JP5784006B2 - １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター - Google Patents
１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター Download PDFInfo
- Publication number
- JP5784006B2 JP5784006B2 JP2012508772A JP2012508772A JP5784006B2 JP 5784006 B2 JP5784006 B2 JP 5784006B2 JP 2012508772 A JP2012508772 A JP 2012508772A JP 2012508772 A JP2012508772 A JP 2012508772A JP 5784006 B2 JP5784006 B2 JP 5784006B2
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- JP
- Japan
- Prior art keywords
- phenyl
- ethyl
- alkyl
- oxazinan
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 ***(*)NC(CC(*)(**)O)=O Chemical compound ***(*)NC(CC(*)(**)O)=O 0.000 description 10
- YZJCNADFGXFEHX-UHFFFAOYSA-N CN(C=CC(I)=C1)C1=O Chemical compound CN(C=CC(I)=C1)C1=O YZJCNADFGXFEHX-UHFFFAOYSA-N 0.000 description 3
- GPDLQTSXVDZBBN-ZETCQYMHSA-N C[C@@H](c(cc1C)ccc1Br)N Chemical compound C[C@@H](c(cc1C)ccc1Br)N GPDLQTSXVDZBBN-ZETCQYMHSA-N 0.000 description 2
- RSISJNOUEDALAD-UHFFFAOYSA-N CC(C)(CN(C=CC(Br)=C1)C1=O)C(OC)=O Chemical compound CC(C)(CN(C=CC(Br)=C1)C1=O)C(OC)=O RSISJNOUEDALAD-UHFFFAOYSA-N 0.000 description 1
- UHDZCMNPZUGRBU-CAWMZFRYSA-N CC(c(cc1)ccc1Br)N(CC[C@](CCCO)(c1ccccc1)O1)C1=O Chemical compound CC(c(cc1)ccc1Br)N(CC[C@](CCCO)(c1ccccc1)O1)C1=O UHDZCMNPZUGRBU-CAWMZFRYSA-N 0.000 description 1
- CSZCYYQUNZFQPS-UHFFFAOYSA-N CC(c(cc1C)ccc1Br)=N Chemical compound CC(c(cc1C)ccc1Br)=N CSZCYYQUNZFQPS-UHFFFAOYSA-N 0.000 description 1
- QRTFRIPKQPOIPI-UHFFFAOYSA-N CC(c(cc1C)ccc1Br)=O Chemical compound CC(c(cc1C)ccc1Br)=O QRTFRIPKQPOIPI-UHFFFAOYSA-N 0.000 description 1
- AXTNXCVKACZAMQ-GDLZYMKVSA-N CC1(C)OB(c(cc2)ccc2C(N(CC[C@](CCc2nnc(C)[o]2)(c2ccccc2)O2)C2=O)=C)OC1(C)C Chemical compound CC1(C)OB(c(cc2)ccc2C(N(CC[C@](CCc2nnc(C)[o]2)(c2ccccc2)O2)C2=O)=C)OC1(C)C AXTNXCVKACZAMQ-GDLZYMKVSA-N 0.000 description 1
- WPDHREZSBLHPET-UHFFFAOYSA-N CCCC(C)C(C)(C(C)(C)O)OBB1OC(C)(C)C(C)(C)O1 Chemical compound CCCC(C)C(C)(C(C)(C)O)OBB1OC(C)(C)C(C)(C)O1 WPDHREZSBLHPET-UHFFFAOYSA-N 0.000 description 1
- BNGMLGRGZGJDRE-RBTNQOKQSA-N CCN(C=C(C=C1)c2ccc([C@H](C)N(CC[C@](CCCO)(c3ccccc3)O3)C3=O)cc2)C1=O Chemical compound CCN(C=C(C=C1)c2ccc([C@H](C)N(CC[C@](CCCO)(c3ccccc3)O3)C3=O)cc2)C1=O BNGMLGRGZGJDRE-RBTNQOKQSA-N 0.000 description 1
- IMUFBRDEXLFPAE-JYFHCDHNSA-N CC[C@@H](c(cc1)ccc1C(C=CN1C)=CC1=O)N(CC[C@](C)(c1ccccc1)O1)C1=O Chemical compound CC[C@@H](c(cc1)ccc1C(C=CN1C)=CC1=O)N(CC[C@](C)(c1ccccc1)O1)C1=O IMUFBRDEXLFPAE-JYFHCDHNSA-N 0.000 description 1
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N CCc1ccccc1 Chemical compound CCc1ccccc1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 1
- FRLYEFGFRWMIMI-UHFFFAOYSA-N CN(C=C(C(Br)=C1)F)C1=O Chemical compound CN(C=C(C(Br)=C1)F)C1=O FRLYEFGFRWMIMI-UHFFFAOYSA-N 0.000 description 1
- BPFLDFIAASCZDB-QMMMGPOBSA-N C[C@@H](c(cc1)ccc1Br)N(C(O)=O)N(C)/N=C(/C)\O Chemical compound C[C@@H](c(cc1)ccc1Br)N(C(O)=O)N(C)/N=C(/C)\O BPFLDFIAASCZDB-QMMMGPOBSA-N 0.000 description 1
- ZNJRRHXFJPZZPP-HRAATJIYSA-N C[C@@H](c(cc1)ccc1Br)N(CC[C@](CC=C)(c1ccccc1)O1)C1=O Chemical compound C[C@@H](c(cc1)ccc1Br)N(CC[C@](CC=C)(c1ccccc1)O1)C1=O ZNJRRHXFJPZZPP-HRAATJIYSA-N 0.000 description 1
- QZHLOQRHCFFNFS-QMHKHESXSA-N C[C@@H](c(cc1)ccc1Br)N(CC[C@](CCC(NNC(C)=O)=O)(c1ccccc1)O1)C1=O Chemical compound C[C@@H](c(cc1)ccc1Br)N(CC[C@](CCC(NNC(C)=O)=O)(c1ccccc1)O1)C1=O QZHLOQRHCFFNFS-QMHKHESXSA-N 0.000 description 1
- VOPVCBPBVGZOQK-YCRPNKLZSA-N C[C@@H](c(cc1)ccc1Br)N(CC[C@](CCC(O)=O)(c1ccccc1)O1)C1=O Chemical compound C[C@@H](c(cc1)ccc1Br)N(CC[C@](CCC(O)=O)(c1ccccc1)O1)C1=O VOPVCBPBVGZOQK-YCRPNKLZSA-N 0.000 description 1
- QIMKZFAYADXKFW-MMTVBGGISA-N C[C@@H](c(cc1)ccc1C(C=C1)=CN(CC(F)(F)F)C1=O)N(CC[C@](CC(C)(C)O)(c1ccccc1)O1)C1=O Chemical compound C[C@@H](c(cc1)ccc1C(C=C1)=CN(CC(F)(F)F)C1=O)N(CC[C@](CC(C)(C)O)(c1ccccc1)O1)C1=O QIMKZFAYADXKFW-MMTVBGGISA-N 0.000 description 1
- WENZRALRTASOGL-PPHZAIPVSA-N C[C@@H](c(cc1)ccc1C(C=CN1)=CC1=O)N(CC[C@](CC(C)(C)O)(c1ccccc1)O1)C1=O Chemical compound C[C@@H](c(cc1)ccc1C(C=CN1)=CC1=O)N(CC[C@](CC(C)(C)O)(c1ccccc1)O1)C1=O WENZRALRTASOGL-PPHZAIPVSA-N 0.000 description 1
- TXNPQZGSVXLGGP-MMTVBGGISA-N C[C@@H](c(cc1)ccc1C(C=CN1C)=CC1=O)N(CC[C@](CC(C)(C)O)(c1ccccc1)O1)C1=O Chemical compound C[C@@H](c(cc1)ccc1C(C=CN1C)=CC1=O)N(CC[C@](CC(C)(C)O)(c1ccccc1)O1)C1=O TXNPQZGSVXLGGP-MMTVBGGISA-N 0.000 description 1
- KXJPWQOWGIEICF-SSOJOUAXSA-N C[C@@H](c(cc1)ccc1C(C=CN1C)=CC1=O)N(CC[C@](CCc1nnc(C)[o]1)(C=C)O1)C1=O Chemical compound C[C@@H](c(cc1)ccc1C(C=CN1C)=CC1=O)N(CC[C@](CCc1nnc(C)[o]1)(C=C)O1)C1=O KXJPWQOWGIEICF-SSOJOUAXSA-N 0.000 description 1
- VKZQXZLGSSMKIU-QMMMGPOBSA-N C[C@@H](c(cc1C)ccc1Br)N(C)O Chemical compound C[C@@H](c(cc1C)ccc1Br)N(C)O VKZQXZLGSSMKIU-QMMMGPOBSA-N 0.000 description 1
- BXQWRZYOOZPLBJ-MMTVBGGISA-N C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N(CC[C@](CC(C)(C)O)(c1ccccc1)O1)C1=O Chemical compound C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N(CC[C@](CC(C)(C)O)(c1ccccc1)O1)C1=O BXQWRZYOOZPLBJ-MMTVBGGISA-N 0.000 description 1
- POHJRJNCZQENQG-UHFFFAOYSA-N O=C1NC=CC(I)=C1 Chemical compound O=C1NC=CC(I)=C1 POHJRJNCZQENQG-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2009/002653 WO2009134400A1 (en) | 2008-05-01 | 2009-04-30 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| USPCT/US2009/002653 | 2009-04-30 | ||
| PCT/US2009/004261 WO2010011314A1 (en) | 2008-07-25 | 2009-07-23 | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| USPCT/US2009/004261 | 2009-07-23 | ||
| PCT/US2010/033157 WO2010127237A2 (en) | 2009-04-30 | 2010-04-30 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525440A JP2012525440A (ja) | 2012-10-22 |
| JP2012525440A5 JP2012525440A5 (https=) | 2013-06-13 |
| JP5784006B2 true JP5784006B2 (ja) | 2015-09-24 |
Family
ID=45478607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508772A Active JP5784006B2 (ja) | 2009-04-30 | 2010-04-30 | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JP5784006B2 (https=) |
| AP (1) | AP2011005948A0 (https=) |
| CL (1) | CL2014001815A1 (https=) |
| CO (1) | CO6501139A2 (https=) |
| IL (1) | IL215249A (https=) |
| MX (1) | MX2011011503A (https=) |
| NZ (1) | NZ595473A (https=) |
| PE (1) | PE20120794A1 (https=) |
| TN (1) | TN2010000467A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2744946A1 (en) * | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2183228B1 (en) * | 2007-07-26 | 2014-08-20 | Vitae Pharmaceuticals, Inc. | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 |
-
2010
- 2010-04-30 NZ NZ595473A patent/NZ595473A/en not_active IP Right Cessation
- 2010-04-30 PE PE2011001866A patent/PE20120794A1/es not_active Application Discontinuation
- 2010-04-30 AP AP2011005948A patent/AP2011005948A0/xx unknown
- 2010-04-30 JP JP2012508772A patent/JP5784006B2/ja active Active
- 2010-04-30 MX MX2011011503A patent/MX2011011503A/es active IP Right Grant
- 2010-10-14 TN TNP2010000467A patent/TN2010000467A1/fr unknown
-
2011
- 2011-09-20 IL IL215249A patent/IL215249A/en not_active IP Right Cessation
- 2011-10-05 CO CO11131281A patent/CO6501139A2/es not_active Application Discontinuation
-
2014
- 2014-07-08 CL CL2014001815A patent/CL2014001815A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2014001815A1 (es) | 2015-02-13 |
| AP2011005948A0 (en) | 2011-10-31 |
| NZ595473A (en) | 2014-01-31 |
| HK1169409A1 (en) | 2013-01-25 |
| JP2012525440A (ja) | 2012-10-22 |
| CO6501139A2 (es) | 2012-08-15 |
| IL215249A0 (en) | 2011-12-29 |
| MX2011011503A (es) | 2011-11-18 |
| IL215249A (en) | 2014-12-31 |
| PE20120794A1 (es) | 2012-07-26 |
| TN2010000467A1 (en) | 2012-05-24 |
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