JP5710241B2 - Liquid oral composition - Google Patents

Description

  The present invention relates to a liquid oral composition having a good feeling of use.

Metal salts such as aluminum salts, zinc salts, and magnesium salts are based on an excellent astringent action, and have the effect of squeezing the gums, suppressing inflammation, hemostasis, and alleviating symptoms of dentin hypersensitivity. It is included in dentifrices and mouthwashes for the prevention of periodontal disease and gingivitis.
However, oral compositions containing a large amount of these astringents have problems such as cloudiness and precipitation, and bitterness and astringency. In order to suppress such disadvantages, a chain hydrocarbon compound or wax is blended (Patent Documents 1 and 2), a sugar alcohol is blended (Patent Document 3), an amino acid or a protein is blended to adjust the pH (Patent Document) 4), the blending ratio with fluorine is adjusted (Patent Document 5).

Japanese Patent Laid-Open No. 10-87458 JP 11-21219 A Japanese Patent Laid-Open No. 10-231237 JP 61-23768 A JP-A-5-155745

However, depending on these technologies, bitterness and astringency cannot be sufficiently suppressed, bitterness and astringency can be suppressed, but astringency is lost. When it mix | blends, the new problem that the usability as a dentifrice or a mouthwash will be spoiled greatly also arises. Such a problem of use feeling in the oral cavity is particularly remarkable in a liquid oral composition such as a mouthwash rather than a toothpaste.
Accordingly, an object of the present invention is to provide a liquid oral composition having improved astringency such as bitterness and astringency while having a sufficient astringency.

  Therefore, the present inventor has combined astringent ingredients such as aluminum salts with various ingredients and studied the astringent action and taste, and as a result, 2-9 mass% glycerin and a certain amount of sucralose are contained in the astringent ingredients. When a liquid oral composition containing a large amount of water is combined with a certain amount of sugar alcohol, the bitterness and astringency during application of the composition to the oral cavity is reduced while having a sense of convergence. Not only surprisingly, the present inventors have found that the aftertaste after applying the composition into the oral cavity is remarkably improved, and completed the present invention.

That is, the present invention includes the following components (A) to (E):
(A) Polyvalent metal salt selected from water-soluble aluminum salt, water-soluble zinc salt and water-soluble magnesium salt 0.02 to 0.3% by mass,
(B) Glycerin 2-9% by mass,
(C) Sucralose 0.002-0.01% by mass,
(D) Sugar alcohol 0.5-10 mass% and (E) Water 75-95 mass%
The mass ratio (B / A) of component (B) to component (A) is 20 to 90, and the mass ratio (C / A) of component (C) to component (A) is 0.02. The liquid oral composition which is -0.1 is provided.

  When the liquid oral composition of the present invention is used, the taste such as bitterness and astringency is improved while having an excellent astringent feeling due to the astringent component, and until the liquid oral composition is applied to the oral cavity. As a result, bitterness and astringency are reduced, and the feeling of use is good from application to application.

  The polyvalent metal salt selected from (A) a water-soluble aluminum salt, a water-soluble zinc salt and a water-soluble magnesium salt used in the present invention is a component that exhibits an astringent action, a gingival squeezing action, an anti-inflammatory action, and the like. Of these, water-soluble aluminum salts are preferred from the viewpoints of astringency and bitterness control. Water-soluble aluminum salts include aluminum lactate, chlorohydroxyaluminum, allantoinhydroxyaluminum, allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, aluminum paraphenolsulfonate, aluminum chloride, alum (potassium aluminum sulfate dodecahydrate), sodium alum (Sodium aluminum sulfate dodecahydrate) Aluminum nitrate and the like can be mentioned. Of these, allantoinchlorohydroxyaluminum and allantoindihydroxyaluminum are particularly preferred from the viewpoints of astringency and astringency.

  Examples of the water-soluble zinc salt include paraphenolsulfonic acid zinc salt, zinc chloride, zinc gluconate, zinc acetate, and zinc sulfate.

  Examples of the water-soluble magnesium salt include magnesium gluconate, magnesium sulfate, magnesium chloride and the like.

  The polyvalent metal salt of component (A) is contained in the liquid oral composition of the present invention in an amount of 0.02 to 0.3% by mass. If it is this range, there will be sufficient convergence effect and bitterness and astringency will be suppressed. More preferable content is 0.05-0.2 mass%, More preferably, it is 0.075-0.15 mass%.

  (B) Glycerin used for this invention has the effect | action which improves the taste of the polyvalent metal salt of a component (A). The content of glycerin is 2 to 9% by mass in the liquid oral composition from the viewpoint of maintaining the bitterness, astringency improving effect and astringent feeling during and after application of the composition of the present invention in the oral cavity, and more preferably. Is 2.5 to 8.5 mass%, more preferably 3 to 8 mass%. When the content of glycerin is small, the effect of improving the taste is not sufficient, and when it is too much, the sweetness is too strong, the aftertaste is deteriorated and the astringent feeling is lost.

  (C) Sucralose used in the present invention is an artificial sweetener and is contained in the liquid oral composition in an amount of 0.002 to 0.01% by mass. When the content is within this range, the interaction with (B) glycerin and (D) sugar alcohol reduces bitterness and astringency not only during application to the oral cavity but also after application. Will be better. The preferred content is 0.0025 to 0.009 mass%, particularly preferably 0.003 to 0.008 mass%.

  Examples of the (D) sugar alcohol used in the present invention include erythritol, xylitol, maltitol, mannitol, sorbitol, lactitol, α-D-glucopyranosyl-1,6-mannitol, α-D-glucopyranosyl-1,6-sorbitol and the like. Of these, erythritol, xylitol, and maltitol are preferable. These can be used alone or in combination of two or more. (D) Content of sugar alcohol is 0.5-10 mass% in a liquid oral cavity composition, 1-10 mass% is preferable, and 3-7 mass% is especially preferable. Within this content range, the astringent action of the polyvalent metal salt is maintained, and the bitterness and astringency improving effect during and after application in the oral cavity is good.

  The mass ratio (B / A) of the component (B) to the component (A) is 20 to 90, preferably 25 to 85, from the viewpoint of improving the bitterness and astringency without impairing the astringency. In particular, 30 to 80 is preferable.

  The mass ratio (C / A) between the component (C) and the component (A) is 0.02 to 0.1 from the standpoint of maintaining astringency and improving bitterness and astringency during application and aftertaste, Preferably it is 0.025-0.9, and 0.03-0.08 is especially preferable.

  In addition, the mass ratio (A / (B + C × 875)) of the component (A), the component (B), and the total amount of (C) adjusted in consideration of the sweetness degree is astringent, during application of the composition and after application From the point of the taste, 0.007 to 0.0135 is preferable, and 0.0077 to 0.0132 is more preferable.

  In addition, the total content of the component (B) and the component (D) is preferably 5 to 15% by mass, more preferably 6 to 12% by mass from the viewpoint of maintaining the astringent action and taste during and after application of the composition. Is preferred.

  The content of (E) water in the liquid oral cavity composition of the present invention is preferably 75 to 95% by mass, more preferably 77 to 93% by mass, and particularly preferably 80 to 93% by mass in terms of the feeling of use.

  The liquid oral composition of the present invention may contain (F) ethanol, but ethanol is preferably not contained from the viewpoint of bitterness and irritation, or preferably 10% by mass or less in the liquid oral composition. Further, it is preferably 8% by mass or less, and particularly preferably 6% by mass or less.

  In the liquid oral cavity composition of the present invention, in addition to the above components, for example, surfactants, wetting agents other than glycerin, pH adjusters, preservatives, bactericides, enzymes, medicinal components other than metal salts, pigments, dyes A fragrance or the like can be appropriately contained.

  Examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant. Of these, nonionic surfactants are preferable from the viewpoint of feeling of use, and polyoxyethylene hydrogenated castor oil is more preferable. The content of the nonionic surfactant is preferably 0.3 to 3% by mass, more preferably 0.5 to 1.5% by mass from the viewpoint of taste and solubility of the oil component.

  Examples of the wetting agent other than glycerin include polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, polypropylene glycol, and the like, and one or more of them can be combined.

  As a fragrance, 1-menthol, carvone, anethole, eugenol, limonene, peppermint oil, spearmint oil, ocimen, n-amyl alcohol, citronellol, α-terpineol, methyl salicylate, methyl acetate, citronole acetate, cineol, linalool, Examples include ethyl linalool, crocodile, thymol, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, perilla oil, clove oil, eucalyptus oil, hatsuka oil, anise oil, and winter green oil.

  Examples of the pH adjuster include monobasic acids such as lactic acid and sodium lactate and salts thereof, sodium hydroxide, potassium hydroxide, and the like, and these can be used in combination.

  The liquid oral cavity composition of the present invention is particularly useful as a mouthwash, liquid toothpaste, and mouthwash.

  Next, an Example is given and this invention is demonstrated.

Examples 1-7 and Comparative Examples 1-10
Mouthwashes with the compositions shown in Tables 1 and 2 were prepared, and 10 panelists contained 10 mL of the composition (mouthwash) in the mouth, and after squeezing for 20 seconds, the taste and astringency were felt by spitting out. evaluated. In addition, unless otherwise indicated in a table | surface, content of each component shows an effective amount (100% conversion value).

(1) Converging feeling Converging feeling was evaluated according to the following three-stage criteria, and indicated as an average value.
Evaluation criteria 1: Tighten 2: Tighten slightly 3: No change

(2) Astringency (in mouthwash) (after mouthwash)
The astringency during mouthwash evaluated the astringency when the composition was included in the mouth. The astringency after mouthwash evaluated the astringency after discharging the composition from the mouth. The degree of astringency was evaluated by the taste according to the following three levels, and the average value was shown.
Evaluation criteria 1: Not astringent 2: Not very astringent 3: Astringent

(3) Bitterness (in mouthwash) (after mouthwash)
The bitterness during the mouthwash was evaluated when the composition was contained in the mouth. The bitterness after mouth-washing evaluated the bitterness after discharging the composition from the mouth. The degree of bitterness was evaluated based on the following three levels, and the average value was shown.
Evaluation criteria 1: Not bitter 2: Not bitter 3: Bitter

  The results are shown in Tables 1 and 2.

  From Tables 1 and 2, the present invention comprises (E) a large amount of water and (A) a polyvalent metal salt, (B) glycerin, (C) sucralose, and (D) a sugar alcohol adjusted to a certain range. It can be seen that the liquid oral composition (mouth rinse) maintains a good astringent feeling while suppressing the bitterness and astringency during application to the oral cavity and after application, and good usability.

Claims (3)

The following components (A) to (E):
(A) 0.02 to 0.3% by mass of a water-soluble aluminum salt selected from allantoinchlorohydroxyaluminum and allantoindihydroxyaluminum ,
(B) Glycerin 2-9% by mass,
(C) Sucralose 0.002-0.01% by mass,
(D) erythritol, xylitol, and sugar alcohols 0.5 to 10 wt% selected from maltitol, and (E) water 75 to 93 wt%
The mass ratio (B / A) of the component (B) and the component (A) is 30 to 80 ,
Weight ratio of component (C) with component (A) (C / A) is Ri der 0.02 to 0.1, and a total content of 5-12 wt% of component (B) and the component (D) Oh Ru liquid oral compositions. (F) or not containing ethanol, or claim 1 Liquid oral composition according containing 10 wt% or less. The liquid oral cavity composition according to claim 1 or 2 , wherein the mass ratio (A / (B + C x 875)) of the component (A), the component (B), and the component (C) is 0.007 to 0.0135.