JP4849980B2 - Toothpaste composition - Google Patents

Description

  The present invention relates to a dentifrice composition containing erythritol.

  In general, the purpose of brushing teeth is to obtain a refreshing feeling and to clean the oral cavity to prevent diseases such as caries and periodontal disease. For example, as a countermeasure against periodontal disease, magnesium sulfate having an astringent action is often used as an active ingredient that gives an effective feeling to gums.

However, magnesium sulfate is a component having an unpleasant taste such as intense bitterness, sardine, and metal taste. If it is too small, it lacks an effective feeling, and if used in a large amount, it causes unpleasant taste such as sashimi. Therefore, it is desired to give a sufficient sense of effectiveness and improve an unpleasant taste. For example, regarding improvement of unpleasant taste such as magnesium salt of a liquid composition, for example, Patent Document 1 describes washing by using a sugar salt such as magnesium sulfate together with an organic acid such as malic acid. Methods have been described for improving the unpleasant taste of mouthpieces. Patent Document 2 describes an oral composition in which a magnesium salt is combined with tea or a tea extract and an organic acid such as citric acid or malic acid.
JP 2004-339158 A JP 2004-269416 A

However, in a composition having a high retention in the oral cavity such as a dentifrice, an unpleasant taste such as magnesium magnesium sulfate is particularly strong, and thus it has not been sufficiently improved by the above technique.
An object of the present invention is to provide a toothpaste composition that has a sufficient astringent action on gums and suppresses itching.

  The present inventor has an astringent effect on gums and an unpleasant taste such as gummy if erythritol having a certain particle size is present in a granular form in a dentifrice composition containing magnesium sulfate and water. It was found that a toothpaste composition having a good refreshing feeling was obtained.

That is, the present invention includes the following components (A) to (D):
(A) Erythritol having a particle size of less than 355 μm 5 to 60% by mass
(B) Magnesium sulfate 0.1-1% by mass
(C) Binder 0.3 to 10% by mass
(D) 1-30% by mass of water
The toothbrushing composition containing this is provided.

  Using the toothpaste composition of the present invention, magnesium sulfate having an astringent action can be efficiently dispersed in the oral cavity, giving an effective feeling to an excellent gum, and having no unpleasant taste such as gummy, Excellent refreshing feeling.

  In the toothpaste composition of the present invention, erythritol is dispersed and present in the form of powder or particles (hereinafter referred to as granules). Therefore, an unpleasant taste such as the stagnation of magnesium sulfate in the composition can be suppressed, and even a small amount can impart an effective feeling to the gums.

  In the present invention, (A) erythritol needs to be contained in a granular form in the dentifrice composition, and its particle size is less than 355 μm. In particular, the particle size of erythritol contained in the toothpaste composition is preferably 3 μm or more, particularly 20 μm or more, and more preferably 40 μm or more, in order to suppress the swallowing of the toothpaste composition due to magnesium sulfate and to give a refreshing feeling. It is preferable that Moreover, it is preferable that it is less than 300 micrometers, and 250 micrometers or less are especially preferable.

  The content of granular erythritol in the toothpaste composition is 5 to 60% by mass, and particularly preferably 10 to 45% by mass. Furthermore, erythritol is a water-soluble substance, and it is preferable to contain erythritol having a solubility or higher in the dentifrice composition in order to be contained in the dentifrice composition during storage as a product. It is preferable to blend an excess amount of erythritol with respect to the water content.

  In addition, in order to contain erythritol in a granular form, in the process of producing a toothpaste composition, after mixing main components such as water, a binder, magnesium sulfate, etc., granular erythritol may be added at the final stage. preferable. By using such a production method, the dissolution of erythritol in water can be adjusted, and it can be present in a granular state in the toothpaste composition. As a method for producing a dentifrice composition, for example, after mixing a magnesium sulfate, a binder, water and other components to sufficiently swell the binder and preparing a dentifrice mucus, a surfactant and an abrasive Or the like, and a method of manufacturing by adding granular erythritol having a particle diameter of less than 355 μm.

  When blended in the toothpaste composition, in consideration of the solubility of erythritol, it is preferable to blend at least a certain amount of erythritol having a particle size that does not dissolve and maintains a granular shape. In the present invention, the granular erythritol blended in the toothpaste composition preferably has a particle diameter of 3 μm or more, particularly 20 μm or more, and more preferably 40 μm or more. In addition, in consideration of dispersibility when contained in the oral cavity, particles having a particle size of 300 μm or less, particularly 200 μm or less are preferable. The blending amount of erythritol is preferably 10 to 65% by mass, particularly 15 to 65% by mass, and more preferably 20 to 55% by mass in the dentifrice composition.

  As the erythritol used in the present invention, those usually available can be used, and examples thereof include crystalline erythritol obtained by recrystallization after fermentation of glucose. As crystalline erythritol, commercially available products such as those manufactured by Nikken Chemical Co., Ltd., Mitsubishi Chemical Foods Co., Ltd., and Celestor are available. When the particle size is large, it is preferable to use a pulverized particle size adjusted. A roller mill, a hammer mill, a high-speed pulverizer, a pulverizer, etc. are generally used to pulverize erythritol, but a high-speed pulverizer and hammer mill that are easy to adjust the particle size and excellent in production efficiency. Is preferred.

  The structure of erythritol includes three isomers of L-erythritol, D-erythritol, and meso-erythritol, and the present invention may have any of these structures.

The erythritol particle size is measured as follows.
Sieve: JIS standard sieve φ75mm
Opening: From the upper stage, a receiver is provided under a sieve having openings of 500 μm, 355 μm, 250 μm, 180 μm, 125 μm, 90 μm and 45 μm, respectively.
Shaker: Micro type electromagnetic vibrator M-2 type (Tsutsui Rikenki Co., Ltd.)
Method: Place 15 g of sample on a 500 μm sieve and classify by shaking for 5 minutes with an electromagnetic vibrator. The total amount of erythritol present on a sieve having openings of 250 μm, 180 μm, 125 μm, 90 μm and 45 μm is defined as erythritol having a particle size of 45 μm or more and less than 355 μm.
The particle size distribution of less than 45 μm can be measured with a dry laser distribution diffraction particle size distribution measuring apparatus.

  (B) Magnesium sulfate is 0.1 to 1% by mass, especially 0.2 to 0.5% by mass in the dentifrice composition, taking into account the astringent feeling when it is contained in the oral cavity and the taste. It is desirable to do.

  (C) Examples of the binder include cellulose derivatives such as carrageenan, pectin, sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, alkali metal alginates such as sodium alginate, xanthan gum, tragacanth gum, gum arabic, guar gum Selected from gums such as karaya gum, locust bean gum, gellan gum, tamarind gum and psyllium seed gum, synthetic binders such as polyvinyl alcohol, sodium polyacrylate and polyvinylpyrrolidone, inorganic binders such as silica gel and aluminum silica gel, etc. And water-soluble polymers. These binders may be used alone or in combination of two or more, and the content thereof is usually 0.3 to 10% by mass based on the whole toothpaste composition, but 0.5% -8 mass% is preferable, and 1-5 mass% is especially preferable.

  (D) 1-30 mass% of water is contained in the dentifrice composition of this invention. In particular, it is preferable that the amount of erythritol is less than the amount of erythritol, particularly 5 to 20% by mass and 8 to 15% by mass, from the viewpoint of containing granular erythritol and suppressing the stagnation derived from magnesium sulfate.

  In addition to the above components, the toothpaste composition of the present invention includes, for example, foaming agents, abrasive powders, wetting agents, flavoring agents, sweetening agents, pH adjusting agents, preservatives, bactericides, enzymes, medicinal ingredients, pigments, A pigment | dye, a fragrance | flavor, etc. can be contained suitably.

  Foaming agents include anionic, nonionic, cationic, and amphoteric surfactants. Examples of the anionic surfactant include sodium lauryl sulfate, an amino acid surfactant, and a sulfosuccinic acid surfactant. Nonionic surfactants include polyglycerol fatty acid esters, sucrose fatty acid esters, fatty acid alkanolamide surfactants such as coconut oil fatty acid diethanolamide, polyoxyethylene hydrogenated castor oil, polyoxyethylene higher alcohol ether, polyoxyethylene Examples include ethylene fatty acid esters, alkyl glucosides, and polyoxyethylene polyoxypropylene copolymers. These foaming agents may be used alone or in combination of two or more, and the content thereof is usually preferably 0.01 to 40% by mass, particularly 0%, based on the entire dentifrice composition. 0.5 to 20% by mass is preferable. In particular, from the viewpoint of foaming properties, it is preferable to include sodium alkyl sulfate, and preferably an alkyl group having 8 to 18 carbon atoms, particularly 10 to 16 carbon atoms, and further 12 to 14 carbon atoms is used in an arbitrary ratio. Can do.

  Abrasive powders include silica-based abrasives such as precipitated silica, silica gel, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate and anhydrous, calcium pyrophosphate, calcium carbonate, alumina, aluminum hydroxide Magnesium acetate, tribasic magnesium phosphate, zeolite, synthetic resin-based abrasive and the like are preferably used. The abrasive powder can be used alone or in combination of two or more. When two or more types are used, two types having different physical properties, for example, combinations having different average particle diameters and RDA values can be used. Specifically, (i) one having an average particle diameter of 1 to 10 μm and an RDA value of 150 to 300 and (ii) one having an average particle diameter of 5 to 20 μm and an RDA value of 50 to 150 can be used in combination. The blending mass ratio of (i) :( ii) is preferably 50:50 to 5:95, and particularly preferably 40:60 to 10:90. These two types of abrasive powder do not need to be selected from the same type, and can be freely selected and used from the above-mentioned abrasive powders. Here, the RDA value (Radioactive Dentin Abrasion) is a scale indicating the abrasiveness of tooth brushing on dentin, and is an RDA test method (Hefferen, Journal of Dental Research 1976, No. 7, 8 p. 50). 563-573). The content of the abrasive powder is preferably 1 to 40% by mass in the dentifrice composition, particularly 5 to 30% by mass, and more preferably 10 to 20% by mass.

  Examples of the wetting agent include glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, polypropylene glycol, maltitol, lactitol, and the like. Can do. The content of these wetting agents is preferably 20 to 80% by mass, particularly 30 to 60% by mass in the dentifrice composition from the viewpoint of preparation of the dentifrice.

  As flavoring agents, l-menthol, carvone, anethole, eugenol, limonene, peppermint oil, spearmint oil, osimene, n-amyl alcohol, citronellol, α-terpineol, methyl salicylate, methyl acetate, citronole acetate, cineol, linalool , Ethyl linalool, crocodile, thymol, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, perilla oil, clove oil, eucalyptus oil, hatsuka oil, anise oil, winter green oil and the like.

  Examples of the sweetener include saccharin sodium, aspartame, sucralose, thaumatin, acesulfame potassium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartine, dextrose, acesulfame and the like.

  Examples of the pH adjuster include citric acid and its salt, phosphoric acid and its salt, malic acid and its salt, gluconic acid and its salt, maleic acid and its salt, aspartic acid and its salt, succinic acid and its salt, Examples include glucuronic acid and its salt, fumaric acid and its salt, glutamic acid and its salt, adipic acid and its salt, hydrochloric acid, alkali metal hydroxide and the like.

  As other various active ingredients, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid; allantochlorohydroxyaluminum, azulene, glycyrrhetinic acid, epidihydrocholesterin, α-bisabolol, glycyrrhizic acid and the like Anti-inflammatory agents such as salts; phenolic compounds such as hinokitiol; antiplasmin agents such as tranexamic acid and epsilon aminocaproic acid; vitamin Es of dl-tocopherol acetate; copper compounds such as copper chlorophyllin sodium and copper gluconate; sodium chloride; Salts such as potassium nitrate; bactericides such as quaternary ammonium compounds such as triclosan, cetylpyridinium chloride, benzethonium chloride, chlorhexidine salts, trichlorocarbanilide; dextranase, mutanase, amylase, chloride Enzymes such as lysozyme; extracts such as sugarcane, duck, clove, rosemary, ugone, safflower; aluminum lactate, strontium chloride, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, polyvinylpyrrolidone, dihydrocholesterol, citric acid Zinc etc. are mentioned.

[Preparation of toothpaste composition]
According to the formulation shown in Table 1, a dentifrice was prepared by the following method.

<Examples 1-5 and Comparative Examples 1-2>
Magnesium sulfate and a pigment were dissolved in a mixed solution of water, sorbitol solution, and glycerin. Separately, polyethylene glycol in which a binder (CMC, carrageenan) was dispersed was dissolved in the above mixed solution, and the binder was sufficiently swollen and cooled to obtain a gel-like mucus. A surfactant (Na lauryl sulfate), an abrasive (anhydrous silicic acid), and granular erythritol were mixed with the gel mucus and dispersed with a paddle mixer to obtain a dentifrice composition.

(1) Evaluation of Convergence Ten subjects took 1g of each brushing composition on a toothbrush and brushed freely for about 2 minutes. The coolness at the time of brushing and the strength of convergence after rinsing the mouth were as follows. Evaluated by criteria. In addition, the result of the determination shown in Table 1 shows the highest evaluation among 10 people.
<Evaluation criteria>
◎: I feel a clear sense of convergence ○: I feel a sense of convergence △: I feel weak but feel a sense of convergence ×: I do not feel a sense of convergence

(2) Evaluation of gummy 10 subjects took 1 g of each brushing composition on a toothbrush and brushed freely for about 2 minutes, and evaluated the strength of gummy after brushing according to the following criteria. In addition, the result of the determination shown in Table 1 shows the highest evaluation among 10 people.
<Evaluation criteria>
◎: Does not feel puffy at all ○: Does not feel puffy almost △: Feels weak puffy ×: Feels puffy

<Result>
Examples 1 to 5 of the present invention were dentifrices that had an astringent feeling and were sufficiently suppressed from being swallowed.
The comparative example 1 which does not contain erythritol has a strong puffy taste, and the astringent feeling hardly felt it. Comparative Example 2 having a low content of granular erythritol was inferior in astringency and low in the suppression of gummy.

Claims (3)

Next components (A) to (D)
(A) 5 to 60% by mass of granular erythritol having a particle diameter of less than 355 μm
(B) Magnesium sulfate 0.1-1% by mass
(C) Binder 0.3 to 10% by mass
(D) 1-30% by mass of water
A toothpaste composition comprising: Next components (A) to (D)
(A) Granular erythritol having a particle diameter of less than 355 μm 15 to 65% by mass
(B) Magnesium sulfate 0.1-1% by mass
(C) Binder 0.3 to 10% by mass
(D) Water 1-20 mass%
The toothpaste composition according to claim 1 obtained by blending.   The method for producing a dentifrice composition according to claim 1 or 2, wherein after mixing magnesium sulfate, a binder and water, granular erythritol having a particle size of 3 µm or more and less than 355 µm is added.