メディカス バイオサイエンシーズ，エルエルシー 網膜剥離の処置のための生体適合性ヒドロゲル製剤
FR3019465B1 (fr) 2014-04-02 2017-06-23 Horus Pharma Composition hyperosmolaire d'acide hyaluronique et son utilisation pour le traitement de l'oedeme corneen
ES2837062T3 (es) 2014-04-17 2021-06-29 Merz Pharma Gmbh & Co Kgaa Composición para mejorar el aspecto de la piel envejecida
US10245324B2 (en) 2014-10-31 2019-04-02 Johnson & Johnson Consumer Inc. Ophthalmic composition
US20170014339A1 (en) * 2015-07-17 2017-01-19 i.com medical GmbH Tear Substitute, Fluid for Being Used as a Tear Substitute, and Method for Producing a Tear Substitute
DE102015226456A1 (de) 2015-12-22 2017-06-22 Heraeus Medical Gmbh Verfahren zur Sterilisation von wässrigen Polysaccharidlösungen und sterile wässrige Polysaccharidlösungen
AR108280A1 (es) 2016-05-05 2018-08-08 Acraf Composición oftálmica que comprende una combinación sinérgica de glucógeno y ácido hialurónico o sal del mismo
ES2909998T3 (es) * 2016-10-14 2022-05-11 I Com Medical Gmbh Método para establecer, restablecer y preservar la homeostasis de la superficie ocular
ES2975184T3 (es) * 2017-10-12 2024-07-03 Solyplus Gmbh Métodos de fabricación de polímeros masivos concentrados y homogéneamente humectados y aplicaciones de los mismos
CN111196917B (zh) * 2018-11-20 2022-10-14 臧唯 内窥镜用视野清晰剂
US20220273545A1 (en) * 2019-08-21 2022-09-01 Shiseido Company, Ltd. Cosmetic
IT201900019724A1 (it) 2019-10-24 2021-04-24 Bmg Pharma S P A “procedimento in solvente organico per la purificazione dell’acido ialuronico sale sodico”
IT202000008299A1 (it) * 2020-04-17 2021-10-17 Glycores 2000 Srl Composizione liquida oftalmica comprendente acido ialuronico lineare a basso peso molecolare
KR102549875B1 (ko) * 2020-09-22 2023-07-03 주식회사 필코리아 필러 정제용 장치
CN112255345A (zh) * 2020-10-20 2021-01-22 山东华熙海御生物医药有限公司 一种测定高分子量透明质酸分子量的方法
KR102762718B1 (ko) * 2022-02-23 2025-02-06 주식회사 스카이테라퓨틱스 고분자 히알루론산의 구조체, 이의 제조방법 및 이를 포함하는 화장료 조성물

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US4141973A (en) 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
DE2837115A1 (de) 1978-08-25 1980-03-06 Bayer Ag Neues verfahren zur herstellung von sterilen feststoffen
US5093487A (en) 1986-01-06 1992-03-03 Mobay Corporation Low viscosity high molecular weight filter sterilizable hyaluronic acid
RU2067841C1 (ru) * 1994-01-28 1996-10-20 Научно-производственная фирма "Нарт" Способ получения ароматизатора
IT1273011B (it) 1994-07-25 1997-07-01 Trhecnopharma S A Preparato oftalmico per l'uso come lacrima artificiale
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US6149864A (en) 1998-06-25 2000-11-21 Massachusetts Institute Of Technology Supercritical fluid sterilization method
CH692919A5 (fr) 1999-01-28 2002-12-13 Trb Chemedica S A Procédé de purification de l'acide hyaluronique à poids moléculaire élevé.
KR100354606B1 (ko) 2000-02-01 2002-09-30 주식회사 중외제약 다목적 콘택트 렌즈 관리 용액 조성물
FR2811996B1 (fr) * 2000-07-19 2003-08-08 Corneal Ind Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations
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ATE547122T1 (de) * 2001-11-21 2012-03-15 Novartis Pharma Gmbh Zusammensetzung zur stabilisierung von hyaluronsäure
CN100366296C (zh) 2002-08-07 2008-02-06 梅迪多姆实验室股份有限公司 制备无菌高分子量透明质酸制剂的方法
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US7956180B2 (en) * 2004-05-27 2011-06-07 Novozymes A/S Dried and agglomerated hyaluronic acid product
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DE102005030011A1 (de) 2005-06-17 2006-12-21 Aesculap Ag & Co. Kg Verfahren zur Herstellung von sterilen Polysaccharidlösungen
US20090036554A1 (en) * 2007-08-01 2009-02-05 Burke Susan E Ophthalmic compositions comprising a terpene compound
ES2622834T3 (es) * 2007-11-13 2017-07-07 Bio-Technology General (Israel) Ltd. Procedimiento de esterilización por filtración en estado diluido para biopolímeros viscoelásticos
EP2346513A1 (en) * 2008-09-15 2011-07-27 Bausch & Lomb Incorporated Compositions comprising polymers having amino sugar units and methods of making and using same

Also Published As

Publication number Publication date
EP2400993B1 (en) 2014-12-31
BR112012019008A2 (pt) 2015-09-15
EP2865395A1 (en) 2015-04-29
BR112012019008B1 (pt) 2018-11-13
TW201200171A (en) 2012-01-01
PL2400993T3 (pl) 2015-06-30
US8283463B2 (en) 2012-10-09
TWI405595B (zh) 2013-08-21
US20110195925A1 (en) 2011-08-11
EP2400993A1 (en) 2012-01-04
US8530641B2 (en) 2013-09-10
JP2013518926A (ja) 2013-05-23
BR112012019008B8 (pt) 2018-11-27
WO2011100114A1 (en) 2011-08-18
US20120295869A1 (en) 2012-11-22
ES2531955T3 (es) 2015-03-23

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