JP5654201B2 - 安定な一液型水性歯牙ホワイトニング組成物 - Google Patents
安定な一液型水性歯牙ホワイトニング組成物 Download PDFInfo
- Publication number
- JP5654201B2 JP5654201B2 JP2008553508A JP2008553508A JP5654201B2 JP 5654201 B2 JP5654201 B2 JP 5654201B2 JP 2008553508 A JP2008553508 A JP 2008553508A JP 2008553508 A JP2008553508 A JP 2008553508A JP 5654201 B2 JP5654201 B2 JP 5654201B2
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- Prior art keywords
- hydrogen peroxide
- weight
- composition
- tooth
- tooth bleaching
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims description 208
- 230000002087 whitening effect Effects 0.000 title claims description 47
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 268
- 238000004061 bleaching Methods 0.000 claims description 45
- 239000003381 stabilizer Substances 0.000 claims description 35
- 239000007844 bleaching agent Substances 0.000 claims description 34
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 26
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 21
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 21
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 21
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 18
- 239000000908 ammonium hydroxide Substances 0.000 claims description 18
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 17
- 239000002562 thickening agent Substances 0.000 claims description 16
- 229920002125 Sokalan® Polymers 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 12
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims description 11
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 230000003472 neutralizing effect Effects 0.000 claims description 8
- 239000003230 hygroscopic agent Substances 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920005862 polyol Polymers 0.000 claims description 3
- 150000003077 polyols Chemical class 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 2
- 229960000281 trometamol Drugs 0.000 claims description 2
- 238000009472 formulation Methods 0.000 description 42
- 238000003860 storage Methods 0.000 description 38
- 239000000499 gel Substances 0.000 description 32
- 239000000243 solution Substances 0.000 description 32
- 150000002978 peroxides Chemical class 0.000 description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- 229920000642 polymer Polymers 0.000 description 10
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 9
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 9
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 6
- 239000002738 chelating agent Substances 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000001488 sodium phosphate Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 5
- 238000000354 decomposition reaction Methods 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- SHWNNYZBHZIQQV-UHFFFAOYSA-J EDTA monocalcium diisodium salt Chemical group [Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-J 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 229910021645 metal ion Inorganic materials 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 239000004584 polyacrylic acid Substances 0.000 description 4
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 4
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 3
- 229940078916 carbamide peroxide Drugs 0.000 description 3
- 235000015165 citric acid Nutrition 0.000 description 3
- 210000003298 dental enamel Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000174 gluconic acid Substances 0.000 description 3
- 235000012208 gluconic acid Nutrition 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 3
- 239000000176 sodium gluconate Substances 0.000 description 3
- 235000012207 sodium gluconate Nutrition 0.000 description 3
- 229940005574 sodium gluconate Drugs 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 3
- 235000019801 trisodium phosphate Nutrition 0.000 description 3
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 3
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical compound NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 201000002170 dentin sensitivity Diseases 0.000 description 2
- 229910001882 dioxygen Inorganic materials 0.000 description 2
- IOUCSUBTZWXKTA-UHFFFAOYSA-N dipotassium;dioxido(oxo)tin Chemical compound [K+].[K+].[O-][Sn]([O-])=O IOUCSUBTZWXKTA-UHFFFAOYSA-N 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 235000011083 sodium citrates Nutrition 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 235000011008 sodium phosphates Nutrition 0.000 description 2
- 235000019832 sodium triphosphate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 2
- 230000036347 tooth sensitivity Effects 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- FCKYPQBAHLOOJQ-UHFFFAOYSA-N Cyclohexane-1,2-diaminetetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)C1CCCCC1N(CC(O)=O)CC(O)=O FCKYPQBAHLOOJQ-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000013011 aqueous formulation Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000035587 bioadhesion Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000001201 calcium disodium ethylene diamine tetra-acetate Substances 0.000 description 1
- 235000011188 calcium disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- SHWNNYZBHZIQQV-UHFFFAOYSA-L calcium;disodium;2-[2-[bis(carboxylatomethyl)azaniumyl]ethyl-(carboxylatomethyl)azaniumyl]acetate Chemical compound [Na+].[Na+].[Ca+2].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-L 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000002925 chemical effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- TVQLLNFANZSCGY-UHFFFAOYSA-N disodium;dioxido(oxo)tin Chemical compound [Na+].[Na+].[O-][Sn]([O-])=O TVQLLNFANZSCGY-UHFFFAOYSA-N 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 229940124274 edetate disodium Drugs 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- GWBBVOVXJZATQQ-UHFFFAOYSA-L etidronate disodium Chemical class [Na+].[Na+].OP(=O)([O-])C(O)(C)P(O)([O-])=O GWBBVOVXJZATQQ-UHFFFAOYSA-L 0.000 description 1
- 239000008241 heterogeneous mixture Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229960002163 hydrogen peroxide Drugs 0.000 description 1
- 238000009897 hydrogen peroxide bleaching Methods 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 150000002843 nonmetals Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- BRFMYUCUGXFMIO-UHFFFAOYSA-N phosphono dihydrogen phosphate phosphoric acid Chemical compound OP(O)(O)=O.OP(O)(=O)OP(O)(O)=O BRFMYUCUGXFMIO-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 229940079864 sodium stannate Drugs 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000006076 specific stabilizer Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 150000003606 tin compounds Chemical class 0.000 description 1
- QUBMWJKTLKIJNN-UHFFFAOYSA-B tin(4+);tetraphosphate Chemical compound [Sn+4].[Sn+4].[Sn+4].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QUBMWJKTLKIJNN-UHFFFAOYSA-B 0.000 description 1
- 239000007852 tooth bleaching agent Substances 0.000 description 1
- YQMWDQQWGKVOSQ-UHFFFAOYSA-N trinitrooxystannyl nitrate Chemical compound [Sn+4].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O YQMWDQQWGKVOSQ-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/51—Chelating agents
Description
本願は、米国仮出願第60/764,072号(2006年2月1日出願)(参照により本明細書中に援用される)の利益を主張する。
本発明は何らかの連邦政府資金を使用して開発されたものでなく、本発明者によって独立して開発されたものである。
好ましい組成物の実施例
高貯蔵温度で長期間にわたって安定性を維持することができる安定な歯牙ホワイトニングゲルの組成物は、以下のようなものである。
相1:
6.17% グリセリン
1.29% Carbopol 934P NF
12.81% 脱イオン限外濾過(DIUF)水中の二ナトリウムEDTA溶液(3%)
12.83% DIUF水中のエチドロン酸溶液(3%)
1.38% 水酸化アンモニウム溶液(26ボーメ)
相2:
55.03% 過酸化水素溶液 50%
10.19% Peroxydone XL−10(PVP/H2O2錯体)
相3:
ゆっくりと攪拌しながら相2中に相1を添加
均質になるまで混合
0.30% 水酸化アンモニウム溶液(26ボーメ)を含むpH6.0〜6.5の緩衝液
相1:
5.44% グリセリン
1.47% Carbopol 934P NF
13.01% DIUF水中の二ナトリウムEDTA溶液(3%)
13.17% DIUF水中のエチドロン酸溶液(3%)
1.29% 水酸化アンモニウム溶液(26ボーメ)
相2:
54.90% 過酸化水素溶液 50%
10.20% Peroxydone XL−10(PVP/H2O2錯体)
相3:
ゆっくりと攪拌しながら相2中に相1を添加
均質になるまで混合
0.52% 水酸化アンモニウム溶液(26ボーメ)を含むpH6.0〜6.5の緩衝液
相1:
5.35% グリセリン
1.28% Carbopol 934P NF
12.79% DIUF水中の二ナトリウムEDTA溶液(3%)
12.72% DIUF水中のエチドロン酸溶液(3%)
2.12% 水酸化アンモニウム溶液(30%)
相2:
53.65% 過酸化水素溶液 50%
10.00% Peroxydone XL−10(PVP/H2O2錯体)
相3:
ゆっくりと攪拌しながら相2中に相1を添加
均質になるまで混合
2.09% 水酸化アンモニウム溶液(30%)を含むpH6.0〜6.5の緩衝液
[実施例4]
5.11% グリセリン
1.25% Carbopol 934P NF
12.49% DIUF水中の二ナトリウムEDTA溶液(1%)
12.53% DIUF水中のエチドロン酸溶液(1%)
2.07% 水酸化アンモニウム溶液(30%)
相2:
53.18% 過酸化水素溶液 50%
10.01% Peroxydone XL−10(PVP/H2O2錯体)
相3:
ゆっくりと攪拌しながら相2中に相1を添加
均質になるまで混合
3.36% 水酸化アンモニウム溶液(30%)を含むpH6.0〜6.5の緩衝液
相1:
5.44% グリセリン
1.28% Carbopol 934P NF
13.28% DIUF水中の二ナトリウムEDTA溶液(5%)
13.18% DIUF水中のエチドロン酸溶液(5%)
1.19% 水酸化アンモニウム溶液(26ボーメ)
相2:
53.59% 過酸化水素溶液 50%
10.21% Peroxydone XL−10(PVP/H2O2錯体)
相3:
ゆっくりと攪拌しながら相2中に相1を添加
均質になるまで混合
1.83% 水酸化アンモニウム溶液(26ボーメ)を含むpH6.0〜6.5の緩衝液
相1:
7.08% グリセリン
1.37% Carbopol 934P NF
17.12% DIUF水中の二ナトリウムEDTA溶液(1%)
17.15% DIUF水中のエチドロン酸溶液(1%)
0.93% 水酸化アンモニウム溶液(26ボーメ)
相2:
44.57% 過酸化水素溶液 35%
7.27% Peroxydone XL−10(PVP/H2O2錯体)
相3:
ゆっくりと攪拌しながら相2中に相1を添加
均質になるまで混合
4.51% 水酸化アンモニウム溶液(26ボーメ)を含むpH6.0〜6.5の緩衝液
Claims (10)
- 歯牙表面と接触させるための高温安定性一液型水性歯牙漂白組成物であって、
(a)(i)水性過酸化水素溶液と、(ii)架橋ポリビニルピロリドン/過酸化水素錯体とを含む漂白剤であって、総組成物重量の少なくとも15重量%から成る、漂白剤と、
(b)総組成物重量の0.01重量%〜1.00重量%から成る、1:1の比率のエチレンジアミン四酢酸二ナトリウム塩及びエチドロン酸を含む漂白剤安定化剤と、
を含む、高温安定性一液型水性歯牙漂白組成物。 - 過酸化水素対漂白剤安定化剤の比率が、25:1〜60:1である、請求項1に記載の歯牙漂白組成物。
- 架橋ポリアクリル酸ポリマーと、ポリプラスドン過酸化水素錯体とを少なくとも含む複数の増粘剤をさらに含む、請求項1に記載の歯牙漂白組成物。
- 前記架橋ポリアクリル酸ポリマーの増粘剤が、総組成物重量の1.50重量%未満から成る、請求項3に記載の歯牙漂白組成物。
- 前記増粘剤が、総組成物重量の5.0重量%〜50.0重量%から成る、請求項3に記載の歯牙漂白組成物。
- 前記ポリプラスドン過酸化水素錯体が、総組成物重量の少なくとも10.0重量%から成る、請求項3に記載の歯牙漂白組成物。
- 前記エチレンジアミン四酢酸二ナトリウム塩が、総組成物重量の0.01重量%〜0.50重量%から成る、請求項1に記載の歯牙漂白組成物。
- グリセリン、ポリエチレングリコール、プロピレングリコール、及びソルビトールから成るポリオール群から選択される少なくとも1つの吸湿剤をさらに含み、該少なくとも1つの吸湿剤が、総組成物重量の1.0重量%〜10.0重量%から成る、請求項1に記載の歯牙漂白組成物。
- トリエタノールアミン、トロメタミン、水酸化ナトリウム、水酸化カリウム、及び水酸化アンモニウムから成る群から選択される少なくとも1つの中和剤をさらに含み、該少なくとも1つの中和剤が、総組成物重量の0.50重量%〜5.00重量%から成る、請求項1に記載の歯牙漂白組成物。
- 前記少なくとも1つの中和剤が、前記最終的な歯牙ホワイトニング組成物のpHを6.0〜7.0に調節する、請求項9に記載の歯牙漂白組成物。
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Application Number | Priority Date | Filing Date | Title |
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US76407206P | 2006-02-01 | 2006-02-01 | |
US60/764,072 | 2006-02-01 | ||
PCT/US2007/061477 WO2007090192A2 (en) | 2006-02-01 | 2007-02-01 | Stable one-part aqueous tooth whitening composition |
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JP2009525352A JP2009525352A (ja) | 2009-07-09 |
JP5654201B2 true JP5654201B2 (ja) | 2015-01-14 |
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Country Status (6)
Country | Link |
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US (1) | US8574555B2 (ja) |
EP (1) | EP1986953A4 (ja) |
JP (1) | JP5654201B2 (ja) |
AU (1) | AU2007211012A1 (ja) |
CA (1) | CA2637266A1 (ja) |
WO (1) | WO2007090192A2 (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110171145A1 (en) * | 2010-01-14 | 2011-07-14 | Garrett Caldwell | Tooth whitener and stain remover |
US9949477B2 (en) | 2010-12-30 | 2018-04-24 | Kimberly-Clark Worldwide, Inc. | Durable antimicrobial composition |
MY161688A (en) * | 2011-09-30 | 2017-05-15 | Regenetiss Inc | Tooth whitening composition containing colloidal platinum |
JP5615968B1 (ja) * | 2013-12-19 | 2014-10-29 | 株式会社エイ・アイ・シー | 歯牙用漂白剤、及び歯牙の漂白方法 |
JP6494968B2 (ja) * | 2014-09-26 | 2019-04-03 | 株式会社ジーシー | 歯牙漂白用組成物 |
KR102102116B1 (ko) * | 2015-07-31 | 2020-04-20 | 가부시키가이샤 지씨 | 치아 표백용 조성물 |
US20180153781A1 (en) | 2016-12-06 | 2018-06-07 | Colgate-Palmolive Company | Oral Care Compositions and Methods of Use |
EP3541348B1 (en) * | 2016-12-06 | 2022-04-27 | Colgate-Palmolive Company | Oral care compositions and methods of use |
US11712408B2 (en) * | 2019-04-16 | 2023-08-01 | The Procter & Gamble Company | Semisolid oral dispersions comprising active agents |
US10849729B2 (en) | 2019-04-16 | 2020-12-01 | The Procter & Gamble Company | Multi-phase oral care compositions |
US11224760B2 (en) * | 2019-04-16 | 2022-01-18 | The Procter & Gamble Company | Semisolid oral dispersions comprising bleaching agents |
US11559473B2 (en) | 2019-04-16 | 2023-01-24 | The Procter & Gamble Company | Semisolid oral dispersions comprising active agents |
CN113942980B (zh) * | 2021-11-11 | 2023-11-03 | 河南慧泽生物工程有限公司 | 一种过氧化氢稳定剂 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5012A (en) * | 1847-03-13 | Cutting- stone | ||
US4021A (en) * | 1845-05-01 | Isaac l | ||
US4633181A (en) * | 1983-08-11 | 1986-12-30 | Regents Of The University Of Calif. | Apparatus and method for increasing the sensitivity of a nuclear magnetic resonance probe |
JPH01201244A (ja) * | 1988-02-08 | 1989-08-14 | Toshiba Corp | Mri装置のインピーダンス自動調整装置 |
US5759440A (en) | 1989-07-20 | 1998-06-02 | Interox (Societe Anonyme) | Stabilized aqueuous solution of hydrogen peroxide and process for stabilizing an aqueous solution of hydrogen peroxide |
US5032178A (en) | 1990-02-02 | 1991-07-16 | Demetron Research Corporation | Dental composition system and method for bleaching teeth |
US5036426A (en) * | 1990-02-22 | 1991-07-30 | Board Of Regents, The University Of Texas System | Method and apparatus for tuning and matching an NMR coil |
DE4013111C2 (de) * | 1990-04-25 | 1994-05-26 | Spectrospin Ag | HF-Empfangsspulenanordnung für NMR-Spektrometer |
US5059417A (en) | 1990-06-26 | 1991-10-22 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Peroxide gel dentifrice |
US5171564A (en) | 1991-09-13 | 1992-12-15 | Colgate-Palmolive | Aqueous tooth whitening dentifrice |
US5258710A (en) * | 1992-03-27 | 1993-11-02 | General Electric Company | Cryogenic probe for NMR microscopy |
US5508613A (en) * | 1994-08-29 | 1996-04-16 | Conductus, Inc. | Apparatus for cooling NMR coils |
WO1997007777A1 (en) | 1995-08-15 | 1997-03-06 | Robert Eric Montgomery | Peroxidase-activating oral compositions |
AU7245596A (en) | 1995-09-25 | 1997-04-17 | Robert Eric Montgomery | Tooth bleaching compositions |
BR9710779A (pt) | 1996-07-29 | 2000-10-24 | Robert Eric Montgomery | Composições de dióxido de cloro para clarear dente |
US6475469B1 (en) | 1996-11-21 | 2002-11-05 | Applied Dental Sciences, Inc. | Compositions for removing tooth stains |
US5851748A (en) * | 1996-12-12 | 1998-12-22 | Eastman Kodak Company | Photographic materials and process comprising a particular acylacetanilide yellow dye-forming coupler |
US5858332A (en) * | 1997-01-10 | 1999-01-12 | Ultradent Products, Inc. | Dental bleaching compositions with high concentrations of hydrogen peroxide |
US6221341B1 (en) | 1997-11-19 | 2001-04-24 | Oraceutical Llc | Tooth whitening compositions |
US6348518B1 (en) | 1997-12-10 | 2002-02-19 | R. Eric Montgomery | Compositions for making an artificial prosthesis |
US6162055A (en) | 1998-02-13 | 2000-12-19 | Britesmile, Inc. | Light activated tooth whitening composition and method of using same |
US6458340B1 (en) | 1998-09-10 | 2002-10-01 | Den-Mat Corporation | Desensitizing bleaching gel |
DE19844895C2 (de) * | 1998-09-30 | 2000-10-05 | Wilfried Hellmuth Bergmann | Probenkopf für ein NMR-Spektrometer |
US6555020B1 (en) | 1998-10-29 | 2003-04-29 | Den-Mat Corporation | Stable tooth whitening gels containing high percentages of hydrogen peroxide |
US7785572B2 (en) | 2000-03-17 | 2010-08-31 | Lg Household And Health Care Ltd. | Method and device for teeth whitening using a dry type adhesive |
US6485709B2 (en) | 2001-01-23 | 2002-11-26 | Addent Inc. | Dental bleaching gel composition, activator system and method for activating a dental bleaching gel |
US6500408B2 (en) | 2001-01-27 | 2002-12-31 | Jc Technologies, Inc. | Enamel-safe tooth bleach and method for use |
JP4037716B2 (ja) * | 2001-09-27 | 2008-01-23 | 日本電子株式会社 | 核磁気共鳴装置の多重同調回路およびプローブ |
WO2004103303A2 (en) * | 2003-05-16 | 2004-12-02 | Britesmile Development, Inc. | Therapeutic dental composition |
US20050123502A1 (en) | 2003-10-07 | 2005-06-09 | Chan Shing Y. | Nicotine containing oral compositions |
DE10361347B4 (de) * | 2003-12-16 | 2012-01-19 | Bruker Biospin Gmbh | Probenkopf für Kernresonanzmessungen |
GB0401113D0 (en) * | 2004-01-19 | 2004-02-18 | Glaxo Group Ltd | Tooth whitening composition |
JP2007531771A (ja) | 2004-04-01 | 2007-11-08 | スミスクライン・ビーチャム・コーポレイション | 溶解可能な歯のホワイトニングストリップ |
US20060045854A1 (en) | 2004-08-27 | 2006-03-02 | Lynette Zaidel | Oral care composition with cross-linked polymer peroxide |
US20060051384A1 (en) * | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Antiseptic compositions and methods of use |
US20060147394A1 (en) | 2004-12-30 | 2006-07-06 | Ramachandra Shastry | Tooth whitening composition containing cross-linked polymer-peroxides |
JP2007008874A (ja) * | 2005-06-30 | 2007-01-18 | Gc Corp | ペースト状の歯科用漂白材 |
AU2006296014B2 (en) * | 2005-09-28 | 2011-12-08 | Mitsubishi Gas Chemical Company, Inc. | Teeth whitening material and teeth whitening method |
-
2007
- 2007-02-01 AU AU2007211012A patent/AU2007211012A1/en not_active Abandoned
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- 2007-02-01 EP EP07717516A patent/EP1986953A4/en not_active Withdrawn
- 2007-02-01 JP JP2008553508A patent/JP5654201B2/ja active Active
- 2007-02-01 WO PCT/US2007/061477 patent/WO2007090192A2/en active Application Filing
- 2007-02-01 US US11/670,229 patent/US8574555B2/en active Active
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CA2637266A1 (en) | 2007-08-09 |
EP1986953A2 (en) | 2008-11-05 |
US20070202059A1 (en) | 2007-08-30 |
AU2007211012A1 (en) | 2007-08-09 |
WO2007090192A2 (en) | 2007-08-09 |
WO2007090192A3 (en) | 2007-12-13 |
US8574555B2 (en) | 2013-11-05 |
JP2009525352A (ja) | 2009-07-09 |
EP1986953A4 (en) | 2011-04-20 |
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