JP5714230B2 - 発現上昇のための細菌リーダー配列 - Google Patents

発現上昇のための細菌リーダー配列 Download PDF

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Publication number
JP5714230B2
JP5714230B2 JP2009548414A JP2009548414A JP5714230B2 JP 5714230 B2 JP5714230 B2 JP 5714230B2 JP 2009548414 A JP2009548414 A JP 2009548414A JP 2009548414 A JP2009548414 A JP 2009548414A JP 5714230 B2 JP5714230 B2 JP 5714230B2
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Prior art keywords
polypeptide
protein
nucleic acid
acid molecule
sequence
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Expired - Fee Related
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Japanese (ja)
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JP2010517532A5 (enExample
JP2010517532A (ja
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コールマン，ラッセル，ジョン
レタラック，ダイアン
シュナイダー，ジェーン，シー．
ラムサイアー，トーマス，エム．
ハーシュバーガー，チャールス，ダグラス
リー，ステーシー，エル．
レスニック，ソル
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フェネックス インコーポレイテッド
フェネックス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2009548414A 2007-01-31 2008-01-30 発現上昇のための細菌リーダー配列 Expired - Fee Related JP5714230B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US88748607P 2007-01-31 2007-01-31
US88747607P 2007-01-31 2007-01-31
US60/887,486 2007-01-31
US60/887,476 2007-01-31
PCT/US2008/052434 WO2008094986A2 (en) 2007-01-31 2008-01-30 Bacterial leader sequences for increased expression

Related Child Applications (1)

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JP2015047870A Division JP6495690B2 (ja) 2007-01-31 2015-03-11 発現上昇のための細菌リーダー配列

Publications (3)

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JP2010517532A JP2010517532A (ja) 2010-05-27
JP2010517532A5 JP2010517532A5 (enExample) 2014-10-23
JP5714230B2 true JP5714230B2 (ja) 2015-05-07

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JP2009548414A Expired - Fee Related JP5714230B2 (ja) 2007-01-31 2008-01-30 発現上昇のための細菌リーダー配列
JP2015047870A Active JP6495690B2 (ja) 2007-01-31 2015-03-11 発現上昇のための細菌リーダー配列
JP2018027221A Pending JP2018102305A (ja) 2007-01-31 2018-02-19 発現上昇のための細菌リーダー配列

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JP2015047870A Active JP6495690B2 (ja) 2007-01-31 2015-03-11 発現上昇のための細菌リーダー配列
JP2018027221A Pending JP2018102305A (ja) 2007-01-31 2018-02-19 発現上昇のための細菌リーダー配列

Country Status (10)

Country Link
US (3) US7618799B2 (enExample)
EP (2) EP2468869B1 (enExample)
JP (3) JP5714230B2 (enExample)
KR (1) KR101491867B1 (enExample)
CN (2) CN101641441A (enExample)
AU (1) AU2008210538B2 (enExample)
BR (1) BRPI0807834A2 (enExample)
CA (1) CA2677179C (enExample)
PL (1) PL2468869T3 (enExample)
WO (1) WO2008094986A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520292A (ja) * 2013-03-15 2016-07-14 パナシア ファーマシューティカルズ， インコーポレイテッド ＨＡＡＨ（アスパルチル−（アスパラギニル）−β−ヒドロキシラーゼ）を標的とする治療用癌ワクチン

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