JP5740772B2 - 二重特異性免疫サイトカインドック−アンド−ロック（ｄｎｌ）複合体及びその治療的使用 - Google Patents

二重特異性免疫サイトカインドック−アンド−ロック（ｄｎｌ）複合体及びその治療的使用 Download PDF

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JP5740772B2
JP5740772B2 JP2012527002A JP2012527002A JP5740772B2 JP 5740772 B2 JP5740772 B2 JP 5740772B2 JP 2012527002 A JP2012527002 A JP 2012527002A JP 2012527002 A JP2012527002 A JP 2012527002A JP 5740772 B2 JP5740772 B2 JP 5740772B2
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antigen
mab
antibody
dnl
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JP2013503184A (ja
JP2013503184A5 (OSRAM
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チャン，チエン−シン
ゴールデンバーグ，デービッド，エム．
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アイビーシー ファーマスーティカルズ，インコーポレイテッド
アイビーシー ファーマスーティカルズ，インコーポレイテッド
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Priority claimed from US12/752,649 external-priority patent/US8034352B2/en
Priority claimed from US12/754,140 external-priority patent/US8722047B2/en
Priority claimed from US12/754,740 external-priority patent/US8562988B2/en
Application filed by アイビーシー ファーマスーティカルズ，インコーポレイテッド, アイビーシー ファーマスーティカルズ，インコーポレイテッド filed Critical アイビーシー ファーマスーティカルズ，インコーポレイテッド
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • A61P35/00—Antineoplastic agents
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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JP2012527002A 2009-08-31 2010-08-27 二重特異性免疫サイトカインドック−アンド−ロック（ｄｎｌ）複合体及びその治療的使用 Active JP5740772B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US23842409P 2009-08-31 2009-08-31
US61/238,424 2009-08-31
US12/644,146 2009-12-22
US12/644,146 US7981398B2 (en) 2005-04-06 2009-12-22 PEGylation by the dock and lock (DNL) technique
US12/731,781 2010-03-25
US12/731,781 US8003111B2 (en) 2005-04-06 2010-03-25 Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivo
US12/752,649 2010-04-01
US12/752,649 US8034352B2 (en) 2005-04-06 2010-04-01 Tetrameric cytokines with improved biological activity
US12/754,140 US8722047B2 (en) 2005-03-03 2010-04-05 Humanized anti-HLA-DR antibodies
US12/754,140 2010-04-05
US12/754,740 2010-04-06
US12/754,740 US8562988B2 (en) 2005-10-19 2010-04-06 Strategies for improved cancer vaccines
PCT/US2010/046889 WO2011025904A1 (en) 2009-08-31 2010-08-27 Bispecific immunocytokine dock-and-lock (dnl) complexes and therapeutic use thereof

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JP2015080993A Division JP5999217B2 (ja) 2009-08-31 2015-04-10 二重特異性免疫サイトカインドック−アンド−ロック（ｄｎｌ）複合体及びその治療的使用

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JP2013503184A JP2013503184A (ja) 2013-01-31
JP2013503184A5 JP2013503184A5 (OSRAM) 2013-09-19
JP5740772B2 true JP5740772B2 (ja) 2015-07-01

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JP2015080993A Active JP5999217B2 (ja) 2009-08-31 2015-04-10 二重特異性免疫サイトカインドック−アンド−ロック（ｄｎｌ）複合体及びその治療的使用

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EP (1) EP2473186A4 (OSRAM)
JP (2) JP5740772B2 (OSRAM)
CN (1) CN102481348A (OSRAM)
AU (1) AU2010286642B2 (OSRAM)
CA (1) CA2772572A1 (OSRAM)
IN (1) IN2012DN01331A (OSRAM)
WO (1) WO2011025904A1 (OSRAM)

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JP2013503184A (ja) 2013-01-31
CA2772572A1 (en) 2011-03-03
EP2473186A4 (en) 2013-07-10
CN102481348A (zh) 2012-05-30
JP5999217B2 (ja) 2016-09-28
AU2010286642B2 (en) 2016-03-10
AU2010286642A1 (en) 2012-02-16
JP2015157832A (ja) 2015-09-03
EP2473186A1 (en) 2012-07-11
WO2011025904A1 (en) 2011-03-03
IN2012DN01331A (OSRAM) 2015-06-05

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