JP5699393B2 - トロンビンインヒビター - Google Patents
トロンビンインヒビター Download PDFInfo
- Publication number
- JP5699393B2 JP5699393B2 JP2010512807A JP2010512807A JP5699393B2 JP 5699393 B2 JP5699393 B2 JP 5699393B2 JP 2010512807 A JP2010512807 A JP 2010512807A JP 2010512807 A JP2010512807 A JP 2010512807A JP 5699393 B2 JP5699393 B2 JP 5699393B2
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- JP
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- Prior art keywords
- thrombin
- variegin
- inhibitor
- seq
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Biotechnology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0711779.9A GB0711779D0 (en) | 2007-06-18 | 2007-06-18 | Thrombin inhibitor |
| GB0711779.9 | 2007-06-18 | ||
| PCT/IB2008/002109 WO2008155658A2 (en) | 2007-06-18 | 2008-06-18 | Thrombin inhibitor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010530238A JP2010530238A (ja) | 2010-09-09 |
| JP2010530238A5 JP2010530238A5 (cg-RX-API-DMAC10.html) | 2011-08-04 |
| JP5699393B2 true JP5699393B2 (ja) | 2015-04-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512807A Expired - Fee Related JP5699393B2 (ja) | 2007-06-18 | 2008-06-18 | トロンビンインヒビター |
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| Country | Link |
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| US (1) | US9217027B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2185185B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5699393B2 (cg-RX-API-DMAC10.html) |
| CN (1) | CN102026652B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2008264890A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2691243A1 (cg-RX-API-DMAC10.html) |
| GB (1) | GB0711779D0 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2008155658A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE480561T1 (de) | 2004-10-19 | 2010-09-15 | Lonza Ag | Verfahren zur festphasen-peptidsynthese |
| GB0711779D0 (en) | 2007-06-18 | 2007-07-25 | Univ Singapore | Thrombin inhibitor |
| GB0907698D0 (en) * | 2009-05-05 | 2009-06-10 | Univ Singapore | Method of modifying serine protease inhibitors |
| JP5937612B2 (ja) * | 2010-12-02 | 2016-06-22 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 血液安定剤を含む採血用デバイス |
| GB201121513D0 (en) | 2011-12-14 | 2012-01-25 | Cambridge Entpr Ltd | Thrombin-binding antibody molecules and uses thereof |
| US9518128B2 (en) | 2011-12-14 | 2016-12-13 | Janssen Pharmaceuticals, Inc. | Thrombin-binding antibody molecules |
| EP2950718A4 (en) * | 2013-02-01 | 2016-09-21 | Becton Dickinson Co | BLUTSAMMELVORRICHTUNGEN WITH CONTACT PATH -HEMMENDEN ADDITIVES |
| GB201310948D0 (en) * | 2013-06-19 | 2013-07-31 | Cambridge Entpr Ltd | Screening methods |
| GB201406863D0 (en) * | 2014-04-16 | 2014-05-28 | Univ Leeds | Compositions comprising variegin |
| WO2015191632A1 (en) | 2014-06-10 | 2015-12-17 | Biomatrica, Inc. | Stabilization of thrombocytes at ambient temperatures |
| US10906946B2 (en) * | 2015-06-18 | 2021-02-02 | National University Of Singapore | Thrombin inhibitors |
| ES2946184T3 (es) | 2015-12-08 | 2023-07-13 | Biomatrica Inc | Reducción de la velocidad de eritrosedimentación |
| AU2017376839B2 (en) * | 2016-12-16 | 2021-01-14 | IBMC (Instituto de Biologia Molecular e Cellular) | Thrombin inhibitors for treatment of stroke and related coagulative disorders |
| BR102017005783A2 (pt) * | 2017-03-21 | 2018-10-02 | Fund Butantan | processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos |
| WO2019030706A1 (en) | 2017-08-10 | 2019-02-14 | Janssen Pharmaceutica Nv | ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY |
| WO2019035055A1 (en) | 2017-08-16 | 2019-02-21 | Janssen Pharmaceutica Nv | ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS |
| US12073926B2 (en) * | 2020-09-21 | 2024-08-27 | Instrumentation Laboratory Company | Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample |
Family Cites Families (11)
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| CA1341032C (en) * | 1987-01-23 | 2000-06-20 | John L. Krstenansky | Anticoagulant peptides |
| US5196404B1 (en) | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
| US6060451A (en) | 1990-06-15 | 2000-05-09 | The National Research Council Of Canada | Thrombin inhibitors based on the amino acid sequence of hirudin |
| EP0725797B1 (en) | 1993-10-25 | 2001-01-10 | National Research Council Of Canada | Bivalent thrombin inhibitors |
| AU3479495A (en) | 1994-09-30 | 1996-04-26 | Ppl Therapeutics (Scotland) Ltd | Alpha-1-antitrypsin and antithrombine-iii variants |
| GB9506212D0 (en) | 1995-03-27 | 1995-05-17 | Iaf Biochem Int | Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component |
| GB9613718D0 (en) | 1996-06-29 | 1996-08-28 | Thrombosis Res Inst | Thrombin inhibitors |
| US5985833A (en) | 1996-09-17 | 1999-11-16 | Wisconsin Alumni Research Foundation | Thrombin inhibitor |
| GB0209249D0 (en) | 2002-04-23 | 2002-06-05 | Evolutec Ltd | Anticoagulants |
| US7456152B2 (en) | 2003-02-27 | 2008-11-25 | National Research Council Of Canada | Peptide inhibitors of thrombin as potent anticoagulants |
| GB0711779D0 (en) | 2007-06-18 | 2007-07-25 | Univ Singapore | Thrombin inhibitor |
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2007
- 2007-06-18 GB GBGB0711779.9A patent/GB0711779D0/en not_active Ceased
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2008
- 2008-06-18 CN CN200880102585.0A patent/CN102026652B/zh active Active
- 2008-06-18 WO PCT/IB2008/002109 patent/WO2008155658A2/en not_active Ceased
- 2008-06-18 US US12/665,256 patent/US9217027B2/en not_active Expired - Fee Related
- 2008-06-18 AU AU2008264890A patent/AU2008264890A1/en not_active Abandoned
- 2008-06-18 JP JP2010512807A patent/JP5699393B2/ja not_active Expired - Fee Related
- 2008-06-18 CA CA2691243A patent/CA2691243A1/en not_active Abandoned
- 2008-06-18 EP EP08789059.6A patent/EP2185185B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| CN102026652A (zh) | 2011-04-20 |
| WO2008155658A8 (en) | 2009-09-03 |
| GB0711779D0 (en) | 2007-07-25 |
| CA2691243A1 (en) | 2008-12-24 |
| JP2010530238A (ja) | 2010-09-09 |
| WO2008155658A2 (en) | 2008-12-24 |
| US20130183237A1 (en) | 2013-07-18 |
| CN102026652B (zh) | 2014-06-04 |
| EP2185185A2 (en) | 2010-05-19 |
| US9217027B2 (en) | 2015-12-22 |
| WO2008155658A3 (en) | 2010-03-04 |
| AU2008264890A1 (en) | 2008-12-24 |
| EP2185185B1 (en) | 2016-05-04 |
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