GB0711779D0 - Thrombin inhibitor - Google Patents

Thrombin inhibitor

Info

Publication number
GB0711779D0
GB0711779D0 GBGB0711779.9A GB0711779A GB0711779D0 GB 0711779 D0 GB0711779 D0 GB 0711779D0 GB 0711779 A GB0711779 A GB 0711779A GB 0711779 D0 GB0711779 D0 GB 0711779D0
Authority
GB
United Kingdom
Prior art keywords
thrombin inhibitor
thrombin
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB0711779.9A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institute Of Zoology Of Slovak Academy
OF SCIENCES
Original Assignee
National University of Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University of Singapore filed Critical National University of Singapore
Priority to GBGB0711779.9A priority Critical patent/GB0711779D0/en
Publication of GB0711779D0 publication Critical patent/GB0711779D0/en
Priority to EP08789059.6A priority patent/EP2185185B1/en
Priority to AU2008264890A priority patent/AU2008264890A1/en
Priority to PCT/IB2008/002109 priority patent/WO2008155658A2/en
Priority to US12/665,256 priority patent/US9217027B2/en
Priority to CA2691243A priority patent/CA2691243A1/en
Priority to JP2010512807A priority patent/JP5699393B2/ja
Priority to CN200880102585.0A priority patent/CN102026652B/zh
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
GBGB0711779.9A 2007-06-18 2007-06-18 Thrombin inhibitor Ceased GB0711779D0 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
GBGB0711779.9A GB0711779D0 (en) 2007-06-18 2007-06-18 Thrombin inhibitor
EP08789059.6A EP2185185B1 (en) 2007-06-18 2008-06-18 Variegin from amblyomma variegatum is a direct thrombin inhibitor
AU2008264890A AU2008264890A1 (en) 2007-06-18 2008-06-18 Variegin from amblyomma variegatum is a direct thrombin inhibitor
PCT/IB2008/002109 WO2008155658A2 (en) 2007-06-18 2008-06-18 Thrombin inhibitor
US12/665,256 US9217027B2 (en) 2007-06-18 2008-06-18 Thrombin inhibitor
CA2691243A CA2691243A1 (en) 2007-06-18 2008-06-18 Thrombin inhibitor
JP2010512807A JP5699393B2 (ja) 2007-06-18 2008-06-18 トロンビンインヒビター
CN200880102585.0A CN102026652B (zh) 2007-06-18 2008-06-18 凝血酶抑制剂

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0711779.9A GB0711779D0 (en) 2007-06-18 2007-06-18 Thrombin inhibitor

Publications (1)

Publication Number Publication Date
GB0711779D0 true GB0711779D0 (en) 2007-07-25

Family

ID=38332312

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB0711779.9A Ceased GB0711779D0 (en) 2007-06-18 2007-06-18 Thrombin inhibitor

Country Status (8)

Country Link
US (1) US9217027B2 (cg-RX-API-DMAC10.html)
EP (1) EP2185185B1 (cg-RX-API-DMAC10.html)
JP (1) JP5699393B2 (cg-RX-API-DMAC10.html)
CN (1) CN102026652B (cg-RX-API-DMAC10.html)
AU (1) AU2008264890A1 (cg-RX-API-DMAC10.html)
CA (1) CA2691243A1 (cg-RX-API-DMAC10.html)
GB (1) GB0711779D0 (cg-RX-API-DMAC10.html)
WO (1) WO2008155658A2 (cg-RX-API-DMAC10.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE480561T1 (de) 2004-10-19 2010-09-15 Lonza Ag Verfahren zur festphasen-peptidsynthese
GB0711779D0 (en) 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
GB0907698D0 (en) * 2009-05-05 2009-06-10 Univ Singapore Method of modifying serine protease inhibitors
JP5937612B2 (ja) * 2010-12-02 2016-06-22 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 血液安定剤を含む採血用デバイス
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
EP2950718A4 (en) * 2013-02-01 2016-09-21 Becton Dickinson Co BLUTSAMMELVORRICHTUNGEN WITH CONTACT PATH -HEMMENDEN ADDITIVES
GB201310948D0 (en) * 2013-06-19 2013-07-31 Cambridge Entpr Ltd Screening methods
GB201406863D0 (en) * 2014-04-16 2014-05-28 Univ Leeds Compositions comprising variegin
WO2015191632A1 (en) 2014-06-10 2015-12-17 Biomatrica, Inc. Stabilization of thrombocytes at ambient temperatures
US10906946B2 (en) * 2015-06-18 2021-02-02 National University Of Singapore Thrombin inhibitors
ES2946184T3 (es) 2015-12-08 2023-07-13 Biomatrica Inc Reducción de la velocidad de eritrosedimentación
AU2017376839B2 (en) * 2016-12-16 2021-01-14 IBMC (Instituto de Biologia Molecular e Cellular) Thrombin inhibitors for treatment of stroke and related coagulative disorders
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
US12073926B2 (en) * 2020-09-21 2024-08-27 Instrumentation Laboratory Company Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
US5196404B1 (en) 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US6060451A (en) 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
EP0725797B1 (en) 1993-10-25 2001-01-10 National Research Council Of Canada Bivalent thrombin inhibitors
AU3479495A (en) 1994-09-30 1996-04-26 Ppl Therapeutics (Scotland) Ltd Alpha-1-antitrypsin and antithrombine-iii variants
GB9506212D0 (en) 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
GB9613718D0 (en) 1996-06-29 1996-08-28 Thrombosis Res Inst Thrombin inhibitors
US5985833A (en) 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
GB0209249D0 (en) 2002-04-23 2002-06-05 Evolutec Ltd Anticoagulants
US7456152B2 (en) 2003-02-27 2008-11-25 National Research Council Of Canada Peptide inhibitors of thrombin as potent anticoagulants
GB0711779D0 (en) 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor

Also Published As

Publication number Publication date
CN102026652A (zh) 2011-04-20
WO2008155658A8 (en) 2009-09-03
CA2691243A1 (en) 2008-12-24
JP5699393B2 (ja) 2015-04-08
JP2010530238A (ja) 2010-09-09
WO2008155658A2 (en) 2008-12-24
US20130183237A1 (en) 2013-07-18
CN102026652B (zh) 2014-06-04
EP2185185A2 (en) 2010-05-19
US9217027B2 (en) 2015-12-22
WO2008155658A3 (en) 2010-03-04
AU2008264890A1 (en) 2008-12-24
EP2185185B1 (en) 2016-05-04

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Legal Events

Date Code Title Description
COOA Change in applicant's name or ownership of the application

Owner name: INSTITUTE OF ZOOLOGY OF THE SLOVAK ACADEMY

Free format text: FORMER APPLICANT(S): KAZIMIROVA, MARIA

Owner name: OF SCIENCES

Free format text: FORMER APPLICANT(S): KAZIMIROVA, MARIA

AT Applications terminated before publication under section 16(1)