JP5711138B2 - 高濃度の低粘度懸濁液 - Google Patents

高濃度の低粘度懸濁液 Download PDF

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Publication number
JP5711138B2
JP5711138B2 JP2011536414A JP2011536414A JP5711138B2 JP 5711138 B2 JP5711138 B2 JP 5711138B2 JP 2011536414 A JP2011536414 A JP 2011536414A JP 2011536414 A JP2011536414 A JP 2011536414A JP 5711138 B2 JP5711138 B2 JP 5711138B2
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JP
Japan
Prior art keywords
suspension
particles
viscosity
protein
concentration
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2011536414A
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English (en)
Japanese (ja)
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JP2012508744A (ja
JP2012508744A5 (enExample
Inventor
キース ピー． ジョンストン
キース ピー． ジョンストン
マリア アンドレア マズスキー
マリア アンドレア マズスキー
ジョシュア イングストロム
ジョシュア イングストロム
ミゲル アンジェロ ロドリゲス
ミゲル アンジェロ ロドリゲス
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University of Texas System
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University of Texas System
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Publication of JP2012508744A publication Critical patent/JP2012508744A/ja
Publication of JP2012508744A5 publication Critical patent/JP2012508744A5/ja
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A61K38/385—Serum albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2011536414A 2008-11-16 2009-11-10 高濃度の低粘度懸濁液 Expired - Fee Related JP5711138B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11508008P 2008-11-16 2008-11-16
US61/115,080 2008-11-16
PCT/US2009/063852 WO2010056657A2 (en) 2008-11-16 2009-11-10 Low viscosity highly concentrated suspensions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014247793A Division JP2015083582A (ja) 2008-11-16 2014-12-08 高濃度の低粘度懸濁液

Publications (3)

Publication Number Publication Date
JP2012508744A JP2012508744A (ja) 2012-04-12
JP2012508744A5 JP2012508744A5 (enExample) 2013-02-21
JP5711138B2 true JP5711138B2 (ja) 2015-04-30

Family

ID=42170660

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011536414A Expired - Fee Related JP5711138B2 (ja) 2008-11-16 2009-11-10 高濃度の低粘度懸濁液
JP2014247793A Pending JP2015083582A (ja) 2008-11-16 2014-12-08 高濃度の低粘度懸濁液

Family Applications After (1)

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JP2014247793A Pending JP2015083582A (ja) 2008-11-16 2014-12-08 高濃度の低粘度懸濁液

Country Status (7)

Country Link
US (2) US8779094B2 (enExample)
EP (1) EP2376522A4 (enExample)
JP (2) JP5711138B2 (enExample)
KR (1) KR20110103961A (enExample)
CA (1) CA2743789C (enExample)
IL (1) IL212919A (enExample)
WO (1) WO2010056657A2 (enExample)

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CA2792517C (en) * 2010-03-09 2020-03-24 Janssen Biotech, Inc. Non-aqueous high concentration reduced viscosity suspension formulations
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AU2012225277A1 (en) * 2011-03-10 2013-09-26 Board Of Regents, The University Of Texas System Protein nanoparticle dispersions
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WO2013070692A1 (en) 2011-11-07 2013-05-16 Battelle Memorial Institute Processes for delivery of viscous drug therapies
MY188825A (en) * 2012-05-18 2022-01-06 Genentech Inc High-concentration monoclonal antibody formulations
HK1220120A1 (zh) * 2013-03-15 2017-04-28 Ansun Biopharma, Inc. 制造注射蛋白质微粒悬浮液的方法
IL312865B2 (en) 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
CN103976947B (zh) * 2014-06-05 2016-08-17 段明星 一种含酶油悬浮剂及其制备方法与应用
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JP7781743B2 (ja) * 2019-09-13 2025-12-08 エレクトロフィ，インコーポレイテッド 疾患の処置のための治療用生物学的作用剤の送達のための組成物及び方法
JP2023522627A (ja) 2020-04-17 2023-05-31 エレクトロフィ，インコーポレイテッド 連続的な液滴形成及び脱水によって粒子を形成する方法

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Also Published As

Publication number Publication date
EP2376522A2 (en) 2011-10-19
WO2010056657A8 (en) 2010-08-26
CA2743789C (en) 2017-10-31
JP2012508744A (ja) 2012-04-12
CA2743789A1 (en) 2010-05-20
US20140378370A1 (en) 2014-12-25
US20110280864A1 (en) 2011-11-17
IL212919A (en) 2017-07-31
IL212919A0 (en) 2011-07-31
JP2015083582A (ja) 2015-04-30
EP2376522A4 (en) 2013-12-25
WO2010056657A3 (en) 2010-10-14
WO2010056657A2 (en) 2010-05-20
US8779094B2 (en) 2014-07-15
KR20110103961A (ko) 2011-09-21

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