AU2007228341B2 - Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy - Google Patents
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- AU2007228341B2 AU2007228341B2 AU2007228341A AU2007228341A AU2007228341B2 AU 2007228341 B2 AU2007228341 B2 AU 2007228341B2 AU 2007228341 A AU2007228341 A AU 2007228341A AU 2007228341 A AU2007228341 A AU 2007228341A AU 2007228341 B2 AU2007228341 B2 AU 2007228341B2
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Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| CA2530421C (en) | 2003-06-27 | 2015-04-21 | Ethicon, Incorporated | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| PL1971681T3 (pl) | 2005-12-16 | 2018-01-31 | Depuy Synthes Products Inc | Kompozycje oraz sposoby do hamowania niepożądanej odpowiedzi immunologicznej w przypadku transplantacji z brakiem zgodności tkankowej |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| ES2537641T3 (es) * | 2006-03-23 | 2015-06-10 | Pluristem Ltd. | Métodos de expansión celular y usos de células y medios acondicionados producidos de este modo para terapia |
| ES2524443T3 (es) | 2006-11-13 | 2014-12-09 | DePuy Synthes Products, LLC | Expansión in vitro de células postparto usando microportadores |
| HRP20130765T1 (hr) * | 2007-02-12 | 2013-10-25 | Anthrogenesis Corporation | Lijeäśenje protuupalnih bolesti putem matiäśnih stanica posteljice |
| JP5162784B2 (ja) * | 2007-07-11 | 2013-03-13 | 日東電工株式会社 | 細胞培養基材及びその製造方法並びに細胞培養方法 |
| AU2013267050B2 (en) * | 2007-09-19 | 2016-01-07 | Pluristem Ltd. | Adherent cells from adipose or placenta tissues and use thereof in therapy |
| CN107028981B (zh) * | 2007-09-19 | 2021-04-20 | 普拉里斯坦有限公司 | 来自脂肪或胎盘组织的粘附细胞及其在治疗中的用途 |
| CN102123717A (zh) | 2008-05-27 | 2011-07-13 | 普拉里斯坦有限公司 | 治疗炎性结肠疾病的方法 |
| MX339624B (es) | 2008-08-20 | 2016-06-02 | Anthrogenesis Corp | Composiciones mejoradas de celulas y metodos para preparar las mismas. |
| CN102282249A (zh) * | 2008-09-02 | 2011-12-14 | 普拉里斯坦有限公司 | 来自胎盘组织的粘附细胞及其在治疗中的用途 |
| US9096827B2 (en) * | 2008-09-02 | 2015-08-04 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
| US20110256108A1 (en) * | 2008-09-02 | 2011-10-20 | Moran Meiron | Methods of selection of cells for transplantation |
| CA2747794C (en) | 2008-12-19 | 2018-10-30 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of lung and pulmonary diseases and disorders |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| CN102498204B (zh) | 2009-03-26 | 2015-02-04 | 德普伊新特斯产品有限责任公司 | 人脐带组织细胞作为用于阿尔茨海默病的疗法 |
| AU2010322808B9 (en) | 2009-11-30 | 2014-08-07 | Pluri Biotech Ltd | Adherent cells from placenta and use of same in disease treatment |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| ES2572211T3 (es) | 2010-05-27 | 2016-05-30 | Pluristem Ltd | Regeneración de músculo esquelético utilizando células madre mesenquimales |
| PL2611906T3 (pl) * | 2010-08-31 | 2024-05-27 | Gallant Pet, Inc. | Ogólnoustrojowe terapie allogenicznymi komórkami macierzystymi do leczenia chorób u kotów i psów |
| WO2012048298A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| KR101811912B1 (ko) | 2011-03-04 | 2017-12-22 | 아메드 에이치. 알-칸타니 | 스킨 크림 |
| EP3260533B1 (en) * | 2011-03-22 | 2019-09-11 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
| SG10201601537QA (en) | 2011-04-15 | 2016-04-28 | Pluristem Ltd | Methods and systems for harvesting cells |
| HK1202251A1 (en) | 2011-11-07 | 2015-09-25 | Hina W. Chaudhry | Methods of cardiac repair |
| ITTO20111183A1 (it) * | 2011-12-21 | 2013-06-22 | Univ Degli Studi Torino | Mezzo condizionato ottenuto da cellule staminali mesenchimali placentari e suo uso nel trattamento terapeutico della preeclampsia |
| US9950014B2 (en) | 2012-09-04 | 2018-04-24 | Pluristem Ltd. | Methods for prevention and treatment of preeclampsia |
| PL2739720T3 (pl) | 2012-09-06 | 2015-06-30 | Pluristem Ltd | Układy i sposoby hodowli komórek |
| US10351910B2 (en) | 2013-02-20 | 2019-07-16 | Pluristem Ltd | Gene and protein expression properties of adherent stromal cells cultured in 3D |
| WO2014141111A1 (en) | 2013-03-14 | 2014-09-18 | Pluristem Ltd. | Methods for prevention and treatment of graft-versus-host disease |
| RU2525143C1 (ru) * | 2013-03-22 | 2014-08-10 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации-Институт медико-биологических проблем Российской академии наук | СПОСОБ ЭКСПАНСИИ МОНОНУКЛЕАРНЫХ КЛЕТОК ПУПОВИННОЙ КРОВИ (пкМНК) ex vivo В ПРИСУТСТВИИ МУЛЬТИПОТЕНТНЫХ СТРОМАЛЬНЫХ МЕЗЕНХИМАЛЬНЫХ КЛЕТОК (ММСК) |
| RU2539750C2 (ru) * | 2013-04-09 | 2015-01-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ оценки иммуносупрессивных свойств мезенхимальных стромальных клеток человека |
| WO2015004609A2 (en) | 2013-07-09 | 2015-01-15 | Pluristem Ltd. | Adherent cells from placenta and use thereof in treatment of injured tendons |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| WO2015025059A1 (en) * | 2013-08-23 | 2015-02-26 | Fundacion Pública Andaluza Progreso Y Salud | Cd105-negative multipotent mesenchymal stromal cells |
| WO2015073918A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
| WO2015132729A1 (en) | 2014-03-04 | 2015-09-11 | Pluristem Ltd. | Systems and methods for growing and harvesting cells |
| US11008547B2 (en) | 2014-03-25 | 2021-05-18 | Terumo Bct, Inc. | Passive replacement of media |
| WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
| RU2644650C2 (ru) | 2014-12-01 | 2018-02-13 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток и способ его получения |
| WO2016098061A1 (en) | 2014-12-18 | 2016-06-23 | Pluristem Ltd. | Methods and compositions for treating and preventing muscle wasting disorders |
| US20180015125A1 (en) | 2015-03-23 | 2018-01-18 | Pluristem Ltd. | Use of adherent stromal cells for enhancing hematopoiesis in a subject in need thereof |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| RU2628092C1 (ru) * | 2016-02-10 | 2017-08-14 | Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации - Институт медико-биологических проблем Российской академии наук (ГНЦ РФ - ИМБП РАН) | Способ получения МСК-ассоциированных недифференцированных гемопоэтических клеток-предшественников с фенотипов CD34+/CD133+ |
| AU2017218143B2 (en) * | 2016-02-12 | 2023-08-03 | Cell Care Therapeutics, Inc. | Adipose tissue derived mesenchymal stromal cell conditioned media and methods of making and using the same |
| AU2017220148A1 (en) | 2016-02-18 | 2018-07-19 | Pluristem Ltd. | Methods and compositions for treating cancers and neoplasms |
| US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
| RU2708329C2 (ru) | 2016-05-31 | 2019-12-05 | Общество с ограниченной ответственностью "Т-Хелпер Клеточные Технологии" | Материал стволовых клеток, композиции и способы применения |
| EP3464563B1 (en) | 2016-06-06 | 2021-07-28 | Pluristem Ltd. | Altered adherent stromal cells and methods of producing and using same |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US20200080147A1 (en) * | 2017-02-20 | 2020-03-12 | Pluristem Ltd. | Methods and compositions for tumor assessment |
| JP7204730B2 (ja) * | 2017-03-31 | 2023-01-16 | セラム バイオメディカル， インコーポレイテッド | 生体適合性馴化細胞培地組成物およびその使用 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| US11629332B2 (en) | 2017-03-31 | 2023-04-18 | Terumo Bct, Inc. | Cell expansion |
| WO2018198012A1 (en) | 2017-04-24 | 2018-11-01 | Pluristem Ltd. | Methods and compositions for treating neurological disorders |
| AU2018257315A1 (en) * | 2017-04-25 | 2019-11-28 | Sapporo Medical University | Method for producing mesenchymal stem cells, therapeutic effect marker of mesenchymal stem cells, method for determining therapeutic effects of mesenchymal stem cells, and cellular preparation containing mesenchymal stem cells |
| IL260253A (en) | 2017-07-03 | 2019-01-31 | Pluristem Ltd | Methods and compounds for removing adherent cells |
| WO2019175773A1 (en) | 2018-03-12 | 2019-09-19 | Universidade Do Porto | Compositions for use in the treatment of musculoskeletal conditions and methods for producing the same leveraging the synergistic activity of two different types of mesenchymal stromal/stem cells |
| EP3786280A4 (en) | 2018-04-25 | 2022-02-16 | Sapporo Medical University | Cell sheet for vital transplantation and method for producing same |
| US20240082313A1 (en) * | 2021-01-26 | 2024-03-14 | The Trustees Of Indiana University | Pharmaceutical compositions and their methods of use |
| CN112813002B (zh) * | 2021-02-07 | 2022-11-08 | 天津科技大学 | 一株耐热短乳杆菌及其后生素制剂的应用 |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| US12209689B2 (en) | 2022-02-28 | 2025-01-28 | Terumo Kabushiki Kaisha | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030235563A1 (en) * | 2002-04-19 | 2003-12-25 | Strom Stephen C. | Placental derived stem cells and uses thereof |
| US20050265980A1 (en) * | 2004-05-14 | 2005-12-01 | Becton, Dickinson And Company | Cell culture environments for the serum-free expansion of mesenchymal stem cells |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5266476A (en) | 1985-06-18 | 1993-11-30 | Yeda Research & Development Co., Ltd. | Fibrous matrix for in vitro cell cultivation |
| US5032508A (en) * | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
| US5902741A (en) * | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5863531A (en) * | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US6326198B1 (en) | 1990-06-14 | 2001-12-04 | Regents Of The University Of Michigan | Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US6010696A (en) | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5168085A (en) | 1991-05-20 | 1992-12-01 | Corning Incorporated | Multi-stage twc system |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US5629186A (en) | 1994-04-28 | 1997-05-13 | Lockheed Martin Corporation | Porous matrix and method of its production |
| US5736396A (en) | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US5925567A (en) | 1995-05-19 | 1999-07-20 | T. Breeders, Inc. | Selective expansion of target cell populations |
| US6132463A (en) | 1995-05-19 | 2000-10-17 | Etex Corporation | Cell seeding of ceramic compositions |
| DE69634303T2 (de) | 1995-11-16 | 2006-01-05 | Case Western Reserve University, Cleveland | Chondrogene in vitro induktion von menschlichen mensenchymalen stammzellen |
| US6087129A (en) * | 1996-01-19 | 2000-07-11 | Betagene, Inc. | Recombinant expression of proteins from secretory cell lines |
| US6335195B1 (en) | 1997-01-28 | 2002-01-01 | Maret Corporation | Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation |
| US6291240B1 (en) * | 1998-01-29 | 2001-09-18 | Advanced Tissue Sciences, Inc. | Cells or tissues with increased protein factors and methods of making and using same |
| ATE227338T1 (de) | 1998-03-18 | 2002-11-15 | Massachusetts Inst Technology | Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane |
| JP4526186B2 (ja) | 1998-06-08 | 2010-08-18 | オシリス セラピューティクス，インコーポレイテッド | 造血幹細胞を試験管内で維持する方法と組成物 |
| US6153432A (en) | 1999-01-29 | 2000-11-28 | Zen-Bio, Inc | Methods for the differentiation of human preadipocytes into adipocytes |
| ES2338405T3 (es) * | 1999-02-04 | 2010-05-07 | Pluristem Ltd. | Metodo y aparato para mantenimiento y expasion de celulas madre hemopoyeticas y/o celulas progenitoras. |
| CN1352696A (zh) * | 1999-03-10 | 2002-06-05 | 匹兹堡大学联邦制高等教育 | 脂肪来源的干细胞和网格 |
| US6372494B1 (en) * | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| AU4860900A (en) | 1999-06-02 | 2000-12-18 | Lifebank Services, L.L.C. | Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells |
| US6555374B1 (en) | 1999-08-19 | 2003-04-29 | Artecel Sciences, Inc. | Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof |
| EP1261694B1 (en) | 2000-02-26 | 2008-01-16 | Artecel, Inc. | Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof |
| US6916640B2 (en) * | 2000-10-12 | 2005-07-12 | Agency For Science, Technology And Research | Multi-layer cell encapsulation for tissue engineering |
| WO2002046373A1 (en) * | 2000-12-06 | 2002-06-13 | Hariri Robert J | Method of collecting placental stem cells |
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| NZ528035A (en) * | 2001-02-14 | 2005-07-29 | Robert J Hariri | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| NZ527849A (en) * | 2001-02-14 | 2006-09-29 | Anthrogenesis Corp | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| CN1596303A (zh) * | 2001-11-09 | 2005-03-16 | 阿特塞尔科学公司 | 利用基质细胞支持胚胎干细胞和成体干细胞的方法和组合物 |
| JP2003180334A (ja) * | 2001-12-17 | 2003-07-02 | Japan Science & Technology Corp | 三次元高密度細胞培養用モジュール |
| US7504099B2 (en) | 2001-12-27 | 2009-03-17 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods of inducing or enhancing connective tissue repair |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| WO2004076642A2 (en) | 2003-02-27 | 2004-09-10 | The Rockefeller University | Method for modulating epithelial stem cell lineage |
| CA2530421C (en) * | 2003-06-27 | 2015-04-21 | Ethicon, Incorporated | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US6924458B2 (en) | 2003-07-17 | 2005-08-02 | Great Computer Corp. | Auxiliary focusing tool for laser marker |
| DE102004043256B4 (de) * | 2004-09-07 | 2013-09-19 | Rheinische Friedrich-Wilhelms-Universität Bonn | Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension |
| WO2006105152A2 (en) | 2005-03-31 | 2006-10-05 | Stemnion, Inc. | Amnion-derived cell compositions, methods of making and uses thereof |
| US20100233130A1 (en) * | 2006-02-06 | 2010-09-16 | Pluristem Ltd. | Method and Apparatus for Maintenance and Expansion of Hematopoietic Stem Cells From Mononuclear Cells |
| ES2537641T3 (es) * | 2006-03-23 | 2015-06-10 | Pluristem Ltd. | Métodos de expansión celular y usos de células y medios acondicionados producidos de este modo para terapia |
| EP3260533B1 (en) * | 2011-03-22 | 2019-09-11 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
-
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030235563A1 (en) * | 2002-04-19 | 2003-12-25 | Strom Stephen C. | Placental derived stem cells and uses thereof |
| US20050265980A1 (en) * | 2004-05-14 | 2005-12-01 | Becton, Dickinson And Company | Cell culture environments for the serum-free expansion of mesenchymal stem cells |
Non-Patent Citations (3)
| Title |
|---|
| Dominici M et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, Cytotherapy. January 2006, 8(4), p315-317 * |
| Wu Qing-Fa et al: Cultivation of human mesenchymal stem cells on macroporous CultiSpher G microcarriers, Journal of Experimental Hemotology. February 2003, 11(1), pages 15-21 * |
| Zhang y et al. Comparison of mesenchymal stem cells from human placenta and bone marrow, Chinese Medical Journal. 2004, 117(6), p882-887 * |
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