JP5735251B2 - 新規アジュバント - Google Patents
新規アジュバント Download PDFInfo
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- JP5735251B2 JP5735251B2 JP2010229981A JP2010229981A JP5735251B2 JP 5735251 B2 JP5735251 B2 JP 5735251B2 JP 2010229981 A JP2010229981 A JP 2010229981A JP 2010229981 A JP2010229981 A JP 2010229981A JP 5735251 B2 JP5735251 B2 JP 5735251B2
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Images
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
一般式(1)
[2]前記一般式(1)で表される化合物は、下記の一般式(2)で表されるピロロキノリンキノン及び/またはその塩であることを特徴とする、[1]に記載のワクチン。
一般式(2)
[4]前記抗原がインフルエンザウイルス抗原であることを特徴とする[1]ないし[3]のいずれか1項に記載のワクチン。
[5]前記インフルエンザウイルス抗原がヘマグルチニン(HA)、ノイラミニダーゼ(NA)、マトリックス1(M1)、マトリックス2(M2)、核タンパク(NP)からなる群より選ばれた少なくとも1種又は2種以上の抗原であることを特徴とする[4]に記載のワクチン
[6]前記抗原が抗原を構成する全長のアミノ酸配列、または前記アミノ酸配列のうち1もしくは数個のアミノ酸が欠失、置換もしくは付加されたアミノ酸配列、または前記のいずれかのアミノ酸配列の部分配列、もしくは前記アミノ酸配列を含有するポリペプチドであることを特徴とする[5]に記載のワクチン。
[7]前記[1]から[6]のいずれか1項に記載のワクチンの製造方法。
[8]前記[1]から[6]のいずれか1項に記載のワクチンを用いた投与方法。
[9]前記一般式(1)で表されるピロロキノリン類及び/またはその塩を含有するアジュバント。
[10]前記一般式(1)で表される化合物は、前記一般式(2)で表されるピロロキノリンキノン及び/またはその塩であることを特徴とする、[9]に記載のアジュバント。
[11]前記ピロロキノリンキノンの塩がピロロキノリンキノン二ナトリウムであることを特徴とする、[10]に記載のアジュバント。
[12]前記[9]から[11]のいずれか1項に記載のアジュバントの製造方法。
[13]前記[9]から[11]のいずれか1項に記載のアジュバントを用いた投与方法。
一般式(1)
Claims (9)
- 前記ピロロキノリンキノンの塩がピロロキノリンキノン二ナトリウムであることを特徴とする、請求項2に記載のワクチン。
- 前記抗原がインフルエンザウイルス抗原であることを特徴とする請求項1ないし請求項3のいずれか1項に記載のワクチン。
- 前記インフルエンザウイルス抗原がヘマグルチニン(HA)、ノイラミニダーゼ(NA)、マトリックス1(M1)、マトリックス2(M2)、核タンパク(NP)からなる群より選ばれた少なくとも1種又は2種以上の抗原であることを特徴とする請求項4に記載のワクチン。
- 前記抗原が抗原を構成する全長のアミノ酸配列、または前記アミノ酸配列のうち1もしくは数個のアミノ酸が欠失、置換もしくは付加されたアミノ酸配列、または前記のいずれかのアミノ酸配列の部分配列、もしくは前記アミノ酸配列を含有するポリペプチドであることを特徴とする請求項5に記載のワクチン。
- 請求項1に記載の一般式(1)で表されるピロロキノリン類及び/またはその塩を含有するアジュバント。
- 請求項1に記載の一般式(1)で表される化合物は、請求項2に記載の一般式(2)で表されるピロロキノリンキノン及び/またはその塩であることを特徴とする、請求項7に記載のアジュバント。
- 前記ピロロキノリンキノンの塩がピロロキノリンキノン二ナトリウムであることを特徴とする、請求項8に記載のアジュバント。
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