JP5730025B2 - 口腔用組成物 - Google Patents
口腔用組成物 Download PDFInfo
- Publication number
- JP5730025B2 JP5730025B2 JP2011004222A JP2011004222A JP5730025B2 JP 5730025 B2 JP5730025 B2 JP 5730025B2 JP 2011004222 A JP2011004222 A JP 2011004222A JP 2011004222 A JP2011004222 A JP 2011004222A JP 5730025 B2 JP5730025 B2 JP 5730025B2
- Authority
- JP
- Japan
- Prior art keywords
- salt
- mass
- cetylpyridinium chloride
- composition
- glycyrrhizic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 73
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 52
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 52
- 150000003839 salts Chemical class 0.000 claims description 52
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 51
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 50
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 50
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 50
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 50
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 50
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 50
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 36
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- 210000000214 mouth Anatomy 0.000 claims description 18
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 claims description 17
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
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- 230000000855 fungicidal effect Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- SVIJYLPSHPPVQF-UHFFFAOYSA-N 2-[2,2-diaminoethyl(dodecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCN(CC(N)N)CC(O)=O SVIJYLPSHPPVQF-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
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- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
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- 125000000217 alkyl group Chemical group 0.000 description 2
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- 229960003500 triclosan Drugs 0.000 description 1
- 239000010913 used oil Substances 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Description
項1.
(i)塩化セチルピリジニウム、(ii)グリチルリチン酸又はその塩、(iii)プロピレングリコール、1,3−ブチレングリコール、及びエタノールからなる群より選択される少なくとも1種のアルコール、並びに(iv)l−メントールを含有し、
塩化セチルピリジニウムに対するグリチルリチン酸又はその塩の質量比(グリチルリチン酸又はその塩/塩化セチルピリジニウム)が1以上である、口腔用組成物。
項2.
(i)を0.05〜0.5質量%、(ii)を0.05〜0.5質量%含有する、項1に記載の口腔用組成物。
項3.
(iii)を1〜30質量%、(iv)を0.01〜2質量%含有する、項1又は2に記載の口腔用組成物。
(i)塩化セチルピリジニウム、
(ii)グリチルリチン酸又はその塩、
(iii)プロピレングリコール、1,3−ブチレングリコール、及びエタノールからなる群より選択される少なくとも1種のアルコール、並びに
(iv)l−メントール
を含有する。そして、塩化セチルピリジニウムに対するグリチルリチン酸又はその塩の質量比(グリチルリチン酸又はその塩/塩化セチルピリジニウム)が1以上である。
<CPCを含有する組成物の殺菌力の検討>
表1〜表5に記載の組成に従って、CPC、GK2、各種アルコール(プロピレングリコール、1,3−ブチレングリコール、エタノール、グリセリン、ソルビット)、及びl−メントールを精製水に溶解させ、各種溶液組成物(各実施例、各比較例、及び各参考例:表1〜表5参照)を調製した。表1〜表5の数値は、CPC、GK2、各種アルコール、及びl−メントールが、それぞれ当該溶液組成物中に含有される量(質量%)を示す。また、表4及び表5には、GK2とCPCの質量比(GK2/CPC)の値も併せて示す。表中、各成分量が空欄である場合は、その成分は含まれないことを示す。なお、表1〜表3に記載の各例のGK2とCPCの質量比(GK2/CPC)は、いずれも2である。
〔試験方法〕
菌液の調製
健常人4名より無刺激唾液を採取し、等量ずつ混合し、均一に撹拌した。当該唾液混合溶液を、以下の検討で菌液(口腔内細菌含有液)として使用した。
試験方法
反応用プレート(96穴タイタープレート)の各ウェルに各溶液組成物を200μLずつ分注し、さらにそれぞれのウェルに菌液20μLを添加し、ピペッティングにより攪拌した。30秒後に各ウェルから溶液を20μLずつ採取し、培養用プレート(96穴タイタープレート)の各ウェル(TSB/Y/VH培地100μLが分注済み)に添加して混合した。菌液添加後から1、2、3、4、5、10、20分後についても同様の処理を行った。
Claims (3)
- (i)塩化セチルピリジニウムを0.1〜0.3質量%、
(ii)グリチルリチン酸又はその塩を0.1〜0.5質量%、
(iii)プロピレングリコール、1,3−ブチレングリコール、及びエタノールからなる群より選択される少なくとも1種のアルコールを2〜25質量%、並びに
(iv)l−メントールを0.03〜2質量%
含有し、
塩化セチルピリジニウムに対するグリチルリチン酸又はその塩の質量比(グリチルリチン酸又はその塩/塩化セチルピリジニウム)が1以上である、口腔用組成物。 - アルコールの合計含有量に対してプロピレングリコールを質量比で50%以上含有する、請求項1に記載の口腔用組成物。
- 医薬品である、請求項1又は2に記載の口腔用組成物。
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JP6610001B2 (ja) * | 2015-05-28 | 2019-11-27 | ライオン株式会社 | 液体口腔用組成物 |
JP6758955B2 (ja) * | 2016-06-30 | 2020-09-23 | サンスター株式会社 | 口腔用ペースト状組成物 |
JP6879719B2 (ja) * | 2016-11-24 | 2021-06-02 | サンスター株式会社 | 口腔用及び/又は咽喉用組成物 |
JP2018108963A (ja) * | 2016-12-29 | 2018-07-12 | サンスター株式会社 | 液状口腔咽喉薬 |
JP7081002B2 (ja) * | 2021-01-12 | 2022-06-06 | サンスター株式会社 | 液状口腔咽喉薬 |
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JP4761017B2 (ja) * | 2004-04-01 | 2011-08-31 | ライオン株式会社 | 口臭抑制用口腔内貼付剤 |
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JP2006316009A (ja) * | 2005-05-13 | 2006-11-24 | Lion Corp | 口腔内貼付剤及びその製造方法 |
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