JP5775454B2 - 固定化生物学的実体 - Google Patents

固定化生物学的実体 Download PDF

Info

Publication number
JP5775454B2
JP5775454B2 JP2011526514A JP2011526514A JP5775454B2 JP 5775454 B2 JP5775454 B2 JP 5775454B2 JP 2011526514 A JP2011526514 A JP 2011526514A JP 2011526514 A JP2011526514 A JP 2011526514A JP 5775454 B2 JP5775454 B2 JP 5775454B2
Authority
JP
Japan
Prior art keywords
heparin
layer
functionalized
cationic polymer
medical device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2011526514A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012502678A5 (enExample
JP2012502678A (ja
Inventor
オスカルソン，ステファン
ラーマン，マルティナ
レオンテイン，カリン
ベストベルイ，ロベルト
Original Assignee
カルメダ アクティエボラーグ
カルメダ アクティエボラーグ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by カルメダ アクティエボラーグ, カルメダ アクティエボラーグ filed Critical カルメダ アクティエボラーグ
Publication of JP2012502678A publication Critical patent/JP2012502678A/ja
Publication of JP2012502678A5 publication Critical patent/JP2012502678A5/ja
Application granted granted Critical
Publication of JP5775454B2 publication Critical patent/JP5775454B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0035—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a polymer with positively charged atoms in the polymeric backbone, e.g. ionenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2011526514A 2008-09-15 2009-09-15 固定化生物学的実体 Active JP5775454B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0816783.5A GB0816783D0 (en) 2008-09-15 2008-09-15 Immobilised biological entities
GB0816783.5 2008-09-15
PCT/EP2009/061981 WO2010029189A2 (en) 2008-09-15 2009-09-15 Immobilised biological entities

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015047952A Division JP6122052B2 (ja) 2008-09-15 2015-03-11 固定化生物学的実体

Publications (3)

Publication Number Publication Date
JP2012502678A JP2012502678A (ja) 2012-02-02
JP2012502678A5 JP2012502678A5 (enExample) 2012-12-27
JP5775454B2 true JP5775454B2 (ja) 2015-09-09

Family

ID=39930120

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011526514A Active JP5775454B2 (ja) 2008-09-15 2009-09-15 固定化生物学的実体
JP2015047952A Active JP6122052B2 (ja) 2008-09-15 2015-03-11 固定化生物学的実体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015047952A Active JP6122052B2 (ja) 2008-09-15 2015-03-11 固定化生物学的実体

Country Status (8)

Country Link
US (3) US8992963B2 (enExample)
EP (1) EP2340057B1 (enExample)
JP (2) JP5775454B2 (enExample)
AU (1) AU2009290833B2 (enExample)
CA (1) CA2732939C (enExample)
ES (1) ES2550147T3 (enExample)
GB (1) GB0816783D0 (enExample)
WO (1) WO2010029189A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015147051A (ja) * 2008-09-15 2015-08-20 カルメダ アクティエボラーグ 固定化生物学的実体

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8021677B2 (en) 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US9114194B2 (en) 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
US8496953B2 (en) 2006-05-12 2013-07-30 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity following sterilization
US8986713B2 (en) 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
US8591932B2 (en) 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
GB201004101D0 (en) 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
RU2625756C2 (ru) 2011-03-11 2017-07-18 В.Л. Гор Энд Ассошиейтс, Инк. Усовершенствованные иммобилизованные биологические объекты
WO2014152423A1 (en) * 2013-03-15 2014-09-25 Bard Access Systems, Inc. Antithrombic coatings and uses thereof
WO2015048619A2 (en) * 2013-09-30 2015-04-02 Teleflex Medical Incorporated Stabilized enzyme compositions
US9795721B2 (en) * 2013-11-28 2017-10-24 Toray Industries, Inc. Antithrombotic material
US11839698B2 (en) 2014-03-13 2023-12-12 W. L. Gore & Associates, Inc. Drug composition and coating
WO2015188716A1 (zh) * 2014-06-09 2015-12-17 上海微创医疗器械（集团）有限公司 一种抗凝血涂层及其涂覆方法
AU2016267435B2 (en) * 2015-05-27 2019-03-14 Toray Industries, Inc. Antithrombotic material
AU2019232163B2 (en) * 2018-03-09 2025-11-20 Carmeda Ab Improvements to processes for immobilising biological entities
US20190275213A1 (en) 2018-03-09 2019-09-12 Carmeda Ab Immobilising biological entities
AU2019354085B2 (en) * 2018-10-03 2025-06-05 Carmeda Ab Immobilised biological entities
AU2021324051A1 (en) * 2020-08-14 2023-02-09 Idris Oncology B.V. A process for applying a coating comprising one or more polysaccharides with binding affinity for bioanalytes onto the surface of a medical sampling device, and the medical sampling device for capture of bioanalytes provided with the coating
EP4032560A1 (en) * 2021-01-25 2022-07-27 Centre National pour la Recherche Scientifique Implantable material in contact with blood and uses thereof
US11685856B2 (en) * 2021-05-21 2023-06-27 Baker Hughes Oilfield Operations Llc Branched polyethyleneimine (B-PE) as oilfield metal naphthenate inhibitors

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2818376A (en) 1956-12-28 1957-12-31 Hanson Van Winkle Munning Co Nickel plating
GB1508823A (en) 1974-04-01 1978-04-26 Oxy Metal Industries Corp Electrodeposition of metal deposits
SE456347B (sv) 1982-02-09 1988-09-26 Ird Biomaterial Ab Ytmodifierat fast substrat samt forfarande for framstellning derav
SE8200751L (sv) 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
HU186656B (en) 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives, acid additionak salts and pharmaceutical compositions containing them
JPH09103481A (ja) 1989-05-11 1997-04-22 Kanegafuchi Chem Ind Co Ltd 生体適合性に優れた表面を有する医療用具およびその製造方法
JPH0357896A (ja) 1989-07-26 1991-03-13 Zexel Corp 可変容量型ベーン型圧縮機
JP2710444B2 (ja) 1989-09-18 1998-02-10 旭化成工業株式会社 医療材料の製造法
US5049403A (en) 1989-10-12 1991-09-17 Horsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5213898A (en) 1989-10-12 1993-05-25 Norsk Hydro A.S. Process for the preparation of surface modified solid substrates
JPH07122048B2 (ja) 1989-11-30 1995-12-25 テルモ株式会社 官能基導入基材およびその製造方法ならびにこれらを用いた医療用材料および医療用器具
JP3093375B2 (ja) 1991-11-01 2000-10-03 株式会社東海メディカルプロダクツ 抗血栓性物質の固定化方法
DE19604173C2 (de) 1996-02-06 2000-07-06 Hartwig Hoecker Verfahren zur Erzeugung antithrombogener Oberflächen auf extrakorporal und/oder intrakorporal zu verwendenden medizinischen Gegenständen
US5855618A (en) 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
NO984143L (no) * 1998-09-09 2000-03-10 Norsk Hydro As Ny prosess for å fremstille overflatemodifiserende stoffer
NO984144L (no) 1998-09-09 2000-03-10 Carmeda Ab Sammensetning som omfatter heparin som et ikke-trombogent overflatebelegg
EP1152013B1 (en) 1998-11-10 2008-04-23 Netech Inc. Functional chitosan derivative
SE515295C2 (sv) 1999-11-23 2001-07-09 Medicarb Ab Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat
AU2001238485A1 (en) 2000-02-18 2001-08-27 The Immune Response Corporation Methods and compositions for gene delivery
JP4071938B2 (ja) * 2001-01-18 2008-04-02 富士フイルム株式会社 インクジェット記録用シート
US20050059068A1 (en) 2001-05-23 2005-03-17 Stratagene California Compositions and methods using dendrimer-treated microassays
US6787179B2 (en) * 2001-06-29 2004-09-07 Ethicon, Inc. Sterilization of bioactive coatings
EP1441865A4 (en) 2001-09-18 2010-04-07 Eidgenoess Tech Hochschule METHOD AND DEVICE FOR COATING SURFACES FOR REDUCING PROTEIN ADSORPTION AND CELL ADHESION AND PRESENTING LIGANDS
SI1501566T1 (sl) 2002-05-09 2008-12-31 Hemoteq Ag S hemakompatibilnim slojem prekriti medicinski proizvodi, njihova izdelava in uporaba
ATE469135T1 (de) * 2002-05-30 2010-06-15 Scripps Research Inst Kupferkatalysierte ligierung von aziden und acetylenen
WO2004055160A2 (en) 2002-12-13 2004-07-01 The Trustees Of Columbia University In The City Of New York Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
PL1603603T3 (pl) * 2003-02-28 2015-07-31 Biointeractions Ltd System sieci polimerowych dla urządzeń medycznych oraz sposoby zastosowania
US9561309B2 (en) * 2004-05-27 2017-02-07 Advanced Cardiovascular Systems, Inc. Antifouling heparin coatings
CA2573561A1 (en) 2004-07-22 2006-02-02 The Scripps Research Institute Polymeric materials via click chemistry
US9290617B2 (en) 2005-07-06 2016-03-22 Molly S. Shoichet Method of biomolecule immobilization on polymers using click-type chemistry
US20070020620A1 (en) 2005-07-14 2007-01-25 Finn M G Compositions and methods for coupling a plurality of compounds to a scaffold
EP1934265A4 (en) 2005-09-15 2009-06-24 Univ Utah Res Found POLYMER COMPOSITIONS AND METHODS OF MAKING AND USING SAME
US7811555B2 (en) 2005-12-30 2010-10-12 Cordis Corporation Tri-branched biologically active copolymer
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
US8021677B2 (en) * 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US8986713B2 (en) 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
EP2052045A4 (en) * 2006-08-18 2012-09-12 Commw Scient Ind Res Org POLYMERIC COATINGS AND METHODS FOR FORMING SAME
ITMI20061726A1 (it) 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
WO2008090554A2 (en) 2007-01-22 2008-07-31 Elutex Ltd. Modified conductive surfaces prepared by electrografting of diazonium salts
US20090018646A1 (en) * 2007-07-10 2009-01-15 Zhao Jonathon Z Coating Employing an Anti-Thrombotic Conjugate
FR2920435A1 (fr) 2007-08-29 2009-03-06 Arkema France Compositions aqueuses acides de nettoyage, leur procede de preparation et leur utilisation
FR2920436A1 (fr) 2007-08-30 2009-03-06 Rhodia Operations Sas Composition de traitement de fils ou fibres d'articles textiles
GB0816783D0 (en) * 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities
GB201004101D0 (en) 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015147051A (ja) * 2008-09-15 2015-08-20 カルメダ アクティエボラーグ 固定化生物学的実体

Also Published As

Publication number Publication date
JP2015147051A (ja) 2015-08-20
GB0816783D0 (en) 2008-10-22
US8992963B2 (en) 2015-03-31
WO2010029189A2 (en) 2010-03-18
US10064978B2 (en) 2018-09-04
EP2340057B1 (en) 2015-07-22
US20150045508A1 (en) 2015-02-12
AU2009290833A1 (en) 2010-03-18
CA2732939C (en) 2017-08-22
WO2010029189A3 (en) 2011-03-03
JP2012502678A (ja) 2012-02-02
HK1159530A1 (en) 2012-08-03
EP2340057A2 (en) 2011-07-06
US20180326118A1 (en) 2018-11-15
AU2009290833B2 (en) 2015-05-07
ES2550147T3 (es) 2015-11-04
JP6122052B2 (ja) 2017-04-26
CA2732939A1 (en) 2010-03-18
US20100074938A1 (en) 2010-03-25

Similar Documents

Publication Publication Date Title
JP6122052B2 (ja) 固定化生物学的実体
JP6693983B2 (ja) 固定された生物学的実体
EP3375462B1 (en) Improvements to immobilised biological entities
HK1159530B (en) Immobilised biological entities
HK1174861A (en) Immobilised biological entities
HK1174861B (en) Immobilised biological entities

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120831

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121106

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131217

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140314

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140324

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20141111

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150311

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20150312

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150427

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150623

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150703

R150 Certificate of patent or registration of utility model

Ref document number: 5775454

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250