AU2009290833B2 - Immobilised biological entities - Google Patents

Immobilised biological entities Download PDF

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Publication number
AU2009290833B2
AU2009290833B2 AU2009290833A AU2009290833A AU2009290833B2 AU 2009290833 B2 AU2009290833 B2 AU 2009290833B2 AU 2009290833 A AU2009290833 A AU 2009290833A AU 2009290833 A AU2009290833 A AU 2009290833A AU 2009290833 B2 AU2009290833 B2 AU 2009290833B2
Authority
AU
Australia
Prior art keywords
heparin
functionalized
cationic polymer
layer
polyamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2009290833A
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English (en)
Other versions
AU2009290833A1 (en
Inventor
Martina Lahmann
Karin Leontein
Stefan Oscarson
Robert Vestberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carmeda AB
Original Assignee
Carmeda AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carmeda AB filed Critical Carmeda AB
Publication of AU2009290833A1 publication Critical patent/AU2009290833A1/en
Application granted granted Critical
Publication of AU2009290833B2 publication Critical patent/AU2009290833B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0035—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a polymer with positively charged atoms in the polymeric backbone, e.g. ionenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AU2009290833A 2008-09-15 2009-09-15 Immobilised biological entities Active AU2009290833B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0816783.5 2008-09-15
GBGB0816783.5A GB0816783D0 (en) 2008-09-15 2008-09-15 Immobilised biological entities
PCT/EP2009/061981 WO2010029189A2 (en) 2008-09-15 2009-09-15 Immobilised biological entities

Publications (2)

Publication Number Publication Date
AU2009290833A1 AU2009290833A1 (en) 2010-03-18
AU2009290833B2 true AU2009290833B2 (en) 2015-05-07

Family

ID=39930120

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009290833A Active AU2009290833B2 (en) 2008-09-15 2009-09-15 Immobilised biological entities

Country Status (8)

Country Link
US (3) US8992963B2 (enExample)
EP (1) EP2340057B1 (enExample)
JP (2) JP5775454B2 (enExample)
AU (1) AU2009290833B2 (enExample)
CA (1) CA2732939C (enExample)
ES (1) ES2550147T3 (enExample)
GB (1) GB0816783D0 (enExample)
WO (1) WO2010029189A2 (enExample)

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US9114194B2 (en) 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
US8021677B2 (en) 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US8986713B2 (en) 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
US8496953B2 (en) 2006-05-12 2013-07-30 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity following sterilization
GB0816783D0 (en) * 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities
US8591932B2 (en) 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
GB201004101D0 (en) 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
CA2828797C (en) * 2011-03-11 2020-03-10 Gore Enterprise Holdings, Inc. Single point attachment of heparin to hyperbranched polymers and coatings thereof
US20140272232A1 (en) * 2013-03-15 2014-09-18 Bard Access Systems, Inc. Antithrombic coatings and uses thereof
JP6185662B2 (ja) * 2013-09-30 2017-08-23 テレフレックス メディカル インコーポレイテッド 安定化酵素組成物
EP3078389B1 (en) * 2013-11-28 2020-04-01 Toray Industries, Inc. Antithrombotic material
US11839698B2 (en) 2014-03-13 2023-12-12 W. L. Gore & Associates, Inc. Drug composition and coating
WO2015188716A1 (zh) * 2014-06-09 2015-12-17 上海微创医疗器械（集团）有限公司 一种抗凝血涂层及其涂覆方法
WO2016190407A1 (ja) * 2015-05-27 2016-12-01 東レ株式会社 抗血栓性材料
US20190275213A1 (en) 2018-03-09 2019-09-12 Carmeda Ab Immobilising biological entities
CA3093027A1 (en) * 2018-03-09 2019-09-12 Carmeda Ab Improvements to processes for immobilising biological entities
WO2020070258A1 (en) 2018-10-03 2020-04-09 Carmeda Ab Immobilised biological entities
US20230213505A1 (en) * 2020-08-14 2023-07-06 Idris Oncology B.V. A process for applying a coating comprising one or more polysaccharides with binding affinity for bioanalytes onto the surface of a medical sampling device, and the medical sampling device for capture of bioanalytes provided with the coating
EP4032560A1 (en) * 2021-01-25 2022-07-27 Centre National pour la Recherche Scientifique Implantable material in contact with blood and uses thereof
US11685856B2 (en) * 2021-05-21 2023-06-27 Baker Hughes Oilfield Operations Llc Branched polyethyleneimine (B-PE) as oilfield metal naphthenate inhibitors

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US20050032081A1 (en) * 2002-12-13 2005-02-10 Jingyue Ju Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
US20050266038A1 (en) * 2004-05-27 2005-12-01 Thierry Glauser Antifouling heparin coatings
WO2008019450A1 (en) * 2006-08-18 2008-02-21 Commonwealth Scientific And Industrial Research Organisation Polymeric coatings and methods for forming them
US20080089919A1 (en) * 2006-05-12 2008-04-17 Cleek Robert L Immobilized Biologically Active Entities Having a High Degree of Biological Activity

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Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6461665B1 (en) * 1998-09-09 2002-10-08 Carmeda Ab Process for preparing surface modification substances
US20050032081A1 (en) * 2002-12-13 2005-02-10 Jingyue Ju Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
US20040170752A1 (en) * 2003-02-28 2004-09-02 Luthra Ajay K. Polymeric network system for medical devices and methods of use
US20050266038A1 (en) * 2004-05-27 2005-12-01 Thierry Glauser Antifouling heparin coatings
US20080089919A1 (en) * 2006-05-12 2008-04-17 Cleek Robert L Immobilized Biologically Active Entities Having a High Degree of Biological Activity
WO2008019450A1 (en) * 2006-08-18 2008-02-21 Commonwealth Scientific And Industrial Research Organisation Polymeric coatings and methods for forming them

Also Published As

Publication number Publication date
JP2012502678A (ja) 2012-02-02
US10064978B2 (en) 2018-09-04
EP2340057B1 (en) 2015-07-22
JP6122052B2 (ja) 2017-04-26
HK1159530A1 (en) 2012-08-03
AU2009290833A1 (en) 2010-03-18
WO2010029189A3 (en) 2011-03-03
EP2340057A2 (en) 2011-07-06
US8992963B2 (en) 2015-03-31
US20180326118A1 (en) 2018-11-15
US20100074938A1 (en) 2010-03-25
CA2732939A1 (en) 2010-03-18
WO2010029189A2 (en) 2010-03-18
JP5775454B2 (ja) 2015-09-09
CA2732939C (en) 2017-08-22
JP2015147051A (ja) 2015-08-20
GB0816783D0 (en) 2008-10-22
ES2550147T3 (es) 2015-11-04
US20150045508A1 (en) 2015-02-12

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