KR102044938B1 - Toothpaste composition for using pumping type container - Google Patents

Abstract

The present invention relates to a dentifrice composition for use in a pumped container comprising a liquid polyol and a sugar alcohol. The present invention solves the problem of hardening or rapid increase in viscosity due to the increase in viscosity or viscosity when the toothpaste composition is applied to a pump-type container in which contact with air is active, and provides a toothpaste composition having excellent emotional quality.

Description

Toothpaste composition for using pumping type container}

The present invention relates to a dentifrice composition for use in a pumped container, and more particularly to a dentifrice composition that can prevent the phenomenon of solidification in the pumped container.

Paste toothpaste, first developed by Colgate in the United States, was sold in aluminum tubes and used these tubes until the 1970s. The development of such a paste-type toothpaste container as a laminated film material, as in modern times, may be referred to as the development of polymer and polymer processing technology. However, in the case of such a tube-type toothpaste, it is a reality that there are many inconveniences in use due to the remaining amount during tube discharge and high viscosity of a paste-like product. In order to improve the loosening properties of the toothpaste, such as liquid toothpaste products having flow characteristics in a plastic container has been released, but if flows too well, it is difficult to effectively deliver the drug in the toothpaste products to the teeth and gums flowing on the toothbrush. In order to improve consumer convenience, the next application was to apply a vacuum pump-type plastic container to discharge high-viscosity paste. Some products are commercially available, but there is a price problem and loosening of existing paste toothpaste. This weak characteristic is present.

Generally, sorbitol is used as a humectant and a humectant used in paste. In the case of sorbitol is used to provide a 70% solution, but when water is dried there is a problem that is converted to a solid. For this reason, efforts have been made to improve consumer convenience by using deep pumps (dispenser pumps, pumping containers) used in shampoos or body washes. As a result, the contents are dried, the viscosity is increased, and the problem of not being discharged and even hardening occurs, which has not been sold commercially.

Liquid polyols that can solve the problem of hardening has a characteristic that gives a bitter taste there is a problem that is not favored by consumers emotionally. Therefore, the development of a technology for a toothpaste composition that can be used in a deep pump while solving the emotional discomfort by using a relatively low-cost and sweet solid polyol and a liquid polyol that can give a non-solid properties.

Therefore, the present invention is to solve the above problems, to provide a liquid toothpaste composition excellent in viscosity retention.

In addition, the present invention is to improve the ease of use by allowing the toothpaste composition to be used without the phenomenon of hardening due to viscosity changes.

The present invention is to provide a toothpaste composition that can be pumped without a sudden increase in viscosity and firmness even in the use of sugar alcohol in a container such as a vent pump deeply and can offset the bitter taste emotionally.

In order to solve the above problems, the present invention comprises a toothpaste composition for use in a pumped container, including both sugar alcohol and liquid polyol, preferably by using a sugar alcohol and a liquid polyol together in a pumped container, the contents are constant It is possible to maintain the viscosity, and provides a toothpaste composition with improved drying phenomenon.

The inventors of the present invention have found a problem that when the toothpaste composition is in direct contact with external air, such as a pumping container, the toothpaste composition is easily hardened and cannot serve as a toothpaste, thereby completing the present invention.

In particular, the sugar alcohol used as a moisturizing component of the toothpaste composition may have a moisturizing effect, but it has been found that the toothpaste composition easily hardens when the contacted water evaporates.

In order to improve the above problems, the inventors of the present invention was to encapsulate the sugar alcohol and the liquid polyol contained in the toothpaste composition by reacting with each other to encapsulate the liquid polyol surrounding the sugar alcohol, to prevent the exposure of the sugar alcohol.

As described above, the liquid polyol may exist as a structure surrounding the sugar alcohol, and the hydroxyl group or the ether group of the liquid polyol and the hydroxyl group of the sugar alcohol may form hydrogen bonds with each other. Because.

The inventors of the present invention have realized that the problem of the discharge due to the firmness and sudden viscosity change due to the hydrogen bond as described above can be solved and completed the present invention.

As used herein, the term "pumping, deep pump or dispenser pump" refers to a structure that can simply discharge the contents stored in the container to the outside through the discharge port through the pumping action using the pressing portion of the container. Specifically, it means a structure that discharges the toothpaste composition inside the container to the outside of the container through the pumping action of the piston, that is, the contents from the inner bottom of the container to the outside by the piston mounted inside the container by the pumping action May be discharged.

Referring to FIG. 1, the present invention will be described using sorbitol as an example.

Sorbitol has 6 hydroxy groups bonded to 6 carbons, and when the sorbitol is in contact with water, 6 waters are hydrogen-bonded to 1 sorbitol molecule to form crystallized water, It has a crystalline form and shows hardening properties.

Therefore, one or more of the six hydroxy groups covalently bonded to the six carbons contained in one molecule of sorbitol to form a hydrogen bond with the liquid polyol for use in the deep pump to reduce the hard or rapid viscosity change.

The sugar alcohol is also called a solid polyol, a solidified polyol, erythritol, arabitol, xylitol, ribitol, sorbitol, mannitol, galactitol, maltitol, lactitol or a mixture thereof can be used, to achieve the object of the present invention In view of the following, sorbitol may be preferably used, and there is no limitation in the form of sorbitol liquid, amorphous sorbitol, crystalline sorbitol, and the like.

The sugar alcohol may be included 1 to 70% by weight relative to the total weight of the composition.

If the content is less than 1% by weight sugar alcohol does not improve even if the sensitivity is improved, if it exceeds 70% by weight because the toothpaste composition may cause a problem.

The liquid polyol refers to a polyol present in the liquid phase at room temperature, rather than being dissolved in water and exhibiting wettability, such as sugar alcohol.

The liquid polyol prevents the drying phenomenon that may occur when the liquid toothpaste is in contact with the air to maintain a constant viscosity of the liquid toothpaste, and thus serves to prevent the contents from solidifying.

As the liquid polyol, polyethylene glycol 200 to 600, glycerol, propylene glycol, ethylene glycol, polypropylene glycol, or a mixture thereof may be used, and in terms of achieving the object of the present invention, glycerol, polyethylene glycol 300 or Mixtures of these may be used.

The liquid polyol may include 10 wt% to 85 wt% based on the total weight of the composition, and a molar ratio of the hydroxyl group or the ether group of the liquid polyol hydrogen-bonded with the hydroxy group of the sugar alcohol may be 0.2 times or more.

When the liquid polyol is included in an amount of more than 85% by weight based on the total weight, a problem occurs in that the formulation is not made. When applying the composition of the hardening or there may be a problem that the viscosity rises sharply.

When the liquid polyol has a high content ratio of hydroxy groups to carbon, such as glycerin or propylene glycol, but a low molecular weight, the sugar alcohol and the liquid polyol have a strong hydrogen bonding force. However, since there is a problem that re-separation and rearrangement can easily occur due to the vapor pressure, it can solve the problem of the toothpaste composition hardening and a sudden change in viscosity at the above ratio.

In addition, when the liquid polyol has a high molecular weight, such as polyethylene glycol, the high molecular weight liquid polyol and the sugar alcohol are hydrogen-bonded to encapsulate the sugar alcohol. When the molar ratio is at least 1: 0.2, it can suppress the change in the hard or abrupt viscosity.

Liquid toothpaste composition of the present invention further comprises a liquid polyol in addition to the abrasive.

The toothpaste composition of the present invention, in addition to the sugar alcohol and liquid polyol, the toothpaste composition of the present invention is a conventional component according to the formulation and the purpose of use, abrasives, flavoring agents, sweeteners, pharmaceutical agents, pH adjusters, preservatives, binders, foaming agents It may further include a brightener.

The abrasive may include any one selected from the group consisting of calcium hydrogen phosphate, precipitated silica, fumed silica, colloidal silica, zeolite, calcium carbonate, hydrous alumina, kaolin, cellulose, and mixtures thereof.

The abrasive may be included in less than 50% by weight, even if the abrasive is not used can be expected to remove the plaque by the solids and toothbrush in the toothpaste, if exceeding 50% by weight can cause tooth damage.

Flavoring agents and sweetening agents can be added to the composition of the present invention to suit consumer preferences. Flavoring agents remain in the oral cavity and continually exude fragrance to help maintain freshness.

As a flavoring agent, mints such as peppermint and spearmint, and fragrances such as menthol, eucalyptol, anetol, thymol, etc., which can enhance freshness, can be used.Wintergreen, methyl salicylate, eugenol, melon, strawberry, orange, Vanillin and the like can be used.

Generally, flavoring agents can be used in the range of 0.001 to 10% by weight of the total weight of the composition.

In addition, sweeteners may be added to the compositions of the present invention to overcome the basic taste the formulation may have. Sweeteners persist in the development of saliva by providing a lasting taste while remaining in the mouth.

As the sweetener, one or two or more kinds of saccharin, sucralose, sugar, xylitol, sorbitol, lactose, mannitol, maltitol, erythritol, aspartame, taurine, saccharin salt and D-tryptophan may be used. Among saccharin salts, saccharin sodium is the most widely used. The amount of sweetener is generally used in the range of 0.001 to 20% by weight of the total weight of the composition.

As a medicinal agent used for oral hygiene, it is possible to use ingredients such as caries prevention, gum disease prevention, tartar deposition prevention, and whitening. Drugs used to prevent tooth decay include compounds recognized as safe by the US Food and Drug Administration, including fluoride ions. Examples of the compound that can be used as a source of fluorine ions include sodium fluoride, sodium monofluorophosphate, tin fluoride, and ammonium fluoride.

The amount of fluorine may vary depending on the country, but it is common to use one or two or more kinds of these sources, preferably to have a fluorine ion concentration in the range of 850 to 1500 ppm.

Remineralizing agents can also act as a caries preventer. Remineralization plays a role in regenerating and restoring hydroxyapatite, a major component of teeth. The main component of hydroxyapatite consists of divalent calcium cations and phosphate anions. Therefore, it can be a remineralizing agent if it contains at least one of calcium divalent ions or phosphate anions so as to simultaneously supply calcium ions and phosphate ions or to shift chemical equilibrium in the oral cavity toward the formation of hydroxyapatite. Substances that provide calcium and phosphorus include hydroxyapatite, dicalcium phosphate, calcium chloride, casein phosphate, calcium glycophosphate, sodium monophosphate, dibasic sodium phosphate, sodium triphosphate, potassium monophosphate, This includes potassium diphosphate, potassium triphosphate, and the like. In general, the remineralizing agent is preferably used in the range of 0.001 to 20% by weight of the entire composition. If it is less than 0.001% by weight, the remineralization effect is lowered. If it is more than 20% by weight, the agent may lose its original properties.

One purpose of using oral hygiene products is to prevent gum disease as well as to alleviate gum disease that is progressing through antiseptic or anti-inflammatory action against harmful microorganisms in the oral cavity that survive in the oral cavity. For this purpose, isopropylmethylphenol, cyclohexidine, cetylpyridinium chloride, triclosan, xantholizol, and thick extract, which are known as antimicrobial agents, can be used, and for the anti-inflammatory action, centella asiatica quantitative extract and dipotassium glycyrizine Vitamins and enzymes, aminocaproic acid, allatoin and derivatives thereof may also be used. The agonist is characterized by containing 0.005% to 5% by weight. If the drug content is less than 0.005 it is difficult to show the drug, when containing more than 5% by weight has the disadvantage of changing the taste of the basic basin.

In addition to gum disease, hydrogen peroxide, carbamide peroxide, calcium peroxide, and the like, which have a whitening effect, may be used, and sodium pyrophosphate, acidic pyrophosphate, potassium pyrophosphate, sodium metaphosphate, etc. may also be used to obtain tartar deposition inhibitory effect. Generally, these agonists are generally used in the range of 0.001 to 10% by weight of the total weight of the composition.

As the pH adjuster, phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium stannate and the like can be used, the acidity of the composition for oral cavity is generally 5 to 8.

As the binder, carboxymethyl cellulose sodium, carbomer, carrageenan, xanthan gum, alginate and the like may be used alone or in combination of two or more thereof. The amount of the binder is generally 0.1 to 5% by weight, preferably 0.5 to 3% by weight based on the total weight of the composition for oral cavity.

Benzoic acid, methyl paraben, propyl paraben, sodium benzoate, etc. can be used as a preservative.

Examples of the foaming agent include sodium alkyl sulfate, sodium lauryl sulfate, alkyl salucinate, lauryl salucinate, cocoyl glutamate sodium salt, myrithroyl glutamate sodium salt, cocamidopropyl betaine, sucrose fatty acid ester, and sorbitan fatty acid ester. And anionic, amphoteric, and nonionic surfactants such as copolymers of polyoxyethylene polyoxypropylene (poloxamer) can be used alone or in combination of two or more thereof.

The amount of such foaming agent is generally 0.2 to 5% by weight, preferably 0.5 to 3.5% by weight based on the total weight of the composition for oral cavity.

Titanium oxide is used as the brightener, and preferably 0.1% to 2% by weight.

The method for preparing the dentifrice composition of the present invention may be prepared according to a method commonly prepared in the art.

The present invention provides a dentifrice composition having an improved hardening problem by contact with an external atmosphere.

The toothpaste composition of the present invention is improved in the phenomenon that the hardening or sudden increase in viscosity occurs when applied to the pump-type container is easy to enter the outside air.

In the industry, the toothpaste composition hardens due to contact with external air despite the convenience of use of the pumping container, and there is a problem in that it is difficult to use the toothpaste composition in the pumping container. It is possible to solve the problem and develop a convenient formulation.

Therefore, the present invention has a great advantage that the manufacturing cost of the product can be lowered by applying a pump type container that can be manufactured inexpensively and conveniently instead of the vacuum pump type, which has been heavily invested in the industry.

In particular, the present invention solves the problem of the toothpaste hardening while providing a good emotional quality by reacting the liquid polyol was not good quality with sugar alcohol.

Figure 1 shows the mechanism by which glycerin prevents direct contact of sorbitol with water.
2 is a view showing a mechanism for minimizing the direct contact of sugar alcohol with water using polyethylene glycol 300, a high molecular weight liquid polyol.

Hereinafter, the following examples and the like will be described in order to describe the present invention in more detail. However, embodiments according to the present invention can be modified in many different forms and the scope of the present invention should not be construed as being limited to the embodiments described below. Embodiments of the present invention are provided by way of example in order to facilitate a specific understanding of the present invention.

Example  1 to 5 and Comparative example  1 to 2

Toothpaste compositions of Examples and Comparative Examples were prepared with the components and composition ratios shown in Table 1 below. The liquid polyol and the solid polyol (or sugar alcohol) are mixed first to induce hydrogen bonds, and secondly, the powder components such as agonists, xanthan gum, saccharin, preservatives, and surfactants are completely dispersed in purified water and flavor solution. After mixing the mixture, and then, if necessary, an abrasive such as silica and a medicament were added and mixed under vacuum to prepare a toothpaste composition.

The following content units are by weight.

Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 1 Comparative Example 2 Precipitated silica 0.00 15.00 15.00 15.00 15.00 0.00 15.00 glycerin 35.00 35.00 30.00 20.00 10.00 5.00 5.00 Sorbitol 70% solution 45.00 45.00 45.00 45.00 45.00 50.00 50.00 Sodium lauryl sulfate 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Saccharin Sodium 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Paraoxybenzoic acid ester 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Xanthan Gum 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Vitamin E 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Spices 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Purified water 15.23 0.23 5.23 15.23 25.23 40.23 25.23

Example  6 to 10 watts Comparative example 3 to  4

Toothpaste compositions of Examples and Comparative Examples were prepared with the components and composition ratios shown in Table 2 below. The liquid polyol and the solid or solidified polyol are mixed first to induce hydrogen bonds, and the second component is completely dispersed by dispersing powder components such as agonists, xanthan gum, saccharin, preservatives and surfactants in the fragrance. Next, an abrasive and an agonist such as silica were added thereto, and mixed under vacuum to prepare a toothpaste composition.

Example
6 Example
7 Example
8 Example
9 Example
10 Comparative example
3 Comparative example
4 Precipitated silica 15.00 15.00 15.00 15.00 15.00 15.00 15.00 glycerin 20.00 20.00 10.00 5.00 Polyethylene Glycol 300 20.00 10.00 5 Propylene glycol 20.00 Sorbitol 70% solution 50.00 50.00 40.00 40.00 40.00 60.00 60.00 Erythritol 10.00 Xylitol 10.00 10.00 Sodium lauryl sulfate 2.00 2.00 2.00 2.00 2.00 2.00 2.00 Saccharin Sodium 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Paraoxybenzoic acid ester 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Xanthan Gum 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Vitamin E 0.20 0.20 0.20 0.20 0.20 0.20 0.20 Spices 1.00 1.00 1.00 1.00 1.00 1.00 1.00 Purified water 10.23 10.23 10.23 10.23 10.23 15.23 15.23

Example  And Comparative Example  Liquid Polyol / Of solid phase (solidifying) polyols  ratio

The ratio of the liquid polyol and the solid polyol of the Examples and Comparative Examples of Tables 1 and 2 was measured by using the oxygen-containing water to the carbon number, for example, the number of oxygen in the hydroxyl group of glycerin is 3 per molecule In the case of sorbitol, the number of hydroxy groups per molecule was 6, and in the case of 70% liquid, the ratio was calculated by multiplying 0.7 by the number of moles of oxygen.

Example Example Example Example Example Comparative example Comparative example One 2 3 4 5 One 2 Liquid polyol / solid polyol hydroxy group molar ratio 1.10 1.10 0.94 0.63 0.31 0.14 0.14 Example
6 Example
7 Example
8 Example
9 Example
10 Comparative example
3 Comparative example
4 Liquid polyol / solid polyol hydroxy group molar ratio 0.35 0.46 0.52 0.52 0.29 0.12 0.07

As shown in Table 3, it was confirmed that the molar ratio of the solid polyol (sugar alcohol) and the liquid polyol showed a value of 0.2 or more in the examples, and in the case of Comparative Examples 1 to 4, the values were less than 0.2. .

Viscosity Changes Over Time

In order to observe the change in viscosity with time of Examples and Comparative Examples of Tables 1 to 2 was carried out the following experiment.

Viscosity measurement

For the toothpaste prepared in Examples 1 to 10 and Comparative Examples 1 to 4 of Tables 1 to 2 immediately after the preparation and in a dip pump 2 months and 12 months after the viscosity change at 25 ℃ Brookfield Viscometer (DV- Ⅲ Ultra Rheometer) RVT type was used to measure the viscosity value by rotating the rotational speed at a speed of 10 revolutions per minute using the spindle number 7, the results are shown in Table 4 below.

Viscosity (× 1,000 cP) Right after manufacturing 1 month 12 months Example 1 25.6 34.9 41.5 Example 2 25.1 32.3 42.8 Example 3 25.6 31.1 41.0 Example 4 25.2 34.5 40.2 Example 5 25.7 31.8 43.5 Example 6 25.4 33.2 40.1 Example 7 25.8 32.8 40.6 Example 8 25.3 33.1 40.2 Example 9 25.5 33.0 43.1 Example 10 25.9 34.8 44.0 Comparative Example 1 25.2 54.5 More than 200 Comparative Example 2 25.5 54.0 More than 200 Comparative Example 3 25.5 53.9 More than 200 Comparative Example 4 25.8 54.3 More than 200

According to the content of sorbitol used as a comparative example, when it was left for 12 months at room temperature, it was found that the measurement of viscosity was impossible due to the phenomenon of the surface of toothpaste hardening. Was observed. However, even when the abrasive content is increased in the change of properties according to the abrasive content, the viscosity change does not appear to be significant. Epic no significant change in viscosity over time was observed. When the low content of liquid polyol is contained, the viscosity change over time is remarkable. When the low content of liquid polyol and solid polyol is contained at the same time, the viscosity increases sharply and then hardens after long time. I could confirm This can be hoped that the low content of the liquid polyol was able to maintain the discharge characteristics at the beginning, but it is difficult to discharge over time. In addition, it was confirmed that the discharge characteristics did not change when the dip pump was used due to the rapid viscosity change even when the type and content of the abrasive and the liquid polyol were used. Therefore, it was confirmed that the combination of the liquid polyol and the abrasive allows the use of a deep pump without a sudden viscosity change and hardening in an air-flowing container.

Deep pump Discharge

After applying the toothpaste composition prepared by the method of Examples 1 to 10 and Comparative Examples 1 to 4 to a 250 milliliter capacity deep pump was continuously pumped to the remaining amount to 20 grams or less to evaluate the discharge characteristics. The results are shown in Table 5.

Discharge characteristics Early 1 month 12 months Example 1 Discharge completed Discharge completed Discharge completed Example 2 Discharge completed Discharge completed Discharge completed Example 3 Discharge completed Discharge completed Discharge completed Example 4 Discharge completed Discharge completed Discharge completed Example 5 Discharge completed Discharge completed Discharge completed Example 6 Discharge completed Discharge completed Discharge completed Example 7 Discharge completed Discharge completed Discharge completed Example 8 Discharge completed Discharge completed Discharge completed Example 9 Discharge completed Discharge completed Discharge completed Example 10 Discharge completed Discharge completed Discharge completed Comparative Example 1 Discharge completed 200 milliliters No discharge Comparative Example 2 Discharge completed 200 milliliters No discharge Comparative Example 3 Discharge completed 195 milliliters No discharge Comparative Example 4 Discharge completed 190 milliliters No discharge

When the hydroxyl group molar ratio of the solid polyol and the liquid polyol used as the comparative example was less than 0.2, all contents were discharged after the initial preparation, but after 1 month, the contents were not completely discharged and about 1/5 of the contents remained. After 12 months, it was found that discharge was impossible in all the comparative examples.

It could be confirmed that even when the liquid polyol contained a molar ratio of 0.2 or less, a sudden viscosity change and a hardening phenomenon were exhibited.

On the other hand, in the case of Example, the viscosity was increased by the evaporation of water, but the viscosity was gradually increased by the hydroxy period hydrogen bonding of the liquid polyol and the solid polyol, but it was found that the hardening phenomenon could be prevented. Even in all the toothpaste composition was confirmed that no remaining. This can be said that the rapid change in viscosity when using the solid polyol to be achieved in the present invention is a phenomenon that the solid polyol occurs by evaporation of water and exposed to the surface of the pump.

Claims (4)

Toothpaste composition stored in the pumping type container in which the outside air is introduced is discharged to the outside by the pumping action of the piston from the inside of the container,
The toothpaste composition may be sugar alcohol, which is erythritol, arabitol, xylitol, ribitol, sorbitol, mannitol, galactitol, maltitol, lactitol or a mixture thereof; And
Polyethylene glycol 200 to 600, glycerol, propylene glycol, ethylene glycol, polypropylene glycol or a mixture of liquid polyols thereof, and all
The molar ratio of the hydroxy group of the sugar alcohol and the hydroxy group or ether group of the liquid polyol is at least 1: 0.2,
The liquid polyol is 10 wt% to 85 wt% based on the total weight of the composition,
A pumping toothpaste product that improves the hardening of the toothpaste composition stored in the pumping container in which external air is introduced by combining the sugar alcohol and the liquid polyol. The pumping toothpaste product of claim 1, wherein the liquid polyol is glycerol, polyethylene glycol 300 or a mixture thereof. The pumping dentifrice product according to claim 1, wherein the sugar alcohol contains 1 to 60% by weight based on the total weight of the composition. The pumping toothpaste product according to claim 1, wherein at least one hydroxy group of the sugar alcohol is hydrogen bonded to the hydroxy group or the ether group of the liquid polyol.

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