JP5663135B2 - 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法 - Google Patents

腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法 Download PDF

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JP5663135B2
JP5663135B2 JP2008501411A JP2008501411A JP5663135B2 JP 5663135 B2 JP5663135 B2 JP 5663135B2 JP 2008501411 A JP2008501411 A JP 2008501411A JP 2008501411 A JP2008501411 A JP 2008501411A JP 5663135 B2 JP5663135 B2 JP 5663135B2
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JP2008536487A (ja
JP2008536487A5 (enExample
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マーク ダブリュー. ローデル,
マーク ダブリュー. ローデル,
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ユーシーエル ビジネス ピーエルシー
ユーシーエル ビジネス ピーエルシー
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0646Natural killers cells [NK], NKT cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/15Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48Blood cells, e.g. leukemia or lymphoma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/49Breast
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/50Cellular immunotherapy characterised by the use of allogeneic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
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JP2008501411A 2005-03-17 2006-03-16 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法 Expired - Fee Related JP5663135B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0505508.2 2005-03-17
GB0505508A GB0505508D0 (en) 2005-03-17 2005-03-17 Method
GB0514288A GB0514288D0 (en) 2005-07-12 2005-07-12 Method
GB0514288.0 2005-07-12
PCT/GB2006/000960 WO2006097743A2 (en) 2005-03-17 2006-03-16 Method for actvating natural killer cells by tumor cell preparation in vitro

Related Child Applications (2)

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JP2012224042A Division JP5906168B2 (ja) 2005-03-17 2012-10-09 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法
JP2014212302A Division JP2015012876A (ja) 2005-03-17 2014-10-17 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法

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JP2008536487A JP2008536487A (ja) 2008-09-11
JP2008536487A5 JP2008536487A5 (enExample) 2009-03-12
JP5663135B2 true JP5663135B2 (ja) 2015-02-04

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JP2012224042A Active JP5906168B2 (ja) 2005-03-17 2012-10-09 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法
JP2014212302A Withdrawn JP2015012876A (ja) 2005-03-17 2014-10-17 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法

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JP2014212302A Withdrawn JP2015012876A (ja) 2005-03-17 2014-10-17 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法

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US (3) US8257970B2 (enExample)
EP (2) EP2399594B1 (enExample)
JP (3) JP5663135B2 (enExample)
AU (1) AU2006224313B2 (enExample)
CA (1) CA2601197C (enExample)
DK (1) DK1863905T3 (enExample)
ES (1) ES2566335T3 (enExample)
PL (1) PL1863905T3 (enExample)
WO (1) WO2006097743A2 (enExample)

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EP3712258B1 (en) 2006-04-14 2025-01-01 Astellas Institute for Regenerative Medicine Hemangio-colony forming cells
BRPI0913108A2 (pt) * 2008-05-29 2017-06-20 Trangene S A método ex-vivo para testar se um paciente responderá terapeuticamente a um método de tratamento, uso de níveis de células exterminadores naturais ativadas como um biomarcador, e, kit
WO2011004201A1 (en) * 2009-07-10 2011-01-13 Mark Lowdell Preserved compositions of activated nk cells and methods of using the same
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
KR102108245B1 (ko) 2011-11-30 2020-05-08 아스텔라스 인스티튜트 포 리제너러티브 메디슨 중간엽 간질 세포 및 이에 관련된 용도
WO2013132256A1 (en) 2012-03-07 2013-09-12 Ucl Business Plc Compositions and methods for treating viral-mediated infection and disease in immunocompromised individuals
US9938498B2 (en) 2012-05-07 2018-04-10 Nkmax Co., Ltd. Method for the induction and expansion of natural killer cells derived from peripheral blood mononuclear cells
WO2013168978A1 (ko) * 2012-05-07 2013-11-14 고려대학교 산학협력단 말초혈액단핵구 유래 자연 살해세포의 유도 및 증식 방법
CN104471059B (zh) 2012-07-12 2018-04-17 珠海横琴爱姆斯坦生物科技有限公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
EP3973967A1 (en) 2012-12-21 2022-03-30 Astellas Institute for Regenerative Medicine Methods for production of platelets from pluripotent stem cells and compositions thereof
US10961506B2 (en) * 2014-09-04 2021-03-30 Stemcell Technologies Inc. Soluble antibody complexes for T cell or NK cell activation and expansion
US10758567B2 (en) * 2015-09-16 2020-09-01 Immune Ventures LLC In vivo priming of natural killer cells
JP6850297B2 (ja) * 2015-12-07 2021-03-31 イミューン ベンチャーズ, リミテッド ライアビリティ カンパニーImmune Ventures, Llc ナチュラルキラー細胞の生体内プライミング
CN110582565A (zh) * 2017-03-15 2019-12-17 免疫创业投资有限责任公司 自然杀伤细胞的体内致敏
EP3746095A4 (en) 2018-02-01 2021-04-21 Nkmax Co., Ltd. Method of producing natural killer cells and composition for treating cancer
CN120535649A (zh) 2018-08-30 2025-08-26 免疫生物公司 单链嵌合多肽和其用途
CN112888445B (zh) * 2018-08-30 2025-06-10 免疫生物公司 治疗老年化相关病症的方法
NZ772550A (en) 2018-08-30 2025-08-29 Immunitybio Inc Multi-chain chimeric polypeptides and uses thereof
JP6838750B2 (ja) * 2019-01-21 2021-03-03 株式会社ガイアバイオメディシン Nk細胞を含む細胞集団の製造方法
KR20220035394A (ko) * 2019-06-21 2022-03-22 에이치씨더블유 바이올로직스, 인크. 다중-사슬 키메라 폴리펩티드 및 이의 용도
WO2021163298A1 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of activating regulatory t cells
AU2021220870A1 (en) 2020-02-11 2022-08-04 Immunitybio, Inc. Methods of treating age-related and inflammatory diseases
KR20220140535A (ko) 2020-02-11 2022-10-18 에이치씨더블유 바이올로직스, 인크. 크로마토그래피 수지 및 이의 용도
US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
KR20250118299A (ko) * 2024-01-29 2025-08-06 인하대학교 산학협력단 전기자극 시스템을 활용한 자연살해세포의 암세포 살상 능력 증진 방법

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US7435596B2 (en) * 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell

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EP2399594B1 (en) 2019-08-14
US9655925B2 (en) 2017-05-23
AU2006224313A1 (en) 2006-09-21
US20140079678A1 (en) 2014-03-20
EP1863905B1 (en) 2016-01-20
US8257970B2 (en) 2012-09-04
CA2601197C (en) 2017-06-06
US8637308B2 (en) 2014-01-28
JP2013009686A (ja) 2013-01-17
WO2006097743A2 (en) 2006-09-21
PL1863905T3 (pl) 2016-07-29
US20120328587A1 (en) 2012-12-27
ES2566335T3 (es) 2016-04-12
WO2006097743A3 (en) 2006-12-14
JP2015012876A (ja) 2015-01-22
JP2008536487A (ja) 2008-09-11
JP5906168B2 (ja) 2016-04-20
EP2399594A1 (en) 2011-12-28
EP1863905A2 (en) 2007-12-12
CA2601197A1 (en) 2006-09-21
HK1112483A1 (zh) 2008-09-05
DK1863905T3 (en) 2016-04-04
AU2006224313B2 (en) 2011-08-11
US20080166326A1 (en) 2008-07-10

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