MX2010012648A - Analogos de acetaminofeno solubles en agua. - Google Patents
Analogos de acetaminofeno solubles en agua.Info
- Publication number
- MX2010012648A MX2010012648A MX2010012648A MX2010012648A MX2010012648A MX 2010012648 A MX2010012648 A MX 2010012648A MX 2010012648 A MX2010012648 A MX 2010012648A MX 2010012648 A MX2010012648 A MX 2010012648A MX 2010012648 A MX2010012648 A MX 2010012648A
- Authority
- MX
- Mexico
- Prior art keywords
- acetaminophen
- compound
- pain
- prodrug
- dosage
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical class CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title claims abstract description 493
- 229960005489 paracetamol Drugs 0.000 claims abstract description 246
- 239000000203 mixture Substances 0.000 claims abstract description 91
- 238000000034 method Methods 0.000 claims abstract description 82
- 238000009472 formulation Methods 0.000 claims abstract description 79
- 201000010099 disease Diseases 0.000 claims abstract description 60
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- 208000002193 Pain Diseases 0.000 claims abstract description 59
- 230000036407 pain Effects 0.000 claims abstract description 55
- 206010037660 Pyrexia Diseases 0.000 claims abstract description 40
- 150000001875 compounds Chemical class 0.000 claims description 95
- -1 methylhexital Chemical compound 0.000 claims description 46
- 238000011282 treatment Methods 0.000 claims description 38
- 150000003839 salts Chemical class 0.000 claims description 32
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- 208000014674 injury Diseases 0.000 claims description 27
- 230000006378 damage Effects 0.000 claims description 26
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- 239000012453 solvate Substances 0.000 claims description 19
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- 208000037906 ischaemic injury Diseases 0.000 claims description 12
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 10
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 7
- 229960004193 dextropropoxyphene Drugs 0.000 claims description 6
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims description 6
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 6
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- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 4
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims description 4
- 229960003529 diazepam Drugs 0.000 claims description 4
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- DDLIGBOFAVUZHB-UHFFFAOYSA-N midazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NC=C2CN=C1C1=CC=CC=C1F DDLIGBOFAVUZHB-UHFFFAOYSA-N 0.000 claims description 4
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- ATOTUUBRFJHZQG-UHFFFAOYSA-N 2-amino-2-methylpropan-1-ol;8-bromo-1,3-dimethyl-7h-purine-2,6-dione Chemical compound CC(C)(N)CO.O=C1N(C)C(=O)N(C)C2=C1NC(Br)=N2 ATOTUUBRFJHZQG-UHFFFAOYSA-N 0.000 claims description 3
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- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 claims description 3
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims description 3
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- 229960002390 flurbiprofen Drugs 0.000 claims description 3
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims description 3
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims description 3
- 229960000240 hydrocodone Drugs 0.000 claims description 3
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims description 3
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- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 3
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- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/094—Esters of phosphoric acids with arylalkanols
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A61K9/0012—Galenical forms characterised by the site of application
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
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- Hospice & Palliative Care (AREA)
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- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
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| US5477408P | 2008-05-20 | 2008-05-20 | |
| PCT/US2009/044743 WO2009143295A1 (en) | 2008-05-20 | 2009-05-20 | Water-soluble acetaminophen analogs |
Publications (1)
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| MX2010012648A true MX2010012648A (es) | 2010-12-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010012648A MX2010012648A (es) | 2008-05-20 | 2009-05-20 | Analogos de acetaminofeno solubles en agua. |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US20110212926A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2291348A4 (cg-RX-API-DMAC7.html) |
| JP (6) | JP5757864B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101698028B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN105254662A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009249067A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0912326A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2724877C (cg-RX-API-DMAC7.html) |
| IL (1) | IL209382A0 (cg-RX-API-DMAC7.html) |
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| RU (1) | RU2010151952A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009143295A1 (cg-RX-API-DMAC7.html) |
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| RU2010151953A (ru) | 2008-05-20 | 2012-06-27 | Ньюроджесэкс, Инк. (Us) | Карбонатные продукты и способы их применения |
| CA2946445C (en) | 2008-05-20 | 2019-01-08 | Acorda Therapeutics, Inc. | Hepatoprotectant acetaminophen mutual prodrugs |
| AU2009249067A1 (en) | 2008-05-20 | 2009-11-26 | Neurogesx, Inc. | Water-soluble acetaminophen analogs |
| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| ES2779225T3 (es) * | 2011-04-08 | 2020-08-14 | Sphaera Pharma Pte Ltd | Reactivos de merilformilo sustituido y procedimiento de uso de los mismos para modificar propiedades fisicoquímicas y/o farmacocinéticas de compuestos |
| CA2849731C (en) | 2011-09-22 | 2020-01-14 | Acorda Therapeutics, Inc. | Acetaminophen conjugates, compositions and methods of use thereof |
| CA2919892C (en) | 2013-08-12 | 2019-06-18 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| EP3169315B1 (en) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| CN117164657A (zh) | 2014-08-12 | 2023-12-05 | 莫纳什大学 | 定向淋巴的前药 |
| AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| AU2015335941B2 (en) | 2014-10-21 | 2021-04-01 | Abbvie Inc. | Carbidopa and L-dopa prodrugs and their use to treat Parkinson's disease |
| CA3013751C (en) | 2015-03-03 | 2023-08-08 | Kindred Biosciences, Inc. | Compositions and methods for treatment and prevention of pyrexia in horses |
| CA2997106C (en) | 2015-09-08 | 2024-06-04 | Monash University | Lymph directing prodrugs |
| EP4295909A3 (en) * | 2016-04-20 | 2024-07-17 | AbbVie Inc. | Carbidopa and l-dopa prodrugs and methods of use |
| EP3675838A4 (en) | 2017-08-29 | 2021-04-21 | PureTech LYT, Inc. | LIPID PRODRUGS DIRECTED TO THE LYMPHATIC SYSTEM |
| US11883497B2 (en) | 2017-08-29 | 2024-01-30 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
| US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
| US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
| WO2019126378A1 (en) | 2017-12-19 | 2019-06-27 | Ariya Therapeutics, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
| MX2021005776A (es) | 2018-11-15 | 2021-07-02 | Abbvie Inc | Formulaciones farmaceuticas para administracion subcutanea. |
| US11389409B2 (en) | 2019-08-30 | 2022-07-19 | Remedy Diagnostics LLC | Transdermal device comprising acetaminophen prodrug |
| US20210268115A1 (en) | 2020-02-05 | 2021-09-02 | Puretech Lyt, Inc. | Lipid prodrugs of neurosteroids |
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| FR2444043A1 (fr) * | 1978-12-15 | 1980-07-11 | Bottu | Nouveau derive du paracetamol, son procede de preparation et son utilisation en therapeutique |
| DK406686D0 (da) * | 1986-08-26 | 1986-08-26 | Hans Bundgaard | Carboxylsyrederivater |
| US5001115A (en) * | 1989-05-17 | 1991-03-19 | University Of Florida | Prodrugs of biologically active hydroxyaromatic compounds |
| WO1991009831A1 (en) * | 1989-12-26 | 1991-07-11 | Nova Pharmaceutical Corporation | Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use |
| US5627165A (en) * | 1990-06-13 | 1997-05-06 | Drug Innovation & Design, Inc. | Phosphorous prodrugs and therapeutic delivery systems using same |
| US5272171A (en) * | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US6750216B2 (en) * | 1996-03-08 | 2004-06-15 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| IT1282736B1 (it) * | 1996-05-21 | 1998-03-31 | Angelini Ricerche Spa | Uso di derivati del p-amminofenolo per preparare composizioni farmaceutiche utili nel trattamento di malattie neurodegenerative |
| AU731225C (en) * | 1997-05-15 | 2001-10-18 | Drug Innovation & Design, Inc. | Acyclovir diester derivatives |
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| JP2002501926A (ja) * | 1998-01-29 | 2002-01-22 | ブリストル−マイヤーズ スクイブ カンパニー | ジアリール１、３、４−オキサジアゾロンのホスフェート誘導体 |
| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
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| CA2946445C (en) * | 2008-05-20 | 2019-01-08 | Acorda Therapeutics, Inc. | Hepatoprotectant acetaminophen mutual prodrugs |
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| CA2849731C (en) | 2011-09-22 | 2020-01-14 | Acorda Therapeutics, Inc. | Acetaminophen conjugates, compositions and methods of use thereof |
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- 2009-05-20 MX MX2010012648A patent/MX2010012648A/es active IP Right Grant
- 2009-05-20 CN CN201510381430.7A patent/CN105254662A/zh active Pending
- 2009-05-20 WO PCT/US2009/044743 patent/WO2009143295A1/en not_active Ceased
- 2009-05-20 BR BRPI0912326A patent/BRPI0912326A2/pt not_active IP Right Cessation
- 2009-05-20 US US12/993,088 patent/US20110212926A1/en not_active Abandoned
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- 2009-05-20 CN CN2009801282182A patent/CN102149672A/zh active Pending
- 2009-05-20 RU RU2010151952/04A patent/RU2010151952A/ru not_active Application Discontinuation
- 2009-05-20 KR KR1020107027998A patent/KR101698028B1/ko not_active Expired - Fee Related
- 2009-05-20 EP EP09751523.3A patent/EP2291348A4/en not_active Withdrawn
- 2009-05-20 JP JP2011510691A patent/JP5757864B2/ja not_active Expired - Fee Related
-
2010
- 2010-11-17 IL IL209382A patent/IL209382A0/en unknown
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2014
- 2014-03-13 JP JP2014049672A patent/JP2014111658A/ja not_active Withdrawn
-
2016
- 2016-02-01 JP JP2016016971A patent/JP6063072B2/ja not_active Expired - Fee Related
- 2016-03-22 US US15/077,802 patent/US9981998B2/en not_active Expired - Fee Related
- 2016-12-15 JP JP2016242968A patent/JP2017057217A/ja not_active Withdrawn
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2018
- 2018-04-25 US US15/962,934 patent/US10442826B2/en not_active Expired - Fee Related
- 2018-05-23 JP JP2018098716A patent/JP2018135392A/ja not_active Withdrawn
-
2019
- 2019-09-09 US US16/565,173 patent/US11021498B2/en not_active Expired - Fee Related
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2020
- 2020-04-20 JP JP2020074690A patent/JP2020114876A/ja not_active Withdrawn
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|---|---|
| CN105254662A (zh) | 2016-01-20 |
| US11021498B2 (en) | 2021-06-01 |
| US20110212926A1 (en) | 2011-09-01 |
| JP2017057217A (ja) | 2017-03-23 |
| CN102149672A (zh) | 2011-08-10 |
| JP5757864B2 (ja) | 2015-08-05 |
| AU2009249067A1 (en) | 2009-11-26 |
| US10442826B2 (en) | 2019-10-15 |
| JP2020114876A (ja) | 2020-07-30 |
| US20160264605A1 (en) | 2016-09-15 |
| BRPI0912326A2 (pt) | 2015-10-06 |
| US20200002364A1 (en) | 2020-01-02 |
| KR20110018897A (ko) | 2011-02-24 |
| JP6063072B2 (ja) | 2017-01-18 |
| JP2016084359A (ja) | 2016-05-19 |
| KR101698028B1 (ko) | 2017-01-26 |
| US9981998B2 (en) | 2018-05-29 |
| US20190092795A1 (en) | 2019-03-28 |
| CA2724877C (en) | 2016-09-13 |
| IL209382A0 (en) | 2011-01-31 |
| EP2291348A1 (en) | 2011-03-09 |
| CA2724877A1 (en) | 2009-11-26 |
| RU2010151952A (ru) | 2012-06-27 |
| WO2009143295A1 (en) | 2009-11-26 |
| JP2018135392A (ja) | 2018-08-30 |
| EP2291348A4 (en) | 2013-05-15 |
| JP2014111658A (ja) | 2014-06-19 |
| JP2011520977A (ja) | 2011-07-21 |
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