JP2012525440A5 - - Google Patents
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- Publication number
- JP2012525440A5 JP2012525440A5 JP2012508772A JP2012508772A JP2012525440A5 JP 2012525440 A5 JP2012525440 A5 JP 2012525440A5 JP 2012508772 A JP2012508772 A JP 2012508772A JP 2012508772 A JP2012508772 A JP 2012508772A JP 2012525440 A5 JP2012525440 A5 JP 2012525440A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- structural formula
- hsd1
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 35
- 201000010099 disease Diseases 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 102000008645 11-beta-Hydroxysteroid Dehydrogenase Type 1 Human genes 0.000 claims 6
- 108010088011 11-beta-Hydroxysteroid Dehydrogenase Type 1 Proteins 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 150000004682 monohydrates Chemical class 0.000 claims 4
- 238000000634 powder X-ray diffraction Methods 0.000 claims 4
- 230000005855 radiation Effects 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 1
- -1 2-hydroxy-2-methylpropyl Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2009/002653 WO2009134400A1 (en) | 2008-05-01 | 2009-04-30 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| USPCT/US2009/002653 | 2009-04-30 | ||
| PCT/US2009/004261 WO2010011314A1 (en) | 2008-07-25 | 2009-07-23 | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| USPCT/US2009/004261 | 2009-07-23 | ||
| PCT/US2010/033157 WO2010127237A2 (en) | 2009-04-30 | 2010-04-30 | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012525440A JP2012525440A (ja) | 2012-10-22 |
| JP2012525440A5 true JP2012525440A5 (https=) | 2013-06-13 |
| JP5784006B2 JP5784006B2 (ja) | 2015-09-24 |
Family
ID=45478607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508772A Active JP5784006B2 (ja) | 2009-04-30 | 2010-04-30 | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JP5784006B2 (https=) |
| AP (1) | AP2011005948A0 (https=) |
| CL (1) | CL2014001815A1 (https=) |
| CO (1) | CO6501139A2 (https=) |
| IL (1) | IL215249A (https=) |
| MX (1) | MX2011011503A (https=) |
| NZ (1) | NZ595473A (https=) |
| PE (1) | PE20120794A1 (https=) |
| TN (1) | TN2010000467A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2744946A1 (en) * | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2183228B1 (en) * | 2007-07-26 | 2014-08-20 | Vitae Pharmaceuticals, Inc. | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 |
-
2010
- 2010-04-30 NZ NZ595473A patent/NZ595473A/en not_active IP Right Cessation
- 2010-04-30 PE PE2011001866A patent/PE20120794A1/es not_active Application Discontinuation
- 2010-04-30 AP AP2011005948A patent/AP2011005948A0/xx unknown
- 2010-04-30 JP JP2012508772A patent/JP5784006B2/ja active Active
- 2010-04-30 MX MX2011011503A patent/MX2011011503A/es active IP Right Grant
- 2010-10-14 TN TNP2010000467A patent/TN2010000467A1/fr unknown
-
2011
- 2011-09-20 IL IL215249A patent/IL215249A/en not_active IP Right Cessation
- 2011-10-05 CO CO11131281A patent/CO6501139A2/es not_active Application Discontinuation
-
2014
- 2014-07-08 CL CL2014001815A patent/CL2014001815A1/es unknown
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