JP5722524B2 - 補体活性を抑制することによる同種移植片の生存の延長 - Google Patents

補体活性を抑制することによる同種移植片の生存の延長 Download PDF

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JP5722524B2
JP5722524B2 JP2008557383A JP2008557383A JP5722524B2 JP 5722524 B2 JP5722524 B2 JP 5722524B2 JP 2008557383 A JP2008557383 A JP 2008557383A JP 2008557383 A JP2008557383 A JP 2008557383A JP 5722524 B2 JP5722524 B2 JP 5722524B2
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antibody
composition
allograft
drug
complement
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JP2009528369A (ja
JP2009528369A5 (cg-RX-API-DMAC7.html
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ラッセル ピー. ローター,
ラッセル ピー. ローター,
ハオ ワン,
ハオ ワン,
チェン チョン,
チェン チョン,
Original Assignee
アレクシオン ファーマシューティカルズ, インコーポレイテッド
アレクシオン ファーマシューティカルズ, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2008557383A 2006-03-02 2007-03-02 補体活性を抑制することによる同種移植片の生存の延長 Expired - Fee Related JP5722524B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77885906P 2006-03-02 2006-03-02
US60/778,859 2006-03-02
PCT/US2007/005290 WO2007103134A2 (en) 2006-03-02 2007-03-02 Prolongation of survival of an allograft by inhibiting complement activity

Related Child Applications (1)

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JP2013105946A Division JP2013155202A (ja) 2006-03-02 2013-05-20 補体活性を抑制することによる同種移植片の生存の延長

Publications (3)

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JP2009528369A JP2009528369A (ja) 2009-08-06
JP2009528369A5 JP2009528369A5 (cg-RX-API-DMAC7.html) 2011-02-24
JP5722524B2 true JP5722524B2 (ja) 2015-05-20

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JP2008557383A Expired - Fee Related JP5722524B2 (ja) 2006-03-02 2007-03-02 補体活性を抑制することによる同種移植片の生存の延長
JP2013105946A Withdrawn JP2013155202A (ja) 2006-03-02 2013-05-20 補体活性を抑制することによる同種移植片の生存の延長

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US (1) US20100135992A1 (cg-RX-API-DMAC7.html)
EP (2) EP2918269A1 (cg-RX-API-DMAC7.html)
JP (2) JP5722524B2 (cg-RX-API-DMAC7.html)
KR (2) KR101527225B1 (cg-RX-API-DMAC7.html)
CN (1) CN101437501B (cg-RX-API-DMAC7.html)
AU (1) AU2007224250B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0708424A2 (cg-RX-API-DMAC7.html)
CA (1) CA2644020C (cg-RX-API-DMAC7.html)
DK (1) DK1988882T3 (cg-RX-API-DMAC7.html)
ES (1) ES2530637T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20150182T1 (cg-RX-API-DMAC7.html)
IL (1) IL193623A0 (cg-RX-API-DMAC7.html)
MX (1) MX2008011054A (cg-RX-API-DMAC7.html)
NZ (1) NZ570802A (cg-RX-API-DMAC7.html)
PL (1) PL1988882T3 (cg-RX-API-DMAC7.html)
PT (1) PT1988882E (cg-RX-API-DMAC7.html)
RS (1) RS53864B1 (cg-RX-API-DMAC7.html)
RU (1) RU2445975C2 (cg-RX-API-DMAC7.html)
SG (1) SG171578A1 (cg-RX-API-DMAC7.html)
SI (1) SI1988882T1 (cg-RX-API-DMAC7.html)
WO (1) WO2007103134A2 (cg-RX-API-DMAC7.html)

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Publication number Publication date
KR101527225B1 (ko) 2015-06-08
DK1988882T3 (en) 2015-02-23
AU2007224250A1 (en) 2007-09-13
CN101437501B (zh) 2012-09-05
IL193623A0 (en) 2009-08-03
SG171578A1 (en) 2011-06-29
PT1988882E (pt) 2015-02-17
KR20080098543A (ko) 2008-11-10
EP1988882A2 (en) 2008-11-12
RS53864B1 (sr) 2015-08-31
JP2009528369A (ja) 2009-08-06
RU2445975C2 (ru) 2012-03-27
RU2008139118A (ru) 2010-04-10
MX2008011054A (es) 2009-03-03
AU2007224250B2 (en) 2012-05-03
KR20140124023A (ko) 2014-10-23
CA2644020C (en) 2016-05-10
PL1988882T3 (pl) 2015-04-30
JP2013155202A (ja) 2013-08-15
WO2007103134A3 (en) 2008-09-12
WO2007103134A2 (en) 2007-09-13
BRPI0708424A2 (pt) 2011-05-31
HK1120444A1 (en) 2009-04-03
NZ570802A (en) 2012-03-30
US20100135992A1 (en) 2010-06-03
SI1988882T1 (sl) 2015-07-31
CN101437501A (zh) 2009-05-20
ES2530637T3 (es) 2015-03-04
EP2918269A1 (en) 2015-09-16
CA2644020A1 (en) 2007-09-13
KR101650264B1 (ko) 2016-08-22
EP1988882B1 (en) 2014-12-17
HRP20150182T1 (hr) 2015-06-05

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