JP2009528369A5 - - Google Patents
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- JP2009528369A5 JP2009528369A5 JP2008557383A JP2008557383A JP2009528369A5 JP 2009528369 A5 JP2009528369 A5 JP 2009528369A5 JP 2008557383 A JP2008557383 A JP 2008557383A JP 2008557383 A JP2008557383 A JP 2008557383A JP 2009528369 A5 JP2009528369 A5 JP 2009528369A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- drug
- mammal
- allograft
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 89
- 241000124008 Mammalia Species 0.000 claims 26
- 239000003814 drug Substances 0.000 claims 25
- 239000003018 immunosuppressive agent Substances 0.000 claims 25
- 229940079593 drug Drugs 0.000 claims 23
- 229940124589 immunosuppressive drug Drugs 0.000 claims 23
- 230000024203 complement activation Effects 0.000 claims 16
- 230000001684 chronic effect Effects 0.000 claims 13
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 12
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 12
- 102100031506 Complement C5 Human genes 0.000 claims 10
- 238000009472 formulation Methods 0.000 claims 9
- 230000000694 effects Effects 0.000 claims 8
- 229930105110 Cyclosporin A Natural products 0.000 claims 7
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical group CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 7
- 108010036949 Cyclosporine Proteins 0.000 claims 7
- 229960001265 ciclosporin Drugs 0.000 claims 7
- -1 OKT3 Substances 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 229960002224 eculizumab Drugs 0.000 claims 4
- 230000002519 immonomodulatory effect Effects 0.000 claims 4
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 4
- 230000004083 survival effect Effects 0.000 claims 4
- IDINUJSAMVOPCM-UHFFFAOYSA-N 15-Deoxyspergualin Natural products NCCCNCCCCNC(=O)C(O)NC(=O)CCCCCCN=C(N)N IDINUJSAMVOPCM-UHFFFAOYSA-N 0.000 claims 2
- 102100022002 CD59 glycoprotein Human genes 0.000 claims 2
- 108010028773 Complement C5 Proteins 0.000 claims 2
- 102100025680 Complement decay-accelerating factor Human genes 0.000 claims 2
- 229920000742 Cotton Polymers 0.000 claims 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
- ZSNYYEIGOZADKA-UHFFFAOYSA-N Cyclosporin L Natural products CCC1NC(=O)C(C(O)C(C)CC=CC)NC(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZSNYYEIGOZADKA-UHFFFAOYSA-N 0.000 claims 2
- 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 claims 2
- 101000856022 Homo sapiens Complement decay-accelerating factor Proteins 0.000 claims 2
- 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 102100039373 Membrane cofactor protein Human genes 0.000 claims 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
- 229960004669 basiliximab Drugs 0.000 claims 2
- 229950010231 brequinar Drugs 0.000 claims 2
- PHEZJEYUWHETKO-UHFFFAOYSA-N brequinar Chemical compound N1=C2C=CC(F)=CC2=C(C(O)=O)C(C)=C1C(C=C1)=CC=C1C1=CC=CC=C1F PHEZJEYUWHETKO-UHFFFAOYSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 108010047295 complement receptors Proteins 0.000 claims 2
- 102000006834 complement receptors Human genes 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960004397 cyclophosphamide Drugs 0.000 claims 2
- 229960002806 daclizumab Drugs 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 230000001861 immunosuppressant effect Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960000681 leflunomide Drugs 0.000 claims 2
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960001428 mercaptopurine Drugs 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 2
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 2
- BLUYEPLOXLPVCJ-INIZCTEOSA-N n-[(1s)-2-[4-(3-aminopropylamino)butylamino]-1-hydroxyethyl]-7-(diaminomethylideneamino)heptanamide Chemical compound NCCCNCCCCNC[C@H](O)NC(=O)CCCCCCNC(N)=N BLUYEPLOXLPVCJ-INIZCTEOSA-N 0.000 claims 2
- 229950003203 pexelizumab Drugs 0.000 claims 2
- 150000003212 purines Chemical class 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 229960004641 rituximab Drugs 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 238000010911 splenectomy Methods 0.000 claims 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 2
- 229960001967 tacrolimus Drugs 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 229940045686 antimetabolites antineoplastic purine analogs Drugs 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 230000001506 immunosuppresive effect Effects 0.000 claims 1
- 238000002650 immunosuppressive therapy Methods 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77885906P | 2006-03-02 | 2006-03-02 | |
| US60/778,859 | 2006-03-02 | ||
| PCT/US2007/005290 WO2007103134A2 (en) | 2006-03-02 | 2007-03-02 | Prolongation of survival of an allograft by inhibiting complement activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013105946A Division JP2013155202A (ja) | 2006-03-02 | 2013-05-20 | 補体活性を抑制することによる同種移植片の生存の延長 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528369A JP2009528369A (ja) | 2009-08-06 |
| JP2009528369A5 true JP2009528369A5 (cg-RX-API-DMAC7.html) | 2011-02-24 |
| JP5722524B2 JP5722524B2 (ja) | 2015-05-20 |
Family
ID=38475394
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008557383A Expired - Fee Related JP5722524B2 (ja) | 2006-03-02 | 2007-03-02 | 補体活性を抑制することによる同種移植片の生存の延長 |
| JP2013105946A Withdrawn JP2013155202A (ja) | 2006-03-02 | 2013-05-20 | 補体活性を抑制することによる同種移植片の生存の延長 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013105946A Withdrawn JP2013155202A (ja) | 2006-03-02 | 2013-05-20 | 補体活性を抑制することによる同種移植片の生存の延長 |
Country Status (21)
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007225044C1 (en) | 2006-03-15 | 2018-03-29 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement |
| KR101463631B1 (ko) | 2006-03-31 | 2014-11-19 | 추가이 세이야쿠 가부시키가이샤 | 항체의 혈중 동태를 제어하는 방법 |
| CA2662480C (en) * | 2006-09-05 | 2016-11-08 | Alexion Pharmaceuticals, Inc. | Methods and compositions for the treatment of antibody mediated neuropathies |
| HUE026042T2 (en) | 2006-10-10 | 2016-05-30 | Regenesance B V | Complement inhibition for improved nerve regeneration |
| RU2510400C9 (ru) | 2007-09-26 | 2014-07-20 | Чугаи Сейяку Кабусики Кайся | Способ модификации изоэлектрической точки антитела с помощью аминокислотных замен в cdr |
| US20110111406A1 (en) | 2008-04-11 | 2011-05-12 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| BRPI0921237A2 (pt) | 2008-11-10 | 2015-09-22 | Alexion Pharma Inc | métodos e composições para o tratamento de distúrbios associados ao complemento |
| WO2010126898A1 (en) * | 2009-04-27 | 2010-11-04 | The Trustees Of The University Of Pennsylvania | Methods for reducing the level of alloantibodies in a subject |
| CN102597005A (zh) * | 2009-06-23 | 2012-07-18 | 阿雷克森制药公司 | 与补体蛋白质结合的双特异性抗体 |
| WO2011003098A1 (en) * | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| CN101621801B (zh) * | 2009-08-11 | 2012-11-28 | 华为终端有限公司 | 无线局域网的认证方法、系统及服务器、终端 |
| WO2012073992A1 (ja) | 2010-11-30 | 2012-06-07 | 中外製薬株式会社 | 複数分子の抗原に繰り返し結合する抗原結合分子 |
| EP2709627B1 (en) * | 2011-05-16 | 2020-09-23 | Genzyme Corporation | Induction of immune tolerance by using methotrexate |
| CN102585016B (zh) * | 2012-03-06 | 2014-06-04 | 江苏健德生物药业有限公司 | 一种可同时抑制t、b淋巴细胞功能的免疫融合蛋白、其制备方法及其应用 |
| CN103232542B (zh) * | 2013-02-01 | 2015-05-13 | 殷勇 | 一种双靶标嵌合蛋白 |
| EP3290922A1 (en) | 2013-08-07 | 2018-03-07 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (ahus) biomarker proteins |
| WO2015023972A1 (en) * | 2013-08-16 | 2015-02-19 | Alexion Pharmaceuticals, Inc. | Treatment of graft rejection by administering a complement inhibitor to an organ prior to transplant |
| HUE041809T2 (hu) * | 2013-11-22 | 2019-05-28 | Shire Viropharma Inc | Eljárások antitest által közvetített kilökõdés kezelésére szervbeültetéses páciensekben C1-észteráz inhibitorral |
| NZ631007A (en) * | 2014-03-07 | 2015-10-30 | Alexion Pharma Inc | Anti-c5 antibodies having improved pharmacokinetics |
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| AR103162A1 (es) | 2014-12-19 | 2017-04-19 | Chugai Pharmaceutical Co Ltd | Anticuerpos anti-c5 y métodos para su uso |
| US10968426B2 (en) | 2015-05-08 | 2021-04-06 | President And Fellows Of Harvard College | Universal donor stem cells and related methods |
| WO2017075325A1 (en) * | 2015-10-30 | 2017-05-04 | Alexion Pharmaceuticals, Inc. | A method of inhibiting exacerbations of t cell-mediated allograft vasculopathy |
| RU2742606C2 (ru) * | 2015-12-18 | 2021-02-09 | Чугаи Сейяку Кабусики Кайся | Антитела к с5 и способы их применения |
| JP2019517473A (ja) | 2016-05-27 | 2019-06-24 | アレクシオン ファーマシューティカルズ インコーポレイテッドＡｌｅｘｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 難治性全身型重症筋無力症の処置のための方法 |
| RU2018146847A (ru) * | 2016-06-07 | 2020-07-09 | Новартис Аг | Тесидолумаб для применения в лечении отторжения трансплантата |
| US20190127453A1 (en) * | 2016-06-07 | 2019-05-02 | Novartis Ag | An anti-c5 antibody dosing regimen |
| KR102667023B1 (ko) | 2016-06-14 | 2024-05-21 | 리제너론 파아마슈티컬스, 인크. | 항-c5 항체 및 이의 용도 |
| EP3494991A4 (en) | 2016-08-05 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES |
| PT3658184T (pt) | 2017-07-27 | 2023-11-29 | Alexion Pharma Inc | Formulações de anticorpo anti-c5 de elevada concentração |
| EP3700928A1 (en) | 2017-10-26 | 2020-09-02 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) and atypical hemolytic uremic syndrome (ahus) |
| EP3724226A1 (en) | 2017-12-13 | 2020-10-21 | Regeneron Pharmaceuticals, Inc. | Anti-c5 antibody combinations and uses thereof |
| US20190247560A1 (en) | 2018-02-13 | 2019-08-15 | Gambro Lundia Ab | Extracorporeal devices and methods of treating complement factor related diseases |
| JP7520725B2 (ja) | 2018-05-31 | 2024-07-23 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 小児患者における発作性夜間ヘモグロビン尿症（ｐｎｈ）の治療のための抗ｃ５抗体の用量および投与 |
| EP3802603A1 (en) | 2018-06-04 | 2021-04-14 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-c5 antibodies for treatment of atypical hemolytic uremic syndrome (ahus) in pediatric patients |
| WO2020006266A1 (en) | 2018-06-28 | 2020-01-02 | Alexion Pharmaceuticals, Inc. | Methods of producing anti-c5 antibodies |
| EP4306128A3 (en) | 2018-10-30 | 2024-03-27 | Alexion Pharmaceuticals, Inc. | Subcutaneous dosage and administration of anti-c5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (pnh) |
| CN111449050A (zh) * | 2019-01-20 | 2020-07-28 | 睿诺医疗科技（上海）有限公司 | 环孢菌素类似物及其用途 |
| JP2022532174A (ja) | 2019-05-10 | 2022-07-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 修飾多能性細胞 |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| WO2021068957A1 (en) | 2019-10-12 | 2021-04-15 | Farsight Medical Technology (Shanghai) Co., Ltd. | Treatment and prevention of nephrotoxin-induced kidney injuries |
| WO2021146471A2 (en) * | 2020-01-15 | 2021-07-22 | The Regents Of The University Of California | Transplanted cell protection via inhibition of polymorphonuclear cells |
| CN114245744A (zh) | 2020-04-15 | 2022-03-25 | 睿诺医疗科技（上海）有限公司 | 器官损伤的预防和治疗 |
| CN114532982A (zh) * | 2022-01-12 | 2022-05-27 | 高谋 | 评价干细胞系统移植调控补体活化作用的体系 |
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| DK1755674T3 (en) * | 2004-05-14 | 2015-02-09 | Alexion Pharma Inc | PROLONGED SURVIVAL OF A allograft by inhibiting complement activity |
| CA2566861A1 (en) * | 2004-05-17 | 2005-12-08 | Combinatorx, Incorporated | Methods and reagents for the treatment of immunoinflammatory disorders |
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2007
- 2007-03-02 JP JP2008557383A patent/JP5722524B2/ja not_active Expired - Fee Related
- 2007-03-02 EP EP14198274.4A patent/EP2918269A1/en not_active Withdrawn
- 2007-03-02 RS RS20150109A patent/RS53864B1/sr unknown
- 2007-03-02 HR HRP20150182TT patent/HRP20150182T1/hr unknown
- 2007-03-02 KR KR1020087023398A patent/KR101527225B1/ko not_active Expired - Fee Related
- 2007-03-02 SI SI200731610T patent/SI1988882T1/sl unknown
- 2007-03-02 SG SG201102357-9A patent/SG171578A1/en unknown
- 2007-03-02 RU RU2008139118/15A patent/RU2445975C2/ru not_active IP Right Cessation
- 2007-03-02 KR KR1020147028450A patent/KR101650264B1/ko not_active Expired - Fee Related
- 2007-03-02 PT PT77520187T patent/PT1988882E/pt unknown
- 2007-03-02 WO PCT/US2007/005290 patent/WO2007103134A2/en not_active Ceased
- 2007-03-02 AU AU2007224250A patent/AU2007224250B2/en active Active
- 2007-03-02 BR BRPI0708424-2A patent/BRPI0708424A2/pt not_active IP Right Cessation
- 2007-03-02 MX MX2008011054A patent/MX2008011054A/es active IP Right Grant
- 2007-03-02 ES ES07752018T patent/ES2530637T3/es active Active
- 2007-03-02 US US12/224,567 patent/US20100135992A1/en not_active Abandoned
- 2007-03-02 EP EP07752018.7A patent/EP1988882B1/en not_active Revoked
- 2007-03-02 NZ NZ570802A patent/NZ570802A/en not_active IP Right Cessation
- 2007-03-02 DK DK07752018.7T patent/DK1988882T3/en active
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- 2007-03-02 CN CN200780015830XA patent/CN101437501B/zh active Active
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2008
- 2008-08-21 IL IL193623A patent/IL193623A0/en unknown
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- 2013-05-20 JP JP2013105946A patent/JP2013155202A/ja not_active Withdrawn
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