JP5670055B2 - ヒストンデアセチラーゼ阻害剤に対する癌の耐性を決定する方法 - Google Patents
ヒストンデアセチラーゼ阻害剤に対する癌の耐性を決定する方法 Download PDFInfo
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- JP5670055B2 JP5670055B2 JP2009548433A JP2009548433A JP5670055B2 JP 5670055 B2 JP5670055 B2 JP 5670055B2 JP 2009548433 A JP2009548433 A JP 2009548433A JP 2009548433 A JP2009548433 A JP 2009548433A JP 5670055 B2 JP5670055 B2 JP 5670055B2
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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- C12Q2545/00—Reactions characterised by their quantitative nature
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- C12Q2600/00—Oligonucleotides characterized by their use
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Proteomics, Peptides & Aminoacids (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Animal Behavior & Ethology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88731807P | 2007-01-30 | 2007-01-30 | |
| US60/887,318 | 2007-01-30 | ||
| US91185507P | 2007-04-13 | 2007-04-13 | |
| US60/911,855 | 2007-04-13 | ||
| PCT/US2008/052540 WO2008095050A1 (en) | 2007-01-30 | 2008-01-30 | Methods for determining cancer resistance to histone deacetylase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125267A Division JP2014221049A (ja) | 2007-01-30 | 2014-06-18 | ヒストンデアセチラーゼ阻害剤に対する癌の耐性を決定する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518811A JP2010518811A (ja) | 2010-06-03 |
| JP2010518811A5 JP2010518811A5 (enExample) | 2011-03-17 |
| JP5670055B2 true JP5670055B2 (ja) | 2015-02-18 |
Family
ID=39674490
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548433A Expired - Fee Related JP5670055B2 (ja) | 2007-01-30 | 2008-01-30 | ヒストンデアセチラーゼ阻害剤に対する癌の耐性を決定する方法 |
| JP2014125267A Pending JP2014221049A (ja) | 2007-01-30 | 2014-06-18 | ヒストンデアセチラーゼ阻害剤に対する癌の耐性を決定する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125267A Pending JP2014221049A (ja) | 2007-01-30 | 2014-06-18 | ヒストンデアセチラーゼ阻害剤に対する癌の耐性を決定する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7838234B2 (enExample) |
| EP (2) | EP2993473A1 (enExample) |
| JP (2) | JP5670055B2 (enExample) |
| KR (1) | KR101483805B1 (enExample) |
| CN (1) | CN101657217B (enExample) |
| AU (2) | AU2008210421B2 (enExample) |
| CA (1) | CA2677000A1 (enExample) |
| EA (2) | EA201201640A1 (enExample) |
| NZ (1) | NZ579048A (enExample) |
| WO (1) | WO2008095050A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120090100A (ko) | 2006-12-26 | 2012-08-16 | 파마시클릭스, 인코포레이티드 | 병용 치료에 있어서 히스톤 디아세틸라제 억제제 이용 및 생체표지 감시 방법 |
| US7838234B2 (en) * | 2007-01-30 | 2010-11-23 | Pharmacyclics, Inc. | Methods for determining cancer resistance to histone deacetylase inhibitors |
| DE102008000715B9 (de) * | 2008-03-17 | 2013-01-17 | Sirs-Lab Gmbh | Verfahren zur in vitro Erfasssung und Unterscheidung von pathophysiologischen Zuständen |
| US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
| US9896730B2 (en) | 2011-04-25 | 2018-02-20 | OSI Pharmaceuticals, LLC | Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment |
| US20140243403A1 (en) * | 2011-06-03 | 2014-08-28 | The General Hospital Corporation | Treating colorectal, pancreatic, and lung cancer |
| KR101384667B1 (ko) * | 2011-09-09 | 2014-04-21 | 강원대학교산학협력단 | 항암제인 택솔에 대한 민감성 여부를 판명하는 인자로서의 히스톤 탈아세틸화 효소 3의 용도 |
| CA2845806C (en) | 2011-09-13 | 2019-06-11 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof |
| WO2013071247A1 (en) * | 2011-11-10 | 2013-05-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Gene expression signatures of neoplasm responsiveness to theraphy |
| AP2014007796A0 (en) | 2011-12-22 | 2014-07-31 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| CN102532298B (zh) * | 2012-03-01 | 2013-11-06 | 刘林林 | 与自身抗体特异性结合的abcc3抗原多肽及应用 |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP2839037B1 (en) * | 2012-04-19 | 2018-12-26 | Acetylon Pharmaceuticals, Inc. | Biomarkers to identify patients that will respond to treatment and treating such patients |
| AU2013202506B2 (en) * | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
| TWI649081B (zh) | 2013-08-02 | 2019-02-01 | 製藥公司 | 治療固態腫瘤之方法 |
| JP6749589B2 (ja) * | 2015-07-31 | 2020-09-02 | 国立大学法人北海道大学 | 抗Eva1タンパク質抗体 |
| CN106467914A (zh) * | 2015-08-18 | 2017-03-01 | 华东理工大学 | 靶向人TSPAN8基因的siRNA及其应用 |
| US11015226B2 (en) * | 2015-10-06 | 2021-05-25 | Ontario Institute For Cancer Research (Oicr) | Targeting the histone pathway to detect and overcome anthracyclin resistance |
| WO2017070441A1 (en) * | 2015-10-23 | 2017-04-27 | Icahn School Of Medicine At Mount Sinai | Identifying and treating cancer patients who are suitable for a targeted therapy using an hdac6 inhibitor |
| US10591462B2 (en) | 2016-03-03 | 2020-03-17 | Mohammad Abdolahad | Electrochemical method and device for detecting the effect of anticancer drugs |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| CN106755464A (zh) * | 2017-01-11 | 2017-05-31 | 上海易毕恩基因科技有限公司 | 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途 |
| CN108300783A (zh) * | 2017-01-11 | 2018-07-20 | 上海易毕恩基因科技有限公司 | 用于筛选肠癌和/或胃癌的基因标志物的方法、用该方法筛选的基因标志物及其用途 |
| US20190046513A1 (en) * | 2017-08-10 | 2019-02-14 | Huya Bioscience International, Llc | Combination therapies of hdac inhibitors and tubulin inhibitors |
| CN115044667A (zh) * | 2018-09-21 | 2022-09-13 | 王赞鑫 | 与主动脉夹层疾病相关的snp位点及其应用 |
| MX2022001812A (es) | 2019-08-12 | 2022-03-11 | Regeneron Pharma | Variantes del receptor estimulante de macrofagos 1 (mst1r) y sus usos. |
| CN114829375A (zh) * | 2019-10-07 | 2022-07-29 | 维拉克塔附属公司 | 具有降低的副作用的hdac治疗的剂量 |
| EP3821890A1 (en) * | 2019-11-18 | 2021-05-19 | Strumberg, Dirk | Pharmaceutical compositions comprising an inhibitor of a histon-deacetylase (hdaci) and an agonist of toll-like-receptor 7 and/or 8 (tlr7 and/or tlr8) and their use in the treatment of cancer |
| EP4133108A1 (en) * | 2020-04-09 | 2023-02-15 | Turun yliopisto | Eplin as a biomarker for cancer |
| WO2024128867A1 (ko) * | 2022-12-16 | 2024-06-20 | 한국원자력연구원 | 항-tm4sf4 인간화 항체 및 이의 용도 |
| CN118743746B (zh) * | 2024-06-05 | 2025-06-06 | 中国农业大学 | Clic5基因或clic5蛋白在制备治疗代谢综合征的药物中的应用 |
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| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
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| DE4124345A1 (de) | 1991-07-23 | 1993-01-28 | Gruenenthal Gmbh | Substituierte 3,4-dihydronaphthaline, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| ATE173767T1 (de) | 1992-04-03 | 1998-12-15 | Perkin Elmer Corp | Proben zusammensetzung und verfahren |
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| DE4327365A1 (de) | 1993-08-14 | 1995-02-16 | Boehringer Mannheim Gmbh | Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung |
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| US9128096B2 (en) | 2015-09-08 |
| US20090123374A1 (en) | 2009-05-14 |
| CA2677000A1 (en) | 2008-08-07 |
| AU2008210421A1 (en) | 2008-08-07 |
| WO2008095050A1 (en) | 2008-08-07 |
| EA201201640A1 (ru) | 2013-09-30 |
| JP2014221049A (ja) | 2014-11-27 |
| US20160160286A1 (en) | 2016-06-09 |
| EP2107911A1 (en) | 2009-10-14 |
| EA017985B1 (ru) | 2013-04-30 |
| EA200900927A1 (ru) | 2010-04-30 |
| EP2993473A1 (en) | 2016-03-09 |
| NZ579048A (en) | 2012-05-25 |
| AU2008210421B2 (en) | 2014-03-13 |
| KR20090106417A (ko) | 2009-10-08 |
| KR101483805B1 (ko) | 2015-01-16 |
| US7838234B2 (en) | 2010-11-23 |
| US20110053164A1 (en) | 2011-03-03 |
| CN101657217A (zh) | 2010-02-24 |
| JP2010518811A (ja) | 2010-06-03 |
| EP2107911A4 (en) | 2010-09-22 |
| CN101657217B (zh) | 2013-11-20 |
| AU2014203224A1 (en) | 2014-07-10 |
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