JP5689173B2 - テガフール、ギメラシル、オテラシルカリウム含有有核錠 - Google Patents

テガフール、ギメラシル、オテラシルカリウム含有有核錠 Download PDF

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Publication number
JP5689173B2
JP5689173B2 JP2013516428A JP2013516428A JP5689173B2 JP 5689173 B2 JP5689173 B2 JP 5689173B2 JP 2013516428 A JP2013516428 A JP 2013516428A JP 2013516428 A JP2013516428 A JP 2013516428A JP 5689173 B2 JP5689173 B2 JP 5689173B2
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Prior art keywords
outer shell
dry
orally disintegrating
mass
disintegrating tablet
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Japanese (ja)
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JPWO2012161240A1 (ja
Inventor
拓己 岡本
拓己 岡本
吉澤　隆
隆 吉澤
敬人 大西
敬人 大西
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Taiho Pharmaceutical Co Ltd
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Taiho Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013516428A 2011-05-25 2012-05-24 テガフール、ギメラシル、オテラシルカリウム含有有核錠 Active JP5689173B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013516428A JP5689173B2 (ja) 2011-05-25 2012-05-24 テガフール、ギメラシル、オテラシルカリウム含有有核錠

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2011116884 2011-05-25
JP2011116884 2011-05-25
PCT/JP2012/063260 WO2012161240A1 (ja) 2011-05-25 2012-05-24 テガフール、ギメラシル、オテラシルカリウム含有有核錠
JP2013516428A JP5689173B2 (ja) 2011-05-25 2012-05-24 テガフール、ギメラシル、オテラシルカリウム含有有核錠

Related Child Applications (1)

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JP2014167814A Division JP5769853B2 (ja) 2011-05-25 2014-08-20 テガフール、ギメラシル、オテラシルカリウム含有有核錠

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JPWO2012161240A1 JPWO2012161240A1 (ja) 2014-07-31
JP5689173B2 true JP5689173B2 (ja) 2015-03-25

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JP2014167814A Active JP5769853B2 (ja) 2011-05-25 2014-08-20 テガフール、ギメラシル、オテラシルカリウム含有有核錠

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Country Link
US (1) US20140335174A1 (enExample)
EP (1) EP2716290B1 (enExample)
JP (2) JP5689173B2 (enExample)
KR (2) KR101869127B1 (enExample)
AU (1) AU2012259803B2 (enExample)
BR (1) BR112013030093B1 (enExample)
CA (1) CA2836865C (enExample)
ES (1) ES2671926T3 (enExample)
IL (1) IL229372B (enExample)
MX (1) MX353289B (enExample)
MY (1) MY167883A (enExample)
PH (1) PH12013502323A1 (enExample)
RU (1) RU2601620C2 (enExample)
SG (2) SG194922A1 (enExample)
TW (2) TWI488659B (enExample)
WO (1) WO2012161240A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014218523A (ja) * 2011-05-25 2014-11-20 大鵬薬品工業株式会社 テガフール、ギメラシル、オテラシルカリウム含有有核錠

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107837273A (zh) * 2016-09-18 2018-03-27 江苏金甙生物技术有限公司 一种肠溶替吉奥缓释制剂及其制备方法
CN107865871B (zh) * 2016-09-23 2021-09-03 江苏恒瑞医药股份有限公司 一种替吉奥组合物及其制备方法
CN106619689B (zh) * 2016-12-30 2018-05-01 陈晓华 一种用于治疗癌症的药物组合物、试剂盒及其应用
US20220408745A1 (en) * 2019-09-13 2022-12-29 Meiji Co., Ltd. Solid food and solid milk having hole penetrating first face and second face
CN119365195A (zh) * 2022-06-10 2025-01-24 大鹏药品工业株式会社 含有匹米替比的医药组合物

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CN1660105A (zh) * 2004-12-23 2005-08-31 鲁南制药股份有限公司 含有替加氟、吉莫斯特和氧嗪酸钾的口腔崩解片
CN101380327A (zh) * 2008-10-09 2009-03-11 北京恒瑞康达医药科技发展有限公司 抗癌复合缓释组合物及制备
CN101711765A (zh) * 2009-10-31 2010-05-26 山东新时代药业有限公司 一种含有替加氟、吉美嘧啶和奥替拉西钾的分散片
CN102614183A (zh) * 2012-03-05 2012-08-01 齐鲁制药(海南)有限公司 一种替吉奥的口服制剂

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DE69901938T3 (de) * 1998-03-06 2012-08-02 Aptalis Pharma S.R.L. Schnell zerfallende tablette
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JPWO2010131460A1 (ja) * 2009-05-12 2012-11-01 大鵬薬品工業株式会社 テガフール・ギメラシル・オテラシルカリウム配合剤及びオキサリプラチンを含有する抗腫瘍剤
BR112013030093B1 (pt) * 2011-05-25 2019-12-10 Taiho Pharmaceutical Co Ltd comprimido revestido seco de desintegração oral contendo tegafur, gimeracilo e oteracilo potássico

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WO2003028706A1 (fr) * 2001-09-28 2003-04-10 Sanwa Kagaku Kenkyusho Co.,Ltd Double comprime a desintegration rapide
CN1660105A (zh) * 2004-12-23 2005-08-31 鲁南制药股份有限公司 含有替加氟、吉莫斯特和氧嗪酸钾的口腔崩解片
CN101380327A (zh) * 2008-10-09 2009-03-11 北京恒瑞康达医药科技发展有限公司 抗癌复合缓释组合物及制备
CN101711765A (zh) * 2009-10-31 2010-05-26 山东新时代药业有限公司 一种含有替加氟、吉美嘧啶和奥替拉西钾的分散片
CN102614183A (zh) * 2012-03-05 2012-08-01 齐鲁制药(海南)有限公司 一种替吉奥的口服制剂

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JPN6009059683; 池田和正，他: '抗腫瘍剤「ティーエスワン」の薬理作用と体内動態' 化学療法の領域 Ｖｏｌ．１７，　Ｎｏ．７, 2001, Ｐａｇｅｓ　１３１８-１３３１ *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014218523A (ja) * 2011-05-25 2014-11-20 大鵬薬品工業株式会社 テガフール、ギメラシル、オテラシルカリウム含有有核錠

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Publication number Publication date
MY167883A (en) 2018-09-26
IL229372B (en) 2018-12-31
KR20140037879A (ko) 2014-03-27
KR20170072959A (ko) 2017-06-27
TW201300141A (zh) 2013-01-01
SG194922A1 (en) 2013-12-30
AU2012259803B2 (en) 2016-03-17
SG10201505503WA (en) 2015-09-29
TW201529100A (zh) 2015-08-01
RU2013157528A (ru) 2015-06-27
CA2836865A1 (en) 2012-11-29
BR112013030093A2 (pt) 2016-09-20
RU2601620C2 (ru) 2016-11-10
EP2716290A1 (en) 2014-04-09
US20140335174A1 (en) 2014-11-13
JP5769853B2 (ja) 2015-08-26
EP2716290B1 (en) 2018-03-14
IL229372A0 (en) 2014-01-30
PH12013502323A1 (en) 2014-01-06
MX2013013563A (es) 2013-12-16
KR101869127B1 (ko) 2018-06-19
WO2012161240A1 (ja) 2012-11-29
TWI488659B (zh) 2015-06-21
JPWO2012161240A1 (ja) 2014-07-31
JP2014218523A (ja) 2014-11-20
TWI566787B (zh) 2017-01-21
MX353289B (es) 2018-01-05
CA2836865C (en) 2018-02-27
NZ617625A (en) 2015-10-30
ES2671926T3 (es) 2018-06-11
EP2716290A4 (en) 2014-11-26
BR112013030093B1 (pt) 2019-12-10

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