JP5704637B2 - 歯科用超音波薬剤導入システム - Google Patents
歯科用超音波薬剤導入システム Download PDFInfo
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- JP5704637B2 JP5704637B2 JP2010280905A JP2010280905A JP5704637B2 JP 5704637 B2 JP5704637 B2 JP 5704637B2 JP 2010280905 A JP2010280905 A JP 2010280905A JP 2010280905 A JP2010280905 A JP 2010280905A JP 5704637 B2 JP5704637 B2 JP 5704637B2
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- root canal
- drug
- probe
- ultrasonic
- nanobubbles
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- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- GEGIENATMYITAP-UHFFFAOYSA-N trifluoro(nitro)methane Chemical compound [O-][N+](=O)C(F)(F)F GEGIENATMYITAP-UHFFFAOYSA-N 0.000 description 1
- PGOMVYSURVZIIW-UHFFFAOYSA-N trifluoro(nitroso)methane Chemical compound FC(F)(F)N=O PGOMVYSURVZIIW-UHFFFAOYSA-N 0.000 description 1
- VPAYJEUHKVESSD-UHFFFAOYSA-N trifluoroiodomethane Chemical compound FC(F)(F)I VPAYJEUHKVESSD-UHFFFAOYSA-N 0.000 description 1
- GRGCWBWNLSTIEN-UHFFFAOYSA-N trifluoromethanesulfonyl chloride Chemical compound FC(F)(F)S(Cl)(=O)=O GRGCWBWNLSTIEN-UHFFFAOYSA-N 0.000 description 1
- SLVAEVYIJHDKRO-UHFFFAOYSA-N trifluoromethanesulfonyl fluoride Chemical compound FC(F)(F)S(F)(=O)=O SLVAEVYIJHDKRO-UHFFFAOYSA-N 0.000 description 1
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- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
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- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
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- 239000002672 zinc phosphate cement Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
- A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
- A61C17/0202—Hand-pieces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
- A61C17/16—Power-driven cleaning or polishing devices
- A61C17/20—Power-driven cleaning or polishing devices using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C19/00—Dental auxiliary appliances
- A61C19/06—Implements for therapeutic treatment
- A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C5/00—Filling or capping teeth
- A61C5/40—Implements for surgical treatment of the roots or nerves of the teeth; Nerve needles; Methods or instruments for medication of the roots
Landscapes
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Surgical Instruments (AREA)
Description
以下、添付の図面を参照して本発明の実施形態について具体的に説明する。本発明の実施形態に係る歯科用超音波薬剤導入システム900は、薬剤をナノバブルとの混合状態にて標的部に導入し、超音波導入装置800を使用してその標的部に対して超音波を照射する。
本実施形態では、上述の第1実施形態と異なり、超音波振動子は根管内挿入型プローブ100の先端に設けられているのではなく、プローブ本体150内に設けられる。
上述の第1及び第2実施形態では、プローブ本体150に取り付けられるプローブは根管内に挿入される根管内挿入型プローブであったが、本実施形態では、上述の実施形態と異なり、う蝕部分に押し当てて使用するう蝕治療用プローブである。
本実施形態では、上述の実施形態と異なり、プローブは主として歯周ポケット内に挿入して使用される歯周疾患治療用プローブである。
本実施形態では、上述の実施形態と異なり、プローブは知覚過敏治療用プローブである。
本実施形態では、上述の第1〜第5実施形態と異なり、根尖部照射部110及び側枝照射部120の各超音波振動子に供給される超音波の周波数がランダムに変化する。
本実施形態では、上述の第1実施形態と異なり、側枝照射部120が根管内挿入型プローブ100の円周上に均等に複数設けられる。図19A、19Bは、複数の側枝照射部120a〜120eが根管内挿入型プローブ100に設けられている構成を説明する図であり、そのうち図19Aは概略図であり、図19Bは先端方向からの正面図である。
本実施形態では、上述の第1実施形態と異なり、側枝照射部120が根管内挿入型プローブ100の軸方向に複数設けられる。図20は、複数の側枝照射部120a〜120cが根管内挿入型プローブ100の軸方向に設けられている構成を説明する図である。
抜去したイヌ歯牙を通法通りに髄腔開拡、根管拡大形成(#60まで)を行ったのち、スメアクリーン(日本歯科薬品)にて処理しスメア層の除去を行い、実験使用時まで生理食塩水下にて冷蔵保存した。綿詮にて根管内を十分に乾燥させた後、薬液が根管から漏洩するのを防止するため、あらかじめ根尖部分をユニファストIII(GC社)にて封鎖した。ついで、ナノバブルを濃度が5%又は10%(以下、バブル濃度は体積%である)となるように生理食塩水で希釈し、4.5mg/mlテトラサイクリン(SIGMA088K0680)を含有する薬液を作製した。ここで5%濃度のナノバブルとは、ナノバブルの濃度が6×108個/mlを意味する。10%濃度のナノバブルとは、ナノバブルの濃度が1.2×109個/mlを意味する。テトラサイクリンは、微量の沈着でも、紫外線の照射によって蛍光を発するため、蛍光顕微鏡下で容易に沈着部位を検出することができる。コントロールとしては、マイクロバブル(Optison(Molecular Biosystems Inc.,San Diego))を使用し、濃度5%又は10%の薬液を用いた。ここで5%濃度のマイクロバブルとは、マイクロバブルの濃度が6×108個/mlを意味する。10%濃度のマイクロバブルとは、マイクロバブルの濃度が1.2×109個/mlを意味する。根管内へ20μlの薬液を適応し、超音波発生装置(ソノポール KTAC-4000)を用いて、脱着式照射筒伝搬型プローブ(ランジュバン振動子がプローブ本体内部に設けられるアプリケータタイプ)の超音波素子直径1mmを根管内へ挿入し、機器を動作させた。動作条件としては、電圧30V(メーター表記0.13〜0.20W)或いは31V、周波数1.186MHz、Burst Rate18.8Hz、Duty比50%、適応時間120秒で行った。適応時間経過後、綿詮にて十分に希釈液を除去後、ゲーゼミクロトーム(ライカSP1600)にて150μmの厚さにて切片を作製し、紫外線照射下の実体顕微鏡を用いて検鏡を行った。薬剤の象牙質細管への導入度合いは蛍光反応にて確認した。
アクリル製の人工根管模型を#60まで根管拡大し、10%マイクロバブル及び10%ナノバブルを根管内にそれぞれ注入し、電圧を0、30、60、90Vに変化させて、120秒超音波照射を行った後、直ちに、Dark-light Illuminator(ネッパジーン)を用いて顕微鏡観察し、バブルの破壊の程度を測定した。
上記と同様に根管拡大形成、スメア層の除去を行った後、綿詮にて根管内を十分に乾燥させ、根尖部分をユニファストIII(GC社)にて封鎖した。ついでpEGFP-C1(clontech)を遺伝子導入したカナマイシン耐性のEnterococcusfaecalis(乳酸球菌)を培養した菌液(ブレインハートインヒュージョン(BHI)培地 ニッスイ カナマイシン含有)を5μlずつ各根管へ注入後、ハイシール(松風)にて仮封し、恒温器(ヤマト科学IC602)を用いて、36.8℃、好気条件・湿潤下にて6日間培養し、疑似感染根管を作製した。仮封除去後、生理食塩水3mlにて根管内を洗浄、滅菌ペーパーポイント#55(モリタ)にて乾燥させ、下記表1に示す条件にて薬液調製を行い、根管へ7μl注入した。
イヌ歯牙をinvivoにおいて通法通りに髄腔開拡、根管拡大形成(#60まで)を行ったのち、スメアクリーン(日本歯科薬品)にて処理しスメア層の除去を行い、綿詮にて根管内を十分に乾燥させた後、ついでpEGFP-C1(clontech)を遺伝子導入したカナマイシン耐性のEnterococcusFaecalis(乳酸球菌)を培養した菌液(ブレインハートインヒュージョン(BHI)培地 ニッスイ カナマイシン含有)を10μlずつ根管内へ注入し、リン酸亜鉛セメントで仮封した。ついで、7日後、根管内を生理食塩水3mlで洗浄した。10%濃度ナノバブル、50μg/mlアンピシリンを含有する薬液20μlを根管内へ適応し、超音波発生装置(ソノポールKTAC-4000)を用いて、脱着式照射筒伝搬型プローブ(ランジュバン振動子がプローブ本体内部に設けられるアプリケータタイプ)の超音波素子直径1mmを根管内へ挿入し、電圧30V、周波数1.186MHz、Burst Rate18.8Hz、Duty比50%、適応時間120秒で超音波導入した。適応時間経過後、ゲーゼミクロトーム(ライカSP1600)にて150μmの厚さにて切片を作製し、共焦点レーザー顕微鏡観察を行った。
島津ナノ粒子分布測定装置(SALD−7100、島津製作所)により、実施例1〜4で使用したナノバブル及び実施例1〜3で使用したマイクロバブルの粒径分布を測定した。図26は、ナノバブル及びマイクロバブルの粒径分布を示す図である。図26に示すように、実施例1〜4で使用したナノバブルは、主として100nm〜500nmに粒度分布を有していた。一方、実施例1〜3で使用したナノバブルは、主として1μm〜50μmに粒度分布を有していた。
ウシ抜去歯(前歯部)10本を用いて、根尖部を光重合型アイオノマーセメントにて封鎖した。6%次亜塩素酸ナトリウムにて根管内を処理、洗浄し、オートクレーブにて滅菌した。その後、根管内を滅菌生理食塩水にて十分に洗浄後、根管内をペーパーポイントで乾燥後、E.Coli飽和溶液を充たし、湿箱中にて37℃で一晩培養した。根管内のE.Coli溶液をペーパーポイントにて吸引し、洗浄液、次亜塩素酸ナトリウム1%あるいは0.1%を根管内に充たし、5%ナノバブルを入れ、電圧30V、周波数:1.186MHz、Burst Rate18.8Hz、Pulse Duty比50%、120秒間、超音波をかけた。その後、生理食塩水で十分に洗浄し、根管内にペーパーポイントを入れ1分放置し、ペーパーポイントを培養し、12時間後に細菌量を吸光度OD600にて測定した。結果を表2に示す。
101:開口部
102:中空部
110:根尖部照射部
111:内側電極
112:圧電素子
113:外側電極
120:側枝照射部
121:内側電極
122:圧電素子
123:外側電極
130:う蝕治療用プローブ
131:歯周疾患治療用プローブ
132:薬剤チューブ
140:接続部
150:プローブ本体
160:操作部
177:切替回路
178:乱数発生回路
180:ランジュバン振動子
200:根管
210:主根管
220:側枝
230:根尖部
240:セメント質
241:歯槽骨
242:エナメル質
243:象牙質
244:歯髄
245:歯頸部粘膜上皮
247:象牙芽細胞
248:象牙質細管
249:歯根膜
260:根尖病巣
270:う蝕部
310:ナノバブル
311:細菌
320:薬剤
410:トリガー
411:薬剤貯留部
430:知覚過敏治療用プローブ
450:薬剤導入管
480:歯周ポケット
490:楔形欠損部
800:超音波導入装置
900:歯科用超音波薬剤導入システム
Claims (4)
- 超音波を照射する歯科治療用プロープを用いて標的部に薬剤を導入する歯科用超音波薬剤導入システムであって、
前記薬剤は、ナノパブルと薬剤との混合状態で標的部に導入され、
前記歯科治療用プロープは、プロープ本体と、前記プロープ本体に取り付けられて、前記標的部に前記薬剤を導入するための導入プロープと、を有し、
前記導入プロープにつき、
(1)根管の根尖部側に超音波を照射する根尖部照射部と、根管の側枝側に超音波を照射する側枝照射部とを備え、根管内に挿入されて前記根管内に超音波を伝搬させる根管内挿入型プロープ、
(2)前記プロープ本体には超音波を発生させる超音波振動子が備えられ、その超音波振動子からの超音波をう蝕部に伝搬させるう蝕治療用プローブ、
(3)筒状体と、その筒状体の先端部に設けられて歯周ポケットヘ超音波を伝搬させる歯周ポケツト照射部と、前記筒状体の内部に設けられ、ナノバブルとの混合状態の薬剤を前記歯周ポケットに導入させる薬剤導入管と、を備え、歯周ポケツト内に挿入されて歯周疾患部に超音波を照射する歯周疾患治療用プロープ、又は
(4)歯のエナメル質の楔形欠損部を型取りした楔形欠損部当てと、超音波振動を生じさせる振動子構成部と、前記振動子構成部と前記楔形欠損部当てとの間に設けられた流体が流れる流体路と、を備え、知覚過敏部に超音波を照射する知覚過敏治療用プロープ、の何れかを選択的に使用する、ことを特徴とする歯科用超音波薬剤導入システム。 - 前記標的部は、根尖部の根尖病巣、副根管、象牙質細管、歯周ポケット、及びエナメル質の楔形欠損部のうち少なくとも何れか一つを含むことを特徴とする請求項1に記載の歯科用超音波薬剤導入システム。
- 前記ナノバブルの直径は、10nm以上500nm以下であることを特徴とする請求項1又は2に記載の歯科用超音波薬剤導入システム。
- 前記薬剤が導入される超音波の周波数は、800KHz以上2MHz以下であることを特徴とする請求項1乃至3の何れか1項に記載の歯科用超音波薬剤導入システム。
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JP2007229110A (ja) | 2006-02-28 | 2007-09-13 | Morita Mfg Co Ltd | 歯科用根管治療装置 |
JP2009165499A (ja) * | 2006-04-12 | 2009-07-30 | Nippon Sozai Kk | 超音波発生用プローブ |
CN2917573Y (zh) * | 2006-06-22 | 2007-07-04 | 张少华 | 超声波根管治疗器 |
JP2008100956A (ja) * | 2006-10-20 | 2008-05-01 | Tohoku Univ | がん治療用組成物 |
WO2009137815A1 (en) | 2008-05-09 | 2009-11-12 | Dentatek Corporation | Apparatus and methods for root canal treatments |
US20090162810A1 (en) | 2007-12-21 | 2009-06-25 | Peter Werner | Ultrasonic dental insert and lighted handpiece assembly |
JP5080961B2 (ja) * | 2007-12-27 | 2012-11-21 | 俊郎 立花 | 眼科用超音波治療装置 |
JP4792474B2 (ja) | 2008-01-21 | 2011-10-12 | 栄基 中山 | 生物ミネラルの製造方法およびその製造装置 |
JP2009189753A (ja) | 2008-02-12 | 2009-08-27 | Hiromichi Kusafuka | バブル口内洗浄液及びバブル口内洗浄方法 |
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CN102802555A (zh) | 2012-11-28 |
US9452036B2 (en) | 2016-09-27 |
EP2514387A1 (en) | 2012-10-24 |
EP2514387B1 (en) | 2018-03-21 |
CN102802555B (zh) | 2016-02-17 |
JP2011143242A (ja) | 2011-07-28 |
WO2011074268A1 (ja) | 2011-06-23 |
US20120270177A1 (en) | 2012-10-25 |
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