JP5763758B2 - Ｋｖ７カリウムチャネル開口薬としてのピペリジニルピリミジンアミド - Google Patents
Ｋｖ７カリウムチャネル開口薬としてのピペリジニルピリミジンアミド Download PDFInfo
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- JP5763758B2 JP5763758B2 JP2013517611A JP2013517611A JP5763758B2 JP 5763758 B2 JP5763758 B2 JP 5763758B2 JP 2013517611 A JP2013517611 A JP 2013517611A JP 2013517611 A JP2013517611 A JP 2013517611A JP 5763758 B2 JP5763758 B2 JP 5763758B2
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36250510P | 2010-07-08 | 2010-07-08 | |
| US61/362,505 | 2010-07-08 | ||
| PCT/IB2011/052686 WO2012004698A1 (en) | 2010-07-08 | 2011-06-20 | Piperidinyl pyrimidine amides as kv7 potassium channel openers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013531006A JP2013531006A (ja) | 2013-08-01 |
| JP2013531006A5 JP2013531006A5 (enExample) | 2014-06-05 |
| JP5763758B2 true JP5763758B2 (ja) | 2015-08-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2013517611A Expired - Fee Related JP5763758B2 (ja) | 2010-07-08 | 2011-06-20 | Ｋｖ７カリウムチャネル開口薬としてのピペリジニルピリミジンアミド |
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| Country | Link |
|---|---|
| US (1) | US8883812B2 (enExample) |
| EP (1) | EP2590961A1 (enExample) |
| JP (1) | JP5763758B2 (enExample) |
| KR (1) | KR101449348B1 (enExample) |
| CN (1) | CN102971307A (enExample) |
| AU (1) | AU2011275393B2 (enExample) |
| CA (1) | CA2804165C (enExample) |
| MX (1) | MX2013000138A (enExample) |
| SG (1) | SG186409A1 (enExample) |
| WO (1) | WO2012004698A1 (enExample) |
| ZA (1) | ZA201300499B (enExample) |
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| WO2013067591A1 (en) * | 2011-11-10 | 2013-05-16 | Relevare Australia Pty Ltd | Topical formulations for pain management |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2014145852A2 (en) | 2013-03-15 | 2014-09-18 | Knopp Biosciences Llc | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
| ES2749103T3 (es) * | 2014-09-12 | 2020-03-19 | Knopp Biosciences Llc | Benzoimidazol-1,2-ilamidas como activadores del canal Kv7 |
| ES3032221T3 (en) * | 2018-02-20 | 2025-07-16 | H Lundbeck As | Alcohol derivatives as kv7 potassium channel openers |
| CN119118926A (zh) | 2018-03-19 | 2024-12-13 | 诺普生物科学有限责任公司 | Kv7通道激活剂组合物和使用方法 |
| AR119521A1 (es) * | 2019-08-02 | 2021-12-22 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
| IL328371A (en) * | 2019-09-17 | 2026-07-01 | Knopp Biosciences Llc | Usage methods for KV7 channel operators |
| WO2021119018A1 (en) * | 2019-12-09 | 2021-06-17 | The Board Of Trustees Of The Leland Stanford Junior University | A method to improve sleep quality in the elderly by controlling excitability of hypocretin neurons |
| WO2021211867A1 (en) * | 2020-04-16 | 2021-10-21 | Attune Neurosciences, Inc. | Kv7 modulators for treating sleep or anxiety disorders |
| KR20230079055A (ko) * | 2020-08-28 | 2023-06-05 | 화이자 인코포레이티드 | 호흡기 병태 모니터링 및 케어를 위한 컴퓨터화된 의사결정 지원 툴 및 의료 디바이스 |
| GB202306914D0 (en) * | 2023-05-10 | 2023-06-21 | Sania Rx Ltd | Method |
| GB2703561A (en) * | 2024-11-08 | 2026-08-05 | Sania Tx Ltd | Method |
| WO2026099781A1 (en) * | 2024-11-08 | 2026-05-15 | Sania Tx Ltd | Method |
| CN119661413B (zh) * | 2024-12-28 | 2025-06-24 | 齐鲁医药学院 | Kv7钾离子通道开放剂及其制备方法和应用 |
| WO2026159425A1 (en) * | 2025-01-22 | 2026-07-30 | Climb Bio, Inc. | Azetidin derivatives as potassium chanel inhibitors |
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| CZ20032233A3 (cs) * | 2001-02-20 | 2004-12-15 | Bristol-Myers Squibb Company | Derivát 2,4-disubstituovaného pyrimidin-5-karboxamidu jako modulátor draslíkového kanálku KCNQ |
| TWI349666B (en) | 2004-03-12 | 2011-10-01 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivatives |
| US7091202B2 (en) * | 2004-09-15 | 2006-08-15 | Bristol-Myers Squibb Company | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators |
| US20080261918A1 (en) * | 2004-12-17 | 2008-10-23 | Graham Andrew Showell | Silicon Compounds and Their Use |
| US7322249B2 (en) | 2005-07-07 | 2008-01-29 | Delphi Technologies, Inc. | Mounting for a probe sensor |
| EP1937653A1 (en) * | 2005-09-09 | 2008-07-02 | H.Lundbeck A/S | Pyrimidine derivatives and their use as kcnq potassium channels openers |
| US7683058B2 (en) * | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
| US20090118285A1 (en) | 2006-02-07 | 2009-05-07 | H. Lundbeck A/S | Use of kcnq-openers for treating or reducing the symptoms of schizophrenia |
| NZ575652A (en) | 2006-08-23 | 2011-08-26 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| CN101790374A (zh) | 2007-08-01 | 2010-07-28 | H.隆德贝克有限公司 | Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途 |
-
2011
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- 2011-06-20 KR KR1020137000377A patent/KR101449348B1/ko not_active Expired - Fee Related
- 2011-06-20 JP JP2013517611A patent/JP5763758B2/ja not_active Expired - Fee Related
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- 2011-06-20 SG SG2012093761A patent/SG186409A1/en unknown
- 2011-06-20 EP EP11738482.6A patent/EP2590961A1/en not_active Withdrawn
- 2011-06-20 WO PCT/IB2011/052686 patent/WO2012004698A1/en not_active Ceased
- 2011-06-20 AU AU2011275393A patent/AU2011275393B2/en not_active Ceased
- 2011-06-20 MX MX2013000138A patent/MX2013000138A/es active IP Right Grant
- 2011-06-20 CA CA2804165A patent/CA2804165C/en not_active Expired - Fee Related
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| CN102971307A (zh) | 2013-03-13 |
| WO2012004698A1 (en) | 2012-01-12 |
| ZA201300499B (en) | 2013-09-25 |
| EP2590961A1 (en) | 2013-05-15 |
| AU2011275393B2 (en) | 2014-04-10 |
| JP2013531006A (ja) | 2013-08-01 |
| SG186409A1 (en) | 2013-02-28 |
| KR101449348B1 (ko) | 2014-10-08 |
| MX2013000138A (es) | 2013-03-05 |
| US20130150391A1 (en) | 2013-06-13 |
| CA2804165C (en) | 2015-02-24 |
| KR20130031323A (ko) | 2013-03-28 |
| AU2011275393A1 (en) | 2013-01-10 |
| CA2804165A1 (en) | 2012-01-12 |
| US8883812B2 (en) | 2014-11-11 |
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