ZA201300499B - Piperidinyl pyrimidine amides as kv7 potassium channel openers - Google Patents
Piperidinyl pyrimidine amides as kv7 potassium channel openersInfo
- Publication number
- ZA201300499B ZA201300499B ZA2013/00499A ZA201300499A ZA201300499B ZA 201300499 B ZA201300499 B ZA 201300499B ZA 2013/00499 A ZA2013/00499 A ZA 2013/00499A ZA 201300499 A ZA201300499 A ZA 201300499A ZA 201300499 B ZA201300499 B ZA 201300499B
- Authority
- ZA
- South Africa
- Prior art keywords
- potassium channel
- channel openers
- piperidinyl pyrimidine
- pyrimidine amides
- amides
- Prior art date
Links
- -1 Piperidinyl pyrimidine amides Chemical class 0.000 title 1
- 229940127315 Potassium Channel Openers Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36250510P | 2010-07-08 | 2010-07-08 | |
| PCT/IB2011/052686 WO2012004698A1 (en) | 2010-07-08 | 2011-06-20 | Piperidinyl pyrimidine amides as kv7 potassium channel openers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201300499B true ZA201300499B (en) | 2013-09-25 |
Family
ID=44487037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2013/00499A ZA201300499B (en) | 2010-07-08 | 2013-01-18 | Piperidinyl pyrimidine amides as kv7 potassium channel openers |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8883812B2 (enExample) |
| EP (1) | EP2590961A1 (enExample) |
| JP (1) | JP5763758B2 (enExample) |
| KR (1) | KR101449348B1 (enExample) |
| CN (1) | CN102971307A (enExample) |
| AU (1) | AU2011275393B2 (enExample) |
| CA (1) | CA2804165C (enExample) |
| MX (1) | MX2013000138A (enExample) |
| SG (1) | SG186409A1 (enExample) |
| WO (1) | WO2012004698A1 (enExample) |
| ZA (1) | ZA201300499B (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013067591A1 (en) * | 2011-11-10 | 2013-05-16 | Relevare Australia Pty Ltd | Topical formulations for pain management |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2014145852A2 (en) | 2013-03-15 | 2014-09-18 | Knopp Biosciences Llc | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
| ES2749103T3 (es) * | 2014-09-12 | 2020-03-19 | Knopp Biosciences Llc | Benzoimidazol-1,2-ilamidas como activadores del canal Kv7 |
| ES3032221T3 (en) * | 2018-02-20 | 2025-07-16 | H Lundbeck As | Alcohol derivatives as kv7 potassium channel openers |
| CN119118926A (zh) | 2018-03-19 | 2024-12-13 | 诺普生物科学有限责任公司 | Kv7通道激活剂组合物和使用方法 |
| AR119521A1 (es) * | 2019-08-02 | 2021-12-22 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
| IL328371A (en) * | 2019-09-17 | 2026-07-01 | Knopp Biosciences Llc | Usage methods for KV7 channel operators |
| WO2021119018A1 (en) * | 2019-12-09 | 2021-06-17 | The Board Of Trustees Of The Leland Stanford Junior University | A method to improve sleep quality in the elderly by controlling excitability of hypocretin neurons |
| WO2021211867A1 (en) * | 2020-04-16 | 2021-10-21 | Attune Neurosciences, Inc. | Kv7 modulators for treating sleep or anxiety disorders |
| KR20230079055A (ko) * | 2020-08-28 | 2023-06-05 | 화이자 인코포레이티드 | 호흡기 병태 모니터링 및 케어를 위한 컴퓨터화된 의사결정 지원 툴 및 의료 디바이스 |
| GB202306914D0 (en) * | 2023-05-10 | 2023-06-21 | Sania Rx Ltd | Method |
| GB2703561A (en) * | 2024-11-08 | 2026-08-05 | Sania Tx Ltd | Method |
| WO2026099781A1 (en) * | 2024-11-08 | 2026-05-15 | Sania Tx Ltd | Method |
| CN119661413B (zh) * | 2024-12-28 | 2025-06-24 | 齐鲁医药学院 | Kv7钾离子通道开放剂及其制备方法和应用 |
| WO2026159425A1 (en) * | 2025-01-22 | 2026-07-30 | Climb Bio, Inc. | Azetidin derivatives as potassium chanel inhibitors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20032233A3 (cs) * | 2001-02-20 | 2004-12-15 | Bristol-Myers Squibb Company | Derivát 2,4-disubstituovaného pyrimidin-5-karboxamidu jako modulátor draslíkového kanálku KCNQ |
| TWI349666B (en) | 2004-03-12 | 2011-10-01 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivatives |
| US7091202B2 (en) * | 2004-09-15 | 2006-08-15 | Bristol-Myers Squibb Company | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators |
| US20080261918A1 (en) * | 2004-12-17 | 2008-10-23 | Graham Andrew Showell | Silicon Compounds and Their Use |
| US7322249B2 (en) | 2005-07-07 | 2008-01-29 | Delphi Technologies, Inc. | Mounting for a probe sensor |
| EP1937653A1 (en) * | 2005-09-09 | 2008-07-02 | H.Lundbeck A/S | Pyrimidine derivatives and their use as kcnq potassium channels openers |
| US7683058B2 (en) * | 2005-09-09 | 2010-03-23 | H. Lundbeck A/S | Substituted pyrimidine derivatives |
| US20090118285A1 (en) | 2006-02-07 | 2009-05-07 | H. Lundbeck A/S | Use of kcnq-openers for treating or reducing the symptoms of schizophrenia |
| NZ575652A (en) | 2006-08-23 | 2011-08-26 | Valeant Pharmaceuticals Int | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
| US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| CN101790374A (zh) | 2007-08-01 | 2010-07-28 | H.隆德贝克有限公司 | Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途 |
-
2011
- 2011-06-20 US US13/808,355 patent/US8883812B2/en not_active Expired - Fee Related
- 2011-06-20 KR KR1020137000377A patent/KR101449348B1/ko not_active Expired - Fee Related
- 2011-06-20 JP JP2013517611A patent/JP5763758B2/ja not_active Expired - Fee Related
- 2011-06-20 CN CN2011800337518A patent/CN102971307A/zh active Pending
- 2011-06-20 SG SG2012093761A patent/SG186409A1/en unknown
- 2011-06-20 EP EP11738482.6A patent/EP2590961A1/en not_active Withdrawn
- 2011-06-20 WO PCT/IB2011/052686 patent/WO2012004698A1/en not_active Ceased
- 2011-06-20 AU AU2011275393A patent/AU2011275393B2/en not_active Ceased
- 2011-06-20 MX MX2013000138A patent/MX2013000138A/es active IP Right Grant
- 2011-06-20 CA CA2804165A patent/CA2804165C/en not_active Expired - Fee Related
-
2013
- 2013-01-18 ZA ZA2013/00499A patent/ZA201300499B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102971307A (zh) | 2013-03-13 |
| WO2012004698A1 (en) | 2012-01-12 |
| EP2590961A1 (en) | 2013-05-15 |
| AU2011275393B2 (en) | 2014-04-10 |
| JP2013531006A (ja) | 2013-08-01 |
| SG186409A1 (en) | 2013-02-28 |
| KR101449348B1 (ko) | 2014-10-08 |
| MX2013000138A (es) | 2013-03-05 |
| US20130150391A1 (en) | 2013-06-13 |
| CA2804165C (en) | 2015-02-24 |
| JP5763758B2 (ja) | 2015-08-12 |
| KR20130031323A (ko) | 2013-03-28 |
| AU2011275393A1 (en) | 2013-01-10 |
| CA2804165A1 (en) | 2012-01-12 |
| US8883812B2 (en) | 2014-11-11 |
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