JP5757864B2 - 水溶性アセトアミノフェン類似体 - Google Patents
水溶性アセトアミノフェン類似体 Download PDFInfo
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- JP5757864B2 JP5757864B2 JP2011510691A JP2011510691A JP5757864B2 JP 5757864 B2 JP5757864 B2 JP 5757864B2 JP 2011510691 A JP2011510691 A JP 2011510691A JP 2011510691 A JP2011510691 A JP 2011510691A JP 5757864 B2 JP5757864 B2 JP 5757864B2
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- JP
- Japan
- Prior art keywords
- acetaminophen
- compound
- pharmaceutically acceptable
- composition
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000002360 preparation method Methods 0.000 claims description 14
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 12
- 239000003937 drug carrier Substances 0.000 claims description 11
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 10
- 239000012535 impurity Substances 0.000 claims description 9
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- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims description 8
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- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 5
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- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims description 4
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- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 4
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- OJLOPKGSLYJEMD-URPKTTJQSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(1e)-4-hydroxy-4-methyloct-1-en-1-yl]-5-oxocyclopentyl]heptanoate Chemical compound CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC OJLOPKGSLYJEMD-URPKTTJQSA-N 0.000 claims description 4
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Landscapes
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| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| ES2779225T3 (es) * | 2011-04-08 | 2020-08-14 | Sphaera Pharma Pte Ltd | Reactivos de merilformilo sustituido y procedimiento de uso de los mismos para modificar propiedades fisicoquímicas y/o farmacocinéticas de compuestos |
| CA2849731C (en) | 2011-09-22 | 2020-01-14 | Acorda Therapeutics, Inc. | Acetaminophen conjugates, compositions and methods of use thereof |
| CA2919892C (en) | 2013-08-12 | 2019-06-18 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
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| CN117164657A (zh) | 2014-08-12 | 2023-12-05 | 莫纳什大学 | 定向淋巴的前药 |
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| AU2015335941B2 (en) | 2014-10-21 | 2021-04-01 | Abbvie Inc. | Carbidopa and L-dopa prodrugs and their use to treat Parkinson's disease |
| CA3013751C (en) | 2015-03-03 | 2023-08-08 | Kindred Biosciences, Inc. | Compositions and methods for treatment and prevention of pyrexia in horses |
| CA2997106C (en) | 2015-09-08 | 2024-06-04 | Monash University | Lymph directing prodrugs |
| EP4295909A3 (en) * | 2016-04-20 | 2024-07-17 | AbbVie Inc. | Carbidopa and l-dopa prodrugs and methods of use |
| EP3675838A4 (en) | 2017-08-29 | 2021-04-21 | PureTech LYT, Inc. | LIPID PRODRUGS DIRECTED TO THE LYMPHATIC SYSTEM |
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| US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
| US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
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| US11389409B2 (en) | 2019-08-30 | 2022-07-19 | Remedy Diagnostics LLC | Transdermal device comprising acetaminophen prodrug |
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| CA2946445C (en) * | 2008-05-20 | 2019-01-08 | Acorda Therapeutics, Inc. | Hepatoprotectant acetaminophen mutual prodrugs |
| RU2010151953A (ru) | 2008-05-20 | 2012-06-27 | Ньюроджесэкс, Инк. (Us) | Карбонатные продукты и способы их применения |
| US8569466B2 (en) | 2008-09-10 | 2013-10-29 | Nnochiri Ekwuribe | Aromatic carboxylic acid derivatives for treatment and prophylaxis of gastrointestinal diseases including colon cancers |
| AU2010224866C1 (en) | 2009-03-16 | 2015-01-15 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
| CA2849731C (en) | 2011-09-22 | 2020-01-14 | Acorda Therapeutics, Inc. | Acetaminophen conjugates, compositions and methods of use thereof |
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- 2009-05-20 MX MX2010012648A patent/MX2010012648A/es active IP Right Grant
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- 2009-05-20 CA CA2724877A patent/CA2724877C/en not_active Expired - Fee Related
- 2009-05-20 CN CN2009801282182A patent/CN102149672A/zh active Pending
- 2009-05-20 RU RU2010151952/04A patent/RU2010151952A/ru not_active Application Discontinuation
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|---|---|
| CN105254662A (zh) | 2016-01-20 |
| US11021498B2 (en) | 2021-06-01 |
| US20110212926A1 (en) | 2011-09-01 |
| JP2017057217A (ja) | 2017-03-23 |
| CN102149672A (zh) | 2011-08-10 |
| AU2009249067A1 (en) | 2009-11-26 |
| US10442826B2 (en) | 2019-10-15 |
| JP2020114876A (ja) | 2020-07-30 |
| US20160264605A1 (en) | 2016-09-15 |
| BRPI0912326A2 (pt) | 2015-10-06 |
| US20200002364A1 (en) | 2020-01-02 |
| KR20110018897A (ko) | 2011-02-24 |
| JP6063072B2 (ja) | 2017-01-18 |
| MX2010012648A (es) | 2010-12-14 |
| JP2016084359A (ja) | 2016-05-19 |
| KR101698028B1 (ko) | 2017-01-26 |
| US9981998B2 (en) | 2018-05-29 |
| US20190092795A1 (en) | 2019-03-28 |
| CA2724877C (en) | 2016-09-13 |
| IL209382A0 (en) | 2011-01-31 |
| EP2291348A1 (en) | 2011-03-09 |
| CA2724877A1 (en) | 2009-11-26 |
| RU2010151952A (ru) | 2012-06-27 |
| WO2009143295A1 (en) | 2009-11-26 |
| JP2018135392A (ja) | 2018-08-30 |
| EP2291348A4 (en) | 2013-05-15 |
| JP2014111658A (ja) | 2014-06-19 |
| JP2011520977A (ja) | 2011-07-21 |
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