JP5728226B2 - 狼瘡の同定と治療のための方法及び組成物 - Google Patents

狼瘡の同定と治療のための方法及び組成物 Download PDF

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JP5728226B2
JP5728226B2 JP2010509537A JP2010509537A JP5728226B2 JP 5728226 B2 JP5728226 B2 JP 5728226B2 JP 2010509537 A JP2010509537 A JP 2010509537A JP 2010509537 A JP2010509537 A JP 2010509537A JP 5728226 B2 JP5728226 B2 JP 5728226B2
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snps
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JP2010528590A (ja
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ティモシー, ダブリュー. ベーレンス,
ティモシー, ダブリュー. ベーレンス,
ジェフリー ホム,
ジェフリー ホム,
ウォード, エー. オートマン,
ウォード, エー. オートマン,
ロバート, ロイヤル グレアム,
ロバート, ロイヤル グレアム,
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Genentech Inc
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JP2010509537A 2007-05-21 2008-05-21 狼瘡の同定と治療のための方法及び組成物 Active JP5728226B2 (ja)

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US93915607P 2007-05-21 2007-05-21
US60/939,156 2007-05-21
US1328307P 2007-12-12 2007-12-12
US61/013,283 2007-12-12
PCT/US2008/064430 WO2008144761A2 (en) 2007-05-21 2008-05-21 Methods and compositions for identifying and treating lupus

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JP2010528590A JP2010528590A (ja) 2010-08-26
JP2010528590A5 JP2010528590A5 (enExample) 2011-07-07
JP5728226B2 true JP5728226B2 (ja) 2015-06-03

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JP2010509537A Active JP5728226B2 (ja) 2007-05-21 2008-05-21 狼瘡の同定と治療のための方法及び組成物
JP2015079282A Active JP6080059B2 (ja) 2007-05-21 2015-04-08 狼瘡の同定と治療のための方法及び組成物
JP2016178303A Pending JP2017035088A (ja) 2007-05-21 2016-09-13 狼瘡の同定と治療のための方法及び組成物
JP2018050492A Pending JP2018126146A (ja) 2007-05-21 2018-03-19 狼瘡の同定と治療のための方法及び組成物

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JP2016178303A Pending JP2017035088A (ja) 2007-05-21 2016-09-13 狼瘡の同定と治療のための方法及び組成物
JP2018050492A Pending JP2018126146A (ja) 2007-05-21 2018-03-19 狼瘡の同定と治療のための方法及び組成物

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008144761A2 (en) * 2007-05-21 2008-11-27 Genentech, Inc. Methods and compositions for identifying and treating lupus
MX2011003273A (es) * 2008-09-26 2011-04-28 Genentech Inc Metodo para tratar, diagnosticar y supervisar lupus.
US20100105061A1 (en) * 2008-10-29 2010-04-29 University Of Southern California Autoimmune genes identified in systemic lupus erythematosus (sle)
CA2749869A1 (en) * 2009-03-03 2010-09-10 Merck Serono S.A. Bank1 related snps and sle and/or ms susceptibility
US20130034544A1 (en) 2009-10-07 2013-02-07 Genentech, Inc. Methods for treating, diagnosing, and monitoring lupus
WO2011109338A1 (en) * 2010-03-01 2011-09-09 Alexion Pharmaceuticals Inc. Methods and compositions for treating degos' disease
WO2012109427A1 (en) * 2011-02-10 2012-08-16 Genqual Corporation Methods of prognosing and administering treatment for inflammatory disorders
US20130317006A1 (en) 2012-05-24 2013-11-28 Amy Yasko Use of polymorphisms for identifying individuals at risk of developing autism
WO2015081052A1 (en) 2013-11-27 2015-06-04 Yasko Amy Use of polymorphisms for identifying individuals at risk of developing autism
MY194686A (en) * 2015-06-24 2022-12-15 Oxford BioDynamics PLC Detection of chromosome interactions
CN110459312B (zh) * 2018-05-07 2024-01-12 深圳华大生命科学研究院 类风湿性关节炎易感位点及其应用
EP4076671A4 (en) * 2019-12-18 2024-04-17 The Children's Hospital Of Philadelphia Novel druggable targets for the treatment of inflammatory diseases such as systemic lupus erythematosus (sle) and methods for diagnosis and treatment using the same
KR20240021336A (ko) 2022-08-09 2024-02-19 심재홍 수액 채취장치의 냉각기 구조
CN116030889A (zh) * 2023-02-16 2023-04-28 复旦大学 一种线粒体异质性分布中分配差异率计算的模型化方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657760A (en) 1979-03-20 1987-04-14 Ortho Pharmaceutical Corporation Methods and compositions using monoclonal antibody to human T cells
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4683203A (en) 1984-04-14 1987-07-28 Redco N.V. Immobilized enzymes, processes for preparing same, and use thereof
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
IE61148B1 (en) 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5225212A (en) * 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
SG48759A1 (en) 1990-01-12 2002-07-23 Abgenix Inc Generation of xenogenic antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ES2246502T3 (es) * 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
KR20050085971A (ko) 1995-04-27 2005-08-29 아브게닉스, 인크. 면역화된 제노마우스 유래의 인간 항체
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
WO1997045559A1 (en) 1996-05-29 1997-12-04 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
WO1998024893A2 (en) 1996-12-03 1998-06-11 Abgenix, Inc. TRANSGENIC MAMMALS HAVING HUMAN IG LOCI INCLUDING PLURAL VH AND Vλ REGIONS AND ANTIBODIES PRODUCED THEREFROM
JP2004507226A (ja) 2000-05-30 2004-03-11 ピーイー コーポレイション (エヌワイ) ライゲーションおよび増幅の組み合わせを用いて標的核酸を検出するための方法
US6900016B1 (en) 2000-09-08 2005-05-31 Applera Corporation Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof
ZA200303132B (en) * 2000-10-20 2004-09-23 Expression Diagnostics Inc Leukocyte expression profiling.
US7205106B1 (en) 2001-07-20 2007-04-17 Roche Molecular Systems, Inc. Association of polymorphisms in IL4-related genes with autoimmune disease
JP2003061677A (ja) * 2001-08-28 2003-03-04 Olympus Optical Co Ltd 全身性エリテマトーデスの感受性遺伝子およびその使用
US20030119004A1 (en) 2001-12-05 2003-06-26 Wenz H. Michael Methods for quantitating nucleic acids using coupled ligation and amplification
US7022476B2 (en) * 2002-02-26 2006-04-04 New York Society For Ruptured And Crippled Maintaining The Hospital For Special Surgery Human FcγRIIB gene polymorphisms for assessing development of systemic lupus erythematosus and compositions for use thereof
KR20040105744A (ko) * 2002-03-01 2004-12-16 라브겐, 인코퍼레이티드 게놈 변이의 신속한 분석법
CA2519476A1 (en) 2003-03-18 2004-09-30 Applera Corporation Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
WO2005086872A2 (en) * 2004-03-10 2005-09-22 Celera, An Applera Corporation Business Ptpn22 polymorphisms in diagnosis and therapy
WO2006097463A2 (en) * 2005-03-15 2006-09-21 Ares Trading S.A. Compositions and methods for treating and diagnosing inflammatory disorders
ES2383966T3 (es) 2005-08-05 2012-06-27 Genentech, Inc. Métodos y composiciones para detectar trastornos autoinmunes
US20070269827A1 (en) * 2006-05-18 2007-11-22 Oklahoma Medical Research Foundation Predicting and Diagnosing Patients With Autoimmune Disease
WO2008144761A2 (en) * 2007-05-21 2008-11-27 Genentech, Inc. Methods and compositions for identifying and treating lupus
MX2011003273A (es) * 2008-09-26 2011-04-28 Genentech Inc Metodo para tratar, diagnosticar y supervisar lupus.

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MX353428B (es) 2018-01-12
EP2612924A2 (en) 2013-07-10
CN104593488A (zh) 2015-05-06
CA2690608C (en) 2020-07-21
MX378733B (es) 2025-03-10
ES2661249T3 (es) 2018-03-28
IL201949A0 (en) 2010-06-16
JP2018126146A (ja) 2018-08-16
HK1255086A1 (en) 2019-08-02
BRPI0811930B1 (pt) 2019-11-05
CN108753946A (zh) 2018-11-06
CN103298950A (zh) 2013-09-11
JP2017035088A (ja) 2017-02-16
EP2612924A3 (en) 2013-10-23
AU2008254582A1 (en) 2008-11-27
KR20190015629A (ko) 2019-02-13
MX343167B (es) 2016-10-26
HK1209459A1 (en) 2016-04-01
CN103298950B (zh) 2015-01-21
KR101729431B1 (ko) 2017-04-21
EP3318643A3 (en) 2018-06-20
EP3318643A2 (en) 2018-05-09
US20110046094A1 (en) 2011-02-24
RU2009147281A (ru) 2011-06-27
CN104593488B (zh) 2018-06-12
MX2009012531A (es) 2009-12-03
BRPI0811930A2 (pt) 2014-11-25
KR20150133861A (ko) 2015-11-30
WO2008144761A3 (en) 2009-07-02
JP2010528590A (ja) 2010-08-26
KR20100021612A (ko) 2010-02-25
HK1189246A1 (en) 2014-05-30
WO2008144761A2 (en) 2008-11-27
CA2690608A1 (en) 2008-11-27
EP2612924B1 (en) 2017-12-20
KR101947093B1 (ko) 2019-02-12
EP2158335A2 (en) 2010-03-03
JP2015164426A (ja) 2015-09-17
BRPI0811930B8 (pt) 2021-05-25
KR101651678B1 (ko) 2016-08-26
KR20170042831A (ko) 2017-04-19
JP6080059B2 (ja) 2017-02-15

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