MX2011011503A - Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. - Google Patents
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1.Info
- Publication number
- MX2011011503A MX2011011503A MX2011011503A MX2011011503A MX2011011503A MX 2011011503 A MX2011011503 A MX 2011011503A MX 2011011503 A MX2011011503 A MX 2011011503A MX 2011011503 A MX2011011503 A MX 2011011503A MX 2011011503 A MX2011011503 A MX 2011011503A
- Authority
- MX
- Mexico
- Prior art keywords
- 11beta
- hydroxysteroid dehydrogenase
- cyclic inhibitors
- cortisol
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, lo1, lo2, lo5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2009/002653 WO2009134400A1 (en) | 2008-05-01 | 2009-04-30 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| PCT/US2009/004261 WO2010011314A1 (en) | 2008-07-25 | 2009-07-23 | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| PCT/US2010/033157 WO2010127237A2 (en) | 2009-04-30 | 2010-04-30 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011011503A true MX2011011503A (en) | 2011-11-18 |
Family
ID=45478607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011011503A MX2011011503A (en) | 2009-04-30 | 2010-04-30 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1. |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JP5784006B2 (en) |
| AP (1) | AP2011005948A0 (en) |
| CL (1) | CL2014001815A1 (en) |
| CO (1) | CO6501139A2 (en) |
| HK (1) | HK1169409A1 (en) |
| IL (1) | IL215249A (en) |
| MX (1) | MX2011011503A (en) |
| NZ (1) | NZ595473A (en) |
| PE (1) | PE20120794A1 (en) |
| TN (1) | TN2010000467A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2393807B1 (en) * | 2009-02-04 | 2013-08-14 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5451611B2 (en) * | 2007-07-26 | 2014-03-26 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | Cyclic inhibitor of 11β-hydroxysteroid dehydrogenase 1 |
-
2010
- 2010-04-30 NZ NZ595473A patent/NZ595473A/en not_active IP Right Cessation
- 2010-04-30 AP AP2011005948A patent/AP2011005948A0/en unknown
- 2010-04-30 MX MX2011011503A patent/MX2011011503A/en active IP Right Grant
- 2010-04-30 JP JP2012508772A patent/JP5784006B2/en active Active
- 2010-04-30 PE PE2011001866A patent/PE20120794A1/en not_active Application Discontinuation
- 2010-10-14 TN TNP2010000467A patent/TN2010000467A1/en unknown
-
2011
- 2011-09-20 IL IL215249A patent/IL215249A/en not_active IP Right Cessation
- 2011-10-05 CO CO11131281A patent/CO6501139A2/en not_active Application Discontinuation
-
2012
- 2012-10-16 HK HK12110197.6A patent/HK1169409A1/en not_active IP Right Cessation
-
2014
- 2014-07-08 CL CL2014001815A patent/CL2014001815A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ595473A (en) | 2014-01-31 |
| IL215249A (en) | 2014-12-31 |
| IL215249A0 (en) | 2011-12-29 |
| HK1169409A1 (en) | 2013-01-25 |
| CL2014001815A1 (en) | 2015-02-13 |
| JP2012525440A (en) | 2012-10-22 |
| AP2011005948A0 (en) | 2011-10-31 |
| TN2010000467A1 (en) | 2012-05-24 |
| JP5784006B2 (en) | 2015-09-24 |
| PE20120794A1 (en) | 2012-07-26 |
| CO6501139A2 (en) | 2012-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |