JP5733894B2 - 細胞を拡大培養するための方法ならびに該方法によって作製される細胞および馴化培地の治療のための使用 - Google Patents

細胞を拡大培養するための方法ならびに該方法によって作製される細胞および馴化培地の治療のための使用 Download PDF

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JP5733894B2
JP5733894B2 JP2009502327A JP2009502327A JP5733894B2 JP 5733894 B2 JP5733894 B2 JP 5733894B2 JP 2009502327 A JP2009502327 A JP 2009502327A JP 2009502327 A JP2009502327 A JP 2009502327A JP 5733894 B2 JP5733894 B2 JP 5733894B2
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JP2009531059A (ja
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シャイ メレツキ,
シャイ メレツキ,
ザミ アバーマン,
ザミ アバーマン,
オラ バーガー,
オラ バーガー,
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プルリステム リミテッド
プルリステム リミテッド
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JP2009502327A 2006-03-23 2007-03-22 細胞を拡大培養するための方法ならびに該方法によって作製される細胞および馴化培地の治療のための使用 Active JP5733894B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78476906P 2006-03-23 2006-03-23
US60/784,769 2006-03-23
US84708806P 2006-09-26 2006-09-26
US60/847,088 2006-09-26
PCT/IL2007/000380 WO2007108003A2 (en) 2006-03-23 2007-03-22 Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy

Related Child Applications (1)

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JP2011133774A Division JP5766041B2 (ja) 2006-03-23 2011-06-16 対象の造血系を増強させるための医薬組成物

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JP2009531059A JP2009531059A (ja) 2009-09-03
JP2009531059A5 JP2009531059A5 (enExample) 2010-04-08
JP5733894B2 true JP5733894B2 (ja) 2015-06-10

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JP2009502327A Active JP5733894B2 (ja) 2006-03-23 2007-03-22 細胞を拡大培養するための方法ならびに該方法によって作製される細胞および馴化培地の治療のための使用
JP2011133774A Active JP5766041B2 (ja) 2006-03-23 2011-06-16 対象の造血系を増強させるための医薬組成物
JP2013263148A Active JP5941454B2 (ja) 2006-03-23 2013-12-20 対象の造血系を増強させるための医薬組成物

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JP2011133774A Active JP5766041B2 (ja) 2006-03-23 2011-06-16 対象の造血系を増強させるための医薬組成物
JP2013263148A Active JP5941454B2 (ja) 2006-03-23 2013-12-20 対象の造血系を増強させるための医薬組成物

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US (2) US20110129447A1 (enExample)
EP (5) EP2366775B1 (enExample)
JP (3) JP5733894B2 (enExample)
KR (2) KR101557256B1 (enExample)
CN (1) CN105296415A (enExample)
AU (1) AU2007228341B2 (enExample)
BR (1) BRPI0709349A2 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10722541B2 (en) 2011-03-22 2020-07-28 Pluristem Ltd. Methods for treating radiation or chemical injury

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9592258B2 (en) 2003-06-27 2017-03-14 DePuy Synthes Products, Inc. Treatment of neurological injury by administration of human umbilical cord tissue-derived cells
CA2530421C (en) 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
US8790637B2 (en) 2003-06-27 2014-07-29 DePuy Synthes Products, LLC Repair and regeneration of ocular tissue using postpartum-derived cells
US9572840B2 (en) 2003-06-27 2017-02-21 DePuy Synthes Products, Inc. Regeneration and repair of neural tissue using postpartum-derived cells
PL1971681T3 (pl) 2005-12-16 2018-01-31 Depuy Synthes Products Inc Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej
US9125906B2 (en) 2005-12-28 2015-09-08 DePuy Synthes Products, Inc. Treatment of peripheral vascular disease using umbilical cord tissue-derived cells
ES2537641T3 (es) * 2006-03-23 2015-06-10 Pluristem Ltd. Métodos de expansión celular y usos de células y medios acondicionados producidos de este modo para terapia
ES2524443T3 (es) 2006-11-13 2014-12-09 DePuy Synthes Products, LLC Expansión in vitro de células postparto usando microportadores
HRP20130765T1 (hr) * 2007-02-12 2013-10-25 Anthrogenesis Corporation Lijeäśenje protuupalnih bolesti putem matiäśnih stanica posteljice
JP5162784B2 (ja) * 2007-07-11 2013-03-13 日東電工株式会社 細胞培養基材及びその製造方法並びに細胞培養方法
AU2013267050B2 (en) * 2007-09-19 2016-01-07 Pluristem Ltd. Adherent cells from adipose or placenta tissues and use thereof in therapy
CN107028981B (zh) * 2007-09-19 2021-04-20 普拉里斯坦有限公司 来自脂肪或胎盘组织的粘附细胞及其在治疗中的用途
CN102123717A (zh) 2008-05-27 2011-07-13 普拉里斯坦有限公司 治疗炎性结肠疾病的方法
MX339624B (es) 2008-08-20 2016-06-02 Anthrogenesis Corp Composiciones mejoradas de celulas y metodos para preparar las mismas.
CN102282249A (zh) * 2008-09-02 2011-12-14 普拉里斯坦有限公司 来自胎盘组织的粘附细胞及其在治疗中的用途
US9096827B2 (en) * 2008-09-02 2015-08-04 Pluristem Ltd. Adherent cells from placenta tissue and use thereof in therapy
US20110256108A1 (en) * 2008-09-02 2011-10-20 Moran Meiron Methods of selection of cells for transplantation
CA2747794C (en) 2008-12-19 2018-10-30 Advanced Technologies And Regenerative Medicine, Llc Treatment of lung and pulmonary diseases and disorders
US10179900B2 (en) 2008-12-19 2019-01-15 DePuy Synthes Products, Inc. Conditioned media and methods of making a conditioned media
CN102498204B (zh) 2009-03-26 2015-02-04 德普伊新特斯产品有限责任公司 人脐带组织细胞作为用于阿尔茨海默病的疗法
AU2010322808B9 (en) 2009-11-30 2014-08-07 Pluri Biotech Ltd Adherent cells from placenta and use of same in disease treatment
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
ES2572211T3 (es) 2010-05-27 2016-05-30 Pluristem Ltd Regeneración de músculo esquelético utilizando células madre mesenquimales
PL2611906T3 (pl) * 2010-08-31 2024-05-27 Gallant Pet, Inc. Ogólnoustrojowe terapie allogenicznymi komórkami macierzystymi do leczenia chorób u kotów i psów
WO2012048298A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
KR101811912B1 (ko) 2011-03-04 2017-12-22 아메드 에이치. 알-칸타니 스킨 크림
SG10201601537QA (en) 2011-04-15 2016-04-28 Pluristem Ltd Methods and systems for harvesting cells
HK1202251A1 (en) 2011-11-07 2015-09-25 Hina W. Chaudhry Methods of cardiac repair
ITTO20111183A1 (it) * 2011-12-21 2013-06-22 Univ Degli Studi Torino Mezzo condizionato ottenuto da cellule staminali mesenchimali placentari e suo uso nel trattamento terapeutico della preeclampsia
US9950014B2 (en) 2012-09-04 2018-04-24 Pluristem Ltd. Methods for prevention and treatment of preeclampsia
PL2739720T3 (pl) 2012-09-06 2015-06-30 Pluristem Ltd Układy i sposoby hodowli komórek
US10351910B2 (en) 2013-02-20 2019-07-16 Pluristem Ltd Gene and protein expression properties of adherent stromal cells cultured in 3D
WO2014141111A1 (en) 2013-03-14 2014-09-18 Pluristem Ltd. Methods for prevention and treatment of graft-versus-host disease
RU2525143C1 (ru) * 2013-03-22 2014-08-10 Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации-Институт медико-биологических проблем Российской академии наук СПОСОБ ЭКСПАНСИИ МОНОНУКЛЕАРНЫХ КЛЕТОК ПУПОВИННОЙ КРОВИ (пкМНК) ex vivo В ПРИСУТСТВИИ МУЛЬТИПОТЕНТНЫХ СТРОМАЛЬНЫХ МЕЗЕНХИМАЛЬНЫХ КЛЕТОК (ММСК)
RU2539750C2 (ru) * 2013-04-09 2015-01-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ оценки иммуносупрессивных свойств мезенхимальных стромальных клеток человека
WO2015004609A2 (en) 2013-07-09 2015-01-15 Pluristem Ltd. Adherent cells from placenta and use thereof in treatment of injured tendons
US20150037436A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
WO2015025059A1 (en) * 2013-08-23 2015-02-26 Fundacion Pública Andaluza Progreso Y Salud Cd105-negative multipotent mesenchymal stromal cells
WO2015073918A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
WO2015132729A1 (en) 2014-03-04 2015-09-11 Pluristem Ltd. Systems and methods for growing and harvesting cells
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
WO2016049421A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled feed
RU2644650C2 (ru) 2014-12-01 2018-02-13 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток и способ его получения
WO2016098061A1 (en) 2014-12-18 2016-06-23 Pluristem Ltd. Methods and compositions for treating and preventing muscle wasting disorders
US20180015125A1 (en) 2015-03-23 2018-01-18 Pluristem Ltd. Use of adherent stromal cells for enhancing hematopoiesis in a subject in need thereof
EP3297694A1 (en) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
RU2628092C1 (ru) * 2016-02-10 2017-08-14 Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ - ИМБП РАН) Способ получения МСК-ассоциированных недифференцированных гемопоэтических клеток-предшественников с фенотипов CD34+/CD133+
AU2017218143B2 (en) * 2016-02-12 2023-08-03 Cell Care Therapeutics, Inc. Adipose tissue derived mesenchymal stromal cell conditioned media and methods of making and using the same
AU2017220148A1 (en) 2016-02-18 2018-07-19 Pluristem Ltd. Methods and compositions for treating cancers and neoplasms
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
RU2708329C2 (ru) 2016-05-31 2019-12-05 Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" Материал стволовых клеток, композиции и способы применения
EP3464563B1 (en) 2016-06-06 2021-07-28 Pluristem Ltd. Altered adherent stromal cells and methods of producing and using same
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US20200080147A1 (en) * 2017-02-20 2020-03-12 Pluristem Ltd. Methods and compositions for tumor assessment
JP7204730B2 (ja) * 2017-03-31 2023-01-16 セラム バイオメディカル, インコーポレイテッド 生体適合性馴化細胞培地組成物およびその使用
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
WO2018198012A1 (en) 2017-04-24 2018-11-01 Pluristem Ltd. Methods and compositions for treating neurological disorders
AU2018257315A1 (en) * 2017-04-25 2019-11-28 Sapporo Medical University Method for producing mesenchymal stem cells, therapeutic effect marker of mesenchymal stem cells, method for determining therapeutic effects of mesenchymal stem cells, and cellular preparation containing mesenchymal stem cells
IL260253A (en) 2017-07-03 2019-01-31 Pluristem Ltd Methods and compounds for removing adherent cells
WO2019175773A1 (en) 2018-03-12 2019-09-19 Universidade Do Porto Compositions for use in the treatment of musculoskeletal conditions and methods for producing the same leveraging the synergistic activity of two different types of mesenchymal stromal/stem cells
EP3786280A4 (en) 2018-04-25 2022-02-16 Sapporo Medical University Cell sheet for vital transplantation and method for producing same
US20240082313A1 (en) * 2021-01-26 2024-03-14 The Trustees Of Indiana University Pharmaceutical compositions and their methods of use
CN112813002B (zh) * 2021-02-07 2022-11-08 天津科技大学 一株耐热短乳杆菌及其后生素制剂的应用
GB2619893A (en) 2021-03-23 2023-12-20 Terumo Bct Inc Cell capture and expansion
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly
USD1099116S1 (en) 2022-09-01 2025-10-21 Terumo Bct, Inc. Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5266476A (en) 1985-06-18 1993-11-30 Yeda Research & Development Co., Ltd. Fibrous matrix for in vitro cell cultivation
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US6326198B1 (en) 1990-06-14 2001-12-04 Regents Of The University Of Michigan Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US6010696A (en) 1990-11-16 2000-01-04 Osiris Therapeutics, Inc. Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells
US5168085A (en) 1991-05-20 1992-12-01 Corning Incorporated Multi-stage twc system
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5925567A (en) 1995-05-19 1999-07-20 T. Breeders, Inc. Selective expansion of target cell populations
US6132463A (en) 1995-05-19 2000-10-17 Etex Corporation Cell seeding of ceramic compositions
DE69634303T2 (de) 1995-11-16 2006-01-05 Case Western Reserve University, Cleveland Chondrogene in vitro induktion von menschlichen mensenchymalen stammzellen
US6087129A (en) * 1996-01-19 2000-07-11 Betagene, Inc. Recombinant expression of proteins from secretory cell lines
US6335195B1 (en) 1997-01-28 2002-01-01 Maret Corporation Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation
US6291240B1 (en) * 1998-01-29 2001-09-18 Advanced Tissue Sciences, Inc. Cells or tissues with increased protein factors and methods of making and using same
ATE227338T1 (de) 1998-03-18 2002-11-15 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
JP4526186B2 (ja) 1998-06-08 2010-08-18 オシリス セラピューティクス,インコーポレイテッド 造血幹細胞を試験管内で維持する方法と組成物
US6153432A (en) 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
ES2338405T3 (es) * 1999-02-04 2010-05-07 Pluristem Ltd. Metodo y aparato para mantenimiento y expasion de celulas madre hemopoyeticas y/o celulas progenitoras.
CN1352696A (zh) * 1999-03-10 2002-06-05 匹兹堡大学联邦制高等教育 脂肪来源的干细胞和网格
US6372494B1 (en) * 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
AU4860900A (en) 1999-06-02 2000-12-18 Lifebank Services, L.L.C. Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
EP1261694B1 (en) 2000-02-26 2008-01-16 Artecel, Inc. Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof
US6916640B2 (en) * 2000-10-12 2005-07-12 Agency For Science, Technology And Research Multi-layer cell encapsulation for tissue engineering
WO2002046373A1 (en) * 2000-12-06 2002-06-13 Hariri Robert J Method of collecting placental stem cells
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
NZ528035A (en) * 2001-02-14 2005-07-29 Robert J Hariri Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
NZ527849A (en) * 2001-02-14 2006-09-29 Anthrogenesis Corp Post-partum mammalian placenta, its use and placental stem cells therefrom
CN1596303A (zh) * 2001-11-09 2005-03-16 阿特塞尔科学公司 利用基质细胞支持胚胎干细胞和成体干细胞的方法和组合物
JP2003180334A (ja) * 2001-12-17 2003-07-02 Japan Science & Technology Corp 三次元高密度細胞培養用モジュール
US7504099B2 (en) 2001-12-27 2009-03-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods of inducing or enhancing connective tissue repair
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
WO2003089619A2 (en) * 2002-04-19 2003-10-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Placental derived stem cells and uses thereof
WO2004076642A2 (en) 2003-02-27 2004-09-10 The Rockefeller University Method for modulating epithelial stem cell lineage
CA2530421C (en) * 2003-06-27 2015-04-21 Ethicon, Incorporated Repair and regeneration of ocular tissue using postpartum-derived cells
US6924458B2 (en) 2003-07-17 2005-08-02 Great Computer Corp. Auxiliary focusing tool for laser marker
WO2005113751A1 (en) * 2004-05-14 2005-12-01 Becton, Dickinson And Company Cell culture environments for the serum-free expansion of mesenchymal stem cells
DE102004043256B4 (de) * 2004-09-07 2013-09-19 Rheinische Friedrich-Wilhelms-Universität Bonn Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension
WO2006105152A2 (en) 2005-03-31 2006-10-05 Stemnion, Inc. Amnion-derived cell compositions, methods of making and uses thereof
US20100233130A1 (en) * 2006-02-06 2010-09-16 Pluristem Ltd. Method and Apparatus for Maintenance and Expansion of Hematopoietic Stem Cells From Mononuclear Cells
ES2537641T3 (es) * 2006-03-23 2015-06-10 Pluristem Ltd. Métodos de expansión celular y usos de células y medios acondicionados producidos de este modo para terapia
EP3260533B1 (en) * 2011-03-22 2019-09-11 Pluristem Ltd. Methods for treating radiation or chemical injury

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10722541B2 (en) 2011-03-22 2020-07-28 Pluristem Ltd. Methods for treating radiation or chemical injury

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