JP5728226B2 - 狼瘡の同定と治療のための方法及び組成物 - Google Patents
狼瘡の同定と治療のための方法及び組成物 Download PDFInfo
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- JP5728226B2 JP5728226B2 JP2010509537A JP2010509537A JP5728226B2 JP 5728226 B2 JP5728226 B2 JP 5728226B2 JP 2010509537 A JP2010509537 A JP 2010509537A JP 2010509537 A JP2010509537 A JP 2010509537A JP 5728226 B2 JP5728226 B2 JP 5728226B2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
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- G—PHYSICS
- G06—COMPUTING OR CALCULATING; COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q99/00—Subject matter not provided for in other groups of this subclass
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2533/00—Reactions characterised by the enzymatic reaction principle used
- C12Q2533/10—Reactions characterised by the enzymatic reaction principle used the purpose being to increase the length of an oligonucleotide strand
- C12Q2533/101—Primer extension
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Business, Economics & Management (AREA)
- Business, Economics & Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Theoretical Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Transplantation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93915607P | 2007-05-21 | 2007-05-21 | |
| US60/939,156 | 2007-05-21 | ||
| US1328307P | 2007-12-12 | 2007-12-12 | |
| US61/013,283 | 2007-12-12 | ||
| PCT/US2008/064430 WO2008144761A2 (en) | 2007-05-21 | 2008-05-21 | Methods and compositions for identifying and treating lupus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015079282A Division JP6080059B2 (ja) | 2007-05-21 | 2015-04-08 | 狼瘡の同定と治療のための方法及び組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010528590A JP2010528590A (ja) | 2010-08-26 |
| JP2010528590A5 JP2010528590A5 (enExample) | 2011-07-07 |
| JP5728226B2 true JP5728226B2 (ja) | 2015-06-03 |
Family
ID=40122294
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509537A Active JP5728226B2 (ja) | 2007-05-21 | 2008-05-21 | 狼瘡の同定と治療のための方法及び組成物 |
| JP2015079282A Active JP6080059B2 (ja) | 2007-05-21 | 2015-04-08 | 狼瘡の同定と治療のための方法及び組成物 |
| JP2016178303A Pending JP2017035088A (ja) | 2007-05-21 | 2016-09-13 | 狼瘡の同定と治療のための方法及び組成物 |
| JP2018050492A Pending JP2018126146A (ja) | 2007-05-21 | 2018-03-19 | 狼瘡の同定と治療のための方法及び組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015079282A Active JP6080059B2 (ja) | 2007-05-21 | 2015-04-08 | 狼瘡の同定と治療のための方法及び組成物 |
| JP2016178303A Pending JP2017035088A (ja) | 2007-05-21 | 2016-09-13 | 狼瘡の同定と治療のための方法及び組成物 |
| JP2018050492A Pending JP2018126146A (ja) | 2007-05-21 | 2018-03-19 | 狼瘡の同定と治療のための方法及び組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20110046094A1 (enExample) |
| EP (3) | EP2612924B1 (enExample) |
| JP (4) | JP5728226B2 (enExample) |
| KR (4) | KR101729431B1 (enExample) |
| CN (3) | CN104593488B (enExample) |
| AU (1) | AU2008254582A1 (enExample) |
| BR (1) | BRPI0811930B8 (enExample) |
| CA (1) | CA2690608C (enExample) |
| ES (1) | ES2661249T3 (enExample) |
| HK (1) | HK1255086A1 (enExample) |
| IL (1) | IL201949A0 (enExample) |
| MX (3) | MX343167B (enExample) |
| RU (1) | RU2009147281A (enExample) |
| WO (1) | WO2008144761A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX343167B (es) * | 2007-05-21 | 2016-10-26 | Genentech Inc * | Metodos y composiciones para identificar y tratar lupus. |
| BRPI0913778A2 (pt) * | 2008-09-26 | 2015-10-20 | Genentech Inc | "métodos de identificação de lúpus, para prever a responsividade, de diagnóstico, para auxiliar o diagnóstico, usos de um agente terapêutico, métodos de identificação, métodos, métodos para selecionar um paciente, para avaliar se um sujeito nestá em risco de desenvolver lúpus, de diagnóstico de lúpus, para prognóstico de lúpus e para auxiliar o prognóstico" |
| US20100105061A1 (en) * | 2008-10-29 | 2010-04-29 | University Of Southern California | Autoimmune genes identified in systemic lupus erythematosus (sle) |
| EP2403959A1 (en) * | 2009-03-03 | 2012-01-11 | Merck Serono S.A. | Bank1 related snps and sle and/or ms susceptibility |
| CA2777055C (en) * | 2009-10-07 | 2021-04-06 | Genentech, Inc. | Methods for treating, diagnosing, and monitoring lupus |
| KR20130009784A (ko) * | 2010-03-01 | 2013-01-23 | 알렉시온 파마슈티칼스, 인코포레이티드 | 악성 위축성 구진증을 치료하는 방법 및 조성물 |
| US20140112913A1 (en) * | 2011-02-10 | 2014-04-24 | Genqual Corporation | Methods of prognosing and administering treatment for inflammatory disorders |
| US20130317006A1 (en) | 2012-05-24 | 2013-11-28 | Amy Yasko | Use of polymorphisms for identifying individuals at risk of developing autism |
| WO2015081052A1 (en) | 2013-11-27 | 2015-06-04 | Yasko Amy | Use of polymorphisms for identifying individuals at risk of developing autism |
| EP3314015B1 (en) * | 2015-06-24 | 2024-07-31 | Oxford BioDynamics PLC | Detection of chromosome interactions |
| CN110459312B (zh) * | 2018-05-07 | 2024-01-12 | 深圳华大生命科学研究院 | 类风湿性关节炎易感位点及其应用 |
| EP4076671A4 (en) * | 2019-12-18 | 2024-04-17 | The Children's Hospital Of Philadelphia | Novel druggable targets for the treatment of inflammatory diseases such as systemic lupus erythematosus (sle) and methods for diagnosis and treatment using the same |
| KR20240021336A (ko) | 2022-08-09 | 2024-02-19 | 심재홍 | 수액 채취장치의 냉각기 구조 |
| CN116030889B (zh) * | 2023-02-16 | 2026-01-02 | 复旦大学 | 一种线粒体异质性分布中分配差异率计算的模型化方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4683203A (en) * | 1984-04-14 | 1987-07-28 | Redco N.V. | Immobilized enzymes, processes for preparing same, and use thereof |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5225212A (en) * | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| DK0546073T3 (da) * | 1990-08-29 | 1998-02-02 | Genpharm Int | Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| DE69637481T2 (de) | 1995-04-27 | 2009-04-09 | Amgen Fremont Inc. | Aus immunisierten Xenomäusen stammende menschliche Antikörper gegen IL-8 |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| CA2255774C (en) | 1996-05-29 | 2008-03-18 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| CA2616914C (en) | 1996-12-03 | 2012-05-29 | Abgenix, Inc. | Egfr-binding antibody |
| WO2001092579A2 (en) | 2000-05-30 | 2001-12-06 | Pe Corporation (Ny) | Methods for detecting target nucleic acids using coupled ligation and amplification |
| US6900016B1 (en) * | 2000-09-08 | 2005-05-31 | Applera Corporation | Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof |
| CA2426540A1 (en) * | 2000-10-20 | 2002-07-25 | Biocardia, Inc. | Leukocyte expression profiling |
| US7205106B1 (en) | 2001-07-20 | 2007-04-17 | Roche Molecular Systems, Inc. | Association of polymorphisms in IL4-related genes with autoimmune disease |
| JP2003061677A (ja) * | 2001-08-28 | 2003-03-04 | Olympus Optical Co Ltd | 全身性エリテマトーデスの感受性遺伝子およびその使用 |
| US20030119004A1 (en) * | 2001-12-05 | 2003-06-26 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| US7022476B2 (en) * | 2002-02-26 | 2006-04-04 | New York Society For Ruptured And Crippled Maintaining The Hospital For Special Surgery | Human FcγRIIB gene polymorphisms for assessing development of systemic lupus erythematosus and compositions for use thereof |
| IL163600A0 (en) * | 2002-03-01 | 2005-12-18 | Ravgen Inc | Methods for detection of genetic disorders |
| JP2006521812A (ja) | 2003-03-18 | 2006-09-28 | アプレラ コーポレイション | 慢性関節リウマチに関連する遺伝的多型、その検出方法および使用 |
| WO2005086872A2 (en) * | 2004-03-10 | 2005-09-22 | Celera, An Applera Corporation Business | Ptpn22 polymorphisms in diagnosis and therapy |
| EP1863927A2 (en) * | 2005-03-15 | 2007-12-12 | Ares Trading S.A. | Compositions and methods for treating and diagnosing inflammatory disorders |
| CA2614455A1 (en) | 2005-08-05 | 2007-02-15 | Genentech, Inc. | Methods and compositions for detecting autoimmune disorders |
| US20070269827A1 (en) * | 2006-05-18 | 2007-11-22 | Oklahoma Medical Research Foundation | Predicting and Diagnosing Patients With Autoimmune Disease |
| MX343167B (es) * | 2007-05-21 | 2016-10-26 | Genentech Inc * | Metodos y composiciones para identificar y tratar lupus. |
| BRPI0913778A2 (pt) * | 2008-09-26 | 2015-10-20 | Genentech Inc | "métodos de identificação de lúpus, para prever a responsividade, de diagnóstico, para auxiliar o diagnóstico, usos de um agente terapêutico, métodos de identificação, métodos, métodos para selecionar um paciente, para avaliar se um sujeito nestá em risco de desenvolver lúpus, de diagnóstico de lúpus, para prognóstico de lúpus e para auxiliar o prognóstico" |
-
2008
- 2008-05-21 MX MX2009012531A patent/MX343167B/es active IP Right Grant
- 2008-05-21 EP EP12192837.8A patent/EP2612924B1/en active Active
- 2008-05-21 AU AU2008254582A patent/AU2008254582A1/en not_active Abandoned
- 2008-05-21 US US12/600,248 patent/US20110046094A1/en not_active Abandoned
- 2008-05-21 MX MX2016010728A patent/MX353428B/es unknown
- 2008-05-21 KR KR1020157032728A patent/KR101729431B1/ko active Active
- 2008-05-21 KR KR1020177009940A patent/KR101947093B1/ko active Active
- 2008-05-21 ES ES12192837.8T patent/ES2661249T3/es active Active
- 2008-05-21 JP JP2010509537A patent/JP5728226B2/ja active Active
- 2008-05-21 BR BRPI0811930A patent/BRPI0811930B8/pt active IP Right Grant
- 2008-05-21 MX MX2018000448A patent/MX378733B/es unknown
- 2008-05-21 CN CN201410815214.4A patent/CN104593488B/zh active Active
- 2008-05-21 EP EP08769569A patent/EP2158335A2/en not_active Withdrawn
- 2008-05-21 EP EP17191337.9A patent/EP3318643A3/en not_active Withdrawn
- 2008-05-21 WO PCT/US2008/064430 patent/WO2008144761A2/en not_active Ceased
- 2008-05-21 CN CN201810571366.2A patent/CN108753946A/zh active Pending
- 2008-05-21 KR KR1020197003511A patent/KR20190015629A/ko not_active Withdrawn
- 2008-05-21 KR KR1020097026436A patent/KR101651678B1/ko active Active
- 2008-05-21 CA CA2690608A patent/CA2690608C/en active Active
- 2008-05-21 CN CN200880025560.5A patent/CN103298950B/zh active Active
- 2008-05-21 RU RU2009147281/10A patent/RU2009147281A/ru unknown
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2009
- 2009-11-05 IL IL201949A patent/IL201949A0/en unknown
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