TN2010000467A1 - Cyclic inhibitors of 11 beta hydroxysterioid dehydrogenase 1 - Google Patents

Cyclic inhibitors of 11 beta hydroxysterioid dehydrogenase 1

Info

Publication number
TN2010000467A1
TN2010000467A1 TNP2010000467A TN2010000467A TN2010000467A1 TN 2010000467 A1 TN2010000467 A1 TN 2010000467A1 TN P2010000467 A TNP2010000467 A TN P2010000467A TN 2010000467 A TN2010000467 A TN 2010000467A TN 2010000467 A1 TN2010000467 A1 TN 2010000467A1
Authority
TN
Tunisia
Prior art keywords
hydroxysterioid
dehydrogenase
beta
cyclic inhibitors
cortisol
Prior art date
Application number
TNP2010000467A
Other languages
French (fr)
Inventor
David A Claremon
Linghang Zhuang
Katerina Leftheris
Colin M Tice
Zhenrong Xu
Yuanjie Ye
Suresh B Singh
Salvacion Cacatian
Wei Zhao
Frank Himmelsbach
Original Assignee
Vitae Pharmaceuticals Inc
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45478607&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2010000467(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2009/002653 external-priority patent/WO2009134400A1/en
Application filed by Vitae Pharmaceuticals Inc, Boehringer Ingelheim Int filed Critical Vitae Pharmaceuticals Inc
Publication of TN2010000467A1 publication Critical patent/TN2010000467A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 -HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
TNP2010000467A 2009-04-30 2010-10-14 Cyclic inhibitors of 11 beta hydroxysterioid dehydrogenase 1 TN2010000467A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/002653 WO2009134400A1 (en) 2008-05-01 2009-04-30 Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
TN2010000467A1 true TN2010000467A1 (en) 2012-05-24

Family

ID=45478607

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2010000467A TN2010000467A1 (en) 2009-04-30 2010-10-14 Cyclic inhibitors of 11 beta hydroxysterioid dehydrogenase 1

Country Status (10)

Country Link
JP (1) JP5784006B2 (en)
AP (1) AP2011005948A0 (en)
CL (1) CL2014001815A1 (en)
CO (1) CO6501139A2 (en)
HK (1) HK1169409A1 (en)
IL (1) IL215249A (en)
MX (1) MX2011011503A (en)
NZ (1) NZ595473A (en)
PE (1) PE20120794A1 (en)
TN (1) TN2010000467A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2744946A1 (en) * 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2183228B1 (en) * 2007-07-26 2014-08-20 Vitae Pharmaceuticals, Inc. CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1

Also Published As

Publication number Publication date
MX2011011503A (en) 2011-11-18
CO6501139A2 (en) 2012-08-15
IL215249A0 (en) 2011-12-29
CL2014001815A1 (en) 2015-02-13
AP2011005948A0 (en) 2011-10-31
HK1169409A1 (en) 2013-01-25
NZ595473A (en) 2014-01-31
JP5784006B2 (en) 2015-09-24
PE20120794A1 (en) 2012-07-26
JP2012525440A (en) 2012-10-22
IL215249A (en) 2014-12-31

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