KR101792198B1 - Oral care composition - Google Patents

Abstract

The present invention relates to a dentifrice composition comprising xanthan gum and an incrementing polymer, and more particularly to a composition exhibiting excellent elasticity even at low viscosity due to the synergistic effect of xanthan gum and a gradual polymer. The dentifrice composition of the present invention has substantially no change in viscosity with time, and is remarkably improved in shape retention, flowability and dispersion stability.

Description

Oral care composition

The present invention relates to a composition for oral care, and more particularly, to a composition for oral care having excellent formability, flowability and dispersion stability.

Generally, toothpastes can be divided into a high-viscosity paste formulation in the form of a tube and a liquid toothpaste in a low viscosity.

In case of paste toothpaste, dispersion stability is favorable, and it is advantageous to formulate various active ingredients, and it is advantageous to maintain shape after distributing toothpaste to toothbrush from a container because of its good shape. However, fluidity is insufficient due to high viscosity, And there is a lot of disadvantages in usage which requires a lot of force.

On the other hand, liquid toothpaste has excellent releasability, but has poor dispersion stability, which limits the formulation of various active ingredients, resulting in phase separation of toothpaste formulation during distribution or use, resulting in loss of commerciality. In addition, since the toothbrush is insufficiently formed, the toothpaste can not be maintained in a uniform shape after the toothpaste is dispensed from the toothbrush.

Korean Patent Application No. 2001-7004081 discloses a liquid tooth cleaning gel in which the ratio of water to wetting agent is adjusted. However, there is a problem in the formability and fluidity of the liquid tooth cleaning gel. In Korean Patent Application No. 2002-0053430, it was tried to improve the formability and fluidity by using casein sodium. However, it is not sufficient to give a feeling of comfortable feeling to consumers, and the problem that the quality of sensibility is poor due to casein sodium have.

In addition, in the case of such a general high-viscosity paste toothpaste or liquid toothpaste, it is not applicable to various types of containers. In the case of a high-viscosity paste type toothpaste, it is difficult to discharge by applying a deep tube type pump, and when the time passes, the viscosity is further increased to make it impossible to discharge. In case of liquid toothpaste, Do.

Therefore, it is characterized by having elasticity even at a low viscosity, and there is little change in viscosity with time, and it is required to develop an oral composition which can be applied to various containers and methods of use by greatly improving the formability, flowability and dispersion stability .

SUMMARY OF THE INVENTION Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and an object of the present invention is to provide a composition for oral care having high shape retention ability.

The present invention also provides a composition for oral care with improved fluidity and dispersion stability.

Further, the oral care composition of the present invention can be applied to various containers to improve convenience in use.

In order to solve the above problems, the present invention provides a dentifrice composition containing elasticity, including xanthan gum, having elasticity even at low viscosity, including a xanthan gum and an incrementing polymer.

Particularly, the present invention provides a dentifrice composition which hardly causes a change in viscosity with time, and has excellent formability, fluidity and dispersion stability. Further, the present invention is characterized in that the shape-retaining, flowability and dispersion stability are improved as described above, so that there is no particular limitation on the method of use and the container to be used, so that the present invention can be applied to various types of products.

The inventors of the present invention have found the surprising fact that when xanthan gum, particularly xanthan gum and incrementing polymer, are included together, it imparts excellent elasticity to the dentifrice composition and improves the formation of the dentifrice composition and completes the present invention.

Therefore, the dentifrice composition of the present invention can be applied to a pumping-type container because of the physical properties as described above, thus providing ease of use.

The term " elastic " used in the present invention means a property that an object deformed by an external force tends to return to its original shape when a force is removed, and means a characteristic of an object It was used as a broad concept. That is, the dentifrice composition is used in a broad sense including all properties that attempt to maintain the initial shape and height after discharging the dentifrice composition at the discharge port.

The term 'dip pump, pumping type or dispenser pump' as used herein refers to a structure capable of simply discharging contents stored in a container through a discharge port through a pumping operation using a pressing portion of the container. Specifically, it means that the dentifrice composition inside the container is discharged to the outside of the container through the pumping action of the piston. That is, by the piston pumped into the container by the pumping action, Can be discharged.

Further, the inventors of the present invention have found that when the xanthan gum, preferably xanthan gum and the incrementing polymer are included together, there is a lack of fluidity in a conventional high viscosity paste type product, and an excessive force is required when the product is discharged from a tube. And the like. In addition, the present invention has been completed on the basis of the findings that it is possible to improve the dispersion stability and the problem of formation of the toothpaste in liquid toothpaste.

In particular, it is an object of the present invention to provide a dentifrice composition which can maintain a uniform shape even at a low viscosity in order to simultaneously solve the problems of paste toothpaste and liquid toothpaste.

As used herein, the term "low viscosity or low viscosity" refers to a viscosity of from 5,000 to 20,000 cps at 25 ° C, Brookfield, RV-5, 20 rpm, preferably at 25 ° C, Brookfield, RV-5, 20 rpm, ≪ / RTI >

Also, as used herein, the term " high viscosity or high viscosity " refers to viscosity not measured at 25 ° C, Brookfield, RV-5, 20 rpm.

Wherein the incremental polymer is selected from the group consisting of starch, carbomer, gellan gum, gelatin, guar gum, locust bean gum, alginic acid, arabinogam, carrageenan, agar, pectin, leish, cellulose and derivatives thereof Or more.

The cellulose and derivatives thereof include any one selected from the group consisting of carboxymethylcellulose sodium, hydroxymethylcellulose, hydroxypropylmethylcellulose, methylethylcellulose, and mixtures thereof.

The dentifrice composition of the present invention may contain more than 0.5 wt% to less than 3 wt% of xanthan gum, preferably 1 to 2.8 wt%, more preferably 1.5 to 2.5 wt%, based on the total weight of the composition.

If the amount of the xanthan gum is less than 0.5% by weight, the dentifrice composition will have a liquid form and the effect of imparting elasticity will be insufficient. If the amount is more than 3% by weight, Which causes discomfort.

In addition, the dentifrice composition of the present invention may further comprise 0.05 to 1% by weight based on the total weight of the composition.

When the content of the incrementing polymer is less than 0.05% by weight, the effect of imparting elasticity is weak. When the content of the incrementing polymer is more than 1% by weight, the increase of the cost is increased compared with the increase of the effect, .

The dentifrice composition of the present invention may have a viscosity of 5,000 to 20,000 cP at 25 ° C, Brookfield, RV-5, 20 rpm, preferably 5,000 to 20,000 cps at 25 ° C, Brookfield, RV- cP. < / RTI >

The dentifrice composition having such a viscosity has been found to be excellent in shape retention when a product is made into a product, and thus the present invention has been completed. Particularly, when the composition is discharged from a container having a diameter of 0.3 to 1.0 cm from the container in an area of 2 cm in width and 1 cm in length, the initial height is 0.15 to 0.55 cm, the height is 0.1 to 0.45 cm after 30 seconds .

The inventors of the present invention have found that the dentifrice composition of the present invention has the above-mentioned characteristics. It has been found through experiments that the viscosity of the toothpaste of the present invention has elasticity even at a viscosity lower than that of a conventional paste dentifrice, Respectively.

In addition to the xanthan gum and the thickening polymer, the dentifrice composition of the present invention can be used as a wetting agent, an abrasive, a flavoring agent, a sweetener, a pharmacological agent, a pH adjuster, a preservative, Foaming agents, brighteners, and the like.

The wetting agent may be used alone or in combination of a group consisting of concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycols and propylene glycol, and the amount thereof is 1 to 70% by weight based on the total weight of the oral care composition .

The abrasive may be one selected from the group consisting of precipitated silica, silica gel, zirconium silicate, calcium monohydrogenphosphate, anhydrous calcium hydrogenphosphate, hydrated alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate and aluminum silicate Etc. may be used. The amount of the abrasive to be used is generally 1 to 60% by weight based on the total weight of the oral composition.

A flavoring agent and a sweetening agent may be added to the composition of the present invention to suit the taste of the consumer. Flavors remain in the mouth and continue to emit fragrance so that the exhilaration can continue.

Melt such as peppermint and spearmint, wintergreen, methyl salicylate, yugenol, melon, strawberry, orange, vanillin and the like can be used as the flavoring agent.

In general, the flavoring agent may be used in the range of 0.001 to 10% by weight of the total composition weight.

In addition, a sweetening agent may be added to the composition of the present invention to overcome the basic taste that the formulation may have. The sweetener keeps saliva in the oral cavity by continuing to provide taste.

As the sweetening agent, saccharine, sucralose, sugar, xylitol, sorbitol, lactose, mannitol, maltitol, erythritol, aspartame, taurine, saccharin salt and D-tryptophan may be used alone or in combination. Among saccharin salts, saccharin sodium is the most widely used. The amount of the sweetener is generally in the range of 0.001 to 20% by weight based on the total weight of the composition.

The medicinal effective agent used for oral hygiene may be a composition having effects such as prevention of tooth decay, prevention of gum disease, prevention of dental calculus deposition, and whitening. Medicinal products for tooth decay include compounds recognized as safe by the US Food and Drug Administration, including fluoride ions. Compounds that can be used as a source of fluoride ions include sodium fluoride, sodium fluorophosphate, tin fluoride, and ammonium fluoride.

Although the content of fluorine may vary depending on the country, it is common to use a mixture of one or more of these sources so as to have a fluoride ion concentration preferably in the range of 850 to 1500 ppm.

Remineralizers may also act as a preventative for cavities. Remineralization plays a role in regenerating and restoring hydroxyapatite, a major component of teeth. The main component of hydroxyapatite consists of divalent calcium cations and phosphate anions. Therefore, if calcium ion or phosphate ion is supplied at the same time, or calcium ion or phosphate anion is contained in the oral cavity to move the hydroxyapatite to the side where the chemical equilibrium is generated, it can be a remineralizing agent. The material providing calcium and phosphorus is selected from the group consisting of hydroxyapatite, calcium phosphate dibasic, calcium chloride, casein phosphopeptide, calcium glycerophosphate, sodium phosphate monobasic, sodium phosphate dibasic, sodium monophosphate, potassium monophosphate, Potassium phosphate dibasic, potassium phosphate dibasic and the like. In general, it is preferable to use the resealing agent in the range of 0.001 to 20% by weight of the total composition. If the amount is less than 0.001% by weight, the effect of re-crystallization is deteriorated. If the amount is more than 20% by weight, the properties inherent to the formulation are lost.

One of the purposes of using oral hygiene products is to prevent gum disease as well as to alleviate gum disease which is progressing through sterilization or anti-inflammatory action of harmful microorganisms in oral cavity which are alive in the oral cavity. For this purpose, it is possible to use isopropylmethylphenol, cyclohexidine, cetylpyridinium chloride, triclosan, xanthorizole and the like which are known as antimicrobial agents. In order to have anti-inflammatory action, vitamins and enzymes, aminocaproic acid, Derivatives and the like can also be used. The pharmaceutical agent is characterized by containing 0.005 wt% to 5 wt%. When the content of the active agent is less than 0.005, it is difficult to exhibit its effect. When the content exceeds 5% by weight, the taste of the basic base is changed.

In addition to gum disease, hydrogen peroxide, carbamide peroxide, and calcium peroxide, which exhibit a whitening effect, can be used. Sodium pyrophosphate, sodium pyrophosphate, sodium pyrophosphate, sodium metaphosphate and the like are also used to obtain dental deposit inhibition effect. Generally, these pharmacologically active agents are generally used in the range of 0.001 to 10% by weight of the total weight of the composition.

As the pH adjusting agent, phosphoric acid, sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium tartrate and the like can be used, and the acidity of the composition for oral use is generally 5 to 8.

As foaming agents, anionic and nonionic surfactants such as sodium alkylsulfate, sodium laurylsulfate, sucrose fatty acid esters and sorbitan fatty acid esters can be used singly or in combination of two or more.

As the preservative, benzoic acid, methylparaben, propylparaben, sodium benzoate and the like can be used.

As foaming agent, a copolymer of sodium lauryl sulfate, an anionic surfactant, polyoxyethylene polyoxypropylene (non-ionic surfactant), polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester and the like can be used . The amount of the foaming agent to be used is generally 0.5 to 5% by weight, preferably 0.5 to 3.5% by weight, based on the total weight of the oral composition.

The brightener is titanium oxide, suitably used in an amount of 0.1% to 2% by weight.

The method for producing the dentifrice composition of the present invention can be produced according to a method conventionally produced in the art.

The dentifrice composition according to the present invention can have excellent elasticity even at a low viscosity.

In addition, there is almost no change in viscosity with time, and the invention has remarkably improved formability, fluidity and dispersion stability.

Disclosed is a dentifrice composition which solves the problems of general paste type toothpaste and liquid toothpaste, and is applicable to various containers and methods of use.

A dentifrice composition and a pumped product that can be applied to a pump-type container using the physical properties of the dentifrice composition of the present invention.

FIG. 1 is a view showing a toothpaste discharging table for confirming the formation of a toothpaste composition.
FIG. 2 is a view showing a state in which the pump is damaged because the contents are not properly discharged from the pump-type container.
Fig. 3 is a questionnaire for consumer evaluation for consumer evaluation of the dentifrice composition of the present invention.
FIG. 4 is a graph showing the result of a consumer evaluation of the dentifrice composition of the present invention. FIG.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. The embodiments of the present invention are provided by way of example to facilitate a specific understanding of the present invention.

The oral compositions (Examples 1 to 9) according to the present invention and the conventional oral compositions (Comparative Examples 1 to 4) for comparison were prepared at the composition ratios shown in Tables 1 and 2 below.

The preparation method is as follows: Powder components such as a sorbitol aqueous solution and a glycerin, which are wet components, are dispersed and diluted with purified water, followed by primary mixing in a mixer, then an abrasive such as dental type silica and xanthan gum And finally, sodium lauryl sulfate as a foaming agent, perfume ingredients and the like were added and mixed in a vacuum state to prepare an oral composition. In the following Tables 1 and 2, the unit is% by weight.

Examples 1 to 7 Name Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Precipitated silica 14.0 14.0 14.0 14.0 14.0 14.0 14.0 Concentrated glycerin 30.0 30.0 30.0 30.0 30.0 30.0 30.0 Sorbitol aqueous solution 30.0 30.0 30.0 30.0 30.0 30.0 30.0 Sodium lauryl sulfate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Spices 1.0 1.0 1.0 1.0 1.0 1.0 1.0 saccharin 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Xanthan gum 0.5 1.0 2.0 3.0 1.0 1.0 1.0 Increasing polymer 0 0 0 0 Carboxymethylcellulose sodium 0.3 Carbomer 0.3 Gellangom 0.3 Purified water To100 To100 To100 To 100 To100 To100 To100

Comparative Examples 1 to 6 Name Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Precipitated silica 14.0 14.0 14.0 14.0 14.0 14.0 Concentrated glycerin 30.0 30.0 30.0 30.0 30.0 30.0 Sorbitol aqueous solution 30.0 30.0 30.0 30.0 30.0 30.0 Sodium lauryl sulfate 1.0 1.0 1.0 1.0 1.0 1.0 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 Spices 1.0 1.0 1.0 1.0 1.0 1.0 saccharin 1.0 1.0 1.0 1.0 1.0 1.0 Xanthan gum 0.3 3.5 0 0 0 0 Increasing polymer 0 0 0 Carboxymethylcellulose sodium 0.3 Carbomer 0.3 Gellangom 0.3 Purified water To100 To 100 To100 To100 To 100 To 100

In the case of efficacy verification, the formability evaluation, initial viscosity, viscosity over time, and change in discharge characteristics with time were observed for the examples and comparative examples, and the usability and feeling of use were further evaluated.

Experimental Example  One: Beam formation  evaluation

1) Experimental method

The same amount of oral composition as in Examples and Comparative Examples was injected into each box of the tooth paste dispenser for confirmation of formation as shown in Fig. 1, and the maximum height at the initial stage and the maximum height after 30 seconds were measured, The retentivity was evaluated.

1 is a toothpaste discharging table for confirming the formation of a toothpaste composition. In the toothpaste discharging table, individual chambers have a width of 2 cm and a length of 1 cm and a space of 0.5 cm between the chambers. And various compositions are simultaneously ejected and observed.

2) Experimental results

As can be seen in Table 3 below, when xanthan gum was added in an amount of 0.5 to 3% by weight of the composition, the shape retention and retention of the composition were increased, especially when additional incremental polymer was added, It was confirmed that the beam formation was significantly increased.

Height change observation table division Initial height (cm) Height after 30 seconds (cm) Example 1 0.21 0.18 Example 2 0.30 0.25 Example 3 0.40 0.34 Example 4 0.45 0.39 Example 5 0.42 0.41 Example 6 0.43 0.43 Example 7 0.43 0.42 Comparative Example 1 0.10 0.04 Comparative Example 2 0.50 0.40 Comparative Example 3 0 0 Comparative Example 4 0.10 0 Comparative Example 5 0.09 0 Comparative Example 6 0.10 0

Experimental Example  2: Measurement of viscosity change

1) Experimental method

Initial viscosity and viscosity after 4 weeks were measured for each of the examples and comparative examples at 25 캜 immediately after the mixing of the oral composition under the following viscosity measuring conditions.

Viscosity measurement conditions: Brookfield, RV-5, 20 rpm, 5 cycle

2) Experimental results

As can be seen in Table 4 below, when xanthan gum was added in an amount of 0.5 to 3% by weight in the composition, it was confirmed that the viscosity of the composition hardly changed with the lapse of time.

Viscosity change table division Initial viscosity ( cps ) Viscosity after 4 weeks ( cps ) Example 1 5,000 5,200 Example 2 8,000 8,300 Example 3 11,000 11,100 Example 4 20,000 20,500 Example 5 11,000 11,200 Example 6 10,800 11,100 Example 7 11,100 11,300 Comparative Example 1 3,000 3,500 Comparative Example 2 25,000 26,000 Comparative Example 3 1,000 1,200 Comparative Example 4 2,800 3,000 Comparative Example 5 2,600 2,800 Comparative Example 6 3,000 3,100

Experimental Example  3: Over time Dischargeability  change

1) Experimental method

The composition of Example 3 and Comparative Examples 1 to 4 was packed in a vessel to which a dip tube type pump was applied, and discharging property of each product was observed at the initial stage, the second stage and the fourth stage while being kept at 50 캜 and a room temperature.

2) Experimental results

As can be seen in Table 5 below, it was confirmed that when xanthan gum was added in an amount of 0.5 to 3% by weight in the composition, dischargeability and pump restoring force were excellent.

Particularly, in Comparative Example 1 in which xanthan gum was added in an amount of 0.3 wt% and in Comparative Examples 3 to 4 in which no gum arabic was added, the contents were ejected in various directions due to low viscosity, and the content of xanthan gum was 3.5 wt% , The contents were not discharged and the pump was damaged as shown in Fig. 2 after 4 weeks.

division Initial Discharge after 2 weeks After 4 weeks Example  3 50 ℃ Discharge completed Discharge completed Discharge completed Room temperature Discharge completed Discharge completed Discharge completed Comparative Example  One 50 ℃ Discharge completed / contents 튐 Discharge completed / contents 튐 Discharge completed / contents 튐 Room temperature Discharge completed / contents 튐 Discharge completed / contents 튐 Discharge completed / contents 튐 Comparative Example  2 50 ℃ Discharge completed Discharge difficulty No discharge Room temperature Discharge completed Discharge difficulty No discharge Comparative Example  3 50 ℃ Discharge completed / contents 튐 Discharge completed / contents 튐 Discharge completed / contents 튐 Room temperature Discharge completed / contents 튐 Discharge completed / contents 튐 Discharge completed / contents 튐 Comparative Example  4 50 ℃ Discharge completed / contents 튐 Discharge completed / contents 튐 Discharge completed / contents 튐 Room temperature Discharge completed / contents 튐 Discharge completed / contents 튐 Discharge completed / contents 튐

Experimental Example  4: Through consumer evaluation Feeling  And usability comparison

1) Subjects to be tested

The subjects were 30 open - minded male and female volunteers in their 20s and 30s.

2) Experimental method

A new toothpaste was given once a week to the subjects and only the corresponding toothpaste was used. The questionnaire was used to evaluate the feeling of use and usability.

3) Experiment toothpaste

The composition of Example 3 and Comparative Examples 1 to 4 was put in a container to which a pump of the deep tube type was applied, and was dispensed with an experimental toothpaste. All compositions were applied with the same fragrance and hue to prevent smell or hue in advance.

4) Survey items

And evaluated using a questionnaire for consumer evaluation as shown in FIG.

5) Experimental results

The results of the consumer evaluation show that the composition of Example 4 is the most satisfactory in terms of container use (discharge), toothpaste appearance quality, toothpaste releasing property, washing feeling and overall satisfaction as shown in FIG. 4 below.

Claims (13)

delete A dentifrice composition for pumping toothpaste products comprising 0.05 to 1% by weight, based on the total weight of carboxymethylcellulose sodium, carbomer or a mixture thereof; And
0.5 to 3% by weight of xanthan gum relative to the total weight of the composition,
Wherein the dentifrice composition has a viscosity of 5,000 to 20,000 cP at 25 ° C, Brookfield, RV-5, and 20 rpm. delete delete delete delete The composition according to claim 2, wherein the composition has an initial height of 0.15 to 0.55 cm when discharging 1 g of the composition from a container having a diameter of 0.3 to 1.0 cm and a width of 2 cm and a length of 1 cm, ≪ / RTI > to 0.45 cm. i) 0.5 to 3% by weight of xanthan gum relative to the total weight of the composition
ii) a carboxymethylcellulose sodium or a carborer in an amount of 0.05-1% by weight based on the total weight of the composition and having a viscosity of 5,000 to 20,000 cP at 25 ° C, Brookfield, RV-5, Including pumped toothpaste products. delete delete delete delete The composition according to claim 8, wherein the composition has an initial height of 0.15 to 0.55 cm and a height of from 0.1 to 0.45 after 30 seconds upon ejection of 1 g in a 2 cm wide and 1 cm long area of the composition having a diameter of 0.3 to 1.0 cm. cm. < / RTI >

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